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241. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - Long-term PN can lead to serious side effects such as liver damage, the risk of which increases the … If teduglutide proves to be generally tolerable in patients with SBS over the long term, reductions … There have been no reports of death or long-term device-related complications such as migration or … In the absence of results from randomized controlled trials and long-term trials, some experts are … Long-term outcomes of an endoscopic myotomy for achalasia: the POEM procedure.

242. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1412.pdf
     January 01, 2015 - Degludec ultra-long-acting insulin (Tresiba) and degludec plus aspart (Ryzodeg) for treatment of type … The delivery system is intended to be used for long-term subcutaneous delivery at a controlled rate … Experts generally agreed that the initial cost of the device would likely be offset by the long-term … other long term delivery system available on the market. … Alimera Sciences provides details on FDA approval of ILUVIEN as the first long-term treatment for

243. Abnormal-Uterine-Bleeding Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/abnormal-uterine-bleeding_research-protocol.pdf
     November 21, 2011 - Terms like menorrhagia (abnormally long or heavy menses) and metrorrhagia (bleeding at irregular intervals … ), were often linked with timing (short or long intervals) and amount (heavy or light) to infer whether … Task Force on Long- Acting Systemic Agents for Fertility Regulation. … The levonorgestrel-releasing intrauterine system provides a reliable, long-term treatment option for … Long-acting reversible contraceptives: intrauterine devices and the contraceptive implant.

244. Back (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/back.pdf
     January 01, 2011 - • Internet  discussions tend to be fueled and dominated by long term survivors • Little discussion … decision o Therapy with possible fatal side effects, no benefit o Therapy to continue current QOL as long

245. Goal Setting (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/delilberative-methods-design-gupta.pdf
     May 29, 2025 - based on the activities, outputs, and short-term outcomes o Long-Term  Expected changes in policy

246. AHRQ Evidence-based Practice Center Program Research Gaps Summary: Telehealth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ehc-research-gaps-telehealth.pdf
     April 01, 2023 - expanding telehealth for a range of uses (e.g., from primary to critical care, and post-acute and long-term … technology, and other resources, as well as limited understanding of the rural context and lack of long-term … Outcomes • Measure outcomes at multiple time points to understand differences in short and long-term … supplement in-person care resulted in similar rates of contraceptive use (oral contraception, condoms, or long-acting

247. Disposition of Comments: Comparative Effectiveness Review No. 273_Treatment of Stages I-III Squamous Cell Anal Cancer: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-disposition-comments.pdf
     August 20, 2024 - • Some reviewers felt that the long-term update (post hoc, secondary analyses) of the RTOG 9811 … “Long-term comparative effectiveness of MMC versus cisplatin for non-metastatic SCCA in terms of oncologic

248. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - that modify the disease or better manage symptoms to keep patients as independent as possible for as long … and MCI include short-acting insulin (Novolin® R), rapid-acting insulin aspartate (NovoLog®), and long … of daily living] scale for adults with AD (p <0.05).”7 Results reported in 2013 from a study using long … Acceptance and adoption: Experts anticipated that the drug’s well-known safety profile and long history … Therapeutic effects of long-acting intranasal insulin Detemir for Alzheimer's dementia or mild cognitive

249. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-gain-prevention_research-protocol.pdf
     January 01, 2020 - of non-obese weight is considered to be an adult weight between a BMI of 18.5 and 29.9 kg/m2 with long-term … □ Orlistat, the Food and Drug Administration (FDA)-approved medication for long-term (>1 year) weight … List of FDA-approved weight management devices or pharmaceutical agents approved for long-term use … Long-term non- pharmacological weight loss interventions for adults with prediabetes. … The clinical effectiveness and cost- effectiveness of long-term weight management schemes for adults

250. Executive summary_Comparative Effectiveness Review No. 250_Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2024 Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-executive-sum.pdf
     January 01, 2024 - dronabinol Long-acting opioids (MME 69.4 (SD 38.9) mg/day) Route of Administration, Formulation … (strength NR) Nabiximols sublingual oromucosal spray, 2.7 mg THC/2.5 mg CBD per 100 mcl Oral long-acting … Study Duration, Weeks (Range) 12 to 208 52 26 24 24 Abbreviations: CBD = cannabidiol; LAO = long-acting … small short-term improvements in pain with some cannabis products, but the impact on moderate or long … adolescents), studies evaluating specific cannabis-based products available in the United States, studies on long-term

251. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - Short-acting or long-acting beta-2 agonists, as well as corticosteroids, may be prescribed to control … One phase III trial is ongoing, evaluating pirfenidone’s long-term safety and efficacy in patients … and emphasized the need for long-term studies. … However, experts thought that patients are likely to accept lumacaftor/ivacaftor if long-term safety … Long-term results of transplantation of normothermic ex vivo perfused donor lungs.

