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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/vitamin-d-calcium_disposition-comments.pdf
    September 15, 2014 - Also the WHI as well as many of the large RCTs did not have baseline end of the study 25-hydroxyvitamin … We did not include meeting abstracts and thus would not have realized a large part of the study population … The literature is comprehensive and the report does not appear to have omitted any large studies. … A large number of observational studies were identified that assessed the association of serum 25(OH … It is likely these men were body builders taking large amounts of different supplements including likely
  2. Diabetes Mellitus (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1506.pdf
    June 01, 2015 - experts cited a growing population with T2DM that is often inadequately managed as demonstrating a large … potential to improve patient health and fill a large unmet need. … Inhaled insulin has not been compared to injected insulin in large randomized, controlled trials. … potential to improve patient health and fill a large unmet need. … Unmet need and health outcomes: Most experts cited a large unmet need for new therapeutic approaches
  3. effectivehealthcare.ahrq.gov/sites/default/files/renal-cancer_disposition-comments.pdf
    February 24, 2016 - While the strength of the conclusions to be derived from retrospective analyses (large single/multicenter … We have included comparative studies of localized renal masses, and thus excluded some of the large … nephrectomy and partial nephrectomy was likely not as prominent as expected due to the influence of the large … For example, a large subset of the articles excluded under "clinically non- localized patients" are … Despite some merit to large, retrospective single-institution studies, the majority of those studies
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0359_10-15-2010.pdf
    January 01, 2010 - Effective Health Care Topic Number: 0305 Document Completion Date: 02-14-12 1 Results of Topic Selection Process & Next Steps  Diagnosis of multiple sclerosis was found to be addressed by a 2011 systematic review on the accuracy of diagnostic tests in multiple sclerosis. Given that the existing re…
  5. effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/multinational-registries-guide-3rd-ed-addendum-white-paper.pdf
    February 01, 2018 - registries, however, are time consuming and resource intensive to establish and conduct, particularly if large … Indeed, a study of cancer epidemiology in eight Southern and Eastern European countries found large … is an important step that may influence the decision to focus on specific countries/regions where large … Colonic stenting as a bridge to surgery in malignant large-bowel obstruction: a report from two large
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/continuous-outcomes-quantitative-synthesis_methods.pdf
    March 01, 2011 - effect on the trial variance, particularly when the average cluster size is quite large. … When sample size is large, the difference between Hedges’ g and Cohen’s d is small and they can be … SMDs of 0.2, 0.5, and 0.8 are suggested corresponding to small, medium, and large effects 53 and … Caution is warranted when RoM is used for small trials with large SDs and large effect sizes. … SMDs of 0.2, 0.5, and 0.8 correspond to small, medium, and large effects.
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_disposition-comments.pdf
    January 27, 2016 - I'm sure it is likely to be relevant but on the other hand we do have evidence from one large international … tempted to under-play the emphasis you put on it and at the very least discuss it more fully and with large … Many large health systems are introducing stewardship interventions in all settings, and it will be … Peer Reviewer #2 (TEP Reviewer) General The large DESCARTE cohort published in Lancet ID is within … Again, there is a very large body of evidence in the literature on these topics.
