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221. Clopidogrel after Drug-Eluting Stent Implantation: Is current practice sufficient (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/stent-clopidogrel-practice_research.pdf
     March 01, 2009 - Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation. … To assess the association between clopidogrel use and long-term clinical outcomes of patients receiving … We sought to assess the association between clopidogrel use and long-term rates of death and death … Comment Our observational results suggest that patients who received long-term clopidogrel therapy … Further, the indications and rationale for long-term clopidogrel regimens and for its discontinuation

222. CER 173 Executive Summary: Diabetes Medications for Adults With Type 2 Diabetes: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
     January 01, 2015 - safety and adverse effects of the drugs, which vary by drug class, with the goal of improving long- … *For studies comparing thiazolidinediones with metformin, we reviewed only HbA1c, long-term outcomes, … Comparative effectiveness of sulfonylureas compared with metformin for long- term all-cause mortality … The comparative long-term benefits and harms of other diabetes medications remain unclear. … Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis.

223. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
     January 01, 2007 - All the same issues noted for RA of short- and long-term risks and safety, as well as performance in … Long-term extension studies of anti-TNF drugs indicated that the rate of adverse events does not increase … What implications such intermediate outcomes have on the long-term progression of the disease remains … Adequately powered, long-term RCTs must also examine different treatment strategies with and without … Adalimumab for long-term treatment of psoriatic arthritis: forty-eight week data from the Adalimumab

224. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_executive.pdf
     October 01, 2006 - angioplasty with stent placements and medical therapies in the treatment of ARAS, particularly after long-term … antiplatelet, and antilipid treatment) compared to renal artery angioplasty with stent placement on long-term … studies that analyzed at least 30 patients who received angioplasty mostly after 1993 and reported long-term … outcomes (Table B) Among the studies reviewed, the value of diagnostic tests either for predicting long-term … Summary/conclusion/comments Key Question 1: Comparisons Angioplasty with or N/A • 2 RCTs evaluated long-term

225. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetic-neuropathy-disposition-170707.pdf
     March 24, 2017 - The 2 newer studies were based on different long acting formulations. … Review with our pharmacist colleagues confirm that the long acting formulations of gabapentin are … For tramadol and tapentadol, we report in the abstract that “opioids have significant long-term risks … for chronic pain conditions, such as fibromyalgia and low back pain, given lack of evidence for long-term … We initially graded the evidence as moderate given the consistency of the results and long- term (6-

226. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
     March 24, 2017 - The 2 newer studies were based on different long acting formulations. … Review with our pharmacist colleagues confirm that the long acting formulations of gabapentin are … For tramadol and tapentadol, we report in the abstract that “opioids have significant long-term risks … for chronic pain conditions, such as fibromyalgia and low back pain, given lack of evidence for long-term … We initially graded the evidence as moderate given the consistency of the results and long- term (6-

227. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
     December 01, 2010 - The long-term consequences of SGAs remain largely unknown.10 There is debate surrounding the efficacy … To capture data on long-term serious adverse events, the inclusion criteria have been modified to include … illness, health-related quality of life, patient satisfaction, health care-system utilization, and long-term … or retrospectiv$ or cohort$ or control$ or volunteer$ or evaluat$ or compar$ or longitudinal or long … term or long-term or longterm or followup or follow up or follow- up).mp. and (study or studies or

228. Crosscutting-Horizon-Scan-High-Impact-1512 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - . 1 Digital Medicines (Proteus Digital Health Feedback System) for Chronic Conditions Requiring Long-Term … 1. * Digital medicines (Proteus Digital Health Feedback System) for chronic conditions requiring long-term … 2 Digital Medicines (Proteus Digital Health Feedback System) for Chronic Conditions Requiring Long-Term … Long-term cost savings may be realized if digital medicines increase adherence enough to improve patient … Adherence to long-term therapies.

229. Crosscutting-Horizon-Scan-High-Impact-1506 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1506.pdf
     June 01, 2015 - . 1 Digital Medicines (Proteus Digital Health Feedback System) for Chronic Conditions Requiring Long-Term … ES-4 Digital Medicines (Proteus Digital Health Feedback System) for Chronic Conditions Requiring Long-Term … 2 Digital Medicines (Proteus Digital Health Feedback System) for Chronic Conditions Requiring Long-Term … Long-term cost savings may be realized if digital medicines increase adherence enough to improve patient … Adherence to long-term therapies.

