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361. GRADING THE STRENGTH OF A BODY OF EVIDENCE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
     November 01, 2013 - increasing dose-response associations, plausible confounding that decreases the observed effect, and large … EPC and GRADE Approaches to Evaluating Evidence The EPCs’ strength of evidence approach is based in large … This additional domain should be considered when the effect size is particularly large. … This choice may be particularly preferable when the evidence includes a large number of findings that … Timing of Reporting Bias Assessments A body of evidence that includes many studies of a large number

362. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cognitive-decline_executive.pdf
     March 01, 2017 - are rarely possible, due to the extended study length required (i.e., >10 years) or the extremely large … including: 1) Meaningful investigation of dementia-onset requires either a long followup period or a large … Conclusion At present, there is not sufficient strength of evidence to justify large-scale investing

363. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_executive.pdf
     March 01, 2017 - are rarely possible, due to the extended study length required (i.e., >10 years) or the extremely large … including: 1) Meaningful investigation of dementia-onset requires either a long followup period or a large … Conclusion At present, there is not sufficient strength of evidence to justify large-scale investing

364. Omega-3 Fatty Acids and Maternal and Child Health: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/omega-3-maternity_executive.pdf
     October 01, 2016 - and a consistent finding of no effects of prenatal maternal supplementation with EPA+DHA among a large … One large observational study on ASD was identified; women with the highest quartile of total PUFA intake … The effect size for the increase in gestational length may not have been large enough to translate to … Observational studies often corrected for a large number of potential confounders, but many important … The findings of large cohort studies are still needed to assess the potential role of n-3 FA status

365. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_disposition-comments.pdf
     October 01, 2010 - future research, including the elderly, those with low EF or large LAD, and people with multiple comorbidities … specifically in patients with heart failure as discussed previously.(4,5) Both of these studies showed quite large … Both studies reported large and statistically significant improvements in SF-36 scores (over 30 point … scores described in Table 6 of the draft report as well as in the studies reviewed above were easily large … changes seen in several randomized AAD trials.(10,11,12) We believe the nonrandomized evidence showing large

366. Renal-Cancer Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
     April 20, 2015 - ratio for percutaneous renal sampling or nephron-sparing surgeries than the population of men with large … Treatments such as robotic partial nephrectomy were still in their infancy, and the large clinical data … rates are between 5-10%, substantial differences between the N of two arms, or when effect size is large … 2002 American Joint Committee on cancer primary tumor classification for renal cell carcinoma using a large … Pierorazio, P.M., et al., Laparoscopic radical nephrectomy for large renal masses: critical assessment

367. Transcript Deliberativemethodswebinar (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/transcript_deliberativemethodswebinar.pdf
     April 19, 2012 - organizations where a major decision is being taken that’s high profile that will effect a very large … As I’ve stated earlier, deliberation can occur over a very large or very small scale, again, depending … Whether you’re going large or small-scale, you know, again, some things to keep in mind: Making sure … So often in a large deliberative forum you may 32 break off into smaller groups to take on some … the larger group, so that you’re not simply doing the same thing over in the small group and the large

368. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea_research-protocol.pdf
     March 15, 2010 - patients with OSA; thus, in most patients, the condition remains undiagnosed and untreated.6 There is a large … Public Comments The large majority of public comments regarding the key questions were either answers … Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based

369. Methods Guide for Medical Test Reviews Chapter 12 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-prognostic_methods.pdf
     July 01, 2012 - Large cohort studies and secondary analyses of clinical trials may contain the most readily available … Conclusion There is a large and rapidly growing literature about prognostic tests. … • A large number of published reports focus on the associations between prognostic indicators and

370. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_disposition-comments.pdf
     June 01, 2010 - Individual cases with large aggregate dosages included both hemophilia and non- hemophilia cases. … cases who were dispensed very large doses. … Individual cases with large aggregate dosages included both hemophilia and non-hemophilia cases. … Unfortunately, the two large, randomized controlled trials on the efficacy and safety of rFVIIa in … Given the large number of figures, the report presents several figures in a size that is smaller than

371. Research Review Title: Infection Prevention and Control for the Emergency Medical Services and 911 Workforce (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-911-workforce-disposition-comments.pdf
     November 01, 2022 - needle sticks, blood to non-intact skin, etc.)”, it might be better to describe respiratory exposure as large … droplet and airborne, or large droplet and aerosol. … Data examined in the papers did not differentiate between large and small droplets, so would not have

