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Total Results: 1,445 records

Showing results for "large".

201. Disposition of Comments Report for Childhood Obesity Prevention Programs: A Comparative Effectiveness Review and Meta-Analysis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/obesity-child_disposition-comments.pdf
     June 10, 2013 - therefore unlikely the approaches being used in these studies, if replicated in the population at large … of the largest effects in the present review, both intervention and control groups showed a very large … SOE can be low if there is one large, high quality study. … SOE can be low if there is one large, high quality study. … We understand that the appendices contain a large amount of information.

202. Topic Brief: Radiation Therapy for Bone Metastases (pdf file)
     effectivehealthcare.ahrq.gov/system/files/docs/topic-brief-radiation-therapy-bone-metastases.pdf
     August 01, 2022 - Incidence of patients with bone metastases at diagnosis of solid tumors in adults: a large population-based … elderly patients with osteolytic spinal bone metastases after palliative radiotherapy : Results from a large … Because a large number of articles were identified, we reviewed a random sample of 200 titles and abstracts … Represents a significant disease burden; large proportion of the population Yes. … Is of high public interest; affects health care decision making, outcomes, or costs for a large proportion

203. S23 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s23.pdf
     October 01, 2007 - times higher odds of stroke compared with no use of this medication.15 This case–control study involved large … change when more information from other studies becomes available, the public health im- pact is too large … She explained that a lot of information about HRT came from large observations of women like Clara and … If women were to learn that the benefits are not certain and a large number of women will not benefit

204. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_executive.pdf
     June 01, 2011 - Given the importance of these issues, it is notable how few large, long-term, head-to-head studies have … Future research should utilize large databases with sufficient sample sizes to obtain more precise estimates … is restricted to patients with essential hypertension, the agents studied here have been compared in large

205. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - surgery’s potential to resolve T2DM rather than just manage the condition could potentially fill a large … Inhaled insulin has not been compared to injected insulin in large randomized, controlled trials. … Unmet need and health outcomes: Most experts agreed that a large unmet need exists for new interventions … potential to improve patient health and fill a large unmet need. … Unmet need and health outcomes: Most experts cited a large unmet need for new therapeutic approaches

206. Disposition of Comments_Comparative Effectiveness Review No. 271, Treatments for Maternal Mental Health Conditions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-271-mental-health-pregnant-disposition-comments.pdf
     July 31, 2024 - (Example Results Table 6, pp 24) Large health disparities exist in perinatal mental health in the … Due to the large body of evidence and resource constraints, we limited the studies included in this … but please consider making it more brief, and making all tables and figures include font that is large … The omission of a large body of research in regarding psychodynamic therapies based on restricted search … I have two critiques on discussion: 1. large body of research has been omitted on parent- infant therapy

207. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_executive.pdf
     May 01, 2010 - Among four studies reporting on late xerostomia, one reported a large statistically significant difference … dissemination of IMRT, reluctance to randomize patients when effects on xerostomia are already known, the large

208. Grading_didactic_faculty_approved (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/grading.ppt
     January 01, 2013 - approach used by the Evidence-based Practice Centers (EPCs) to grade strength of evidence is based in large … Even if the study is a large multicenter trial (i.e., a mega-trial), findings from different centers … Thus, EPC reviewers cannot be certain that a single trial, no matter how large or well designed, presents … Strength of Association Magnitude of effect: Defined as the likelihood that the observed effect is large … Association Scores This additional domain should be considered when the effect size is particularly large

209. Disposition of Comments Report for Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_disposition-comments.pdf
     December 11, 2012 - significant importance since patients with liver metastases secondary to colon cancer represent a large … The strategy for approaching the large # of studies is well thought out and transparent. … Peer Reviewer #5 Results Nor do I see two of the seminal papers on radiofrequency ablation, with large … reimbursement under current regulations, there is often no incentive for these companies to conduct large … The large experience with ablation of liver metastases indicates long-term outcomes similar to that

210. Methods-Guidance-Topics Methods (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-topics_methods.pdf
     January 01, 2010 - Researchers’ success depends in large part on their ability to identify meaningful questions, while … The process for topic identification and refinement is complicated by the large range of potential … questions of patients and clinicians, and whether selected topics truly represent a potentially large … Importance Represents a significant disease burden affecting a large proportion of the population … Is of high public interest, affecting health care decisionmaking, outcomes, or costs for a large proportion

211. Abnormal-Uterine-Bleeding Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/abnormal-uterine-bleeding_executive.pdf
     March 01, 2013 - was captured from the included RCTs for KQ1, reports based on pharmacoepidemiological databases, large … observational studies, large case-controlled studies, and postmarketing surveillance data. … 40 women treated.57 The package insert suggests hypoglycemia is the most serious side effect,71 and large … analyses were not controlled for key confounders like smoking and body mass index),78 while another large … treatment, as reflected in package inserts.91,92 Surveillance studies provide good estimates from large

