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1241. #06 Developmental Delays ADHD, and Autism (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/devdelays_adhd_autism_hi_impact.pdf
      January 01, 2012 - clinical expert thought the device could improve knowledge and understanding about ASDs, which could lead

1242. Noninvasive Testing for Coronary Artery Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-disease-testing_research-protocol.pdf
      January 15, 2015 - certain risk factors for atherosclerosis (lipid disorders, diabetes) and plaque development itself can lead … cases, the plaque may rupture and create a blood clot; this combination of plaque and blood clot may lead

1243. Disposition of Comments CER 194 Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-194-disposition-comments-inhaled-corticosteroids.pdf
      March 19, 2018 - the strength of the evidence for the different approaches assessed (i.e., KQ1, KQ2 and KQ3) could lead … we have added more discussion as to the common reasons for this SOE rating and what may possibly lead … Technically, this is indisputable, but might lead practitioners to wrongly conclude, for example, that

1244. First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update-disposition-170621.pdf
      March 16, 2017 - Section Comment Response TEP 1 Discussion It is in general informative, but some statements could lead … trials had high risk of biases”, while observational studies had only low or moderate risk of bias can lead … We agree that this might lead to misinterpretations.

1245. First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-children-update-disposition-170621.pdf
      March 16, 2017 - Section Comment Response TEP 1 Discussion It is in general informative, but some statements could lead … trials had high risk of biases”, while observational studies had only low or moderate risk of bias can lead … We agree that this might lead to misinterpretations.

1246. Decision Modeling (ppt file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-decision-modeling.ppt
      June 01, 2012 - physicians may not act according to the results, patients may not follow orders, or the intervention may not lead … search terms such as “model(s),” “modeling,” “simulat*,” or terms for decision or economic analysis may lead … using terms such as “model(s),” “modeling,” “simulat*,” or terms for decision or economic analysis may lead

1247. Decision Modeling (ppt file)
      effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-decision-modeling.ppt
      June 01, 2012 - physicians may not act according to the results, patients may not follow orders, or the intervention may not lead … search terms such as “model(s),” “modeling,” “simulat*,” or terms for decision or economic analysis may lead … using terms such as “model(s),” “modeling,” “simulat*,” or terms for decision or economic analysis may lead

1248. Urinary-Incontinence-Treatment Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-treatment_research-protocol.pdf
      September 30, 2010 - in primary urethral incompetence and stress UI.17,18 The differences in baseline mechanisms of UI lead … incontinence or changes in its severity, as perceived by the patient, caregiver, or partner, and may lead … incontinence or changes in its severity, as perceived by the patient, caregiver, or partner, and may lead

1249. Bladder-Cancer-Non-Muscle-Invasive Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/bladder-cancer-non-muscle-invasive_research-protocol.pdf
      July 21, 2014 - Tests with high false positive rates could lead to unnecessary invasive procedures for further evaluation … and tests with high false negative rates could lead to missed diagnoses.

1250. RESPONSE TO REQUEST FOR WORK ASSIGNMENT (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-anticholinergic-medicines_research.pdf
      December 01, 2009 - Patients enrolled in trials, which employ rigid inclusion and exclusion criteria, often lead to selected … We are also unable to measure other important covariates like smoking status which may lead to unmeasured

1251. S5 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/s5.pdf
      October 01, 2007 - missing from auto- mated databases; yet another complication can develop if patients’ characteristics lead

1252. Case Study Comparing Bayesian and Frequentist Approaches for Multiple Treatment Comparisons (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/indirect-comparisons_research.pdf
      March 01, 2013 - Bayesian methods also lead to more clinically interpretable results (through their ability to assign … studies that defined improvement as a reduction of 75 percent in UI episodes (instead of 50 percent) lead … cystocele, and recurrent or active urinary tract infection; patients with abnormal findings on 12-lead

1253. Project Title: Evaluation of Suspicious Skin Lesions Using Non-Invasive Diagnostic Techniques, a Technical Brief (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/skin-lesions-evaluation_research-protocol.pdf
      August 23, 2010 - Project Title: Evaluation of Suspicious Skin Lesions Using Non-Invasive Diagnostic Techniques, a Technical Brief Source: www.effectivehealthcare.ahrq.gov Published Online: August 23, 2010 1 Evidence-based Practice Center Technical Brief Protocol Project Title: Technical Brief - Evaluation of Suspiciou…

1254. Disposition of Comments for CER 177 Agitation Aggression Dementia (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/dementia-agitation-aggression_disposition-comments.pdf
      March 21, 2016 - Consequently the same factors that lead to treatment with antipsychotics are also likely to be causing

1255. Disposition of Comments for CER 161 Major Depressive Disorder (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/major-depressive-disorder-disposition-160504.pdf
      December 08, 2015 - Overall, response and remission rates did not lead to statistically different response or remission … In a chronically recurrent disorder like depression that is a very large advantage and might well lead … CBT” are used in different ways by different researchers and practitioners (and that doing so can lead … This may lead to erroneous conclusions by many readers since few people will take the time to read the … John’s wort did not lead to statistically different rates of rates compared with SGAs” Thank you.

1256. Chronic Kidney Disease Stages 1-3: Screening, Monitoring, and Treatment (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_disposition-comments.pdf
      August 01, 2012 - The reviewer seems to be suggesting that provider knowledge that a patient has CKD might lead to a

1257. PULMONARY with "Discussions" in Exec Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1512.pdf
      December 01, 2015 - Uncontrolled severe asthma may lead to hospitalization or death. … Blocking these receptors is thought to inhibit the cycles of inflammation and repair that lead to lung … completely effective in about 5% of patients with severe asthma.30,32 Uncontrolled severe asthma may lead … These receptors are thought to be involved in cycles of inflammation and repair that lead to lung fibrosis

1258. Future Research Needs for the Comparative Effectiveness of Breathing Exercises and/or Retraining Techniques in the Treatment of Asthma (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-treatment-future_research.pdf
      September 01, 2012 - After developing a preliminary list of evidence gaps based on the CER and discussions with the lead … Lastly, we asked the CER lead author for nominations and recommendations based on her experience working … of evidence gaps by reviewing the CER and discussing the evidence gaps and research needs with the lead … Impact: New research related to this question could potentially lead to improved health care quality

1259. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis—An Update of the 2006 Report. (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-disposition-120516.pdf
      October 01, 2011 - AstraZeneca is committed to the discovery of drugs that will allow patients to lead longer, healthier … completing 6 months as well as though who developed the primary outcome of ulcer which, as per protocol, lead … completing 6 months as well as though who developed the primary outcome of ulcer which, as per protocol, lead … that it is expected to increase according to the demographic change in age distribution, which will lead

1260. Untitled (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/suicide-prevention_research-protocol.pdf
      December 23, 2015 - Untitled Source: www.effectivehealthcare.ahrq.gov Published online: December 23, 2015 Evidence-based Practice Center Systematic Review Protocol Project Title: Suicide Prevention I. Background and Objectives for the Systematic Review Despite advances in the diagnosis and treatment of major mental disord…