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1701. Use of Observational Studies in Systematic Reviews of (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
      June 01, 2010 - gaps with initial consideration of the review questions or after discussion with content experts, may lead … usually require assessment at the individual study level: their consideration a priori will not likely lead … should be considered within and across studies; these flaws potentially invalidate the results (e.g., lead

1702. PHARMACO-EPIDEMIOLOGIC METHODS FOR A STUDY OF (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-cardiovascular-elderly_research.pdf
      February 01, 2009 - Hypoperfusion has been shown to lead to microinfarcts in dementia patients and investigators have proposed … for any improvements in the prevention of cardiac or cerebrovascular events, which could otherwise lead

1703. Han (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/han.pdf
      December 26, 2012 - Han Slide 1: Conceptual, methodological, and ethical problems  in communicating   uncertainty  in clinical  evidence Paul Han, MD, MA, MPH Center for Outcomes Research and Evaluation Maine Medical  Center Slide 2: Communicating  uncertainty in clinical …

1704. Arthritis and Nontraumatic Joint Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1306.pdf
      June 01, 2013 - Cervical DDD occurs when progressive changes in the cervical vertebral discs lead to loss of disc height … This may lead to different outcomes among treatment centers. … MSCs are purported to lead to cartilage regeneration because of the secretion of growth factors by … outcomes: Multilevel DDD presents a significant unmet need for new treatment options because ACDF can lead … However, the mechanism by which these cells lead to cartilage generation is still unclear.33 MSCs may

1705. Diabetes Mellitus (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_june_2012.pdf
      January 01, 2012 - Overall, experts commenting on this topic believe that bariatric surgery has significant potential to lead … also envisioned that early versions of the artificial pancreas would be expensive and most likely lead … Overall, experts commenting on this topic believe that bariatric surgery has the potential to lead

1706. Hepatitis-C Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_executive.pdf
      November 01, 2012 - neuropsychiatric and hematologic adverse effects.23 Such adverse effects can be difficult to tolerate and can lead … regimen recommended by the FDA for antiviral-naïve patients with cirrhosis (4 weeks of dual therapy lead-in … regimens, shorter fixed duration triple therapy boceprevir therapy, and boceprevir without dual therapy lead-in … virologic response Two trials of triple therapy with boceprevir for 48 weeks (4 weeks of dual therapy lead-in … regimens on clinical outcomes in randomized trials or cohort studies is a challenge due to the long lead

1707. Disposition of Comments for Technical Brief 28 MAT Models (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-use-disorder_disposition-comments.pdf
      December 06, 2016 - partnering with physicians to provide MAT.9 Within these arrangements, pharmacists have taken the lead … Lack of provider education in addiction can lead physicians to be uncomfortable treating patients with … University School of Public Health General I believe AHRQ has a very important opportunity to lead … /journals/lancet/article/PIIS0 140- 6736(15)60750-4/abstractPlease do not miss this opportunity to lead … Use of prescription opioids could also lead to use of illicit fentanyl.

1708. PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
      April 01, 2013 - serum total prostate-specific antigen (tPSA) levels was that early detection of prostate tumors would lead … However, screening programs have generated considerable controversy, with concerns expressed that they lead … Lead times and overdetection due to prostate- specific antigen screening: estimates from the European … total prostate specific antigen (tPSA) levels4,5 was that early detection of prostate tumors would lead … Lead times and overdetection due to prostate- specific antigen screening: estimates from the European

1709. Disposition of Comments Report for Technical Brief 14 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-survivor-care-transition_disposition-comments.pdf
      March 18, 2014 - survivorship models, by involving additional clinicians in the health care of the individual, may themselves lead … The point that academic centers took the lead in developing models of survivorship care is missing … populations (specific diseases, specific stages, following particular treatments) is more likely lead … Inadequate care coordination not only may lead to duplication and omission, it may lead to lack of … The early screening can detect impending frailty that could lead to reduced physical functioning or

1710. FRN 39 - Nonoperative and Operative Treatments for Rotator Cuff Tears: Future Research Needs (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/rotator-cuff-tears-future_research.pdf
      February 01, 2013 - KQ 4: Does operative repair compared with nonoperative treatment lead to improved health- related quality … This would lead to greater comparability of populations and outcomes across studies. … Does early vs. late surgical repair (i.e. nonoperative care then surgery) lead to improved HRQoL, … comorbidity information, cuff/tear-specifics, intervention, surgeon and rehabilitation, etc.) can lead … Does operative repair compared with nonoperative treatment lead to improved health-related quality of

