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Total Results: 1,445 records

Showing results for "large".

401. Disposition of Comments: Comparative Effectiveness Review No. 232_Interventions for Breathlessness in Patients With Advanced Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-232-breathlessness-cancer-comments.pdf
     November 19, 2020 - We have carefully considered the comments on opioids - given the large number of studies, most of which … As we have reported in the limitations, outcome reporting across even large, well-done studies was heterogeneous … We have also expanded on the section on non-cancer dyspnea and added in the new, large, well-conducted … Reviewer #6 (TEP) Methods A large body of dyspnea evidence for patients with COPD were excluded. … air oxygen blend (allowing from 21% to 100% FiO2) generating up to 60 L/min flow rates through a large

402. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
     September 01, 2014 - New Engl J Med (2008) 358:1431), as well as in two large highdose atorvastatin monotherapy cIMT studies … Fourth, the results of two large placebo-controlled outcomes trials belie any adverse effect on ischemic … there be an overview page or something like that that would give the reader a heads up about each large … None of the studies, despite being fairly large, found a statistically significant effect. … Any large niacin study (i.e., HPS2-THRIVE) shows a substantial patient withdrawal due to adverse events

403. Making Healthcare Safer IV_Rapid Review: Use of Structured Handoff Protocols for Intrahospital Within-Unit Transitions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/structured-handoff-rapid-research.pdf
     January 01, 2025 - The authors found that studies of SBAR implementation reporting large improvements in fidelity all occurred … The standardisation of handoffs in a large academic paediatric emergency department using I-PASS. … Large-scale implementation of the I-PASS handover system at an academic medical centre. … Was the sample size sufficiently large to provide confidence in the findings? … Was the sample size sufficiently large to provide confidence in the findings?

404. Radiation Therapy for Bone Metastases (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/rt-bone-metatases-final-protocol-amendment.pdf
     August 10, 2022 - biases of various kinds that may invalidate results; “fatal flaws” in design, analysis, or reporting; large … There are also situations where the observational evidence may be upgraded (e.g., large magnitude of … Incidence of patients with bone metastases at diagnosis of solid tumors in adults: a large population-based … and metastases to bone: a 15-year study in 14 two large

405. Binge-Eating Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_research-protocol.pdf
     July 21, 2014 - Eating large amounts of food when not feeling physically hungry d. … subjective binge-eating episode(s) (SBEs), whereby the amount of food consumed is not unambiguously large … of BED and LOC Eating In the diagnosis of BED, the assessment of a patient eating an “objectively large … only with LOC eating (i.e., loss-of-control eating behaviors without having consumed an unusually large … Eating disorder symptoms and weight and shape concerns in a large web-based convenience sample of women

406. Treatments for Schizophrenia in Adults: A Systematic (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
     January 01, 2017 - Although there are a large number of treatments for schizophrenia, it is not clear whether they afford … Due to a very large body of research literature, the review has been focused in several ways (see Methods … After identifying a large body of evidence for Key Question 2, we determined that the funding and timeline … Examining those, we saw a large amount of heterogeneity in how control groups were defined and handled … , Development, and Evaluation working group (GRADE)49-55 criteria for multiple reasons, including large

407. Disposition of Comments_Comparative Effectiveness Review No. 253: Maternal and Child Outcomes Associated With the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/maternal-child-outcomes-wic-disposition-comments.pdf
     April 19, 2022 - Disposition of Comments_Comparative Effectiveness Review No. 253: Maternal and Child Outcomes Associated With the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) Comparative Effectiveness Review Disposition of Comments Report Title: Maternal and Child Outcomes Associated W…

408. Cancer-Ovarian-Contraceptives Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_executive.pdf
     June 01, 2013 - OCs was significantly associated with a decreased risk of dying from invasive ovarian cancer in two large … The two large United Kingdom (U.K.) cohort studies had conflicting results for colorectal cancer mortality … Two large U.K. cohort studies showed a significant reduction in endometrial cancer mortality in women … Two large, fair-quality cohort studies conducted in the U.K. … strategies for ovarian cancer, incorporating OCs—is needed to help clarify whether investing in such a large

409. Disposition of Comments for CER 195 Management of Uterine Fibroids (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-195-disposition-comments-uterine-fibroids.pdf
     December 14, 2017 - Study characteristics are poorly defined-large number of studies and inter-study variability may be … The prior SER which included review of large HRT cohorts with fibroid imagining summarized: We found … Large, well-controlled studies should be used in determining efficacy and not small, biased samples … Are women with large subserosal fibroids really only offered hysterectomy? … Peer reviewer #1 General Comments The strengths include addressing highly relevant questions, large

