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1. Machine-Learning-Tools-Appendix-D (xls file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/machine-learning-tools-appendix-d.xlsx
   January 01, 2024 - Automatically Extracting Numerical Results from Randomized Controlled Trials with Large Language Models … How good are large language models for automated data extraction from randomized trials? … How good are large language models for automated data extraction from randomized trials? … How good are large language models for automated data extraction from randomized trials? … How good are large language models for automated data extraction from randomized trials?

2. Evidence Summary Comparative Effectiveness Review No. 250: Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-other-plant-based-treatments-evidence-summary_0.pdf
   October 01, 2021 - There may be a large increased risk of dizziness and sedation and a moderate increased risk of nausea … Synthetic THC is probably associated with a large increased risk of dizziness. … • Extracted whole-plant high-THC to CBD ratio products may be associated with large increases in … a Effect size: none (i.e., no effect/no statistically significant effect), small, moderate, or large … effect (6) [+] Moderate effect (6) [+] Large effect (6) [+] High-THC – Synthetic, Oral

3. Nonopioid Pharmacologic Treatments for Chronic Pain: Evidence Summary (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
   April 01, 2020 - Large increases were seen with oxcarbazepine. … Oxcarbazepine led to a large increased risk of WAEs. … ++ Moderate + NA NA Sedation Large ++ Large + NA NA Serotonin syndrome No evidence No evidence … + SAE None + None + Blurred vision Large + NA Cognitive effects Large + No evidence Dizziness … Large ++ NA Peripheral edema Large ++ NA Sedation Large ++ None + Weight gain Large ++ NA

4. Executive summary_Comparative Effectiveness Review No. 250_Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2024 Update (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-executive-sum.pdf
   January 01, 2024 - There may be a large increased risk of dizziness and sedation (SOE: low) and a moderate increased risk … THC plus CBD is probably associated with large increased risk of nausea (SOE: moderate). … (high THC to CBD ratio) versus placebo, updated meta-analyses changed pooled estimates for nausea (large … , Oral Moderate effect (6, 1 new)a [] Insufficient (2, 1 new) Large effect (4, 1 new) [ … Large effect (1) [] Insufficient (1) Large effect (1) [] No evidence No evidence Low THC –

5. Evidence Summary_Comparative Effectiveness Review No. 247_Interventional Treatments for Acute and Chronic Pain: Systematic Review (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
   September 01, 2021 - The magnitude of effects was classified as small, moderate or large using previously defined criteria … Kyphoplasty • Kyphoplasty for vertebral compression fracture (2 trials, N=434) was associated with large … reductions in pain and moderate to large improvement in function versus usual care at 1 week and 1 … reduction in pain and small to large improvement in function versus sham radiofrequency at 1 month … usual care Vertebral compression fractures Large ++ Large ++ Moderate + Moderate

6. Evidence Summary_Comparative Effectiveness Review No. 250_Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2022 Update (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-evidence-summary-2022-update_0.pdf
   January 01, 2022 - There may be a large increased risk of dizziness and sedation and a moderate increased risk of nausea … Synthetic THC is probably associated with a large increased risk of dizziness. … • Extracted whole-plant high-THC to CBD ratio products may be associated with large increases in … Results with a small, medium, or large effect that were not statistically significant were considered … Potential effecta (4) [+] Insufficient (1) Large effect (2) [++] Potential effecta (2

7. Executive summary_Comparative Effectiveness Review No. 250_Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2025 Update (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2025-surv-rep-update-executive-sum.pdf
   January 01, 2025 - There may be a large increased risk of dizziness and sedation (SOE: low) and a moderate increased risk … THC plus CBD is probably associated with large increased risk of nausea (SOE: moderate). … effect (6) [] Moderate effect (6) [] Large effect (6) [] High THC – Synthetic or … Purified, Oral Moderate effect (6, 1 new)a [] Insufficient (2, 1 new) Large effect (4, 1 … , Oral Large effect (1) [] Insufficient (1) Large effect (1) [] No evidence No evidence

8. White Paper: Narratively Describing Effects of Interventions in Systematic Reviews (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-roadmap-interventions.pdf
   November 01, 2020 - For example, a relative risk of 5 indicates a very large magnitude of effect (strong association), even … effect In children with anxiety, fluvoxamine may cause a large reduction in anxiety symptoms.4 … effect X results in a large reduction/increase in outcome Moderate effect X reduces/increases outcome … effect X likely results in a large reduction/increase in outcome X probably results in a large reduction … effect (Low certainty of evidence) X may result in a large reduction/increase in outcome The

9. Layout 1 (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain_executive.pdf
   October 01, 2011 - Much of the evidence for increased risks comes from two large colon polyp prevention trials. … In most large observational studies, naproxen was associated with a neutral effect on risk of serious … Large observational studies that stratified patients by age found no clear evidence of different risk … Large, long-term trials with active and placebo- controlled arms would be needed to assess the safety … • Large, long-term trials of the GI and CV safety associated with full-dose aspirin, salsalate, or

10. Designing a Deliberative Forum (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/delilberative-methods-design-abelson.pdf
    May 29, 2025 - Size of group o deliberative events can include large groups of 100 – 1000+ or smaller groups of … meaningful deliberation  Establish clear goals and carefully manage transitions between small and large

11. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_executive.pdf
    October 01, 2007 - In large registries, procedural survival has increased significantly over time. … In large clinical registries, comparative survival after PCI or CABG varied significantly according to … In analyses from large clinical registries of patients with middle spectrum CAD severity, there was no … Nevertheless, some conclusions can be drawn from the evidence provided by randomized trials and large … BARI—Bypass Angioplasty Revascularization Investigation Large U.S.