1711. Wheelchair-Service Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/wheelchair-service_research-protocol.pdf
      July 01, 2010 - Source: www.effectivehealthcare.ahrq.gov Published Online: July 01, 2010 1 Evidence-based Practice Center Systematic Review Protocol Project Title: Technical Brief – Wheeled Mobility (Wheelchair) Service Delivery I. Background and Objectives for the Technical Brief Wheeled mobility or wheelchair use is …

1712. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-update_research-protocol.pdf
      May 07, 2010 - Evidence-based Practice Center Systematic Review Protocol Source: www.effectivehealthcare.ahrq.gov Published Online: May 07, 2010 Evidence-based Practice Center Systematic Review Protocol Project Title: Comparative Effectiveness of Angiotensin Converting Enzyme Inhibitors (ACEIs) …

1713. Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics – Update | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/atypical-antipsychotics-off-label-update/research-protocol
      May 19, 2010 - Current Page Topic Timeline May. 19, 2010 Research Protocol Jun. 1, 2011 Topic Suggestion Sep. 27, 2011 Systematic Review Jan. 12, 2012 Disposition of Comments Report Jul. 5, 2016 Surveillance Report Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics – Update Research Protocol Archi…

1714. Evidence Report on the (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/arthritis-psoriatric_research-protocol.pdf
      December 06, 2010 - are reviewed for completeness and accuracy by a second senior member of the team, most often the lead

1715. Methods Future Research Needs Number 8: Framework for Considering Study Designs (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-framework_research.pdf
      March 01, 2012 - Centers (EPCs); it represents initial guidance, as additional experience with future research needs may lead … for producing a valid result: Selection bias and group differences in patient characteristics may lead

1716. PULMONARY with "Discussions" in Exec Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
      October 01, 2015 - Blocking these receptors is thought to inhibit the cycles of inflammation and lung repair that lead … These receptors are thought to be involved in cycles of inflammation and lung repair that lead to lung … Additionally, some experts thought that an increased pool of donor lungs would lead to more lung transplants

1717. new disposition of comments insulin analogues -- jda revs.xls (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/insulin-analogues-disposition-081229.pdf
      September 01, 2008 - That might inadvertently lead some physicians to use insulin less often, when it is likely that physicians … However, that doent lead to the next step, that "studies should be planned". … So while these are interesting and legitimate questions, the present dstudy does not lead to the conclusion … THERE IS A REAL DANGER THAT THIS CONCLUSION WILL BE MISINTERPRETED BY SOME PARTIES, TO LEAD TO LONGER

1718. DST_Draft_Protocol_Nov_4_2013_clean (2) (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-decision-support-tools_research-protocol.pdf
      November 12, 2013 - For example, choosing to remove or destroy a low-grade prostatic malignancy can lead to complications … tests are often referred to as tests for publication bias; reasons other than publication bias can lead … The following team members will be involved: • The EPC director • The EPC co-director • 1 Project Lead … • 1 Co-project lead/Research Associate • 1 Local Clinical Expert • 1 Project manager 24

1719. Decision Support Tools for Screening and Treatment Decisions in Early Cancer | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/cancer-decision-support-tools/research-protocol
      November 12, 2013 - For example, choosing to remove or destroy a low-grade prostatic malignancy can lead to complications … tests are often referred to as tests for publication bias; reasons other than publication bias can lead … The following team members will be involved: The EPC director The EPC co-director 1 Project Lead … 1 Co-project lead/Research Associate 1 Local Clinical Expert 1 Project manager 1 Program Assistant

1720. Usefulness of Economic Evaluation Data in Systematic Reviews of Evidence (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/economic-evaluation-data_research.pdf
      October 01, 2012 - It may also lead to greater use of incremental effectiveness (and cost) data to make decisions about … This could lead to a loss of income. … key is that in some cases, self-interest of decisionmaking (as suggested by economic theory) would lead … that combine data that may be new to the evaluation as well as data from previous studies and that lead