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Showing results for "lack".

161. 8 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_chou_assessing_harms_when_comparing.pdf
     November 01, 2008 - First, most RCTs lack prespecified hypotheses for harms. 5 Rather, hypotheses are usually designed … insufficient to assess the methods used to select participants. 45 In addition, because such studies lack … , tolerated the medication, and agreed to participate in the extension), are unblinded, and often lack … Observational Studies Because observational studies lack randomization, they should adhere to high … In such cases, CERs should acknowledge the lack of statistical power to assess risk adequately and

162. Template for Reports Developed (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-topic-nomination_methods.pdf
     November 01, 2012 - Potential risk from inaction: -Unintended harms from lack of prioritization of a nominated topic … Figure 2); (2) the importance to the U.S. population and health care system; (3) desirability (or lack … A poorly defined PICO can lead to development of a topic that may miss important populations, lack … Documentation in the Cover Sheet should include the lack of sufficient evidence for a synthesis to be … Clinical consultation is used to confirm a lack of evidence and the need to rely solely on clinical

163. Disposition of Comments: Comparative Effectiveness Review 235_Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD-Repository Evidence Base (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-comments.pdf
     November 04, 2020 - A forthcoming paper is planned to highlight the lack of reporting in this area and we will ensure that … We have added the following section to the portion of the report describing lack of reporting to explain … These data are not presented in Table 3 with other lack of reporting data because many studies reported … A forthcoming paper is planned to highlight the lack of reporting in this area and we will ensure … We have expanded the section describing lack of reporting in the studies to provide more clarification

164. Disposition of Comments for Chronic Urinary Retention: Comparative Effectiveness and Harms of Treatments (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-urinary-retention_disposition-comments.pdf
     September 15, 2014 - Due to the lack of any strong evidence found in current literature, there are few conclusions which … It may also be worthwhile to include in the introduction a statement regarding the relative lack of … As I recall from an earlier conversation, the gene was surprised by the lack of good evidence. … Under limitations on page 13, I would point out that there is a lack of standardization with regards … Unfortunately, given the lack of high levels of evidence, one cannot use this report to inform policy

165. Disposition of Comments_CER 231 Care Interventions for People Living With Dementia and Their Caregivers (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-231-dementia-care-interventions-disposition-comments.pdf
     July 31, 2020 - We believe the issue of lack of assessment is better handled in the preceding report subsection on … It was certainly depressing to see the lack of evidence of so many interventions and millions upon … This paucity of research on an important question suggests a lack of attention, respect and/or lack … Nonetheless, the current lack of effective non- pharmacological interventions raises the question of … lack as an important research gap.

166. DEcIDE 32: The Incident User Design in Comparative Effectiveness Research (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/incident-user-design_research.pdf
     May 01, 2012 - 1 Introduction Comparative effectiveness research includes cohort studies and registries that lack … Because most non-randomized studies lack detailed historical data on pretreatment characteristics, it … One of the limitations of prospective cohorts and registries (that lack computerized pharmacy records … drug use is that it reminds investigators to model a choice among therapies instead of treating the lack … Although cohort studies and registries lack randomization, an analysis based on patients’ prescription

167. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-adherence-interventions_research-protocol.pdf
     August 18, 2011 - medications for these conditions are not adhering to the regimen at their 1-year followup. 3,9 This lack … at the correct dose, and for the correct duration, system factors related to nonadherence include a lack … For example, patients may lack the cognitive ability to understand the need for the medication or how … the skills and resources that support adherence. 20-22 Substance abuse, depression, 5,20,23,24 lack … For studies that lack adequate information to determine inclusion or exclusion, we will retrieve the

168. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_disposition-comments.pdf
     June 01, 2010 - However, a detailed analysis of outpatient use was not possible because of the lack of national data … information is contained via the Novo Nordisk website and in a commentary discussing the trial’s lack … Unfortunately, given the lack of efficacy (as defined from the regulatory perspective) concluded by … In this setting, the consequence of the lack of efficacy of any therapy that might be utilized is the … Introduction Page 7, line 44: "lack of approval outside the United States" would imply that rFVIIa has

169. Topic 0315 Disparities and SMI NSD SJ clean (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0373-14083.pdf
     July 09, 2014 - Disparities represent a lack of efficiency within the health care system and therefore account for additional

170. CER 218 Disposition of Comments: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-disposition-comments.pdf
     April 23, 2019 - In the report introduction, after the statement about the lack of consensus about bisphosphonate drug … differ by age,…” Discussion Public Commenter #8 (ODP/P2P panel) The panel commented that the lack … Current draft comes across that the lack of evidence for fracture reduction across the board with long‐term … Further, the lack of such data from eligible trials and the importance of further investigating this … In the report introduction, after the statement about the lack of consensus about bisphosphonate drug