410. Development of Harmonized Outcome Measures for Use in Patient Registries and Clinical Practice: Methods and Lessons Learned (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-standardized-library.pdf
     February 01, 2019 - A particular strength of registries is their ability to enroll large numbers of patients and follow … suggested cancer and the research team narrowed to colorectal cancer) Among cancers, affects large … nerve ablation device approved in 2016 Up to 12 registries identified from all sources, several large … online but not a lot of publicly available information Funded mix includes associations, systems, large … and another (ICORE) with estimated enrollment of 10,000; 3 others have 200-300 enrollees The 2 large

411. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/estimation-and-reporting_chapter-3.pptx
     January 01, 2013 - examined A small number, typically one or two Moderate and prespecified Not made explicit, but may be large … have broad inclusion/exclusion criteria, allowing for the assessment of comparative effectiveness in large

412. Modeling to evaluate benefits and harms of new diagnostic tests compared to established diagnostic tests – uses and limitations (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/benefits-harms-modeling_research.pdf
     November 19, 2009 - To a large extent, effects of medical tests are indirect in nature. … To attain necessary power, sample sizes become too large, followup duration too long, and costs prohibitively … low risk populations (very low disease prevalence), even very specific tests can yield relatively large

413. Cancer-Drugs-Utilization-Cost Research (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-drugs-utilization-cost_research.pdf
     January 01, 2011 - , and breast cancers dominated expenditures.4 Drugs used in the treatment of cancer account for a large … some anticancer biologics, (2) issues of access, management, and ethics in delivering biologics to large … Such research is especially important given the large number of Medicare beneficia- ries with cancer

414. 13-MDM347013 30..38 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/outcomes-testing-evaluation_research.pdf
     January 01, 2009 - Where there is a large and clear benefit in mortality or morbidity from testing, alternative negative … examples in our paper have been derived from screening, where many have to be invited to achieve a large … not lead to major changes in clinical outcome on a population level, and small negative effects in a large

415. 13-MDM347013 30..38 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/whitepaper4-bossuyt02262010-2.pdf
     January 01, 2009 - Where there is a large and clear benefit in mortality or morbidity from testing, alternative negative … examples in our paper have been derived from screening, where many have to be invited to achieve a large … not lead to major changes in clinical outcome on a population level, and small negative effects in a large

416. Research Protocol: Disparities Within Serious Mental Illness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-illness-disparities_research-protocol.pdf
     July 01, 2015 - Individuals who lived in rural geographic areas had higher suicide death rates than those who resided in large … a large … Disparities in quality of care among publicly insured adults with schizophrenia in four large U.S.

417. Prostate-Cancer-Risk-Assessment-Genes Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-risk-assessment-genes_executive.pdf
     July 01, 2012 - Background Prostate cancer is the fifth most common malignancy in the world,1 with a large variation … The natural history of prostate cancer is highly variable.13 In a large proportion of men, the disease … improvements in prostate cancer risk prediction, screening, and prognostic stratification will depend to a large

418. Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol-amendment.pdf
     March 22, 2023 - biases of various kinds that may invalidate results; “fatal flaws” in design, analysis or reporting; large … For all pooled analyses, we will estimate the magnitude of treatment effects as small, moderate, or large … scale, >10 to 20 points on a 0 to 100-point scale 10 • SMD >0.5 to 0.8 • RR/OR 1.5 to 1.9 Large … There are also situations where the observational evidence may be upgraded (e.g., large magnitude of

419. Treatment of Osteoarthritis of the Knee: An Update Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/osteoarthritis-knee-update-executive-170505.pdf
     May 01, 2017 - However, we identified at least one large recent trial on glucosamine-chondroitin that prompted us to … • Glucosamine + chondroitin: Three large, multi-site RCTs and one smaller RCT found low strength … – Two large RCTs showed significant medium-term benefit of chondroitin alone for pain (low strength … – Three large RCTs showed no long-term benefit of chondroitin alone on pain (moderate strength of … Another quality issue is the large number of RCTs for which adequate concealment of allocation could

420. Radiotherapy Treatments for Head and Neck Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_clinician.pdf
     August 01, 2015 - Radiotherapy Treatments for Head and Neck Cancer Radiotherapy Treatments for Head and Neck Cancer Background Clinical Bottom Line and stereotactic body RT (SBRT). Charged particle-based conformal external-beam RT modalities, such as proton-beam RT (PBT), are also available to treat head and neck cancer, althou…