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281. Ced -Appendix-2 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced%20-appendix-2.xlsx
     May 29, 2025 - CED studies take too long to initiate, enroll, and there is poor communication about their existence. … that a structured collection of additional evidence on real world use would inform the development of long … recently FDA approved therapy because the goals of CED duplicate the goals of FDA CED studies take too long … Requirement H/J: Guardant supports this modified requirement as long as this does not preclude inclusion … that a structured collection of additional evidence on real world use would inform the development of long

282. Executive summary_Comparative Effectiveness Review No. 250_Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2025 Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2025-surv-rep-update-executive-sum.pdf
     January 01, 2025 - dronabinol Long-acting opioids (MME 69.4 [SD 38.9] mg/day) Route of Administration, Formulation … (strength NR) Nabiximols sublingual oromucosal spray, 2.7 mg THC/2.5 mg CBD per 100 mcl Oral long-acting … Study Duration, Weeks (Range) 12 to 208 52 26 24 24 Abbreviations: CBD = cannabidiol; LAO = long … small short-term improvements in pain with some cannabis products, but the impact on moderate or long … adolescents), studies evaluating specific cannabis-based products available in the United States, studies on long-term

283. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/11_pepticulcer_potential_high_impact_june_2012.pdf
     January 01, 2012 - In the absence of randomized or long-term trials for POEM, some experts are uncertain of POEM’s degree … Long-term PN can lead to serious side effects such as liver damage, the risk of which increases the … Additionally, a long-term extension trial demonstrated some patients treated with teduglutide were … In the absence of randomized or long-term trials for POEM, some experts remain unsure how impactful … What are the long-term outcomes for children with SBS? [internet].

284. High-Cholestorol-Medicines-Update Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_executive.pdf
     February 01, 2014 - ) are: KQ 1: For patients who require intensive lipid-modifying therapy, what are the comparative long-term … Additional long-term trials are needed to compare the tolerability, side effects, and harms with prolonged … In order to answer whether there are long-term benefits with respect to mortality, acute coronary events … Once the effectiveness of each combination regimen on long-term clinical outcomes is established, … Additional studies evaluating long-term clinical benefits and harms are needed to better inform clinical

285. CARDIOVASCULAR (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cardiovascular-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - However, some experts noted insufficient information regarding long-term safety and efficacy. … However, some noted insufficient information regarding long-term safety and efficacy. … However, most experts opined that more data concerning safety and long-term outcomes are needed. … data to assess whether the device would reduce long-term costs of care for this patient population … The importance of long-term studies in determining overall impact on health care costs was noted by

286. Executive Summary_The Effect of Protein Intake on Health: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-protein-intake-executive-summary.pdf
     November 01, 2024 - Improving this evidence base will require more robust long-term studies. … This underlines the crucial need for more comprehensive, high quality, long-term research to strengthen

287. Management and Outcomes of Binge-Eating Disorder in Adults: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_clinician.pdf
     May 01, 2016 - Efficacy studies only measured outcomes at the end of treatment (8 weeks to 6 months) and had no long-term … However, most comparative effectiveness studies had long-term followup (at 6 months, at 12 months, … pharmacological interventions only measured outcomes at the end of treatment (6 to 16 weeks) and had no long-term … The report identified several gaps and limitations in the evidence base: �� A critical gap exists in long-term

288. Angina-Heart-Attack-Treatments Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_executive.pdf
     January 01, 2014 - The cornerstone of short- and long-term treatment in all cases is medical therapy with antiplatelet … Antiplatelet therapy initiated during a hospitalization for UA/NSTEMI and continued for long-term management … Short-term versus long-term dual antiplatelet therapy (clopidogrel) (KQ 3a) • 11 studies (5 RCTs, 6 … Key Points: Short-Term Versus Long-Term Dual Antiplatelet Therapy • There was insufficient evidence … Long-term outcome after an early invasive versus selective invasive treatment strategy in patients

289. Disposition of Comments Report for Otitis Media With Effusion (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ear-infection_disposition-comments.pdf
     May 04, 2013 - Usable is a little harder because the document is very long. … We have examined short v. long term tubes in terms of benefit and harms. … Much of the best data for this comes from long-term follow-up of cohorts from RCTs. … nontreatments make no difference in the long run doesn’t adequately address the important issue. … There appears to be debate about the long term impact of TT insertion in regard to hearing.

