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  1. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_surveillance.pdf
    December 01, 2015 - KQ 4: Have improvements in intermediate outcomes (viremia, liver function tests, histologic changes … KQ 4: Have improvements in intermediate outcomes (viremia, liver function tests, histologic changes) … Need for liver transplantation •! Quality of life •! … Improvement in liver histology Settings All settings (including primary care and specialty settings … KQ 4: Have improvements in intermediate outcomes (viremia, liver function tests, histologic changes)
  2. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_surveillance.pdf
    December 01, 2015 - KQ 4: Have improvements in intermediate outcomes (viremia, liver function tests, histologic changes … KQ 4: Have improvements in intermediate outcomes (viremia, liver function tests, histologic changes) … Need for liver transplantation •! Quality of life •! … Improvement in liver histology Settings All settings (including primary care and specialty settings … KQ 4: Have improvements in intermediate outcomes (viremia, liver function tests, histologic changes)
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0404_01-14-2011.pdf
    January 01, 2011 - functional class, improved quality of life); side effects of various drugs (including but not limited to liver
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/distributed-network-ambulatory-therapeutics_research.pdf
    July 01, 2009 - Rates of hypoglycemia, liver injury, and liver failure were rare, and did not differ substantially … Examine comparative safety of medication related adverse events as measured by liver failure, liver … injury, but not liver failure. … Rates of hypoglycemia, liver injury, and liver failure were determined from EHR data. … As was the case in Phase 1, rates of hypoglycemia, liver injury, and liver failure were rare and did
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible.pdf
    January 01, 2021 - associating sugar-rich (particularly fructose rich) diet with increased risk for nonalcoholic fatty liver … Non-Alcoholic Fatty Liver Disease in Overweight Children: Role of Fructose Intake and Dietary Pattern … Carbohydrates and diet patterns in nonalcoholic fatty liver disease in children and adolescents. … KQ Key Questions MHRA Medicines and Healthcare Products Regulatory Agency NAFLD Nonalcoholic Fatty Liver
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/fiber-intake-prepub-final-research-appendix-c.xlsx
    January 01, 2024 - Community 40–65 y; BMI 20–35 kg/m2, habitual WG consumption <24 g/d Diabetes, heart, renal, bowel, liver … , use of medication for dyslipidaemia, T2D or hypertension, diseases including gastrointestinal and liver … the food provided in the study; with or history of endocrine, cardiovascular, arterial hypertension, liver … Pregnancy, Allergies including food allergies, Metal implants, Chronic disease of heart, kidney, or liver … COI) Community nonsmoking, weight-stable males aged 35–55 y history or presence of kidney disease, liver
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/fiber-intake-final-appendix-c.xlsx
    January 01, 2024 - Community 40–65 y; BMI 20–35 kg/m2, habitual WG consumption <24 g/d Diabetes, heart, renal, bowel, liver … COI) Community nonsmoking, weight-stable males aged 35–55 y history or presence of kidney disease, liver … , use of medication for dyslipidaemia, T2D or hypertension, diseases including gastrointestinal and liver … the food provided in the study; with or history of endocrine, cardiovascular, arterial hypertension, liver … Pregnancy, Allergies including food allergies, Metal implants, Chronic disease of heart, kidney, or liver
  8. effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-apf2_0.xlsx
    January 01, 2018 - Placebo-Controlled Trials WAE WAE SAE SAE CV Events CV Events CV Events CV Events GI GI GI GI Liver … Dysfunction Liver Dysfunction Liver Dysfunction Liver Dysfunction Renal Dysfunction Renal Dysfunction … Acetaminophen - Placebo-Controlled Trials WAE WAE SAE SAE Liver Toxicity Liver Toxicity Liver … Toxicity Liver Toxicity Author, Year Quality Pain Population Drug Assessment Time (wk) Time Category … Dysfunction Liver Dysfunction Liver Dysfunction Liver Dysfunction Renal Dysfunction Renal Dysfunction
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
