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221. Thrombosis plays a a key role in the pathophysiology of myocardial infarction-a leading cause of morbidity and mortality. There have been a number of devices proposed for mechanical thrombectomy in patients with in the setting of acute… | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/thrombosis-plays-a-a-key-role-in-the-pathophysiology-of-myocardial-infarction-a-leading-cause-of-morbidity-and-mortality-there-have-been-a-number-of-devices-proposed-for-mechanical-thrombectomy-in-patients-with-in-the-settin

222. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
     February 17, 2016 - Untitled   Source: www.effectivehealthcare.ahrq.gov Published online: February 17, 2016 Evidence-based Practice Center Systematic Review Protocol Project Title: Systematic Review Update of Venous Thromboembolism Prophylaxis in Orthopedic Surgery I. Background and Objectives for the Systematic Review Ma…

223. Nephropathy-Contrast-Induced Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
     October 01, 2015 - Clinicians often worry about the possibility that intravascular administration of contrast media could lead … Care Program 2 in most patients, the acute kidney injury may require renal replacement therapy or lead

224. AHRQ Evidence-based Practice Center Program Research Gaps Summary: Primary Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
     March 01, 2022 - • The increased rate of local reactions could potentially lead to increased rate of injury (e.g … mental health issues) and condition characteristics (trauma, abuse) modify response to treatment and lead … • Haloperidol or second-generation antipsychotics used to prevent or treat delirium may lead to little … (SNRIs) (duloxetine and venlafaxine) cause adverse events more often than placebo and most likely lead … fluoxetine) most likely cause adverse events at a similar frequency to placebo therapy but still may lead

225. DuBenske_Presentation_REVISED_FINAL (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/web-based_dubenske_presenter.pdf
     January 01, 2009 - DuBenske_Presentation_REVISED_FINAL   Source:    Eisenberg  Center  Conference  Series  2009,  Translating  Information  Into  Action:  Improving  Quality  of   Care  Through  Interactive  Media,  Effective  Health  Care  Program  Web  site   (http://www.effectivehe…

226. Executive Summary_Comparative Effectiveness Review No. 259: Partial Breast Irradiation for Breast Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-259-partial-breast-irradiation-executive-summary.pdf
     January 01, 2023 - Executive Summary_Comparative Effectiveness Review No. 259: Partial Breast Irradiation for Breast Cancer Comparative Effectiveness Review Number 259 Partial Breast Irradiation for Breast Cancer Executive Summary Main Points • There was no significant difference between partial breast irrad…

227. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-complaints-tests-children_research-protocol.pdf
     September 29, 2010 - follow-up to a negative RF test when clinical signs, such as symmetrical joint pain and inflammation, lead … effective treatment, JIA can progress and cause damage to cartilage, bone and soft tissues, and may lead … diagnosis has become more common20 and rapid introduction of aggressive immunosuppressive treatment may lead

228. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar-2010_research-protocol.pdf
     January 01, 2010 - The resultant hyperglycemia, if untreated, can lead to long-term complications, including microvascular … Eventually, the impairment in insulin resulting from beta cell dysfunction can lead to insulin deficiency … therapy is associated with an increased risk of hypoglycemia and glycemic instability, 7 which can lead … patients at risk for severer hypoglycemic episodes. 10 Finally, intensive insulin therapy can also lead

229. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rotator-cuff-tear_executive.pdf
     July 01, 2010 - surgical repair compared to late surgical repair (i.e., nonoperative intervention followed by surgery) lead … Does operative repair compared with nonoperative treatment lead to improved health-related quality of

230. Executive Summary_Comparative Effectiveness Review No. 269: Respectful Maternity Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-269-respectful-maternity-care-summary.pdf
     January 01, 2024 - A reliable metric informed by a standard definition could lead to further evaluation and implementation

231. Outcome Definition and Measurement in Observational Comparative Effectiveness Research
     effectivehealthcare.ahrq.gov/sites/default/files/outcome-definition-and-measurement-chapter-6.pptx
     January 01, 2013 - System One should first determine the source of reporting or detection of a medical condition that may lead … Floor and Ceiling Effects Poor content validity can also lead to a mismatch between the distribution … Failure to account for missing PRO data that are related to poor health or death will lead to an overestimate

232. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/sensitivity-analysis-chapter-11.pptx
     January 01, 2013 - Exposure, Outcome, and Covariate Definitions Uncertainty about the appropriate study definitions can lead … time can be summarized, and differences in the time window during which exposure is determined can lead

233. Standardized Library of Atrial Fibrillation Outcome Measures (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-library-afib.pdf
     November 15, 2018 - Standardized Library of Atrial Fibrillation Outcome Measures Research White Paper Standardized Library of Atrial Fibrillation Outcome Measures Research White Paper Standardized Library of Atrial Fibrillation Outcome Measures Prepared for: Agency for Healthcare Research and Quali…

234. Santa_ECCS2012 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/santa_eccs2012.pdf
     February 01, 2013 - common in primary care practice,  that was strongly  supported by the evidence,  and that would lead

235. Restless-Legs Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs_research-protocol.pdf
     December 16, 2011 - for women and older people. 3,4 Different approaches to diagnosing RLS and defining its severity lead … RLS-induced sleep disruption may lead to poor daytime functioning, anxiety, and depression. … , anticonvulsive agents, opiates, and iron. 12 Long-term treatment with dopaminergic agents can lead

236. Disposition of Comments for Venous Thromboembolism Prophylaxis in Orthopedic Surgery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
     March 01, 2012 - surgery patients at a much higher rate than general surgery or other medical patients, and it can lead … Cardio-vascular Therapeutic Area Lead Ortho-McNeil Janssen Scientific Affairs Payal Desai, … Cardio-vascular Therapeutic Area Lead Ortho-McNeil Janssen Scientific Affairs Payal Desai, … Cardio-vascular Therapeutic Area Lead Ortho-McNeil Janssen Scientific Affairs Payal Desai, … Cardio-vascular Therapeutic Area Lead Ortho-McNeil Janssen Scientific Affairs Payal Desai,

237. Disposition of Comments: Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-youth-disposition-comments.pdf
     April 10, 2025 - In addition, this reviewer has concerns that saying there is no evidence for safety planning will lead … authors should acknowledge that the medication part is tricky because many underlying conditions can lead … mentioned much until this point- while important feels like comes out of the blue and warrants a better lead … could lead a person to suicide. We agree that this is important to do in clinical practice. … This might lead to a recommendation that an experimental therapeutics approach would improve study

238. White Paper: Enhancing Systematic Review Methods by Incorporating Unpublished Drug Trials (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/unpublished-drug-trials-white-paper.pdf
     December 01, 2024 - This can lead to inflated efficacy estimates and underestimated harms or burdens, as unpublished studies … Such omissions from systematic reviews may lead to inflated estimates of drug efficacy because unpublished

239. Research Protocol (Amended): Treatment of Acute Pain--An Evidence Map (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-protocol-amended.pdf
     June 10, 2018 - Effective treatment of acute pain can minimize the sensitization of pain pathways and tissue damage that lead … The subjective nature of self-report and provider interpretation can lead to a wide range of treatment

240. White Paper_Supplementing Systematic Review Findings With Healthcare System Data: Pilot Projects From the Agency for Healthcare Research and Quality Evidence-based Practice Center Program (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/pilot-projects-supplementing-white-paper.pdf
     December 01, 2024 - However, limitations in the literature may lead to inconclusive findings in EPC systematic reviews ( … However, limitations in the evidence base often lead to inconclusive findings in EPC reports, or findings … The workgroup met monthly via teleconference, which provided lead investigators with an opportunity