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1. Simulation-Based Comparison of Methods and Meta-Analysis of Proportions and Rates (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/pdf/metanalysis-proportion-rate-comparison_research.pdf
   November 01, 2013 - levels: zero, small, and large. … positive bias and a large proportion RMSE. … positive bias and a large proportion RMSE. … positive bias and a large proportion RMSE. … positive bias and a large proportion RMSE.

2. Improving Access to and Usability of Systematic Review Data for Health Systems Guidelines Development | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/systematic-review-data/methods-report
   February 28, 2019 - Purpose of Project Identify and test interactive methods to make the large amount of data in an Evidence-based … may impede understanding and use in decision processes, but little evidence exists on transforming large … address the identified needs, and (3) to test the ability of selected software/platforms to make the large … this "proof-of-concept" prototype development demonstrate that existing tools could be used to make large

3. Evidence Summary Comparative Effectiveness Review No. 250: Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/cer-250-cannabis-other-plant-based-treatments-evidence-summary.pdf
   October 01, 2021 - There may be a large increased risk of dizziness and sedation and a moderate increased risk of nausea … Synthetic THC is probably associated with a large increased risk of dizziness. … • Extracted whole-plant high-THC to CBD ratio products may be associated with large increases in … a Effect size: none (i.e., no effect/no statistically significant effect), small, moderate, or large … Potential effectb (4) [+] Insufficient (1) Large effect (2) [++] Potential effectb (2) [+]

4. Evidence Summary Comparative Effectiveness Review No. 250: Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-other-plant-based-treatments-evidence-summary_0.pdf
   October 01, 2021 - There may be a large increased risk of dizziness and sedation and a moderate increased risk of nausea … Synthetic THC is probably associated with a large increased risk of dizziness. … • Extracted whole-plant high-THC to CBD ratio products may be associated with large increases in … a Effect size: none (i.e., no effect/no statistically significant effect), small, moderate, or large … Potential effectb (4) [+] Insufficient (1) Large effect (2) [++] Potential effectb (2) [+]

5. Nonopioid Pharmacologic Treatments for Chronic Pain: Evidence Summary (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
   April 01, 2020 - Large increases were seen with oxcarbazepine. … Oxcarbazepine led to a large increased risk of WAEs. … ++ Moderate + NA NA Sedation Large ++ Large + NA NA Serotonin syndrome No evidence No evidence … + SAE None + None + Blurred vision Large + NA Cognitive effects Large + No evidence Dizziness … Large ++ NA Peripheral edema Large ++ NA Sedation Large ++ None + Weight gain Large ++ NA

6. Evidence Summary_Comparative Effectiveness Review No. 247_Interventional Treatments for Acute and Chronic Pain: Systematic Review (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
   September 01, 2021 - The magnitude of effects was classified as small, moderate or large using previously defined criteria … Kyphoplasty • Kyphoplasty for vertebral compression fracture (2 trials, N=434) was associated with large … reductions in pain and moderate to large improvement in function versus usual care at 1 week and 1 … reduction in pain and small to large improvement in function versus sham radiofrequency at 1 month … usual care Vertebral compression fractures Large ++ Large ++ Moderate + Moderate

7. Evidence Summary_Comparative Effectiveness Review No. 247_Interventional Treatments for Acute and Chronic Pain: Systematic Review (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary.pdf
   September 01, 2021 - The magnitude of effects was classified as small, moderate or large using previously defined criteria … Kyphoplasty • Kyphoplasty for vertebral compression fracture (2 trials, N=434) was associated with large … reductions in pain and moderate to large improvement in function versus usual care at 1 week and 1 … reduction in pain and small to large improvement in function versus sham radiofrequency at 1 month … usual care Vertebral compression fractures Large ++ Large ++ Moderate + Moderate

8. Evidence Summary_Comparative Effectiveness Review No. 247_Interventional Treatments for Acute and Chronic Pain: Systematic Review (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
   September 01, 2021 - The magnitude of effects was classified as small, moderate or large using previously defined criteria … Kyphoplasty • Kyphoplasty for vertebral compression fracture (2 trials, N=434) was associated with large … reductions in pain and moderate to large improvement in function versus usual care at 1 week and 1 … reduction in pain and small to large improvement in function versus sham radiofrequency at 1 month … usual care Vertebral compression fractures Large ++ Large ++ Moderate + Moderate

9. Evidence Summary_Comparative Effectiveness Review No. 250_Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2022 Update (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-evidence-summary-2022-update_0.pdf
   January 01, 2022 - There may be a large increased risk of dizziness and sedation and a moderate increased risk of nausea … Synthetic THC is probably associated with a large increased risk of dizziness. … • Extracted whole-plant high-THC to CBD ratio products may be associated with large increases in … Results with a small, medium, or large effect that were not statistically significant were considered … [+] Insufficient (1) Large effect (1) [+] No evidence No evidence Low THC – Topical CBD No

