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1521. Disposition of Comments for Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer: An Update of a 2008 Systematic Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_disposition-comments.pdf
      December 16, 2014 - Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results … The best that can be done is for investigators to continue performing long-term followup studies that … Given detection of smaller volume tumors and histologic upgrading the long term outcomes of detected … ADT; iii) EBRT + short- term ADT vs EBRT + long-term ADT; iv) rP +/- EBRT +/- ADT vs EBRT + ADT; v) … Randomised pilot study of dose escalation using conformal radiotherapy in prostate cancer: long-term

1522. Autism Surveillance (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism_surveillance.pdf
      October 01, 2012 - for Early Intensive Behavioral Interventions (EIBI) are possibly out of date due to new RCTs and long-term … However, we did identify long term follow- up (f/u) of two studies included in the original CER. … NA January 2012 - One expert suggested two reports on long term follow-up of studies included in … January 2012 -No new studies on end of tx results that that predict long-term outcomes were identified … cultural counseling or disease management or health care services or continuum of care or long

1523. Microsoft Word - 3-DKE274__ACEI-ARB-DRI__Comments_Disposition_Table-21_Jan_2011 cyk _2_.docx (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_disposition-comments.pdf
      October 07, 2011 - Methods I am concerned about interpreting ‘long term’ as ’12 weeks or longer.’ … It is nowhere near long enough to assess diabetes, cardiovascular events or mortality. … We agree that the impact of cough on quality of life is likely to be modest over the long term and … evidence gaps in the ability to determine whether or not there are clinically meaningful differences in long-term

1524. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/12_pregnancy_potential_high_impact_2012-12-11.pdf
      January 01, 2012 - Although some experts believe long-term studies are needed to properly evaluate this intervention’s … mothers cannot provide it (whether for health or economic reasons) will put the babies at further long-term … experts believe there may be an initial increase in costs, but the reduction in costs stemming from long-term … expert believes providing another nutrition option for VLBW infants could be critical to improving long-term

1525. Treatment of Osteoarthritis of the Knee: An Update Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-knee-update-disposition-archived.pdf
      May 04, 2017 - We have added the definitions of short-term, medium-term, and long-term to the abstract. … Outcome measures were stratified to short-, medium- and long - term effects. such stratification is … Few clinicians expect long- term effects in chronic pain patients with TENS. … When the results speak of long term effects is this with an application of continual application of … over months duration or are we talking about short term application ( a few weeks, then measure long

1526. Treatment of Osteoarthritis of the Knee: An Update Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/osteoarthritis-knee-update-disposition.pdf
      May 04, 2017 - We have added the definitions of short-term, medium-term, and long-term to the abstract. … Outcome measures were stratified to short-, medium- and long - term effects. such stratification is … Few clinicians expect long- term effects in chronic pain patients with TENS. … When the results speak of long term effects is this with an application of continual application of … over months duration or are we talking about short term application ( a few weeks, then measure long

1527. Cancer-Pancreas Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-pancreas_research-protocol.pdf
      August 09, 2013 - What is the comparative impact of the different imaging strategies on long-term survival and quality … What is the comparative impact of the different imaging strategies on long-term survival and quality … The only timing (t) issue concerns the outcome of long-term survival and quality of life, for which … we will define “long-term” as 1 year or more. … Any Key Questions involving comparative clinical management or long-term survival/quality of life.

1528. Understanding Health-Systems’ Use of and Need for Evidence To Inform Decisionmaking (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/health-systems-research.pdf
      October 01, 2017 - Health-systems feel the standard timeframe to generate systematic reviews is very long, which could … In systematic reviews with moderate to high strength of evidence findings, KIs understand the long rigorous … , ‘Go to this link to see more of it’ but when you click on the link it's like two or three pages long … anticipate, believe it or not, is that you won’t be able to respond quickly enough… When asked how long … In addition, we scheduled each of the interviews for hour-long blocks, limiting the amount of feedback

1529. Fatty-Acids-Cardiovascular-Disease Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/fatty-acids-cardiovascular-disease_research-protocol.pdf
      April 02, 2015 - Systematic Review The Office of Dietary Supplements (ODS), the National Institutes of Health (NIH), has a long … eicosapentaenoic acid [EPA], docosapentaenoic acid [DPA], and docosahexaenoic acid [DHA]) are a group of long … After evaluating evidence linking the very long chain n-3 FA—EPA and DHA—to coronary heart disease and … Adipose tissue FA are thought to reflect long- term intake, erythrocytes FA are thought to reflect the … Long chain omega-3 fatty acids and cardiovascular disease: a systematic review.