230. Misuse of Prescription Stimulants in Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/misuse-prescription-protocol-amendment.pdf
     November 26, 2024 - stimulant medications in adults to understand the patterns / trends in misuse and the short- and long-term … non-fatal  Health measures (cardiovascular, injuries, adverse events)  Psychological outcomes o Long-term … ("Mental Health Outcomes"))) OR ((title: ("short term")) OR (title: ("shorter term")) OR (title: ("long … title: (sequalae))) OR ((abstract: ("short term")) OR (abstract: ("shorter term")) OR (abstract: ("long

231. Radiotherapy Treatments for Head and Neck Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_clinician.pdf
     August 01, 2015 - 75 per- cent of patients with head and neck cancer with curative or palliative intent, often with long-term … �� How the risk of xerostomia might be reduced with the use of IMRT versus 3DCRT �� The potential long-term

232. TND-555-09-03-2013 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-555-09-03-2013.pdf
     January 01, 2013 - What is the evidence that diabetes education results in improved long-term management of diabetes, including … What is the evidence that this knowledge improves long-term metabolic control (i.e., decreases or prevents

233. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - Only one surgical treatment (gastric bypass surgery) has definitively demonstrated long-term efficacy … Food and Drug Administration (FDA)-approved antiobesity pharmacotherapy available for long-term use … The NCD indicated that “the use of the gastric balloon is not covered under Medicare, since the long … Device implantation could have fewer complications than long-term pharmacotherapy for weight loss, … If liraglutide demonstrates safety and long-term efficacy, it could fulfill a large unmet 14

234. #05 DEPRESSION (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/depression_hi_impact.pdf
     October 01, 2014 - effects have led to research on its use to assist in difficult-to-treat cases of PTSD during extra-long … Experts were skeptical about the ability of MDMA-assisted psychotherapy to provide long-term improved … Two experts, however, pointed out that long-term data on the intervention’s benefits have not accrued … However, if more patients with mental health conditions are appropriately managed, long-term costs … and (4) the fact that the health system and current practices do not accommodate extended (8-hour-long

235. Future Research Needs Document (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-cancer-risk-reduction_research.pdf
     October 25, 2010 - Harms - what are the long-term effects of taking raloxifene for 10 or more years? … 2) Target more aggressive types of breast cancer 1) Long-term followup a. … B3: What surveillance mechanisms and intervals optimize short and long term outcomes? C. … Cleveland RJ, Gammon MD, Long C-M, et al. … Long-term metformin use is associated with decreased risk of breast cancer.

236. 8 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-harms_methods.pdf
     November 01, 2008 - when clinical trials are lacking; when generalizability is uncertain; or when investigating rare, long-term … clinical trials is frequently inadequate. 7,8 Second, few RCTs have large enough sample sizes or are long … For example, the Celecoxib Long-term Arthritis Safety Study (CLASS), a major trial of celecoxib, was … Such studies can be excluded from CERs if more reliable long-term, comparative data are available. … Celecoxib Long-term Arthritis Safety Study [see comment].

237. 8 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_chou_assessing_harms_when_comparing.pdf
     November 01, 2008 - when clinical trials are lacking; when generalizability is uncertain; or when investigating rare, long-term … clinical trials is frequently inadequate. 7,8 Second, few RCTs have large enough sample sizes or are long … For example, the Celecoxib Long-term Arthritis Safety Study (CLASS), a major trial of celecoxib, was … Such studies can be excluded from CERs if more reliable long-term, comparative data are available. … Celecoxib Long-term Arthritis Safety Study [see comment].

238. Disposition of Comments for CER 164 Home-Based Primary Care Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/home-based-care_disposition-comments.pdf
     February 16, 2016 - In that table, it is also not clear whether long- term services and supports are included as a required … We did not require that HBPC programs include long term services and supports (LTSS), though as you … We did not exclude cost of the intervention as long as it was included in an outcome (e.g., the cost … This study has been long disputed in the literature. … Whether a care provider following patients into a long-term care facility will be for long term or

239. Prostate-Cancer-Test Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
     October 14, 2011 -  Long-term health outcomes (clinical utility), including reduced mortality/ morbidity and improved …  Long-term health outcomes (clinical utility), including reduced mortality/ morbidity, improved quality … KQ 3  Long-term outcomes: Prostate cancer-related mortality, morbidity, function, quality of life … Long-term outcomes – morbidity, mortality, function, and quality of life Harms – treatment-related … This information will be used to determine if studies of intermediate or long-term outcomes are in the

240. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes_hi_impact.pdf
     March 01, 2012 - Ultra-long-acting insulin (degludec) for treatment of type 2 diabetes ES-3 AHRQ Healthcare … However, given the high risks associated with some forms of bariatric surgery and the long-term lifestyle … However, multiple experts noted the lack of studies of long-term outcomes for patients with BMI <35 … Patients using insulin therapy generally use a long-acting insulin once or twice per day (basal insulin … health.” 65 Collectively, experts commenting on both modifications to exenatide believe that as long