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21. Disposition of Comments Report for Imaging Techniques for the Diagnosis and Staging of Hepatocellular Carcinoma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_disposition-comments.pdf
    October 23, 2014 - The former has at least a chance of characterizing liver lesions while the latter essentially does not … At the end of the day, the liver imaging mix for studies done with the primary aim of HCC detection … Diagnostic criteria (reference standards) varied between trials from explanted liver examination to … For example, in the diagnosis of HCC, BMI, Fatty Liver and Depth of lesions in the liver are potentially … Fatty liver was not evaluated as a potential modifier of diagnostic accuracy.

22. Hepatitis-C-Screening Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_executive.pdf
    November 01, 2012 - of the liver may progress to cirrhosis, which can lead to end-stage liver disease or hepatocellular … , before they develop serious or irreversible liver damage. … or known liver enzyme abnormalities. … Diagnostic accuracy: Enhanced Liver Fibrosis Index (ELF) or Simplified Enhanced Liver Fibrosis Index … Complication rate of percutaneous liver biopsies among persons with advanced chronic liver disease

23. Comparative Effectiveness of β-Adrenergic Antagonists on the Risk of Rehospitalization in Adults with Heart Failure (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-rehospitalization_research.pdf
    November 01, 2007 - of the liver- complete LIVER ICD9D 571 Chronic liver disease and cirrhosis- incomplete LIVER ICD9D … Alcoholic liver disease LIVER OSCR 5713.001 Alcoholic liver disease LIVER OSCR 5714.000 Hepatitis- … OSCR 5715.001 Cirrhosis liver non-alcoholic LIVER OSCR 5715.002 Cirrhosis liver unspecified LIVER … specified liver disorders- complete LIVER ICD9D 573.9 Unspecified disorder of liver- complete LIVER … liver disease- storage LIVER OSCR 5739.005 Metabolic liver disease- other LIVER ICD9D 70.30 Viral

24. Dispostion of Comments Report for Screening for Hepatitis C Virus Infection in Adults (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_disposition-comments.pdf
    November 27, 2012 - liver biopsy and makes no judgment regarding the need for liver biopsy. … Many people drink too much – the patients who end up destroying their livers with ETOH usually have … We revised text throughout the report to replace "liver function test" or "LFT" with the term "liver … In addition, HCV-related liver disease is a leading reason for liver transplants.6 Patients who are … decompensation and liver cancer.

25. Disposition of Comments Report for Local Therapies for Unresectable Primary Hepatocellular Carcinoma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_disposition-comments.pdf
    May 24, 2013 - They vary by liver function, performance status, and tumor stage. … disease, liver failure, and local recurrence (i.e., treatment failure). … are immersed in the area of HCC--as well as those who are involved with patients undergoing RFA for liver … These include (but are not limited to) underlying liver disease, patient performance status, and tumor … Peer Reviewer #4 Results As for comparisons of different local therapies, patient’s liver status

26. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-adherence_research-protocol.pdf
    September 13, 2011 - , liver failure, and liver cancer), quality of life, transmission of HCV, sustained viral response, … cirrhosis ○ Liver failure ○ Liver cancer ○ Quality of life ○ Transmission of HCV • Adverse Effects … transplants  Liver complications o Cirrhosis o Liver failure o Liver cancer  Change of HCV DNA … cirrhosis, liver failure, liver cancer, quality of life, and transmission of HCV. … transplants  Liver complications o Cirrhosis o Liver failure o Liver cancer  Change of HCV DNA

27. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-screening_research-protocol.pdf
    October 20, 2011 - disease in the United States, with the direct medical costs of HCV-related liver disease projected … Does screening for HCV infection in nonpregnant adults without known abnormal liver function tests … Includes individuals without signs or symptoms suggestive of liver disease or known abnormal liver … Includes women without signs or symptoms suggestive of liver disease b. … Sustained virological response, liver function, and histological changes (KQ 6c) d.

28. Managing Gout: A Review of the Research for Adults (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_consumer.pdf
    January 01, 2017 - increase the risk of a gout attack: � Red meats (such as beef, lamb, and pork) and organ meats (such as liver … People with kidney and liver problems should talk with their health care professional before taking … ��Allopurinol and febuxostat may affect how well your liver works. … These medicines can also cause liver damage. … Signs of liver problems can include feeling tired and weak, nausea, vomiting, yellowed skin or eyes

29. Disposition of Comments for Imaging Tests for the Staging of Colorectal Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_disposition-comments.pdf
    November 20, 2014 - The liver lesions were analyzed on a per-lesion basis. … Two studies of interim restaging of colorectal liver metastases included patients with fatty liver … CT for liver metastases, which was based on moderate-strength evidence. … Two studies of interim restaging of colorectal liver metastases included patients with fatty liver … For detecting colorectal liver metastases, MRI is clearly superior to CT. 5.

30. Alcohol-Misuse-Drug-Therapy Consumer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_consumer.pdf
    February 01, 2016 - � People with alcohol use disorder also have a higher risk of: »High blood pressure » Liver problems … ��This medicine can cause liver damage. … Tell your doctor right away if you have signs of liver problems.* Naltrexone (Revia®, Vivitrol®) One … ��People with severe liver problems should not take this medicine. … Tell your doctor if you have ever had liver disease or hepatitis.

31. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1512.pdf
    January 28, 2016 - Twenty percent of patients in the study had liver cirrhosis. … In patients who received a liver transplant, SVR12 was 94%. … Many of these patients have advanced liver disease or other comorbidities. … American Association for the Study of Liver Diseases (AASLD). … In: The International Liver Congress; 2015 Apr 22-26; Vienna (Austria).

32. Refining Key Questions: Interactive Case Study Quiz
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/rfviia.pptx
    May 01, 2010 - transplantation (8 studies) Other liver disease (5 studies) Comparative Studies on Off-Label rFVIIa … Liver Transplant 2005;11:973-9. … due to chronic liver disease. … Liver Transplant 2005;11:895-900. … Activated recombinant factor VII in orthotopic liver transplantation.

33. Refining Key Questions: Interactive Case Study Quiz
    effectivehealthcare.ahrq.gov/sites/default/files/rfviia.pptx
    May 01, 2010 - transplantation (8 studies) Other liver disease (5 studies) Comparative Studies on Off-Label rFVIIa … Liver Transplant 2005;11:973-9. … due to chronic liver disease. … Liver Transplant 2005;11:895-900. … Activated recombinant factor VII in orthotopic liver transplantation.

34. Recombinant-Factor-Viia Clinician (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/recombinant-factor-viia_clinician.pdf
    October 01, 2010 - . ��� Liver transplantation* No effect on mortality, OR time, or ICU length of stay. ��� Possible reduction … Medical Conditions �� Cancer-related conditions. �� Gastrointestinal bleeding not related to liver … disease. �� Hematopoietic stem cell transplantation. �� Liver disease (other than transplantation).

35. The Use of Conjoint Analysis to Elicit Patient Preferences in Selecting Treatment Endpoints (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/mcda-johnson.pdf
    August 27, 2012 - Image: Bar chart showing 3 month, 5-month, and 10-month progression-free survival rates and chance of liver … Image: Bar chart showing 3 month, 5-month, and 10-month progression-free survival rates and chance of liver … Image: Bar chart showing 3 month, 5-month, and 10-month progression-free survival rates and chance of liver … another dashed line from 0.0% to 2.0% with an arrow pointing downward on the 2.0 bar on the chance of liver

36. Colorectal-Cancer-Staging Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_executive.pdf
    September 01, 2014 - liver metastases: Sensitivity: 72.0% to 97.9% Table A. … transplantation, or individuals with chronic liver disease. … For detecting colorectal liver metastases, MRI is superior to CT. … Moderate-strength evidence suggests MRI is superior to CT for detecting colorectal liver metastases … Preoperative staging of patients with liver metastases of colorectal carcinoma.

37. Disposition of Comments_Comparative Effectiveness Review No. 260: Nutrition as Prevention for Improved Cancer Health Outcomes (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-260-improved-cancer-outcomes-disposition-comments.pdf
    May 22, 2023 - For example, for non-alcoholic fatty liver disease- indiced liver fibrosis, some clinical reviewers … are very narrow-minded in insisting that dietary/lifestyle interventions propose/implement liver biopsy-based … confirmation of NASH or liver fibrosis before and after (and in the middle if long- term) the interventions … There are sensitive imaging (MRI, MRE) methods for liver fat/steatosis and liver stiffness/fibrosis … that have been validated against liver biopsy with excellent performance but some clinical reviewers

38. Treatment of Hepatitis C Virus Infection in Adults: Future Research Needs (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-future_research.pdf
    April 01, 2013 - disease, including cirrhosis, liver failure, and hepatocellular cancer. … disease or elevated liver function test. … biopsy vs. those selected for treatment without undergoing a liver biopsy? … Liver biopsy vs. … Treatment of patients with HCV infection with or without liver biopsy.

39. Version-3-Immunity-After-Covid-19-Appendix-Table-B-1 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19-appendix-table-B-1.xlsx
    January 24, 2022 - 109 (80.7) Moderate+severe: 26 (19.3) Becchetti 2021 Humoral response to SARS-CoV-2 infection among liver … transplant recipients 34987065 Humoral response to SARS-CoV-2 infection among liver transplant recipients … Switzerland Belgium Italy The Netherlands Prospective case-control 2 Solid-organ transplant Adult liver … ICU: 0 (0) Caballero-Marcos 2021 Changes in humoral immune response after SARS-CoV-2 infection in liver … immunocompetent patients 33835707 Changes in humoral immune response after SARS-CoV-2 infection in liver

40. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1506.pdf
    December 01, 2015 - disease and the leading cause for liver transplantation in the United States. … Twenty percent of patients in the study had liver cirrhosis. … In patients who received a liver transplant, SVR12 was 94%. … Liver Int. 2012 Feb;32 Suppl 1:108-12. PMID: 22212580. 4. Lam AM, Espiritu C, Bansal S, ET AL. … Top 10 highlights from the Liver Meeting. [internet].