  8. effectivehealthcare.ahrq.gov/sites/default/files/frazee-presentation.pdf
    May 29, 2025 - had to learn to pay attention to were   things that were   either pressing -­‐-­‐ "There's this large … How do you  actually deliver this to large numbers of patients in  a way that's scalable and affordable
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
    September 20, 2013 - screened annually for 10 years, approximately 50 percent will need additional imaging tests, and a large … Given the large variability of cost information among different jurisdictions, we will only consider … tests to increase the specificity of the search strategy; this is a reasonable approach, given the large … have serious errors in design, analysis, or reporting and contain discrepancies in reporting or have large … core needle biopsy 6 and ((needle biopsy or biopsy needle or percutaneous biopsy).de. or (large
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_disposition-comments.pdf
    July 08, 2014 - General General Comments: My impression is that this is not one of AHRQ’s stronger reports but a large … the problems with comparisons to a group of women who are mainly not depressed because there is a large … paragraph In regards to relevance to the CHIP program, is it importance or a matter of relevance that a large … Sentence modified to remove ‘importance’: “The large number of studies conducted in non-US healthcare … need for better research, registries, and how difficult it is to complete controlled studies on a large
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-reconstruction-mastectomy-protocol.pdf
    April 09, 2020 - long-term cancer or rheumatologic health outcomes.12 However, breast implant-associated anaplastic large … acellular dermal matrix, AR = autologous reconstruction, BIA-ALCL = breast implant-associated anaplastic large … This process will make screening more efficient and will enable us to capture the large majority of … deemed to have insufficient evidence to allow for a conclusion (with the exception that a particularly large … reconstruction ASPS American Society of Plastic Surgeons BIA-ALCL breast implant-associated anaplastic large
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-framework-for-conceptualizing-evidence-needs_0.pdf
    December 01, 2017 - However, health care in the U.S. is increasingly delivered by large health systems involving one or … health systems, payers and provider groups under commission or subscription; and Penn Medicine, a large … A similarly designed study in a large academic health care system suggested the same.18 Members of … Clinical Specialty Other Comments Evidence-based practice center established in 2006 to serve a large … Facilitate discussion with groups making large-scale efforts to improve health system decisionmaking
  13. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_executive.pdf
    September 01, 2011 - Similarly, radiographs to assess joint changes may be difficult to interpret because of the large amount … Therefore, trials require large sample sizes with long followup periods. … Large cohort studies will be important for evaluating the risk of adverse events associated with DMARDs
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mass-casualty-events-scarce-resources_executive.pdf
    June 01, 2012 - device, conventional explosive, bioterror attack) incident that suddenly or progressively generates large … Because of the large number of studies reporting the development or implementation of triage systems … particularly triage practiced in prehospital settings where first responders may be required to assess large
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_disposition-comments.pdf
    January 07, 2016 - Page 22 line 36: There is discussion about the large number of CT studies performed each year, attempting … but doesn't that seem inconsisent with the reported magnitude of benefit associated with statin (large … I think one general area that could be improved in this very large document is the quality of editing … Specifically, if there are large well done trials which are either not included in the analysis, or … This needs to be explained to the clinical community at large, as the rationale for exclusion is not
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_disposition-comments.pdf
    June 05, 2013 - Peer Reviewer 5 Methods 64 articles not retrievable – this is a very large number, is this because you … This is a very large not easily read paper (it is written well but just alot of info). … Before recommending bariatric surgery to this large group of people I believe we need much more of … These data are supported and reinforced by a large body of literature in higher BMI populations. … These data are supported and reinforced by a large body of literature in higher BMI populations.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/primary-healthcare-spending-disposition-comments.pdf
    May 17, 2024 - choices about denominator elements as well as numerator elements, and point out how excluding some large … The report concludes that variations in measurement approaches are connected to large differences in … Adaptation is critical in states like California, in which a large share of payments to providers are … Similarly, very large denominators or high overall spending in Medicare may explain the observation … Neither section includes mention of ERISA self-funded health plans, which are prevalent among large
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/rural-telehealth-amended-protocol.pdf
    February 25, 2021 - They have a serious or “fatal” flaw in design, analysis, or reporting; large amounts of missing information … Coverage and utilization of telemedicine services by enrollees in large employer plans. 2020. https: … www.healthsystemtracker.org/brief/coverage-and-utilization-of- telemedicine-services-by-enrollees-in-large-employer-plans … www.healthsystemtracker.org/brief/coverage-and-utilization-of-telemedicine-services-by-enrollees-in-large-employer-plans … www.healthsystemtracker.org/brief/coverage-and-utilization-of-telemedicine-services-by-enrollees-in-large-employer-plans
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/linking-evidence-reviews-methods_0.pdf
    October 01, 2018 - in integrating systematic review findings into organization-specific clinical guidelines within a large … Review (COER) cyberseminar—to facilitate the uptake of EPC report findings by Kaiser Permanente, a large … As with any large organization, the size of the health system, established procedures, and management … EPCs are federally funded entities that conduct large/complex systematic reviews. … Nonetheless both analyses are being driven by one large trial- DREAM trial (notes- good quality large
  20. effectivehealthcare.ahrq.gov/sites/default/files/ch_8-user-guide-to-ocer_130129.pdf
    October 01, 2013 - Large national PBMs, such as Medco Health Solutions or Caremark, administer prescription drug programs … To illustrate, the Cardiovascular Health Study is a large cohort study that was designed to identify … Commercial insurers see large amounts of turnover in their covered patient populations, which often … The populations in data from commercial insurers or Medicaid, however, are so large that reasonable … Use of a large general practice syndromic surveillance system to monitor the progress of the influenza

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