252. Disposition of Comments Report for Interventions To Improve Patient Adherence to Hepatitis C Treatment: Comparative Effectiveness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-treatment-adherence_disposition-comments.pdf
     December 20, 2012 - We modified our future research recommendation to reduce the emphasis on long-term outcomes, and … Definitions are acceptable but I don't think it's reasonable to expect long- term outcomes from these … We have revised our recommendations regarding long-term outcomes. … It otherwise reads as a very long-winded bashing of the literature. … We agree this is a long report.

253. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/11_peptic_ulcer_potential_high_impact_2012-12-111.pdf
     January 01, 2012 - In the absence of randomized controlled trials or long-term trials, some experts were uncertain of … Long-term PN can lead to serious side effects such as liver damage, the risk of which increases the … Additionally, a long-term extension trial demonstrated that some patients treated with teduglutide … Long- term outcomes of an endoscopic myotomy for achalasia: the POEM procedure. … What are the long-term outcomes for children with SBS? [internet].

254. Nonopioid Pharmacologic Treatments for Chronic Pain: Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
     April 01, 2020 - • In the long term, evidence was too limited to draw conclusions. … We recognized that by definition, chronic pain requires treatments that are effective in the long term … Evidence on intermediate- and long-term outcomes was limited to one trial each, with improvements in … In the intermediate and long term, there was not a difference in cardiovascular events between drugs … Evidence on long- term treatment (>12 months) and for quality of life outcomes was sparse.

255. Prostate-Cancer-Therapies-Update Consumer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_consumer.pdf
     January 01, 2016 - age � Your cancer risk level � Your medical history � Other health problems you may have � How long … Some side effects may get better, but some may last a long time or may never go away. … family members � How often you will need to see your doctor for treatment Ask your doctors � How long … � If I have surgery to remove my prostate gland, how long might it take to recover?

256. Disposition of Comments for CER 147 Menopausal Symptoms: Comparative Effectiveness of Therapies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause_disposition-comments.pdf
     March 05, 2015 - If there are no long-term studies of vitamin E that have examined liver toxicity, this should be stated … We have added to the ES, “Although evidence concerning potential long-term benefits are included as … Long term effects of hormone therapy (HT) also were appropriately identified and reviewed, including … As noted above, use of Key Points and graphs help present main points more clearly in such a long and … Also, do you want to more clearly state that menopausal symptoms tend to come on long before the final

257. Progestogens-Preterm-Birth Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth_executive.pdf
     September 01, 2012 - percent of all perinatal morbidity and mortality and are the leading cause of infant mortality and long-term … However, these groups also note interest in assessing long-term safety because the Effective Health … Long-term effects have not been well studied. … Across indications, data are sparse to evaluate influence on near-term and long-term maternal and infant … Ultimately, providing data to support choice of an optimal form of progestogen, to determine whether long-term

258. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_june_2012.pdf
     January 01, 2012 - Ultra-long-acting insulin (degludec) for treatment of T2DM No high-impact potential at this time … However, multiple experts noted the lack of studies of long-term outcomes for patients with BMI <35 … Patients using insulin therapy generally use a long-acting insulin once or twice per day (basal insulin … mechanism of action for subcutaneous infusion of exenatide would “deliver a constant dose over long … However, it is possible that the long-term cost of miniosmotic pump insertion and subcutaneous exenatide

259. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/stem-cell-children_research-protocol.pdf
     November 01, 2010 - comparative harms of HSCT and conventional chemotherapy regarding adverse effects of treatment, long … ERT), substrate reduction with iminosugars, and chaperones regarding adverse effects of treatment, long … : Enzyme-replacement therapy (ERT), substrate reduction with iminosugars, chaperones O: OS; cure; long … HSCT (KQ 1) (KQ 1) (KQ 2) (KQ 1) Final health outcomes  Overall survival  Long … or intervention (KQ 3) (KQ 3) (KQ 4) Final health outcomes  Survival  Cure  Long

260. Behavioral Programs To Help Manage Type 2 Diabetes: A Review of the Research for Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_consumer.pdf
     November 01, 2016 - How long would each program session be? … Having high blood sugar (a condition called “hyperglycemia”) can cause serious health issues in the long