290. Microsoft Word - finbody.doc (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-artery-stenosis_research-2007.pdf
     January 01, 2007 - All four studies reported similar long-term mortality (about 30-40 percent at 5 years). … Long-term follow-up of atherosclerotic renovascular disease. Beneficial effect of ACE inhibition. … Long-term follow-up after renal artery stenting. Wien Klin Wochenschr. 2003;115:788-792. 45. … Long-Term Follow-up of Renal Artery Stenting in an Australian Population. … Percutaneous and open renal revascularizations have equivalent long-term functional outcomes.

291. Hypertension-Pulmonary-Arterial Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_executive.pdf
     April 01, 2013 - least 10 mmHg (20%) to below 40 mmHg while maintaining cardiac output; this predicts a favorable long-term … Calcium channel blockers are associated with long-term (>1 year) improvements in hemodynamics and functional … than monotherapy and what effect monotherapy or combination therapy has on intermediate-term and long-term … prognosis or choice of treatment) and patient outcome efficacy (prognosis related to intermediate and long … Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension.

292. Osteoporosis-Bone-Fracture Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
     March 01, 2012 - Key Question 4: What are the short- and long- term harms (adverse effects) of the included therapies … How does the antifracture benefit vary with long-term continued use of therapy? … How does the antifracture benefit vary with long-term continued use of pharmacotherapy? … How long should we treat? … For how long should the “holiday” last?

293. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer_executive.pdf
     February 01, 2008 - • Many randomized trials are inadequately powered to provide long-term survival outcomes, with the … The natural history of PSA- detected tumors is not known because few men remain untreated for a long … Initiation and completion of long-term, adequately powered randomized trials (particularly comparative … What are the comparative risks, benefits, short- and long-term outcomes of therapies for clinically … Long (conventional) arm Medium 1 trial with an adequate method of allocation. (66 Gy in 33 fractions)

294. Update Topic Brief CER 27 NSD FINAL_SJ final (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_overview.pdf
     January 17, 2014 - diabetes mellitus, what is the comparative effectiveness of treatment options in terms of the following long-term

295. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0283_03-10-2008.pdf
     January 01, 2008 - The nominator also asserts that there is a high cost and uncertainty associated with long-term outcomes

296. Dementia-Agitation-Aggression Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-agitation-aggression_research-protocol.pdf
     November 13, 2014 - includes both informal care (i.e., unpaid care provided by family and friends) and formal care (e.g., long-term … patient), stress, and decreased psychological health.11-13 These symptoms also challenge staff in long-term … frameworks; designed to evaluate behaviors in a wide range of settings (e.g., in-home, hospital, or long-term … functioning; and improve levels of distress among persons with dementia and reduce or delay residential long-term … psychosis); stratified by dementia disease stage, symptom severity, type of dementia and staff of long-term

297. Undescended-Testicle Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/undescended-testicle_executive.pdf
     December 01, 2012 - Primary orchiopexy requires that the vessels be long enough to reach into the scrotum. … Intermediate outcomes include psychological benefits in terms of body image, and long- term goals include … Three poor-quality studies reported long-term fertility outcomes in men who had undergone various surgical … Of particular note is a series of studies by Peter Lee and colleagues that describe long-term outcomes … Studies of long-term outcomes of treatment, both fertility and cancer, are notably missing.

298. Antipsychotics-Adults Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-adults_executive.pdf
     August 01, 2012 - Despite our efforts to identify long- term safety data from observational studies, only two retrospective … Short- and long-term evaluations of the effectiveness of FGAs and SGAs with patient subpopulations, … Only two studies with long-term followup were identified; hence, evidence on these important AEs is … Long- term longitudinal studies of at least 2-year duration are needed to detect important differences … Finally, data on long-term safety are lacking and urgently needed. 14 References 1.

299. Treating Infantile Hemangiomas in Children (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_consumer.pdf
     June 01, 2016 - � How long might it take for the IH to go away on its own? … � How long might my child have to take the medicine? … � What short-term and long-term side effects should I watch for?

300. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_executive.pdf
     September 01, 2011 - Although overall rates of neonatal mortality continue to decline, infants born too early are at risk for long-term … Long-term outcomes have not been reported at all. … testing, long-term lung function, and long-term vision. … Lastly, there should be long-term followup to assess subsequent childhood outcomes. … Use of the subcutaneous terbutaline pump for long-term tocolysis.