-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
June 01, 2010 - gaps with initial consideration of the review questions or after discussion with
content experts, may lead … usually require assessment at the individual study level: their
consideration a priori will not likely lead … should
be considered within and across studies; these
flaws potentially invalidate the results (e.g., lead
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-cardiovascular-elderly_research.pdf
February 01, 2009 - Hypoperfusion has been shown to lead
to microinfarcts in dementia patients and investigators have proposed … for any improvements in the prevention of
cardiac or cerebrovascular events, which could otherwise lead
-
effectivehealthcare.ahrq.gov/sites/default/files/han.pdf
December 26, 2012 - Han
Slide 1: Conceptual, methodological, and ethical problems
in communicating
uncertainty
in clinical
evidence
Paul Han, MD, MA, MPH
Center for Outcomes Research and Evaluation
Maine Medical
Center
Slide 2: Communicating
uncertainty in clinical …
-
effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1306.pdf
June 01, 2013 - Cervical DDD occurs when progressive changes in
the cervical vertebral discs lead to loss of disc height … This may lead to different outcomes among treatment
centers. … MSCs are purported to lead to cartilage regeneration because of the secretion of
growth factors by … outcomes: Multilevel DDD presents a significant unmet need for new
treatment options because ACDF can lead … However, the mechanism by which these cells lead to cartilage
generation is still unclear.33 MSCs may
-
effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_june_2012.pdf
January 01, 2012 - Overall, experts commenting on this topic believe that bariatric
surgery has significant potential to lead … also envisioned that early versions of the artificial pancreas would be expensive and
most likely lead … Overall, experts commenting on this topic believe that bariatric surgery has the potential to lead
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_executive.pdf
November 01, 2012 - neuropsychiatric
and hematologic adverse effects.23 Such adverse effects
can be difficult to tolerate and can lead … regimen recommended by the
FDA for antiviral-naïve patients with cirrhosis (4 weeks of
dual therapy lead-in … regimens,
shorter fixed duration triple therapy boceprevir therapy,
and boceprevir without dual therapy lead-in … virologic
response
Two trials of triple therapy with boceprevir for 48 weeks
(4 weeks of dual therapy lead-in … regimens on clinical outcomes in randomized
trials or cohort studies is a challenge due to the long
lead
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-use-disorder_disposition-comments.pdf
December 06, 2016 - partnering with physicians to provide
MAT.9 Within these arrangements, pharmacists have
taken the lead … Lack of provider education in addiction can
lead physicians to be uncomfortable treating patients
with … University
School of Public
Health
General I believe AHRQ has a very important opportunity to
lead … /journals/lancet/article/PIIS0
140- 6736(15)60750-4/abstractPlease do not miss
this opportunity to lead … Use of prescription opioids could also
lead to use of illicit fentanyl.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
April 01, 2013 - serum total prostate-specific antigen (tPSA)
levels was that early detection of prostate tumors would lead … However, screening programs have generated considerable controversy,
with concerns expressed that they lead … Lead
times and overdetection due to prostate-
specific antigen screening: estimates from
the European … total prostate specific antigen (tPSA)
levels4,5 was that early detection of prostate tumors would lead … Lead
times and overdetection due to prostate-
specific antigen screening: estimates from
the European
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-survivor-care-transition_disposition-comments.pdf
March 18, 2014 - survivorship models, by involving
additional clinicians in the health care of the
individual, may themselves lead … The
point that academic centers took the lead in
developing models of survivorship care is
missing … populations (specific diseases, specific stages,
following particular treatments) is more likely lead … Inadequate care
coordination not only may lead to duplication and
omission, it may lead to lack of … The early screening can detect impending frailty
that could lead to reduced physical functioning or
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rotator-cuff-tears-future_research.pdf