12. Slide 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cf_deliberativemethodswebinar_desigingdeliberativeforum.pdf
    May 29, 2025 - Size of group - deliberative events can include large groups of 100 – 1000+ or smaller groups of … meaningful deliberation • Establish clear goals and carefully manage transitions between small and large

13. Executive Summary - Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2023 Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-executive-summary-2023-update.pdf
    January 01, 2023 - There may be a large increased risk of dizziness and sedation and a moderate increased risk of nausea … Synthetic THC is probably associated with a large increased risk of dizziness. … to10-point scale, >10 to 20 points on a 0 to 100-point scale • SMD >0.5 to 0.8 • RR/OR 1.5 to 1.9 Large … effect (6) [] Moderate effect (6) [] Large effect (6) [] High THC – Synthetic, Oral … Potential effecta (5, 1 new) [] Insufficient (1) Large effect (3, 1 new) [] Potential

14. Executive Summary_Systematic Review: Association of Digestible Carbohydrate Intake With Cardiovascular Disease, Type 2 Diabetes, Obesity, and Body Composition (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible-executive-summary.pdf
    March 01, 2025 - • No clear or consistent dose- response gradient or large effect. … • No clear or consistent dose- response gradient or large effect. … • No clear or consistent dose- response gradient or large effect. … • No clear or consistent dose- response gradient or large effect. … • No clear or consistent dose-response gradient or large effect.

15. Machine Learning Tools To (Semi-)Automate Evidence Synthesis: A Rapid Review and Evidence Map, Version 2 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/white-paper-machine-learning-tools-v2.pdf
    July 01, 2025 - data from large amounts of text (usually from the Internet). … Can large language models replace humans in systematic reviews? … Performance of a Large Language Model in Screening Citations. … High-performance automated abstract screening with large language model ensembles. … Performance of two large language models for data extraction in evidence synthesis.

16. The use of a large language model to create plain language summaries of evidence reviews in healthcare: A feasibility study | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/grant-manuscripts/feasibility-study-abstract

17. Executive Summary: ADHD Diagnosis and Treatment in Children and Adolescents (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-267-adhd-executive-summary.pdf
    March 01, 2024 - • Despite the large body of research, comparative effectiveness and safety information is limited … We identified a large number of diagnostic approaches. … Despite the large body of research, comparative effectiveness and safety information is limited. … Despite the large number of identified studies, some areas remain the subject of future research, including … Implications and Conclusions A large number of diagnostic tools are available to inform the clinical

18. AHRQ Slide Template
    effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-pain-management-grand-rounds-slides.pptx
    March 01, 2022 - Effect Size (N Studies) [SOE]a Comparable THC/CBD Oromucosal Spray Insufficient (5) No effect (2) [+] Large … effect (6) [+] Moderate effect (6) [+] Large effect (6) [+] High-THC – Synthetic, Oral Potential effectb … (4) [+] Insufficient (1) Large effect (2) [++] Potential effectb (2) [+] Moderate effect (3) [+] High-THC … – Extracted From Whole-Plant, Oral Large effect (1) [+] Insufficient (1) Large effect (1) [+] No evidence … (1) a Effect size: none (i.e., no effect/no statistically significant effect), small, moderate, or large

19. Comparative Effectiveness Review No. 266_Cervical Degenerative Disease Treatment: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-266-cdd-executive-summary.pdf
    November 01, 2023 - Mortality, severe dysphagia: Similar (+) Reoperation Insufficient SAE: Moderate to Large … NA Insufficient Similar (++) No evidence Reoperation: Similar (++) AEs: Moderate to Large … ACDF NA Similar (++) Similar (++) No evidence Reoperation: Large, favors cervical … vs. other osteogenic materials Insufficient Insufficient Insufficient Insufficient AEs: Large

20. Evidence Summary for Treatments for Acute Pain: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-evidence-summary.pdf
    December 01, 2020 - The magnitude of effects was classified as small, moderate or large using previously defined criteria … For neck pain with radiculopathy, a cervical collar or exercise might be associated with moderate to large … Acupressure might be associated with moderate to large decreases in pain at 1 day to < 1 week and with … Massage might be associated with moderate to large decrease in pain intensity at <1 day and decreased … NSAIDs are probably associated with moderate to large decrease in pain versus acetaminophen at <1 day