1530. DEcIDE 32: The Incident User Design in Comparative Effectiveness Research (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/incident-user-design_research.pdf
      May 01, 2012 - ......................................................................10 Reduced Ability to Study Long-Term … The challenge is more complicated than it may seem: Some patients take long drug holidays and then … and other variable-reduction methods can help address that problem.36 Reduced Ability to Study Long-Term … Effects Another tradeoff in the incident user design is that it may not allow evaluation of the long … patients who started on an inhaled corticosteroid according to guidelines and then stepped-up to a long-acting

1531. Presentation of Future Research Needs (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/presentations-future_research.pdf
      April 01, 2012 - for Attention Deficit Hyperactivity Disorder: Effectiveness of Treatment in At-Risk Preschoolers; Long-Term … controlled trials of screening, the question about the adverse consequences of screening (or the long-term … available; adjustment for confounding could be an issue Maybe: Most direct way to address long … for longer-term studies are potential limitations Yes: Most efficient method for evaluating long-term … cooperation from the multiple sponsors; if available, could address less common comorbidities, long

1532. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/ear-infection_research-protocol.pdf
      August 07, 2012 - children identified 16 RCTs that included over 1,800 subjects.19 The effects on multiple short- and long-term … followup, the long-term effects could not be determined. … At least five of the included studies considered long-term outcomes, following children 8 years postsurgery … Based on eight RCTs that followed children for as long as 10 years, the review concluded that there … Laser myringotomy in otitis media with effusion: long-term follow-up.

1533. Methods-Guidance-Topics Methods (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-topics_methods.pdf
      January 01, 2010 - focusing on outcomes that matter most to patients, key questions need to identify the overarching, long-range … advantages and disadvantages of a treatment are based on direct evidence about health outcomes from long-term … Newer classes of drugs may result in better long-term outcomes because they have a better metabolic … Belief: A new long-acting opioid drug for relief of pain is likely to play an important role in chronic … Context: The belief that the new drug has an advantage is based on the fact that it has a long half-life

1534. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
      September 01, 2011 - Peer Reviewer #2 Introduction (Pg 17, line 44) Long term complications also include death, blindness … More examples of long-term complications are now included. … Pg 39, line 57) Says evaluated only children with polyarticular JRA, but in fact any subtype as long … Patients were given the option to receive open-label treatment with abatacept in a 5 year follow-up long … and the establishment of a national registry of all JIA patients in an effort to gather meaningful long-term

1535. high-cholesterol-medicines-update-protocol-130516 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
      December 31, 2013 - patients with moderate or high CHD risk, this comparative effectiveness review (CER) will address long-term … The previous CER initially intended to examine the long-term benefits and rates of serious adverse effects … 2: KQ 3: For patients who require intensive lipid-modifying therapy, what are the comparative long … We will include extensions of RCTs of over 24 weeks, as these will provide long-term followup of a trial … Long-­‐ term effects of pravastatin on plasma concentration of C-­‐reactive protein.

1536. Disposition of Comments Report for Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal Cancer (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_disposition-comments.pdf
      December 11, 2012 - Defintion of "liver dominant" disease can be quite variable although as long as it is applied equally … Results Nor do I see two of the seminal papers on radiofrequency ablation, with large numbers and long-term … Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer: long-term results … The large experience with ablation of liver metastases indicates long-term outcomes similar to that … The FDA has raised the bar considerably, requiring long-term clinical endpoints such as progression-free

1537. Ch 11-User-Guide-To-Ocer 130129 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/ch_11-user-guide-to-ocer_130129.pdf
      January 03, 2012 - approach can limit the questions that can be asked in a study, as excluding prevalent users might omit long-term … users (which could overlook risks that arise over long periods of use). … This is a sensible strategy in a general practice setting as these medications may be started long … Yet, as these medications may be used for decades, long-term users are of great interest. … confounding, or it could be used as a basis for discussion about etiology (e.g., does the outcome have a long

1538. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-atrial-fibrillation_research-protocol.pdf
      January 30, 2012 - days), persistent AF (recurrent episodes that last more than 7 days), and permanent AF (an ongoing long-term … capacity  Health services utilization (hospital admissions, office visits, prescription drug use)  Long-term … days) o Persistent AF (recurrent episodes that last more than 7 days) o Permanent AF (an ongoing, long-term … capacity o Health services utilization (hospital admissions, office visits, prescription drug use) o Long-term … A population-based study of the long-term risks associated with atrial fibrillation: 20-year follow-up

1539. Community-Based Participatory Research Slides Text Version (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/lessons-presentation.pdf
      January 01, 2013 - identity § Cooperative and co-learning process § Systems development & local capacity building § Long … time frame between PCOR and CBPR, what lessons can we draw about how to sustain engagement over the long

1540. Slide 1
      effectivehealthcare.ahrq.gov/sites/default/files/introduction-to-user-guide-overview.pptx
      January 01, 2013 - It is estimated that more than half of treatments lack valid evidence of effectiveness (long-term and … estimated that more than half of medical treatments lack valid evidence of effectiveness, particularly for long-term