372. Disposition of Comments: CER 228, Nonopioid Pharmacologic Treatments for Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-228-nonopioid-pharm-chronic-pain-comments.pdf
     April 16, 2020 - that you found no overlapping studies despite not (apparently) explicitly rejecting them points to a large … The large majority of patients have been FORCED to reduce their stable, effective pain medications to … In as much as the opioid crisis and substance abuse is affecting a large number of people in the United

373. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/screening-counseling-interventions-protocol-amendment.pdf
     February 05, 2025 - We may employ Claude 2 (Anthropics), an advanced large language model, to assist us in extracting descriptive … For data extraction, we will use Claude 2 (Anthropics), a large language model, to support us with extracting … Data extraction for evidence synthesis using a large language model: a proof-of-concept study. medRxiv

374. Evidence-based Practice Center Systematic Review Protocol - Management of Infantile Epilepsies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-252-infantile-epilepsies-disposition-comments.pdf
     October 25, 2022 - This was because our TEP generally felt that 1999+ would represent the large bulk of the literature … This was because our TEP generally felt that 1999+ would represent the large bulk of the literature … This was because our TEP generally felt that 1999+ would represent the large bulk of the literature … A registry spanning large geographical areas and reporting observational data would offer other important … A registry spanning large geographical areas and reporting observational data would offer other important

375. Urinary-Incontinence-Treatment Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-treatment_research-protocol.pdf
     September 30, 2010 - Previously published reports need to be updated with evidence from the large number of new publications … They have serious errors in design, analysis, or reporting; large amounts of missing information; or … Large observational cohorts based on national registries, population-based surveys, population-based … Issues in comparisons between meta-analyses and large trials. JAMA 1998; 279:1089-93. 72. … interval 2−9) Daily leakage or drops (~17 g/24 hours, 95% confidence interval 13−22) Leakage of large

376. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_executive.pdf
     December 01, 2011 - The review focuses on adult patients because adults, and particularly elderly adults, carry the large … Moderate-strength evidence from one large, high-quality study demonstrated that vancomycin and fidaxomicin … Fidaxomycin versus Moderate One large, high-quality RCT deomonstrated decreased vancomycin recurrence … Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal … Management and control of a large outbreak of diarrhoea due to Clostridium difficile.

377. Crosscutting Hi Impact (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/crosscutting_hi_impact.pdf
     January 01, 2012 - in rural areas, several experts were skeptical about the program’s ability to be rolled out on a large … chairs and padded/ lined stretchers to improve patient comfort and reduce risk of pressure ulcers; large-faced … Service and the Veterans Health Administration, which use telemedicine delivery systems to serve large … in rural areas, several experts were skeptical about the program’s ability to be rolled out on a large … First, “a large culture change is anticipated,” in that “patients over 65 would be assessed in a different

378. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/01_-arthritis_potential_high_impact_june_2012.pdf
     January 01, 2012 - The evidence base for PRP lacks large, blinded, prospective, randomized, controlled trials. … first-line therapy and actually regenerate joint cartilage and restore function, it would have a large … However, some of the experts stated that large, randomized, double-blind trials are needed to better … In general, the experts thought that tofacitinib would not make a large shift in how RA is treated or … Experts all thought tofacitinib would have a large impact on costs, but diverged in how the impact

379. Noninvasive, Nonpharmacological Treatment for Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharma-treatment-pain_research-protocol-amended.pdf
     September 20, 2017 - Across the conditions and interventions, the literature base is large and complex, which poses another … Large/substantial effects were defined as greater than moderate. … update for journal publication; this will enhance analytic efficiency for this condition given the large … Non-English Language Studies: We will restrict inclusion to English language articles, given the large … There are also situations where the observational evidence may be upgraded (e.g., large magnitude of

380. Noninvasive Testing for Coronary Artery Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-disease-testing_research-protocol.pdf
     January 15, 2015 - A large proportion of ambulatory health care visits are for evaluation of patients with suspected CAD … detect outward remodeling of the coronary artery, which may present a situation in which there is a large … Non-English Language Studies: We will restrict inclusion to English language articles, given the large … There are also situations where the observational evidence may be upgraded (e.g., large magnitude of … complete blockage of the coronary artery resulting in a prolonged period of ischemia; it affects a large