171. Treatment of Osteoarthritis of the Knee: An Update Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/osteoarthritis-knee-update-disposition.pdf
     May 04, 2017 - Peer Reviewer #6 Abstract Page 5, line 47: SoE should be spelled out in the abstract and “lack of … study from the pooled analysis, we did note that it was an outlier and was responsible for the lack … The lack of this information, might be stated in the discussion as these potential outcome measures … Guideline states that there is a lack of “compelling evidence” for their use. … Guideline states that there is a lack of “compelling evidence” for their use.

172. Treatment of Osteoarthritis of the Knee: An Update Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-knee-update-disposition-archived.pdf
     May 04, 2017 - Peer Reviewer #6 Abstract Page 5, line 47: SoE should be spelled out in the abstract and “lack of … study from the pooled analysis, we did note that it was an outlier and was responsible for the lack … The lack of this information, might be stated in the discussion as these potential outcome measures … Guideline states that there is a lack of “compelling evidence” for their use. … Guideline states that there is a lack of “compelling evidence” for their use.

173. Disposition of Comments for CER 166 Calcineurin Inhibitors (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/calcineurin-inhibitor_disposition-comments.pdf
     March 15, 2016 - these and other results may speak to the benefits of using tacrolimus in the clinical setting, the lack … It may therefore be reasonable to draw attention to this missing design element (lack of conventional-dose … We also discuss trial heterogeneity, and note the lack of literature comparing tacrolimus standard … Development Medical Affairs, Americas Discussion At this point, it is important to comment on how the lack … consensus in terms of safety or efficacy We have revised the Discussion section to acknowledge the lack

174. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_disposition-comments.pdf
     March 10, 2010 - The lack of information about who is most likely to experience adverse affects from the drugs. … Results P24, lines 4-9: see above comment about lack of clarity with subgroup comparisons. … The lack of discussion of this data is problematic to its broader application, albeit methodologically … The wording of the sentence should be changed to reflect lack of statistical significance. … The meta-analysis did not show a statistically significant decrease in noninvasive cancers, but the lack

175. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism_executive.pdf
     April 01, 2011 - Individuals with ASDs have impaired social interaction, behavior, and communication,2 including lack … something in which the child is interested); dysfunctional or absent communication and language skills; lack … This lack of comparison groups presents substantial challenges for assessing effectiveness at a population … Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive … Lack of benefit of intravenous synthetic human secretin in the treatment of autism.

176. Screening and Diagnosing Gestational Diabetes Mellitus Disposition of Comments Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gestational-diabetes-screening-diagnosis_disposition-comments.pdf
     January 01, 2020 - For example, the problem of the lack of a "gold standard" for diagnosis of GDM is mentioned but no … Peer Review #9 General In view of the lack of "gold standard" for diagnosis of GDM, I believe there … This report clearly shows the lack of uniformity in diagnosis GDM and shows the continuous relationship … summarizes background, risk factors, screening and diagnostic strategies and problems related to lack … The issues of the lack of a gold standard is not addressed and is critical to advancement of any of

177. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - Barriers to EC use include lack of knowledge or awareness, lack of access, negative attitudes toward … Despite its safety and efficacy, EC use remains low.4 Barriers to use include lack of knowledge or … awareness, lack of access, negative attitudes toward EC, and cost.

178. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1306.pdf
     June 11, 2013 - Barriers to EC use include lack of knowledge or awareness, lack of access, negative attitudes toward … Despite the safety and efficacy of EC, its use remains low.4 Barriers to EC use include lack of knowledge … or awareness, lack of access, negative attitudes toward EC, and high costs.

179. S23 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s23.pdf
     October 01, 2007 - There is limited knowledge and lack of adequate data on the most transparent method of communicating … of Medicine (IOM) forum on understanding the benefits and harms of pharmaceuticals1 highlighted the lack … However, a similar calculation for benefits is not possible, and this lack of transparency might bias … The lack of clarity for this end point might need to be addressed by scientists and physicians together

180. Executive Summary: Systematic Review_Implementing Recommended Mental Health and Substance Use Screening and Counseling Interventions in Primary Care Settings for Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/screening-counseling-interventions-executive-summary.pdf
     April 01, 2025 - and counseling that resulted from implementation approaches, the combination of limited evidence and lack … Although the inclusion of such studies would have resulted in a greater volume of evidence, the lack … This is due to lack of data for certain conditions addressed in the USPSTF and Bright Futures guidelines