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  1. effectivehealthcare.ahrq.gov/products/depression-postpartum-screening/research-protocol
    March 09, 2012 - criteria for major depression improves outcomes. 3,4,23 If a diagnosis of “minor depression” does not lead … As noted above, if treatment of mild depression does not lead to improved outcomes, then this greater … The comments did not lead to significant changes but were helpful in identifying additional factors of
  2. effectivehealthcare.ahrq.gov/products/instrumental-variable-methods/research
    May 14, 2010 - Small violations of IV assumptions can lead to tremendous inconsistency in the IV estimator when the … Variation in formularies, hospital capacity, and prescription drug benefit plan structure can also lead … However, this can lead to bias if the IV is associated with the actual dose within a dose category. 38
  3. effectivehealthcare.ahrq.gov/sites/default/files/transcript_deliberativemethodswebinar.pdf
    April 19, 2012 - connects to how you envision the concrete actions leading to certain outputs and then how these outputs lead … topic on the practical aspects of deliberative methods is synthesizing outputs, and Julia is going to lead … And I would say that there are a number of ways -- a number of things that could lead people to perceive
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_executive.pdf
    February 01, 2014 - These trials have demonstrated that “add-on” combination therapy can lead to superior lipid outcomes … but fails to reduce atherosclerosis or lead to decreased rates of cardiovascular death, MI, revascularization … monotherapy, such as ENHANCE, AIM-HIGH, and ACCORD-Lipid, have demonstrated that combination therapy can lead
  5. Diabetes Mellitus (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_june_2012.pdf
    January 01, 2012 - Overall, experts commenting on this topic believe that bariatric surgery has significant potential to lead … also envisioned that early versions of the artificial pancreas would be expensive and most likely lead … Overall, experts commenting on this topic believe that bariatric surgery has the potential to lead
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-use-disorder_disposition-comments.pdf
    December 06, 2016 - partnering with physicians to provide MAT.9 Within these arrangements, pharmacists have taken the lead … Lack of provider education in addiction can lead physicians to be uncomfortable treating patients with … University School of Public Health General I believe AHRQ has a very important opportunity to lead … /journals/lancet/article/PIIS0 140- 6736(15)60750-4/abstractPlease do not miss this opportunity to lead … Use of prescription opioids could also lead to use of illicit fentanyl.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
    April 01, 2013 - serum total prostate-specific antigen (tPSA) levels was that early detection of prostate tumors would lead … However, screening programs have generated considerable controversy, with concerns expressed that they leadLead times and overdetection due to prostate- specific antigen screening: estimates from the European … total prostate specific antigen (tPSA) levels4,5 was that early detection of prostate tumors would leadLead times and overdetection due to prostate- specific antigen screening: estimates from the European
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/rotator-cuff-tears-future_research.pdf
    February 01, 2013 - KQ 4: Does operative repair compared with nonoperative treatment lead to improved health- related quality … This would lead to greater comparability of populations and outcomes across studies. … Does early vs. late surgical repair (i.e. nonoperative care then surgery) lead to improved HRQoL, … comorbidity information, cuff/tear-specifics, intervention, surgeon and rehabilitation, etc.) can lead … Does operative repair compared with nonoperative treatment lead to improved health-related quality of
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-survivor-care-transition_disposition-comments.pdf
    March 18, 2014 - survivorship models, by involving additional clinicians in the health care of the individual, may themselves lead … The point that academic centers took the lead in developing models of survivorship care is missing … populations (specific diseases, specific stages, following particular treatments) is more likely lead … Inadequate care coordination not only may lead to duplication and omission, it may lead to lack of … The early screening can detect impending frailty that could lead to reduced physical functioning or
  10. Han (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/han.pdf
