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www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/procedure-manual/procedure-manual-section-4-evidence-review-development
June 22, 2025 - Other differences have the potential to cause large divergences between the study's results and what … Questions of the Effectiveness/Efficacy of Interventions
The Task Force strongly prefers multiple large … Multiple large, well-conducted observational studies with consistent results showing a large effect size … Also, large well-conducted observational studies often provide additional evidence even in situations … considered inadequate but high-quality ecological evidence, especially studies demonstrating a very large
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/abdominal-aortic-aneurysm-screening-1996
January 01, 1996 - Large aneurysms are easier to detect than small ones, and it is easier to detect aneurysms in thin people … Among 13 large case-series of surgery for nonruptured aneurysms published since 1980, overall surgical … Among 13 large case-series of surgery for nonruptured aneurysms published since 1980, overall surgical … Of 124 patients aged 65-80 who had large aneurysms detected in a community screening program, 27% were … Of 124 patients aged 65-80 who had large aneurysms detected in a community screening program, 27% were
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-review41/diet-behavioral-counseling-primary-care-adults-2003
January 15, 2003 - We developed a definition of small, medium, and large changes based on the distribution of findings from … When studies reported only change in proportion of calories from total fat, we classified large as a … A relative change of 25 percent or greater was considered large, 10 percent to 24 percent medium, and … Of the 7 low-intensity study arms, 1 (14 percent) produced a large effect, 1 (14 percent) produced a … Medium- to high-intensity interventions generally produced medium or large changes in dietary behavior
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/kHT3WGUaG2wTz2pF_ke7bn
KQ2a
Indirect Grade
assignment,
health equity
Large, nationally
representative
observational … population for
development of new
risk assessment tools
Prospective, large,
nationally
representative … KQ2c Indirect Grade
assignment,
health equity
Large, nationally
representative
observational … population for risk
assessment tool
development
Prospective, large,
nationally
representative … population for model
development
Prospective, large,
nationally
Adult females;
racial and ethnic
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/colorectal-cancer-screening-2002
June 13, 2002 - The combination of FOBT and sigmoidoscopy may detect more cancers and more large polyps than either test … certain whether the potential added benefits of colonoscopy relative to screening alternatives are large … Estimated sensitivity of a single exam is 90% for large polyps and 75% for small polyps (less than 1 … Small and flat polyps are less well visualized on CT colography than are cancers and large polyps. … A case-control study in a large health plan that had implemented rigid sigmoidoscopy screening suggested
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/chronic-obstructive-pulmonary-disease-screening
May 10, 2022 - pharmacologic treatment published since 2015, 13 trials (n = 3657) on nonpharmacologic interventions, and 2 large … Two large observational studies in a screen-relevant population demonstrated an association of the initiation … and pulmonary rehabilitation interventions, and clinician education interventions) (KQ2). 11-23 Two large … In addition to the trial evidence, 2 large observational studies addressing harms of pharmacologic treatment … detect uncommon or longer-term harms
Consistent for no serious harms from treatment trials, but large
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/colorectal-cancer-screening-1996
January 01, 1996 - Changing distribution of primary cancers in the large bowel. … Large colonoscopic neoplasms missed by endoscopy. … Adenomatous lesions of the large bowel: an autopsy survey. … Polyps and cancer of the large bowel: a necropsy study in Liverpool. … A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/ERAa_Bwr7hQxqZZ-X3p8Qh
May 10, 2022 - pharmacologic treatment published since 2015, 13 trials (n = 3657) on
nonpharmacologic interventions, and 2 large … Two large
observational studies in a screen-relevant population demonstrated an association of the
initiation … and pulmonary
rehabilitation interventions, and clinician education interven-
tions) (KQ2).11-23 Two large … to
detect uncommon or
longer-term harms
Consistent for no serious harms
from treatment trials, but large … In addition
to the trial evidence, 2 large observational studies addressing harms
of pharmacologic treatment
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary94/syphilis-infection-in-pregnancy-screening-2009
May 15, 2009 - One study that used a large insurance claims database reported an incidence of anaphylaxis after oral … The first study 10 is a retrospective study that used data from a large database of sera results from … harm of false-positive results 11 evaluated 8892 pregnant women who presented for prenatal care at 4 large … Incidence of allergic reactions associated with antibacterial use in a large, managed care organisation … Enrollment at 4 urban maternity hospitals in Bolivia (large, public, with laboratory infrastructure and
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-review48/hepatitis-b-in-pregnant-women-screening-2009
June 15, 2009 - Purpose: To search for large, high-quality studies related to hepatitis B screening in pregnancy that … meta-analyses; randomized, controlled trials; cohort studies; case-control studies; and case series of large … The goal of this reaffirmation update was to search for large, high-quality studies related to HBV screening … systematic reviews; meta-analyses; randomized, controlled trials; cohort studies; case-control studies; and large … -born women of childbearing age. 8 However, in areas of the United States with large immigrant populations
