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361. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-complaints-tests-children_research-protocol.pdf
     September 29, 2010 - follow-up to a negative RF test when clinical signs, such as symmetrical joint pain and inflammation, lead … effective treatment, JIA can progress and cause damage to cartilage, bone and soft tissues, and may lead … diagnosis has become more common20 and rapid introduction of aggressive immunosuppressive treatment may lead

362. #14 SUBSTANCE ABUSE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/14_substance_abuse_potential_high_impact_2012-12-11.pdf
     January 01, 2012 - population, including low adherence to treatment recommendations and medication diversion, which can lead … low patient adherence to treatment recommendations and medication diversion, either of which can lead

363. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1506.pdf
     June 01, 2015 - Bacterial overgrowth in the small intestine may lead to increased gas production, diarrhea, and weight

364. Use of a Clinical Pathway To Facilitate the Translation and Utilization of AHRQ EPC Report Findings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/clinical-pathway-methods-report.pdf
     December 01, 2018 - This role is responsible for being the project lead and champion, as well as defining the problem being … Studies that appeared to meet the inclusion criteria were retrieved in full and screened by the lead … there are no potential financial or other conflicts in the guideline project funding or among the lead … B Guideline states that the lead authors have no potential financial or other conflicts, but does … C One or more lead authors, or the guideline project as a whole, is funded by a sponsor with potential

365. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rotator-cuff-tear_executive.pdf
     July 01, 2010 - surgical repair compared to late surgical repair (i.e., nonoperative intervention followed by surgery) lead … Does operative repair compared with nonoperative treatment lead to improved health-related quality of

366. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-options-summarizing.ppt
     June 01, 2012 - If the reference standard does not accurately predict the true status, then it is imperfect and will lead … The complex criteria, as well as the subjective nature of signs and symptoms, lead to differentially … A problem with this method occurs when modeling assumptions are incorrect and lead to biased estimates … It is present in 2 to 4 percent of middle-aged adults and can lead to daytime somnolence, cardiovascular

367. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-options-summarizing.ppt
     June 01, 2012 - If the reference standard does not accurately predict the true status, then it is imperfect and will lead … The complex criteria, as well as the subjective nature of signs and symptoms, lead to differentially … A problem with this method occurs when modeling assumptions are incorrect and lead to biased estimates … It is present in 2 to 4 percent of middle-aged adults and can lead to daytime somnolence, cardiovascular

368. Comparative Effectiveness and Safety of Insulin Delivery and Glucose Monitoring Methods for Diabetes Mellitus | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/insulin-blood-sugar-2010/research-protocol
     June 02, 2011 - The resultant hyperglycemia, if untreated, can lead to long-term complications, including microvascular … Eventually, the impairment in insulin resulting from beta cell dysfunction can lead to insulin deficiency … therapy is associated with an increased risk of hypoglycemia and glycemic instability, 7 which can lead … patients at risk for severer hypoglycemic episodes. 10 Finally, intensive insulin therapy can also lead

369. Use of Natriuretic Peptide Measurement in the Management of Heart Failure | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/heart-failure-natriuretic-peptide/research-protocol
     December 20, 2011 - predict morbidity and mortality in HF patients, as well as whether therapies involving BNP or NT-pro-BNP lead … hyponatremia, decreasing peak exercise oxygen uptake, decreasing hematocrit, widened QRS interval on 12-lead … degree of hyponatremia, decreasing peak exercise oxygen uptake, decreasing hematocrit, widened QRS on 12-lead … hyponatremia, decreasing peak exercise oxygen uptake, decreasing hematocrit, widened QRS interval on 12-lead

370. Prostate-Cancer-Test Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
     October 14, 2011 - These programs are based on the premise that PSA testing can lead to early detection of prostate cancer … However, testing total PSA levels to decide which patients should undergo a biopsy has been found to lead … When total PSA testing identifies patients with cancer-positive biopsies, it can again lead to overtreatment

371. Thrombosis plays a a key role in the pathophysiology of myocardial infarction-a leading cause of morbidity and mortality. There have been a number of devices proposed for mechanical thrombectomy in patients with in the setting of acute… | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/thrombosis-plays-a-a-key-role-in-the-pathophysiology-of-myocardial-infarction-a-leading-cause-of-morbidity-and-mortality-there-have-been-a-number-of-devices-proposed-for-mechanical-thrombectomy-in-patients-with-in-the-settin