    December 26, 2012 - Han Slide 1: Conceptual, methodological, and ethical problems  in communicating   uncertainty  in clinical  evidence Paul Han, MD, MA, MPH Center for Outcomes Research and Evaluation Maine Medical  Center Slide 2: Communicating  uncertainty in clinical …
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-decision-support-tools_research-protocol.pdf
    November 12, 2013 - For example, choosing to remove or destroy a low-grade prostatic malignancy can lead to complications … tests are often referred to as tests for publication bias; reasons other than publication bias can lead … The following team members will be involved: • The EPC director • The EPC co-director • 1 Project Lead … • 1 Co-project lead/Research Associate • 1 Local Clinical Expert • 1 Project manager 24
  12. effectivehealthcare.ahrq.gov/products/cancer-decision-support-tools/research-protocol
    November 12, 2013 - For example, choosing to remove or destroy a low-grade prostatic malignancy can lead to complications … tests are often referred to as tests for publication bias; reasons other than publication bias can lead … The following team members will be involved: The EPC director The EPC co-director 1 Project Lead … 1 Co-project lead/Research Associate 1 Local Clinical Expert 1 Project manager 1 Program Assistant
  13. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_executive.pdf
    December 01, 2011 - between diagnostic tests depend on patient or specimen characteristics or the clinical scenarios that lead … toxigenic C. difficile using Bayes’ formula, then the differences in post-test probabilities might not lead … Failures with vapor disinfection systems would be possible and might lead to toxic exposures of personnel … that detect genetic residue related to C. difficile toxin production rather than the toxins per se lead
  14. effectivehealthcare.ahrq.gov/sites/default/files/topic-refinement.ppt
    March 01, 2010 - Lead investigator, senior scientist, research fellow identified Step 3: Selected team performs general … In the human growth hormone project, the core leadership team identified the lead investigator, senior … Doing so might lead to a perception of what the ultimate project results might be, and then the methods
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-framework_research.pdf
    March 01, 2012 - Centers (EPCs); it represents initial guidance, as additional experience with future research needs may lead … for producing a valid result: Selection bias and group differences in patient characteristics may lead
  16. effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
    October 01, 2015 - Blocking these receptors is thought to inhibit the cycles of inflammation and lung repair that lead … These receptors are thought to be involved in cycles of inflammation and lung repair that lead to lung … Additionally, some experts thought that an increased pool of donor lungs would lead to more lung transplants
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/insulin-analogues-disposition-081229.pdf
    September 01, 2008 - That might inadvertently lead some physicians to use insulin less often, when it is likely that physicians … However, that doent lead to the next step, that "studies should be planned". … So while these are interesting and legitimate questions, the present dstudy does not lead to the conclusion … THERE IS A REAL DANGER THAT THIS CONCLUSION WILL BE MISINTERPRETED BY SOME PARTIES, TO LEAD TO LONGER
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/wheelchair-service_research-protocol.pdf
    July 01, 2010 - Source: www.effectivehealthcare.ahrq.gov Published Online: July 01, 2010 1 Evidence-based Practice Center Systematic Review Protocol Project Title: Technical Brief – Wheeled Mobility (Wheelchair) Service Delivery I. Background and Objectives for the Technical Brief Wheeled mobility or wheelchair use is …
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-update_research-protocol.pdf
    May 07, 2010 - Evidence-based Practice Center Systematic Review Protocol Source: www.effectivehealthcare.ahrq.gov Published Online: May 07, 2010 Evidence-based Practice Center Systematic Review Protocol Project Title: Comparative Effectiveness of Angiotensin Converting Enzyme Inhibitors (ACEIs) …
  20. effectivehealthcare.ahrq.gov/products/atypical-antipsychotics-off-label-update/research-protocol
    May 19, 2010 - Current Page Topic Timeline May. 19, 2010 Research Protocol Jun. 1, 2011 Topic Suggestion Sep. 27, 2011 Systematic Review Jan. 12, 2012 Disposition of Comments Report Jul. 5, 2016 Surveillance Report Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics – Update Research Protocol Archi…

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