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141. Disposition of Comments for CER 147 Menopausal Symptoms: Comparative Effectiveness of Therapies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause_disposition-comments.pdf
     March 05, 2015 - Why is liver toxicity of vitamin E not mentioned as an agent-specific toxicity? … Vitamin E is permanently stored in the liver (is fat-soluble) so this should be addressed. … If there are no long-term studies of vitamin E that have examined liver toxicity, this should be stated … Liver toxicity of vitamin E was not included, as there is no evidence of an association (Ann Intern

142. Hepatitis Testing | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/hepatitis-testing

143. Bleeding Disorders | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/bleeding-disorders

144. Disposition of Comments Report for Enzyme-Replacement Therapies for Lysosomal Storage Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lysosomal-storage-diseases-therapies_disposition-comments.pdf
     January 01, 2014 - Liver disease can occur rarely, like lung disease. 2. … Signs and symptoms include anemia, hepatosplenomegaly, skeletal disorders and very rarely, lung or liver … Signs and symptoms include anemia, hepatosplenomegaly, skeletal disorders and very rarely, lung or liver … the phase II/III clinical trial are not included Please populate the columns “Substrate level”, “Liver … Please add substrate level, liver and spleen volume, range of motion to “Outcomes Measured” column.

145. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd-2005_executive.pdf
     January 01, 2005 - reported in this study; in surgical group, 3.7% intraoperative complications (splenic, esophageal, and liver

146. Horizon Scanning Protocol and Operations Manual September 2015 Revision (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ahrq-healthcare-horizon-scan-protocol-operations-manual-151001.pdf
     September 01, 2015 - perspectives, while other experts will be unique to the clinical condition (e.g., lung cancer versus liver … meeting presenting diabetes research X X X X X X X 28 European Association for the Study of the Liver … (EASL) 1, 11 Annual meeting presenting research on diseases that affect the liver X X X X X X … Meeting: American Association for the Study of Liver Diseases 1, 11 Annual meeting presenting … research on diseases of the liver X X X X X X X 63 The Obesity Society’s Annual Scientific Meeting

147. Horizon Scanning Protocol and Operations Manual September 2015 Revision (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ahrq-healthcare-horizon-scan-protocol-operations-manual-151001.pdf
     September 01, 2015 - perspectives, while other experts will be unique to the clinical condition (e.g., lung cancer versus liver … meeting presenting diabetes research X X X X X X X 28 European Association for the Study of the Liver … (EASL) 1, 11 Annual meeting presenting research on diseases that affect the liver X X X X X X … Meeting: American Association for the Study of Liver Diseases 1, 11 Annual meeting presenting … research on diseases of the liver X X X X X X X 63 The Obesity Society’s Annual Scientific Meeting

148. Disposition of Comments Report for CER 134 Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_disposition-comments.pdf
     May 13, 2014 - compelling analysis of extended release naltrexone injection in opioid dependent patients with the chronic liver … Review Key Question 3 and Safety of extended release naltrexone injection in patients with chronic liver … state a current limitation/evidence gap on whether naltrexone can be used for people with various liver … Extended release naltrexone injection is not contraindicated in patients with acute hepatitis or liver … Extended release naltrexone injection is not contraindicated in patients with acute hepatitis or liver

149. Vitamin D | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/vitamin-d

150. Disposition of Comments for CER 195 Management of Uterine Fibroids (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-195-disposition-comments-uterine-fibroids.pdf
     December 14, 2017 - draft report, AHRQ used two relatively small Phase II studies to conclude that Ulipristal elevated liver … The Donnez et al studies 2012 showed no increase in liver function enzymes therefore AHRQ should include … (Allergen) Results Recommendation: AHRQ should focus conclusions pertaining to safety, including liver … The two smallest studies reported modest elevations of liver function enzymes during treatment; another … larger trial documented change in liver function enzymes was comparable to those taking placebo.

151. Prevention, Diagnosis, and Management of Opioids, Opioid Misuse and Opioid Use Disorder in Older Adults: Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioids-oa-protocol.pdf
     June 29, 2019 - unable to tolerate non-opioid analgesics (e.g., non-steroidal anti-inflammatory drugs) due to impaired liver … Underlying patient factors, such as fall risk, cognitive impairment, frailty, liver disease, etc. b.

152. Hypertension-Pulmonary-Arterial Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hypertension-pulmonary-arterial_research-protocol.pdf
     January 30, 2013 - right heart failure  Mortality Adverse effects of intervention(s) Safety of pharmacotherapies (liver … bruising, infection, and transient ischemic attack • KQ 3: Adverse effects of pharmacotherapies (liver … outcomes will be framed to help identify adverse events, including bleeding, bruising, infection, liver

153. Disposition of Comments for CER 168 Infantile Hemangioma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/infantile-hemangioma_disposition-comments.pdf
     January 15, 2016 - always used in one of 4 clinical contexts: For diagnosis (is it a hemangioma or not), detection of liver … Final Health Outcomes: is there a causation for problems with thyroid function related to hemangioma liver … of the review process and have noted that some case series have examined rare presentations such as liver

154. EHC Research Protocol: Management of Colonic Diverticulitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
     January 01, 2019 - impact of incidental findings on CTs conducted to rule out or assess diverticulitis (e.g., abnormal liver … possibility of acute diverticulitis, what are the downstream outcomes related to incidental findings (e.g., liver … condition) • KQ 1d: Incidental findings o Sequelae related to incidental findings (e.g., unnecessary liver

155. Alcohol-Misuse Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse_research-protocol.pdf
     April 28, 2010 - The damage may be either physical (e.g., liver damage from chronic drinking) or mental (e.g., depressive … In 2007, the number of alcoholic liver disease-related deaths was 14,406 and the number of alcohol-induced … The damage may be either physical (e.g., liver damage from chronic drinking) or mental (e.g., depressive

156. Management of Infantile Hemangioma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_clinician.pdf
     June 01, 2016 - These include: �� patients who have IH in functionally sensitive areas (e.g., eyes, liver, or airways

157. Pharmacologic and Mechanical Prophylaxis of Venous Thromboembolism Among Special Populations | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/vte-prophyalaxis/research

158. Nonopioid Pharmacologic Treatments for Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonopioid-pharm-chronic-pain-protocol.pdf
     February 01, 2019 - Specific adverse events for each drug class, such as gastrointestinal events, cardiovascular events, and liver … adverse events, according to drug class, such as gastrointestinal and cardiovascular events, kidney and liver

159. Edema | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/edema

160. Treating Disruptive Behavior Disorders in Children and Teens (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_consumer.pdf
     August 01, 2016 - ��Divalproex can cause life-threatening liver and pancreas problems.