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Showing results for "limitations".

81. Disposition of Comments Report for Local Therapies for Unresectable Primary Hepatocellular Carcinoma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_disposition-comments.pdf
    May 24, 2013 - We agree on the limitations of existing evidence as you identified. … Limitations are adequately described. … Technical Expert #5 Discussion/ Conclusion Implications and limitations discussed clearly Thank you … We agree on the limitations of existing evidence as you identified. … We understand the limitations inherent in this review.

82. Disposition of Comments: Comparative Effectiveness Review No. 239: Acute Treatments for Episodic Migraine (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-239-episodic-migraine-comments.pdf
    December 29, 2020 - A few limitations of the evidence base were noted, such as the inability to conduct subgroup analyses … These limitations were acknowledged in the discussion section of the report.

83. Nephropathy-Contrast-Induced Executive-2016 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive-2016.pdf
    January 01, 2016 - Guide for Effectiveness and Comparative Effectiveness Reviews”10 and considered all domains: study limitations … A body of evidence was assessed as having high study limitations if greater than 50 percent of the studies … A body of evidence was assessed as having low study limitations if most (51% or greater) of the studies … Bodies of evidence not meeting one of the above criteria were assessed as having medium study limitations … The body of evidence was considered high grade if study limitations were low and there were no problems

84. Dispostion of Comments Report for Child and Adolescent Exposure to Trauma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-child-interventions_disposition-comments.pdf
    February 11, 2013 - Likewise, future research efforts could be informed by describing the limitations of the evidence base … TEP #4 Introduction Limitations of the review process (page 160, lines 21-37): I am not clear on why … N/A Peer Reviewer #2 Methods Authors describe limitations of data synthesis due to heterogeneity … N/A TEP #2 Discussion/ Conclusion Implications and limitations well stated. … Given the limitations of the data, the report is understandably unable to endorse specific interventions

85. Evidence Summary: Comparative Effectiveness Review No. 238: Cervical Ripening (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-evidence-summary.pdf
    March 01, 2021 - estimates [too few patients or events], lack of corroborating evidence [a single study], and study limitations … Strengths and Limitations The evidence comparing interventions in the outpatient and inpatient settings … sort_by=field_product_pub_date Main Points Background and Purpose Methods Results Strengths and Limitations

86. Disposition of Comments_Comparative Effectiveness Review No. 246: Management of High-Need, High-Cost Patients: A "Best Fit" Framework Synthesis, Realist Review, and Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/hnhc-disposition-comments.pdf
    October 29, 2021 - criteria for the review that encompassed studies of all high-need, high-cost (HNHC) patients because of limitations … We added an acknowledgement of the time/resource limitations that constrained the further development … o We expanded the limitations section to include the acknowledgement that, because we identified HNHC

87. Therapies for Clinically Localized Prostate Cancer: Evidence Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/prostate-cancer-therapies-summary.pdf
    September 01, 2020 - Limitations Our review findings have several limitations including— • Many randomized trials were … 3Amethods_guide_chapter&sort_by=field_product_pub_date Main Points Background and Purpose Methods Results Limitations

88. Comparative Effectiveness Review No. 272_Genitourinary Syndrome of Menopause: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-272-genitourinary-syndrome-executive-summary.pdf
    July 01, 2024 - Explanations for downgrading: aDowngraded one level for study limitations (one or more trials assessed … bDowngraded one level for inconsistency (effect varied across trials) cDowngraded one level for study limitations … less than OIS of 400) gDowngraded one level for imprecision (no or few events) 8 Limitations … 3Amethods_guide_chapter&sort_by=field_product_pub_date Main Points Background and Purpose Methods Results Limitations

89. CER 218 Disposition of Comments: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-disposition-comments.pdf
    April 23, 2019 - Because of space limitations, we added this information to the discussion of the report and evidence … Moreover, the limitations of the observational studies of ONJ are minimized. … This is evident when compared to the detail provided about the methodological limitations of the AFF … We added this point to the limitations section of the report discussion. … “Limitations” on page ES-16 and “Limitations of the Evidence Base” on pages 85-86 are well written,

90. Disposition of Comments_Systematic Review: Implementing Recommended Mental Health and Substance Use Screening and Counseling Interventions in Primary Care Settings for in Children and Adolescents (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/behavioral-health-screening-disposition-comments.pdf
    April 09, 2025 - Clinical practice implications and limitations are well described. Thank you for your comment. … However, it should be strengthened by adding key points from the implications/limitations section of … , Limitations of our Process, and Future Research Directions portion of the discussion (Sections 4.4 … These limitations are critical to understanding the findings in context. … Public Reviewer: American Academy of Pediatrics Methods Methodology limitations.