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/abdominal-aortic-aneurysm-screening-february-2005
February 15, 2005 - There is, however, a lower prevalence of large AAAs in men who have never smoked compared with men who … Rating: D Recommendation
Rationale : Because of the low prevalence of large AAAs in women, the number … Screening for AAA would most benefit those who have a reasonably high probability of having an AAA large … enough, or that will become large enough, to benefit from surgery. … Rupture rate of large abdominal aortic aneurysms in patients refusing or unfit for elective repair.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/p8bwnFstpfy9KoDSJhT7m5
February 01, 2005 - The USPSTF found good evidence that screening
for AAA and surgical repair of large AAAs (5.5 cm or
more … There is, however, a lower prevalence of large AAAs in
men who have never smoked compared with men who … enough, or that will become large
enough, to benefit from surgery. … Discussion
By definition, an AAA is present when the
infrarenal aortic diameter exceeds 3.0 cm.5 Large … Rupture
rate of large abdominal aortic aneurysms in patients
refusing or unfit for elective repair.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/hypertensive-disorders-pregnancy-screening
September 19, 2023 - study participants were diagnosed with preeclampsia (RR, 0.85 [95% CI, 0.35-2.04]). 1 , 38 , 42 A large … The study population in the large US trial (n = 2328) of a reduced prenatal visit schedule was described … mortality were reported in the reduced visit intervention and routine visit control groups in the 2 large … Estimates of perinatal mortality were not statistically significant in the large US trial (RR, 1.00 [ … 95% CI, 0.54-1.86]) or in the large UK trial (RR, 0.72 [95% CI, 0.27-1.88]). 1 , 38 , 41 , 42 Estimates
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/gWJU-ZynehGyLBVYtDmMow
May 01, 2009 - ized, controlled trials; meta-analyses; systematic reviews; cohort
studies; case–control studies; and large … One study that used a
large insurance claims database reported an incidence of anaphy-
laxis after oral … In addition, we included large ecologic studies
and cohort studies that reported the effect of the imple … The first study (10) is a retrospective study
that used data from a large database of sera results from … Investigators used a large U.S. in-
surance claims database of approximately 10 million pa-
tients to
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www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/procedure-manual/procedure-manual-section-6-methods-arriving-recommendation
July 06, 2017 - How many and how large are the studies that address the key question(s)? Are the results precise? … The consistency of or a large number of individual studies and lack of heterogeneity in pooled results … The Task Force will exercise great caution when making a recommendation that depends in large part on … That is, it places less emphasis on a large RRR in situations of low ARR; it remains interested in an … A large amount of the burden of suffering would be relieved from society (minus the additional burden
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/gestational-diabetes-screening
August 10, 2021 - Three large US studies (n = 161,182) 43 , 45 , 47 found some differences in hospital experiences (eg … Treatment at 24 to 28 Weeks of Gestation
Like the prior USPSTF review, 2 large good-quality RCTs (n … Four new studies were added 28 , 31 , 35 , 36 and 6 new publications 95-100 for 1 large previously … For the new KQ on comparative effectiveness, several trials were located including 3 large trials 19 … , 20 , 24 and 1 very large trial 20 from the US examining highly applicable comparisons.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/LNtA2SDWjpsDwjXvsH4F5m
April 17, 2023 - 1% of
study participants were diagnosed with preeclampsia (RR, 0.85
[95% CI, 0.35-2.04]).1,38,42 A large … The study population in the large US trial (n = 2328)
of a reduced prenatal visit schedule was described … mortality were reported in the reduced
visit intervention and routine visit control groups in the 2 large … Estimates of perinatal mortality were not statistically significant in
the large US trial (RR, 1.00 [ … the
2 US trials (RR, 1.08 [96% CI, 0.92-1.27] and RR, 2.21 [96% CI,
0.45-10.70]).1,38,41,43 In the large
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary4/colorectal-cancer-screening-2008
October 15, 2008 - In settings with sufficient quality control, CT colonography is as sensitive as colonoscopy for large … Accuracy of CT colonography for detection of large adenomas and cancers. … Colonic perforation at CT colonography: assessment of risk in a multicenter large cohort. … Procedural success and complications of large-scale screening colonoscopy. … Sensitivity for large adenomas (≥10 mm) ranged from 77% to 100%.
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www.uspreventiveservicestaskforce.org/uspstf/update-on-methods-insufficient-evidence---table-1
February 01, 2009 - Insufficient Evidence Statements for Screening of Large Population Sub-groups
From the USPSTF Pocket
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/human-immunodeficiency-virus-hiv-infection-pregnant-nonpregnant-adults
November 30, 2023 - Randomized, controlled trials and controlled observational studies KQ 4: Randomized, controlled trials and large … (n≥1,000) controlled observational studies KQ 5: Randomized, controlled trials and large (sample size … outcomes
Study designs
KQs 1, 2: RCTs and controlled observational studies KQ 3: RCTs and large