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181. Research White Paper Managing Missing Data in Patient Registries Addendum Registries for Evaluating Patient Outcomes Third Edition (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
     February 01, 2018 - enrollment.”4 Thus, left truncation results in data missing in the observed cohort due to non-enrollment, leading

182. Vitamin-D-Calcium-Protocol-130611 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/vitamin-d-calcium_research-protocol.pdf
     September 13, 2013 - Vitamin-D-Calcium-Protocol-130611 Source: www.effectivehealthcare.ahrq.gov Published online: June 10, 2013 1 Evidence-based Practice Center Systematic Review Protocol Project Title: Vitamin D and Calcium: A Systematic Review of Health Outcomes I. Background and Objectives for the Systematic R…

183. Ch 3-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_3-user-guide-to-ocer_130129.pdf
     September 21, 2012 - 35 Abstract Patient populations within a research study are heterogeneous. That is, they embody characteristics that vary between individuals, such as age, sex, disease etiology and severity, presence of comorbidities, concomitant exposures, and genetic variants. These varying patient characteristics can potentiall…

184. Environmental, Clinical and Economic Outcomes of Hospital Resources to Prevent Hospital-Acquired Infections (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prevent-hai-protocol.pdf
     April 16, 2024 - Environmental, Clinical and Economic Outcomes of Hospital Resources to Prevent Hospital-Acquired Infections Evidence-based Practice Center Technical Brief Protocol Project Title: Environmental, Clinical and Economic Outcomes of Hospital Resources to Prevent Hospital-Acquired Infections I. Background and …

185. Research Protocol: Diabetes Medications for Adults With Type 2 Diabetes: An Update Focused on Monotherapy and Add-On Therapy to Metformin (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
     January 01, 2015 - to mortality, morbidity, and health care costs.1-3 Diabetes-related complications were the seventh leading … Diabetes increases the risk of cardiovascular-related death nearly two-fold and is the leading cause … However, in 2013, a re- analysis of the pivotal trial substantially reduced the FDA’s concern leading

186. Disposition of Comments for CER 151 Management of Postpartum Hemorrhage (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_disposition-comments.pdf
     April 28, 2015 - postpartum hemorrhage (PPH) is critical to reducing maternal mortality because PPH is one of the leading … most challenging to quantify and analyze since the disease process such as abnormal placentation leading … evidence regarding best practices for PPH, one of the most common complications of pregnancy, and a leading

187. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_research-protocol.pdf
     March 09, 2010 - This is especially important because there is a workforce shortage of pediatric rheumatologists,5 leading

188. Disposition of Comments for Migraine in Adults: Preventive Pharmacologic Treatments (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_disposition-comments.pdf
     April 18, 2013 - of topiramate caused higher risk of anorexia, depression, paresthesia, and difficulty in memory leading … doses of topiramate caused higher risk of anorexia, depression, paresthesia, and difficulty in memory leading … divalproex, and off-label antiepileptics and antidepressants resulted in bothersome adverse effects leading … studies not just these We clarified that both drugs increased a risk of intolerable adverse effects leading

189. Disposition of Comments for CER 183 Tonsillectomy for OSDB (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy-disposition-170415.pdf
     January 17, 2017 - Peer reviewer #1 Methods Globally, the methodology for extraction and selection of the evidence leading … Please note that in the context of adenotonsillar hypertrophy leading to OSDB, application of CPAP … is not well discussed is whether T, A or T+A lead to normalization of the f/u sleep study vs. only leading … , OSDB It would seem that expertise in pediatric sleep medicine was lacking during the processes leading

190. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/01_arthritis_potential_high_impact_2012-12-10.pdf
     January 01, 2012 - Tofacitinib could cause immunosuppression and has a black box warning about serious infections leading

191. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1512.pdf
     December 29, 2015 - levels, which can result in monosodium urate crystals forming and depositing in and around joints, leading … By selectively inhibiting URAT1, lesinurad is thought to promote urinary excretion of uric acid, leading … However, the experts noted that few agents are available to address the underlying mechanisms leading … : Lesinurad is a selective inhibitor of URAT1 intended to promote urinary excretion of uric acid, leading

192. ADHD-Update-protocol-160818 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-update_research-protocol.pdf
     August 18, 2016 - positives, false negatives, and risk of missed condition that can appear as ADHD (i.e., misdiagnosis) leading

193. Module III: Points of Engagement in the EHC Program (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/module-iii-points-of-engagement-in-the-ehc-program.pdf
     May 29, 2025 - Module III: Points of Engagement in the EHC Program …

194. Nephropathy-Contrast-Induced Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
     October 01, 2015 - The leading theories are that CIN results from hypoxic injury of the renal tubules induced by renal … The reported incidence of CIN varies, but it is a leading cause of hospital-acquired kidney failure

195. Treatments for Chronic Pain | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/collections/treatments-for-chronic-pain

196. Topic Brief: Updating Pharmacotherapy for Adults with Alcohol Use Disorders in Outpatient Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/nt_docs/topic-brief-updating-pharmacotherapy.pdf
     September 30, 2022 - Statistical Manual of Mental Disorders (DSM-V) defines AUD as “a maladaptive pattern of alcohol use leading … approximately 88,000 deaths are directly attributed to alcohol annually, making alcohol use the third leading … An estimated 95,000 Americans die from alcohol- related causes annually, making alcohol the third- leading

197. Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings: Systematic Review Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/alcohol-pharma-final-protocol.pdf
     January 01, 2023 - Background and Objectives for the Systematic Review Update Alcohol consumption is the third leading … alcohol misuse) Term Definition Alcohol-use disorder (DSM-5)5 A maladaptive pattern of alcohol use leading … A maladaptive pattern of alcohol use leading to clinically significant impairment or distress, as manifested … dependence from DSM-IV12 (alcoholism, alcohol addiction) A maladaptive pattern of alcohol use, leading

198. White Paper: Narratively Describing Effects of Interventions in Systematic Reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-roadmap-interventions.pdf
     November 01, 2020 - White Paper: Narratively Describing Effects of Interventions in Systematic Reviews Methods White Paper Roadmap for Narratively Describing Effects of Interventions in Systematic Reviews Methods White Paper Roadmap for Narratively Describing Effects of Interventions in Systematic Reviews Prepared for: Agen…

199. Ace-Inhibitor-Arb-Update-Surveillance-160328 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update-surveillance-160328.pdf
     May 29, 2025 - $ARB$azilsartan$medoxomil$in$patents$with$systolic$ BP$of$150"180mm$found$that$adverse$events$leading … $ARB$azilsartan$ medoxomil$in$patents$with$systolic$BP$of$150" 180mm$found$that$adverse$events$leading … $Adverse$events$leading$to$discontinuation$were$less$frequent$with$AZL"M$40$and$80mg$(2.4%$and$3.1%,$ … prompted$speculation$that$blockade$of$plasma$renin$activity$with$aliskiren$could$be$ overwhelmed,$leading … $ARB$azilsartan$ medoxomil$in$patents$with$systolic$ BP$of$150"180mm$found$that$ adverse$events$leading

200. Introduction-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/introduction-user-guide-to-ocer_130129.pdf
     April 26, 2012 - 1 Introduction to Developing a Protocol for Observational Comparative Effectiveness Research: A User’s Guide Scott R. Smith, Ph.D. Agency for Healthcare Research and Quality, Rockville, MD Background When making health care decisions, patients, health care providers, and policymakers routinely seek unbiased inf…