212. Disposition of Comments for CER 183 Tonsillectomy for OSDB (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy-disposition-170415.pdf
     January 17, 2017 - sore throats have a number of problems (too small population, too strict inclusion criteria, too few large … Paradise et al RCT involving only severely affected children with well documented illness (ref 11), large … the first RCT (ref 9), surgical vs. control differences were smaller than in the first RCT (and not large … Comment Response Peer reviewer #1 Results Watchful waiting for T, A or T&A has been pooled as a large … ES-26, line 28: Your statement "Despite the large body of literature, evidence is inadequate to provide

213. Future Research Needs for Hematopoietic Stem-Cell Transplantation in the Pediatric Population (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/stem-cell-children-future_research.pdf
     February 01, 2012 - navigating the complexities of the medical system and medication management instead of giving only a large … With the rising number of affected families, addressing this gap could have a large and beneficial impact … b. information to share with caregivers and peers, and c. provision of tools rather than only a large … As the intervention is non-drug randomization may not offer as large a barrier as in a drug trial. … Due to the complexity and the large number of diseases in the draft HSCT CER we focused on crosscutting

214. FRN 39 - Nonoperative and Operative Treatments for Rotator Cuff Tears: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rotator-cuff-tears-future_research.pdf
     February 01, 2013 - Similar to RCTs, recruitment of large numbers of patients (at least hundreds) are needed to examine … We listed large payers of rotator cuff operative and nonoperative care and industry representatives. … • Data sources: Are there additional outcomes data sources (large health plan, CMS, VA, other)? … If a large proportion of rotator cuff repairs fail early (i.e., en route from the operating room to … Represents a significant disease burden; large proportion or priority population 2b.

215. Systematic Review on Nonopioid Pharmacologic Treatments for Chronic Pain: Surveillance Report 2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-2-nonopioid-pharm-chronic-pain.pdf
     April 01, 2022 - sample sizes of new studies eligible for meta-analysis (meta-analysis performed if new evidence was large … • SOE: Low, based on 19 RCTs Moderate increase in WAEs • SOE: Moderate, based on 26 RCTs Large … increase in cognitive AEs • SOE: Low. based on 8 RCTs Large increase in dizziness, peripheral … short- term Topical capsaicin resulted in moderate increase in application site erythema and a large … increase in risk for cognitive effects, moderate SOE for large increase in risk for sedation).

216. Executive Summary_Systematic Review: Interventions To Improve Care of Bereaved Persons (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-research-executive-summ.pdf
     March 01, 2025 - Limitations We identified a large body of evidence documenting intervention evaluations for bereaved … 2018 and the DSM-5-TR in 2022. 9 Implications and Conclusions Despite the large

217. Long-Term Care for Older Adults Disposition of Comments Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/long-term-care-adults_disposition-comments.pdf
     November 07, 2012 - equal to or below the eligibility level for the Supplemental Security Income (SSI) program or incur large … Reviewer #1 Results The large number of tables in the text of the report were difficult to deal with … HCBS) is still framed as "which is better" since the populations are very different and, by and large … The authors propose a large prospective cohort study with independent data collectors using a common … As will be detailed below, there are a large handful of factually incorrect statements, mostly related

218. Disposition of Comments Report for Comparative Effectiveness Review No. 137 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-update_disposition-comments.pdf
     August 06, 2014 - Large, well-conducted cohort studies with comparisons can be very useful in establishing effectiveness … than real, and are artifacts of constraints that resulted in the reviewers excluding most of the large … Numerous published meta-analyses and other syntheses of data from large numbers of ABA CCTs show that … To a large extent the categorization of interventions was driven from a consumer perspective (i.e., … In large part, the authors refer to the earlier review paper (2011) but this is insufficient.

219. An analytical framework for quantifying components of variability in prescriber decisions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
     April 01, 2010 - exposure effects and so may result in studies underpowered to detect small effects, even in very large … weak, an IV study will be underpowered to detect anything less than a very strong effect, even with large … To see this, imagine including a very large number of random numbers as instruments in the first stage … There is a large literature in economics on testing for whether an IV is necessary. … assume that one has available a valid IV and the test then attempts to determine whether there is a large

220. Hemorrhage-Postpartum Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
     April 01, 2015 - on any outcome is insufficient or moderate, as the observational data are biased and a single very large … with regard to reducing PPH, and assessors of a somewhat subjective outcome were not masked in 1 large … • Conducting additional prospectively designed and reported studies that report data from large national … A floor would suggest that we need very large pragmatic trials aimed not at reducing the occurrence of … of the included studies that suggest benefits are worth pursing on a larger scale, including a scale large