10. Nonopioid Pharmacologic Treatments for Chronic Pain | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/nonopioid-chronic-pain/research
    April 16, 2020 - In general, evidence on quality of life was limited and no treatment achieved a large improvement in … Large increases were seen with oxcarbazepine. … Magnitude of effects were described as small, moderate, or large using previously defined criteria, and … Large increases in risk of adverse events were seen with pregabalin (blurred vision, cognitive effects

11. Treatments for Fibromyalgia in Adult Subgroups | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/fibromyalgia/research
    January 26, 2015 - We focused on patient subgroups rather than overall treatment effects to complement a large systematic

12. Executive Summary - Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2023 Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-executive-summary-2023-update.pdf
    January 01, 2023 - There may be a large increased risk of dizziness and sedation and a moderate increased risk of nausea … Synthetic THC is probably associated with a large increased risk of dizziness. … to10-point scale, >10 to 20 points on a 0 to 100-point scale • SMD >0.5 to 0.8 • RR/OR 1.5 to 1.9 Large … effect (6) [] Moderate effect (6) [] Large effect (6) [] High THC – Synthetic, Oral … Potential effecta (5, 1 new) [] Insufficient (1) Large effect (3, 1 new) [] Potential

13. White Paper: Narratively Describing Effects of Interventions in Systematic Reviews (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-roadmap-interventions.pdf
    November 01, 2020 - For example, a relative risk of 5 indicates a very large magnitude of effect (strong association), even … effect In children with anxiety, fluvoxamine may cause a large reduction in anxiety symptoms.4 … effect X results in a large reduction/increase in outcome Moderate effect X reduces/increases outcome … effect X likely results in a large reduction/increase in outcome X probably results in a large reduction … effect (Low certainty of evidence) X may result in a large reduction/increase in outcome The

14. Topic Suggestion Description | Effective Health Care Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/what-is-the-effectiveness-of-interventions-designed-to-support-children-in-transition-from-pediatric-care-to-adult-care-with-special-health-care-needs-ineffective-transition-planning-can-have-significant-negative-consequences
    January 07, 2013 - negative consequences on children with special health care needs, his/her family, and on the system at large … negative consequences on the children with special health care needs, his/her family, and on the system at large … (For example, you are developing a clinical guideline, working with a policy with large uncertainty about … A very large number of children with special health care needs become adults every day1, and systems … negative consequences on the children with special health care needs, his/her family, and on the system at large

15. Oral Mechanical Bowel Preparation for Colorectal Surgery | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/colorectal-surgery-preparation/research-protocol
    March 26, 2013 - a frequent procedure; in 2009, there were 254,000 surgeries categorized as partial excisions of the large … An analysis of claims from one large insurer demonstrated that the most common indication for colorectal … Patients dislike the large quantities of unpleasant-tasting laxative solutions required and the long … These studies are fairly large and thus have the potential to influence the analyses substantially. … Comparison of oral polyethylene glycol plus a large volume glycerine enema with a large volume glycerine

16. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain_executive.pdf
    October 01, 2011 - Much of the evidence for increased risks comes from two large colon polyp prevention trials. … In most large observational studies, naproxen was associated with a neutral effect on risk of serious … Large observational studies that stratified patients by age found no clear evidence of different risk … Large, long-term trials with active and placebo- controlled arms would be needed to assess the safety … • Large, long-term trials of the GI and CV safety associated with full-dose aspirin, salsalate, or

17. Interventional Treatments for Acute and Chronic Pain: Systematic Review | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/interventional-treatments-pain/research
    September 03, 2021 - Effects were classified as small, moderate, or large using previously defined criteria. Results. … pain and function in older patients with vertebral compression fracture at up to 1 month (moderate to large … trials) is probably more effective for pain and function versus sham at 1 and 3 months (moderate to large

18. Draft Report: Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/draft-report-plant-based-treatment.pdf
    March 01, 2021 - Magnitude of benefit was categorized into no effect, or small, moderate, and large effects. … There was a large increased risk of dizziness and sedation and a moderate increased risk of nausea ( … Synthetic THC is probably associated with a large increased risk of dizziness. … (3) + High-THC – Extracted From Whole-plant, Oral Large effect (1) + Insuff icient (1) Large … (3) + High-THC – Extracted From Whole-plant, Oral Large effect (1) + Insuff icient (1) Large

19. Meta-Analytic Statistical Inferences for Continuous Measure Outcomes as a Function of Effect Size Metric and Other Assumptions | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/statistical-inference/research
    April 10, 2013 - meta-analysis (k = 10, 20, 50, and 100); (2) mean study sample sizes (5 values of N ranging from small to very large … statistical inferences even under such commonly observed circumstances as normal sampling distributions, large … numbers of studies, and studies with large samples, and when effects exhibit heterogeneity.

20. Analysis of Device Shock Patterns Among Patients With Implantable Cardiac Defibrillators (ICDs) | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/cardiac-defibrillators/abstract
    December 15, 2009 - Methods: This study will combine data from a large, national ICD registry with electronic health records … from several large health insurance plans to identify patients who have had an ICD implantation.