91. Disposition of Comments for CER 175 Total Worker Health (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/worker-health_disposition-comments.pdf
    May 31, 2016 - Text about study limitations (in the Discussion section) has been edited to note the concerns about … Limitations well described. I am not aware of missing studies. … Peer Reviewer #5 Discussion The limitations are well described. … The authors should add a discussion of limitations discussed in the response to question 1 of this … We have added addressed this comment above and added text to the conclusion and limitations section

92. Decision-Analytic Modeling to Evaluate Benefits and Harms of Medical Tests – Uses and Limitations | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/benefits-harms-modeling/research

93. Disposition of Comments Report for Pharmacologic and Mechanical Prophylaxis of Venous Thromboembolism Among Special Populations (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/vte-prophyalaxis_disposition-comments.pdf
    May 29, 2013 - We draw attention to the limitations of the underlying sparse data in the report. … The limitations of studies included in the review are discussed in sufficient depth. … We have expanded on the limitations of the systematic review in the discussion. … Limitations carefully stated. … We have expanded on the limitations of the systematic review.

94. Ch 2-User-Guide-To-Ocer 130129 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ch_2-user-guide-to-ocer_130129.pdf
    January 01, 2011 - options for nonexperimental comparative effectiveness research (CER), with their relative advantages and limitations … Limitations The case-control study is difficult to conceptualize. … Limitations The need for controls removes the initial motivation for the case-crossover design and … Limitations The need for repeated events or, alternatively, a rare outcome, and the apparent need to … Advantages and limitations of the new-user design are clearly outlined in the paper by Ray.36 Limitations

95. Interventions for Breathlessness in Patients With Advanced Cancer: Evidence Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
    November 01, 2020 - Strengths and Limitations We identified numerous studies evaluating a variety of nonpharmacological … sort_by=field_product_pub_date Main Points Background and Purpose Methods Results Strengths and Limitations

96. Executive Summary_Comparative Effectiveness Review No. 252: Management of Infantile Epilepsies (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-252-infantile-epilepsies-executive-summary.pdf
    October 01, 2022 - Strengths and Limitations Strengths of the review include an exhaustive search for any evidence on infants … Limitations include the lack of control groups in most studies, exclusion of evidence prior to 1999

97. Disposition of Comments for Evidence Report 224 Omega-3 Fatty Acids (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/omega-3-maternity_disposition-comments.pdf
    October 12, 2016 - Yes, we agree and have attempted to delineate the limitations in the Discussion chapter, which we have … augmented with additional limitations noted by some of the reviewers. … We have now added the issue of confounding for observational studies to the Limitations sections. … We have addressed these kinds of limitations in the Discussion section under "Limitations," where we … We have now added a discussion of this point in the Limitations section of the Discussion.

98. AHRQ Evidence-based Practice Center (EPC) Program (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-march-2023-grand-rounds-slides.pdf
    January 01, 2023 - the availability of telehealth technologies. 23 Limitations … Challenges that may be unique to rural applications • Lack of consulting provider familiarity with limitations … Applicability Issues • Diversity across rural settings • Diversity of technology options or technology limitations … specific clinical uses • Data collection and analysis pre pandemic 53 Additional Limitations … frequent: small sample sizes - Lack of power to detect differences or confirm equivalence Data limitations

99. Disposition of Comments for Evidence Report 222 Youth Suicide Prevention (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicide-prevention_disposition-comments.pdf
    October 04, 2016 - We addressed this under “Barriers to Data Linkage”: “There are several barriers or limitations … TEP #2 Discussion/ conclusion It limitations are clear. Nothing was omitted. … This was added to the Limitations: “Definitions of suicide-related constructs should have validity … TEP #5 Discussion/ conclusion The implications and limitations are clearly discussed. … It may also be useful to highlight the data-related limitations of such databases.

100. Interventions Targeting Sensory Challenges in Children With Autism Spectrum Disorders - An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-interventions-disposition.pdf
     May 26, 2017 - We have added additional discussion of the limitations of this literature to the report as well as … We have added some information on considerations of blinding in these kinds of studies to the Limitations … Peer Reviewer #2 Discussion/Con clusion Both reviews/Limitations of the Comparative Effectiveness … I think that the discussion should be rewritten to better reflect the limitations of the studies that … We have added additional detail about methodologic limitations.