-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/medical-tests-proposals_research.pdf
January 01, 2009 - Guyatt and colleagues recommended
that, in addition, the test be applied to a large number of diverse … in thoughtful considerations of
the quality of the available evidence when making decisions about large-scale … evaluations of
testing, requiring big budgets and large numbers of participants.
-
effectivehealthcare.ahrq.gov/sites/default/files/s38.pdf
October 01, 2007 - arm accounting for these
drop-outs and drop-ins is N/(1 � p1 � p2)2 as long as p1 and
p2 are not too large … Thus, even modest levels of contamina-
tion can have a large impact on the validity of a trial. … consider a trial to evaluate an interven-
tion to improve screening and care for osteoporosis within a
large
-
effectivehealthcare.ahrq.gov/sites/default/files/whitepaper3-lijmer02262010-2.pdf
January 01, 2009 - Guyatt and colleagues recommended
that, in addition, the test be applied to a large number of diverse … in thoughtful considerations of
the quality of the available evidence when making decisions about large-scale … evaluations of
testing, requiring big budgets and large numbers of participants.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
January 01, 2007 - In one large,
retrospective cohort study, anakinra led to statistically
significantly higher overall … Investigators may find large
registries helpful in identifying the same kinds of
patients treated with … surgery in patients with rheumatoid arthritis with special
attention for anti-tumor necrosis factor: a large
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/pressure-ulcer-prevention_research-protocol.pdf
January 10, 2012 - controlled or
comparative observational studies
• KQ 4: randomized trials, cohort studies, and large … If there are large numbers of includable studies for the KQ(s), we may
determine a minimum sample-size … They will have a serious or “fatal” flaw in design, analysis, or reporting;
large amounts of missing
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
October 01, 2015 - If
the magnitude of effect was very large, the SOE could be
upgraded. … Despite the large body of evidence on N-acetylcysteine,
the SOE was low, primarily because of limitations … for preventing
CIN in patients receiving intravenous contrast media,
it may be necessary to perform large
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_executive.pdf
October 01, 2006 - opposed to continued aggressive medical treatment, the
National Institutes of Health has sponsored the large … Although studies
were generally too small to detect any but large
differences in mortality rates, no … There is acceptable evidence that combination
antihypertensive treatment results in large decreases in
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1506.pdf
June 01, 2015 - Comments: Experts evaluating these two interventions thought both drugs
have potential to address a large … Several ongoing, large clinical trials are investigating ketamine’s efficacy for
treating MDD, BPD, … potential applications for indications such as comorbid
suicidal ideation, but they noted a lack of large … Overall, experts thought that these drugs could have a
moderate-to-large impact on patient outcomes
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-research-report-unhealthy-alcohol-use-final.pdf
September 01, 2018 - Competing demands, a large patient
population, and turnover in nursing staff and resident providers … Clinic and visit factors such as competing demands, a large patient population, and
turnover in nursing … was
conducted at the University of North Carolina (UNC) General Internal Medicine (GIM) Clinic, a
large … training
faculty and
residents
NA NA
Barriers Alert fatigue NA Competing
demands in visit;
large
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-genetic_methods.pdf
July 01, 2012 - genetic test results are often derived from analytically complex studies that have
undergone a very large … Genetic test results are sometimes derived from analytically complex studies that have
undergone a very large … investigators recommend using a P value of less than 5 x 10-8 for the threshold of
significance in large … actually arisen from overlapping data sets.16 For example, genome-wide association studies or
other large
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/case-management_executive.pdf
January 01, 2013 - Such programs fall into a
large category of inpatient discharge planning activities
that are beyond … However, in some cases there were consistent
findings in large clinical trials of uniform populations … Implications for Future Research
The existing evidence base includes a large number of
randomized … some cases (particularly the Medicare
Coordinated Care Demonstration [MCCD] trial)13 the
studies had large
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/deliberative-methods-how-to-webinar-text-only.pdf
December 06, 2011 - from
members of the public on a health research topic
Speaker notes: This webinar is part of a large … general public itself that should be able to speak on behalf
of the best interests of the population at large … We know that through our own
experience with insurance…but rarely do we ask the public at large to help
-
effectivehealthcare.ahrq.gov/sites/default/files/deliberative-methods-how-to-webinar-text-only.pdf
December 06, 2011 - from
members of the public on a health research topic
Speaker notes: This webinar is part of a large … general public itself that should be able to speak on behalf
of the best interests of the population at large … We know that through our own
experience with insurance…but rarely do we ask the public at large to help
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_2-user-guide-to-ocer_130129.pdf
January 01, 2011 - to the widespread use of case-control designs
(see below) in pharmacoepidemiologic studies
using large … ad hoc studies, if a case-
control study is nested within an existing cohort
(e.g., based within a large … Why do
we need some large, simple randomized trials?
Statistics in Medicine. 1984;3:409–20.
8. … Controlling confounding when studying large
pharmacoepidemiologic databases: a case study
of the two-stage
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_disposition-comments.pdf
September 10, 2014 - Introduction Same point again about the “large proportion” of women
undergoing biopsy over a 10 year … I don’t think that
amounts to a “large proportion” compared with the rate of at least
one positive … Given the very
large number of studies, we think it is not possible
to discuss each individual study … This is not a "large proportion" as stated. … Introduction page 11, line 17: "large proportion need biopsies" is really not a
fair statement.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-treatment-future_research.pdf
September 01, 2012 - However, such trials would need large sample sizes in order to
account for presumably small-to-modest … Another individual who worked for a large nonprofit
organization that focused on asthma patient advocacy … review of the comparative effectiveness review
Category Research Needs
Population • Studies with large … The
feasibility of conducting RCTs may be also an issue, specifically in finding a sufficiently large … If you were given funding to conduct a large research study in this area, what
would that study look
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/stakeholders-engagement-others_research-2012-1.pdf
January 01, 2012 - details of interest on Web sites because the Web sites, which
were promotional in nature, contained a large … All types of organizations engage stakeholders: private and public; for-profit and not-for-profit;
large … cited more traditional approaches such as electronic or mail surveys, citizen juries, small and
large … Autism Speaks, which have been
able to create and broadly disseminate their messages, have made a large … for CSR http://www.csreurope.org To serve as a political umbrella for mobilizing the
resources of large
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-treatment-future_research.pdf
February 01, 2013 - Recommended study design: (preferable) large long-term clinical trial with women-
only enrollment or … of large enough sample size with stratification of randomization
by sex to allow for meaningful sex-based … A large portion of the care of patients with CAD is
managed by generalists or medicine subspecialists … Since these areas were out of scope for the
original review, it is unclear whether large evidence gaps … Recommended study design: (preferable) large long-term clinical trial with
women-only enrollment or
-
effectivehealthcare.ahrq.gov/sites/default/files/interactive_media_glasgow_presentation.pdf
January 01, 2009 - efficacy
Slide
28:
Summary
of
Multimedia
(MM)
Results
• MM
can
reach
large
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/lung-cancer-nonsurgical-therapies_executive.pdf
June 01, 2013 - The most
common types of NSCLC are
adenocarcinoma, squamous cell
carcinoma, and large cell carcinoma … of bias because the study failed to adjust for
potential confounding resulting from crossover of a large … thought that a tumor size greater than 4 cm or a tumor
location less than 1 cm from the hilum or large … This has been reported in published
single-arm studies reviewed in this CER—for example,
the large … expertise
in QOL measurement, clinical researchers with expertise
in the planning and conduct of large