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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-complaints-tests-children_research-protocol.pdf
    September 29, 2010 - follow-up to a negative RF test when clinical signs, such as symmetrical joint pain and inflammation, lead … effective treatment, JIA can progress and cause damage to cartilage, bone and soft tissues, and may lead … diagnosis has become more common20 and rapid introduction of aggressive immunosuppressive treatment may lead
  2. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/14_substance_abuse_potential_high_impact_2012-12-11.pdf
    January 01, 2012 - population, including low adherence to treatment recommendations and medication diversion, which can lead … low patient adherence to treatment recommendations and medication diversion, either of which can lead
  3. PEPTIC ULCER #11 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1506.pdf
    June 01, 2015 - Bacterial overgrowth in the small intestine may lead to increased gas production, diarrhea, and weight
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/clinical-pathway-methods-report.pdf
    December 01, 2018 - This role is responsible for being the project lead and champion, as well as defining the problem being … Studies that appeared to meet the inclusion criteria were retrieved in full and screened by the lead … there are no potential financial or other conflicts in the guideline project funding or among the lead … B Guideline states that the lead authors have no potential financial or other conflicts, but does … C One or more lead authors, or the guideline project as a whole, is funded by a sponsor with potential
  5. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/rotator-cuff-tear_executive.pdf
    July 01, 2010 - surgical repair compared to late surgical repair (i.e., nonoperative intervention followed by surgery) lead … Does operative repair compared with nonoperative treatment lead to improved health-related quality of
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-options-summarizing.ppt
    June 01, 2012 - If the reference standard does not accurately predict the true status, then it is imperfect and will lead … The complex criteria, as well as the subjective nature of signs and symptoms, lead to differentially … A problem with this method occurs when modeling assumptions are incorrect and lead to biased estimates … It is present in 2 to 4 percent of middle-aged adults and can lead to daytime somnolence, cardiovascular
  7. effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-options-summarizing.ppt
    June 01, 2012 - If the reference standard does not accurately predict the true status, then it is imperfect and will lead … The complex criteria, as well as the subjective nature of signs and symptoms, lead to differentially … A problem with this method occurs when modeling assumptions are incorrect and lead to biased estimates … It is present in 2 to 4 percent of middle-aged adults and can lead to daytime somnolence, cardiovascular
  8. effectivehealthcare.ahrq.gov/products/insulin-blood-sugar-2010/research-protocol
    June 02, 2011 - The resultant hyperglycemia, if untreated, can lead to long-term complications, including microvascular … Eventually, the impairment in insulin resulting from beta cell dysfunction can lead to insulin deficiency … therapy is associated with an increased risk of hypoglycemia and glycemic instability, 7 which can lead … patients at risk for severer hypoglycemic episodes. 10 Finally, intensive insulin therapy can also lead
  9. effectivehealthcare.ahrq.gov/products/heart-failure-natriuretic-peptide/research-protocol
    December 20, 2011 - predict morbidity and mortality in HF patients, as well as whether therapies involving BNP or NT-pro-BNP lead … hyponatremia, decreasing peak exercise oxygen uptake, decreasing hematocrit, widened QRS interval on 12-lead … degree of hyponatremia, decreasing peak exercise oxygen uptake, decreasing hematocrit, widened QRS on 12-lead … hyponatremia, decreasing peak exercise oxygen uptake, decreasing hematocrit, widened QRS interval on 12-lead
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
    October 14, 2011 - These programs are based on the premise that PSA testing can lead to early detection of prostate cancer … However, testing total PSA levels to decide which patients should undergo a biopsy has been found to lead … When total PSA testing identifies patients with cancer-positive biopsies, it can again lead to overtreatment
  11. effectivehealthcare.ahrq.gov/get-involved/nominated-topics/thrombosis-plays-a-a-key-role-in-the-pathophysiology-of-myocardial-infarction-a-leading-cause-of-morbidity-and-mortality-there-have-been-a-number-of-devices-proposed-for-mechanical-thrombectomy-in-patients-with-in-the-settin
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
    December 14, 2015 - I would add that the ionizing radiation concern may delay the ordering of a CT which could then lead … I often miss information on the number of these diagnoses that lead to a change in treatment which … A more important result would be if other pathology was identified, and if the laparoscopy lead to … I am concerned that this study may lead to even higher reliance on radiologic testing that is clearly … and Usability Clarity and Usability: I do not believe that the report in its current form will lead
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar-2010_research-protocol.pdf
    January 01, 2010 - The resultant hyperglycemia, if untreated, can lead to long-term complications, including microvascular … Eventually, the impairment in insulin resulting from beta cell dysfunction can lead to insulin deficiency … therapy is associated with an increased risk of hypoglycemia and glycemic instability, 7 which can lead … patients at risk for severer hypoglycemic episodes. 10 Finally, intensive insulin therapy can also lead
  14. effectivehealthcare.ahrq.gov/products/medicare-utilization-seniors/research
    June 15, 2012 - Data Points #12: Health care use in the first six months of Medicare eligibility for elders: Impact of State support Research Report June 15, 2012 Web Version [NLM Site] Download Main Document PDF 1.4 MB People using assistive technology may not be able to fully access information in these files. For ad…
  15. effectivehealthcare.ahrq.gov/sites/default/files/outcome-definition-and-measurement-chapter-6.pptx
    January 01, 2013 - System One should first determine the source of reporting or detection of a medical condition that may lead … Floor and Ceiling Effects Poor content validity can also lead to a mismatch between the distribution … Failure to account for missing PRO data that are related to poor health or death will lead to an overestimate
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs_research-protocol.pdf
    December 16, 2011 - for women and older people. 3,4 Different approaches to diagnosing RLS and defining its severity lead … RLS-induced sleep disruption may lead to poor daytime functioning, anxiety, and depression. … , anticonvulsive agents, opiates, and iron. 12 Long-term treatment with dopaminergic agents can lead
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/Evidence%20Summary.pdf
    October 01, 2021 - Evidence Summary_Comparative Effectiveness Review No. 246_Management of High-Need High-Cost Patients: A "Best Fit" Framework Synthesis, Realist Review, and Systematic Review Comparative Effectiveness Review Number 246 Management of High-Need, High-Cost Patients: A “Best Fit” Framework Synthesis, Realist Revie…
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hnhc-evidence-summary.pdf
    October 01, 2021 - Evidence Summary_Comparative Effectiveness Review No. 246_Management of High-Need High-Cost Patients: A "Best Fit" Framework Synthesis, Realist Review, and Systematic Review Comparative Effectiveness Review Number 246 Management of High-Need, High-Cost Patients: A “Best Fit” Framework Synthesis, Realist Revie…
  19. effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
    November 01, 2020 - Interventions for Breathlessness in Patients With Advanced Cancer: Evidence Summary Comparative Effectiveness Review Number 232 Interventions for Breathlessness in Patients With Advanced Cancer Evidence Summary Main Points For patients with advanced cancer: • Airflow interventions (fans) were …
  20. effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
    September 01, 2022 - to include an NRSI if its results are likely to be highly biased.4 Results from biased studies can lead … If this assumption, known as the common trends assumption, is not fulfilled, the DiD approach would lead … A heavily biased estimate can be worse than no estimate because it could lead to erroneous conclusions … As a result, poor adjustment (i.e., inadequate or overadjustment) of confounding in NRSIs can lead to … at higher risk of bias will be included with studies at lower risk of bias in the SR, which could lead

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