-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-treatment-adherence_executive.pdf
September 22, 2011 - complications (cirrhosis,
liver failure, and liver cancer), quality of life (QOL),
and transmission … transplants, liver
complications); intermediate outcomes (i.e., change of
HCV DNA from baseline, liver … Liver Int.
2011 Sep;31(8):1090-101. PMID: 21745274.
2. … Liver Int.
2009 May;29(5):721-9. PMID: 19141025.
15. Beste LA, Ioannou GN, Larson MS, et al. … Liver Int.
2011 Apr;31(4):516-24. PMID: 21382162.
17. Julius RJ, Novitsky MA Jr, Dubin WR.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_surveillance.pdf
December 01, 2015 - KQ 4:
Have improvements in intermediate outcomes (viremia, liver function tests, histologic
changes … KQ 4: Have improvements in intermediate outcomes (viremia, liver function tests,
histologic changes) … Need for liver transplantation
•! Quality of life
•! … Improvement in liver histology
Settings All settings (including primary care and specialty settings … KQ 4: Have improvements in intermediate outcomes (viremia, liver function tests, histologic
changes)
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_surveillance.pdf
December 01, 2015 - KQ 4:
Have improvements in intermediate outcomes (viremia, liver function tests, histologic
changes … KQ 4: Have improvements in intermediate outcomes (viremia, liver function tests,
histologic changes) … Need for liver transplantation
•! Quality of life
•! … Improvement in liver histology
Settings All settings (including primary care and specialty settings … KQ 4: Have improvements in intermediate outcomes (viremia, liver function tests, histologic
changes)
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible.pdf
January 01, 2021 - associating sugar-rich
(particularly fructose rich) diet with increased risk for nonalcoholic fatty liver … Non-Alcoholic Fatty Liver Disease in
Overweight Children: Role of Fructose Intake and Dietary Pattern … Carbohydrates and diet patterns in nonalcoholic fatty
liver disease in children and adolescents. … KQ Key Questions
MHRA Medicines and Healthcare Products Regulatory Agency
NAFLD Nonalcoholic Fatty Liver
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/distributed-network-ambulatory-therapeutics_research.pdf
July 01, 2009 - Rates of
hypoglycemia, liver injury, and liver failure were rare, and did not differ substantially … Examine comparative safety of medication related adverse events as
measured by liver failure, liver … injury, but
not liver failure. … Rates of hypoglycemia, liver injury, and liver failure were determined from EHR
data. … As was the case in Phase 1, rates of hypoglycemia, liver injury, and liver failure
were rare and did
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effectivehealthcare.ahrq.gov/health-topics/hepatitis-c
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effectivehealthcare.ahrq.gov/health-topics/cirrhosis
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effectivehealthcare.ahrq.gov/health-topics/bile-duct-diseases
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0398_06-17-2008.pdf
January 01, 2008 - ESA
resistance, malnutrition-inflammation complex syndrome, or other co-morbid conditions
such as liver
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/fiber-intake-final-appendix-c.xlsx
January 01, 2024 - Community 40–65 y; BMI 20–35 kg/m2, habitual WG consumption <24 g/d Diabetes, heart, renal, bowel, liver … COI) Community nonsmoking, weight-stable males aged 35–55 y history or presence of kidney disease, liver … , use of medication for dyslipidaemia, T2D or hypertension, diseases including gastrointestinal and liver … the food provided in the study; with or history of endocrine, cardiovascular, arterial hypertension, liver … Pregnancy, Allergies including food allergies, Metal implants, Chronic disease of heart, kidney, or liver
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fiber-intake-prepub-final-research-appendix-c.xlsx
January 01, 2024 - Community 40–65 y; BMI 20–35 kg/m2, habitual WG consumption <24 g/d Diabetes, heart, renal, bowel, liver … , use of medication for dyslipidaemia, T2D or hypertension, diseases including gastrointestinal and liver … the food provided in the study; with or history of endocrine, cardiovascular, arterial hypertension, liver … Pregnancy, Allergies including food allergies, Metal implants, Chronic disease of heart, kidney, or liver … COI) Community nonsmoking, weight-stable males aged 35–55 y history or presence of kidney disease, liver
-
effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-apf2_0.xlsx
January 01, 2018 - Placebo-Controlled Trials
WAE WAE SAE SAE CV Events CV Events CV Events CV Events GI GI GI GI Liver … Dysfunction Liver Dysfunction Liver Dysfunction Liver Dysfunction Renal Dysfunction Renal Dysfunction … Acetaminophen - Placebo-Controlled Trials
WAE WAE SAE SAE Liver Toxicity Liver Toxicity Liver … Toxicity Liver Toxicity
Author, Year Quality Pain Population Drug Assessment Time (wk) Time Category … Dysfunction Liver Dysfunction Liver Dysfunction Liver Dysfunction Renal Dysfunction Renal Dysfunction
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
January 01, 2015 - specified metformin-based combinations of FDA-approved diabetes medications
(see Table 1) regarding liver … studies where everyone included has at least one of
the following comorbid conditions:
• End-stage liver … for
metformin vs. sulfonylureas except cancer; evidence is high grade from the prior
report):
§ Liver … § Neuropathy
• We will include studies addressing
the following safety outcomes for
KQ3:
§ Liver … less than 3 months; and safety outcomes besides hypoglycemia,
gastrointestinal side effects, and liver
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effectivehealthcare.ahrq.gov/health-topics/hepatitis
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_executive.pdf
January 27, 2012 - rates of early mortality.14-16 They are
associated with hypertension, heart
disease, stroke, cancer, liver … The damage may be either physical
(e.g., liver damage from chronic drinking) or mental (e.g., depressive … , and breast; liver cirrhosis;
chronic pancreatitis; coronary heart disease; stroke;
depression; preterm … Little evidence was available to determine whether
naltrexone can be used for people with various liver … conditions.b
Future studies could evaluate the use of naltrexone for
people with various chronic liver
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effectivehealthcare.ahrq.gov/health-topics/gallbladder-diseases
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/dental-post-transplant-complications-rapid-research.pdf
May 01, 2025 - performed in the United States, with kidney transplants being the most common at 27,000,
followed by liver … an increased risk of death
among patients with a functioning graft.17 In another cohort study with liver … A substantial percentage of liver transplant recipients (~50%) and kidney transplant
recipients (~40% … Association Between Pre-Transplant Oral
Health and Post-Liver Transplant
Complications. … dental
care not of interest
da Silva Santos
2012
Assessment and management of oral health in liver
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effectivehealthcare.ahrq.gov/health-topics/hepatitis-b
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/type-2-diabetes-medications-update_research-protocol.pdf
April 06, 2010 - Hypoglycemia
Liver injury
Congestive heart failure
Severe lactic acidosis
Cancer
Severe … Retinopathy
• Nephropathy
• Neuropathy
The outcomes for Key Question 3 are:
• Hypoglycemia
• Liver … □ For Key Question 3, we included the following outcomes: hypoglycemia, liver injury, congestive … □ We included crossover studies for the outcomes of hypoglycemia, liver injury, and GI side effects
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_executive.pdf
September 01, 2009 - Levels of cholesterol are
influenced by its production in the liver
and the ingestion of dietary fats … Known as statins, these agents
reduce the production of cholesterol in the liver by
binding with the … significant differences between treatments for the
outcomes of withdrawal due to adverse events and liver … In general, studies excluded participants
with statin-associated myopathy, deranged liver
enzymes, high … prerandomization run-in phase to minimize
nonadherence, and conducted frequent laboratory
monitoring for liver