    January 01, 2015 - specified metformin-based combinations of FDA-approved diabetes medications (see Table 1) regarding liver … studies where everyone included has at least one of the following comorbid conditions: • End-stage liver … for metformin vs. sulfonylureas except cancer; evidence is high grade from the prior report): § Liver … § Neuropathy • We will include studies addressing the following safety outcomes for KQ3: § Liver … less than 3 months; and safety outcomes besides hypoglycemia, gastrointestinal side effects, and liver
  10. effectivehealthcare.ahrq.gov/health-topics/hepatitis-c
  11. effectivehealthcare.ahrq.gov/health-topics/cirrhosis
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0398_06-17-2008.pdf
    January 01, 2008 - ESA resistance, malnutrition-inflammation complex syndrome, or other co-morbid conditions such as liver
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/dental-post-transplant-complications-rapid-research.pdf
    May 01, 2025 - performed in the United States, with kidney transplants being the most common at 27,000, followed by liver … an increased risk of death among patients with a functioning graft.17 In another cohort study with liver … A substantial percentage of liver transplant recipients (~50%) and kidney transplant recipients (~40% … Association Between Pre-Transplant Oral Health and Post-Liver Transplant Complications. … dental care not of interest da Silva Santos 2012 Assessment and management of oral health in liver
  14. effectivehealthcare.ahrq.gov/health-topics/bile-duct-diseases
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_executive.pdf
    January 27, 2012 - rates of early mortality.14-16 They are associated with hypertension, heart disease, stroke, cancer, liver … The damage may be either physical (e.g., liver damage from chronic drinking) or mental (e.g., depressive … , and breast; liver cirrhosis; chronic pancreatitis; coronary heart disease; stroke; depression; preterm … Little evidence was available to determine whether naltrexone can be used for people with various liver … conditions.b Future studies could evaluate the use of naltrexone for people with various chronic liver
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/type-2-diabetes-medications-update_research-protocol.pdf
    April 06, 2010 -  Hypoglycemia  Liver injury  Congestive heart failure  Severe lactic acidosis  Cancer  Severe … Retinopathy • Nephropathy • Neuropathy The outcomes for Key Question 3 are: • Hypoglycemia • Liver … □ For Key Question 3, we included the following outcomes: hypoglycemia, liver injury, congestive … □ We included crossover studies for the outcomes of hypoglycemia, liver injury, and GI side effects
  17. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_executive.pdf
    March 01, 2011 - Liver injury 3. Congestive heart failure 4. Severe lactic acidosis 5. Cancer 6. … We also found little evidence regarding liver injury and cancer, outcomes included in the 2007 evidence … Liver injury High The risk of liver injury was similar for thiazolidinediones and sulfonylureas. … Moderate The rates of liver injury were similar between thiazolidinediones and metformin. 15 Table
  18. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_executive.pdf
    September 01, 2009 - Levels of cholesterol are influenced by its production in the liver and the ingestion of dietary fats … Known as statins, these agents reduce the production of cholesterol in the liver by binding with the … significant differences between treatments for the outcomes of withdrawal due to adverse events and liver … In general, studies excluded participants with statin-associated myopathy, deranged liver enzymes, high … prerandomization run-in phase to minimize nonadherence, and conducted frequent laboratory monitoring for liver
  19. effectivehealthcare.ahrq.gov/sites/default/files/lung-cancer-staging_executive.pdf
    April 01, 2016 - localized (the other 4 percent were unstaged).6 The most common sites of metastases for SCLC are the liver … proven or suspected SCLC undergo CT of the chest and abdomen or CT of the chest extending through the liver … pleural effusion, metastases to ipsilateral lung, metastases to contralateral lung, metastases to the liver … Metastases to Adrenal Glands, Liver, or Spleen A single moderate-risk-of-bias study19 reported the single … staging workup consisting of CT of the chest and abdomen or CT of the chest extending through the liver
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_clinician.pdf
    January 01, 2017 - retention may occur with short-term use Allopurinol �� Nausea, upset stomach, diarrhea, and elevated liver … and systemic symptoms (DRESS) syndrome Febuxostat �� Abdominal pain, diarrhea, musculoskeletal pain, liver

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