372. Disposition of Comments for CER 157 Appendicitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
     December 14, 2015 - I would add that the ionizing radiation concern may delay the ordering of a CT which could then lead … I often miss information on the number of these diagnoses that lead to a change in treatment which … A more important result would be if other pathology was identified, and if the laparoscopy lead to … I am concerned that this study may lead to even higher reliance on radiologic testing that is clearly … and Usability Clarity and Usability: I do not believe that the report in its current form will lead

373. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar-2010_research-protocol.pdf
     January 01, 2010 - The resultant hyperglycemia, if untreated, can lead to long-term complications, including microvascular … Eventually, the impairment in insulin resulting from beta cell dysfunction can lead to insulin deficiency … therapy is associated with an increased risk of hypoglycemia and glycemic instability, 7 which can lead … patients at risk for severer hypoglycemic episodes. 10 Finally, intensive insulin therapy can also lead

374. Data Points #12: Health care use in the first six months of Medicare eligibility for elders: Impact of State support | Effective Health Care Program
     effectivehealthcare.ahrq.gov/products/medicare-utilization-seniors/research
     June 15, 2012 - Data Points #12: Health care use in the first six months of Medicare eligibility for elders: Impact of State support Research Report June 15, 2012 Web Version [NLM Site] Download Main Document PDF 1.4 MB People using assistive technology may not be able to fully access information in these files. For ad…

375. Outcome Definition and Measurement in Observational Comparative Effectiveness Research
     effectivehealthcare.ahrq.gov/sites/default/files/outcome-definition-and-measurement-chapter-6.pptx
     January 01, 2013 - System One should first determine the source of reporting or detection of a medical condition that may lead … Floor and Ceiling Effects Poor content validity can also lead to a mismatch between the distribution … Failure to account for missing PRO data that are related to poor health or death will lead to an overestimate

376. Restless-Legs Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs_research-protocol.pdf
     December 16, 2011 - for women and older people. 3,4 Different approaches to diagnosing RLS and defining its severity lead … RLS-induced sleep disruption may lead to poor daytime functioning, anxiety, and depression. … , anticonvulsive agents, opiates, and iron. 12 Long-term treatment with dopaminergic agents can lead

377. Evidence Summary_Comparative Effectiveness Review No. 246_Management of High-Need High-Cost Patients: A "Best Fit" Framework Synthesis, Realist Review, and Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/Evidence%20Summary.pdf
     October 01, 2021 - Evidence Summary_Comparative Effectiveness Review No. 246_Management of High-Need High-Cost Patients: A "Best Fit" Framework Synthesis, Realist Review, and Systematic Review Comparative Effectiveness Review Number 246 Management of High-Need, High-Cost Patients: A “Best Fit” Framework Synthesis, Realist Revie…

378. Evidence Summary_Comparative Effectiveness Review No. 246_Management of High-Need High-Cost Patients: A "Best Fit" Framework Synthesis, Realist Review, and Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hnhc-evidence-summary.pdf
     October 01, 2021 - Evidence Summary_Comparative Effectiveness Review No. 246_Management of High-Need High-Cost Patients: A "Best Fit" Framework Synthesis, Realist Review, and Systematic Review Comparative Effectiveness Review Number 246 Management of High-Need, High-Cost Patients: A “Best Fit” Framework Synthesis, Realist Revie…

379. Interventions for Breathlessness in Patients With Advanced Cancer: Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
     November 01, 2020 - Interventions for Breathlessness in Patients With Advanced Cancer: Evidence Summary Comparative Effectiveness Review Number 232 Interventions for Breathlessness in Patients With Advanced Cancer Evidence Summary Main Points For patients with advanced cancer: • Airflow interventions (fans) were …

380. Methods Guide for Comparative Effectiveness Reviews_Inclusion of Nonrandomized Studies of Interventions in Systematic Reviews of Intervention Effectiveness: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
     September 01, 2022 - to include an NRSI if its results are likely to be highly biased.4 Results from biased studies can lead … If this assumption, known as the common trends assumption, is not fulfilled, the DiD approach would lead … A heavily biased estimate can be worse than no estimate because it could lead to erroneous conclusions … As a result, poor adjustment (i.e., inadequate or overadjustment) of confounding in NRSIs can lead to … at higher risk of bias will be included with studies at lower risk of bias in the SR, which could lead