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241. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/01_-arthritis_potential_high_impact_june_2012.pdf
     January 01, 2012 - This may lead to different outcomes among treatment centers. … MSCs are purported to lead to the regeneration of cartilage due to either the secretion of growth factors … However, the mechanism by which these cells lead to cartilage generation is still unclear. 1 MSCs … The experts thought that tofacitinib could improve health outcomes in patients with RA and might lead … the specialist office to primary care offices, which might allow for earlier treatment, but could lead

242. Healthcare Industry Waste and Lifecycle Assessment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lifecycle-assessment-technical-brief-protocol.pdf
     August 23, 2023 - established pathways for recycling.12 In addition to environmental benefits and resource efficiency can lead … has addressed any variation in modelling parameters, methods, data collection and databases that may lead

243. Healthcare Industry Waste and Lifecycle Assessment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lifecycle-assessment-protocol.pdf
     August 23, 2023 - established pathways for recycling.12 In addition to environmental benefits and resource efficiency can lead … has addressed any variation in modelling parameters, methods, data collection and databases that may lead

244. Comparative Effectiveness of Treatment for Phenylketonuria | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/phenylketonuria/research-protocol
     February 08, 2011 - Current Page Topic Timeline Jun. 17, 2009 Topic Suggestion Feb. 8, 2011 Research Protocol Feb. 22, 2012 Systematic Review Nov. 13, 2012 Disposition of Comments Report Jul. 3, 2013 Surveillance Report Comparative Effectiveness of Treatment for Phenylketonuria Research Protocol Archived February 8, 2011 Download Mai…

245. Disposition of Comments Report for Interventions for Feeding and Nutrition in Cerebral Palsy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cerebral-palsy-feeding_disposition-comments.pdf
     March 20, 2013 - review will help policy makers and researchers understand what types of studies are essential to lead … palsy face many nutritional challenges and “frequently have feeding and swallowing problems that may lead

246. Executive Summary_Comparative Effectiveness Review No. 252: Management of Infantile Epilepsies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-252-infantile-epilepsies-executive-summary.pdf
     October 01, 2022 - Points Background and Purpose Infantile epilepsies have serious short-term health risks and may lead

247. Omega-3 Fatty Acids and Cardiovascular Disease: A Review of the Research for Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/fatty-acids-cardiovascular-disease_consumer.pdf
     July 01, 2017 - Having high cholesterol levels and high blood pressure can increase the risk of CV disease and could lead

248. Hypofractionated Radiation Therapy for Localized Prostate Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypofractionated-radiation-therapy-key-question.pdf
     December 19, 2023 - Hypofractionated Radiation Therapy for Localized Prostate Cancer 1 Hypofractionated Radiation Therapy for Localized Prostate Cancer Background One in eight men in the United States will develop prostate cancer in his lifetime1; prostate cancer is the leading type of cancer among men (age-adjusted incidence rat…

249. Using Deliberative Methods to Engage the Public: Facilitating a Deliberative Session (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/deliberative-methods-facilitation-slides-text.pdf
     January 11, 2017 - • Structured Facilitator Guide o Activity, objective, time, lead

250. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/arthritis_hi_impact.pdf
     January 01, 2014 - This may lead to different outcomes among treatment centers. … Overall, experts did not think that pegloticase use would lead to a major shift in the understanding … In general, experts did not think that rilonacept would lead to a major shift in understanding and … However, the mechanism by which these cells lead to cartilage generation is still unclear. 31 MSCs … In general, the experts did not think that belimumab would lead to a major shift in the understanding

251. Impact of Community Health Worker Certification on Workforce and Service Delivery for Asthma and Other Selected Chronic Diseases | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/asthma/protocol
     June 12, 2019 - Third, certification may lead to the creation of hierarchies among CHWs such that uncertified CHWs are

252. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pepticulcer_hi_impact.pdf
     January 01, 2012 - Long-term PN can lead to serious side effects ES-5 AHRQ Healthcare Horizon Scanning System … estimated mortality rate in infants with SBS is 30%. 24 Long-term parenteral nutrition (PN) can lead … Additionally medical advances are now allowing children with conditions that put them at risk for SBS to lead

253. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1306.pdf
     June 01, 2013 - Slowing disease progression could lead to improved quality of life in patients and reduced costs. … Slowed disease progression could lead to improved patient quality of life and reduced costs. … COPD exacerbations can lead to significant declines in lung function and progression towards respiratory

254. Ch 11-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_11-user-guide-to-ocer_130129.pdf
     January 03, 2012 - presence of uncertainty.5 Uncertainty about the most appropriate way to define drug exposure can lead … This result can lead either to insight into potential unaddressed bias or confounding, or it could be … time can be summarized, and differences in the time window during which exposure is determined can lead … For example, an outcome definition of all cardiovascular events including angina could lead to a different … oversampling of cases exposed to one of the drugs under study (or, similarly, an undersampling) can lead

255. The Effectiveness of Disease-Modifying Antirheumatic Drugs (DMARDS) in Children With Juvenile Idiopathic Arthritis (JIA) | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/juvenile-arthritis-dmards/research-protocol
     March 09, 2010 - , their families, and clinicians are especially excited with the new DMARDs, which they believe may lead … evidence would help these other health care providers in making evidence-based decisions and likely lead … Initially, data will be synthesized qualitatively with a particular focus on design issues that may lead

256. Research White Paper Managing Missing Data in Patient Registries Addendum Registries for Evaluating Patient Outcomes Third Edition (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
     February 01, 2018 - (Lead) IQVIA Zhaohui Su, Ph.D. OM1, Inc. Daniel Westreich, Ph.D. … Competing risks can lead to missing data in certain settings; sometimes a study may be interested in … a mastectomy, can be regarded as a variety of missing data; in other cases, competing risks do not lead … documentation of care provided in either inpatient or outpatient settings, but not both, which can lead … This, in turn, may well lead to incomplete adjustment for confounding by age (in a final regression

257. Research White Paper Managing Missing Data in Patient Registries Addendum Registries for Evaluating Patient Outcomes Third Edition (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
     February 01, 2018 - (Lead) IQVIA Zhaohui Su, Ph.D. OM1, Inc. Daniel Westreich, Ph.D. … Competing risks can lead to missing data in certain settings; sometimes a study may be interested in … a mastectomy, can be regarded as a variety of missing data; in other cases, competing risks do not lead … documentation of care provided in either inpatient or outpatient settings, but not both, which can lead … This, in turn, may well lead to incomplete adjustment for confounding by age (in a final regression

258. Management of Suicidal Thoughts in Youth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-key-question_0.pdf
     January 01, 2019 - Management of Suicidal Thoughts in Youth 1 Management of Suicidal Thoughts in Youth Draft Key Questions Background Suicide is the second leading cause of death among high school-aged youths. In 2019, 18.8% of high school students reported having seriously considered suicide, and groups at even higher r…

259. Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/appendicitis/research
     December 14, 2015 - Current Page Topic Timeline Apr. 17, 2013 Topic Initiated Dec. 10, 2013 Research Protocol Dec. 14, 2015 Systematic Review May. 23, 2016 Disposition of Comments Report Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis Systematic Review Archived December 14, 2015 Web Version [NLM Site] Download…

260. Treatments for Fecal Incontinence: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/fecal-incontinence_clinician.pdf
     July 01, 2016 - issues (impaction, large bowel obstruction) Sacral nerve stimulation Infection, pain, electrode or lead