February 01, 2013 - KQ 4: Does operative repair compared with nonoperative treatment lead to improved health-
related quality … This would lead to greater comparability of populations and outcomes across studies. … Does early vs. late surgical
repair (i.e. nonoperative care
then surgery) lead to improved
HRQoL, … comorbidity information, cuff/tear-specifics,
intervention, surgeon and rehabilitation, etc.) can lead … Does operative repair compared with nonoperative treatment lead to improved health-related
quality of
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/wheelchair-service_research-protocol.pdf
July 01, 2010 - Source: www.effectivehealthcare.ahrq.gov
Published Online: July 01, 2010
1
Evidence-based Practice Center Systematic Review Protocol
Project Title: Technical Brief – Wheeled Mobility (Wheelchair) Service
Delivery
I. Background and Objectives for the Technical Brief
Wheeled mobility or wheelchair use is …
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-update_research-protocol.pdf
May 07, 2010 - Evidence-based Practice Center Systematic Review Protocol
Source: www.effectivehealthcare.ahrq.gov
Published Online: May 07, 2010
Evidence-based Practice Center Systematic Review Protocol
Project Title: Comparative Effectiveness of Angiotensin Converting Enzyme Inhibitors (ACEIs)
…
-
effectivehealthcare.ahrq.gov/products/atypical-antipsychotics-off-label-update/research-protocol
May 19, 2010 - Current Page Topic Timeline May. 19, 2010 Research Protocol Jun. 1, 2011 Topic Suggestion Sep. 27, 2011 Systematic Review Jan. 12, 2012 Disposition of Comments Report Jul. 5, 2016 Surveillance Report Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics – Update
Research Protocol Archi…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/arthritis-psoriatric_research-protocol.pdf
December 06, 2010 - are reviewed for
completeness and accuracy by a second senior member of the team, most often the
lead
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-framework_research.pdf
March 01, 2012 - Centers (EPCs); it represents initial guidance, as additional experience
with future research needs may lead … for producing a valid result: Selection bias and group differences
in patient characteristics may lead
-
effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
October 01, 2015 - Blocking these receptors is thought to
inhibit the cycles of inflammation and lung repair that lead … These receptors are thought to be involved in
cycles of inflammation and lung repair that lead to lung … Additionally, some experts
thought that an increased pool of donor lungs would lead to more lung transplants
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/insulin-analogues-disposition-081229.pdf
September 01, 2008 - That might inadvertently lead some
physicians to use insulin less often, when it is likely that physicians … However, that doent lead to the next step, that
"studies should be planned". … So while these are interesting and legitimate questions, the present dstudy
does not lead to the conclusion … THERE IS A REAL DANGER THAT THIS
CONCLUSION WILL BE MISINTERPRETED BY SOME PARTIES, TO LEAD TO LONGER
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-decision-support-tools_research-protocol.pdf
November 12, 2013 - For
example, choosing to remove or destroy a low-grade prostatic malignancy can lead to
complications … tests are often referred to as tests for publication bias; reasons
other than publication bias can lead … The following team members will be involved:
• The EPC director
• The EPC co-director
• 1 Project Lead … • 1 Co-project lead/Research Associate
• 1 Local Clinical Expert
• 1 Project manager
24
-
effectivehealthcare.ahrq.gov/products/cancer-decision-support-tools/research-protocol
November 12, 2013 - For example, choosing to remove or destroy a low-grade prostatic malignancy can lead to complications … tests are often referred to as tests for publication bias; reasons other than publication bias can lead … The following team members will be involved:
The EPC director
The EPC co-director
1 Project Lead … 1 Co-project lead/Research Associate
1 Local Clinical Expert
1 Project manager
1 Program Assistant
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/economic-evaluation-data_research.pdf
October 01, 2012 - It may also lead to greater use of incremental effectiveness
(and cost) data to make decisions about … This could lead
to a loss of income. … key is that in some cases, self-interest of decisionmaking (as suggested by economic
theory) would lead … that combine data that may be new to the evaluation as
well as data from previous studies and that lead