-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prosthesis_research-protocol.pdf
March 16, 2017 - Knee units not eligible for prosthesis. … Knee units: Single-axis, constant friction knee. … Knee units: Single-axis, constant friction knee. … Knee units: Any ankle knee system appropriate. … , below the knee, or above the ankle.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_appendixes.pdf
January 01, 2006 - naproxen 500 bid 944 6
Niccoli OA of the hand, hip or knee 25 diclofenac 50 mg tid 90 2
Saag OA of … knee or hip and flare (for
NSAID users) or acetominophen
user. … Excluded aspirin 81mg
users.
12.5, 25 ibuprofen 800 tid 667 6
Saag OA of knee or hip and flare … Excluded aspirin 81mg
users.
12.5, 25 diclofenac 50 tid 693 52
Truitt OA of knee or hip 12.5, … ;
fibromyalgia; and other painful or disabling condition affecting the knee.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-rept-1-acute-pain.pdf
May 01, 2022 - Knee Surg
Sports Traumatol Arthrosc.
2021;29(5):1362-9. doi: 10.1007/s00167-
020-06401-x. … Knee.
2021;29:216-21. doi:
10.1016/j.knee.2021.01.020. PMID:
33640620. … Opioid use patterns after primary total knee
replacement. … knee arthroplasty. … J Knee Surg. 2020 doi:
10.1055/s-0040-1721035. PMID: 33241542.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-disposition-120516.pdf
October 01, 2011 - completing a new guideline
related to pharmacologic and non-pharmacologic
treatment of OA of the hip, knee … Rates of knee arthroplasty were not reported in the RCTs
included in the systematic reviews. … Structure-
modifying effects of chondroitin sulfate in knee
osteoarthritis: an updated meta-analysis … Chondroitins 4 and 6 sulfate in
osteoarthritis of the knee: a randomized,
controlled trial. … The primary efficacy outcome for knee
osteoarthritis was the Huskisson’s VAS and for
psoriasis was
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-report-testing-machine-learning-tool-chronic-pain.pdf
November 01, 2020 - ((chronic or pain) and (back or spine or spinal or cervical or radicular or neck or knee or
hip)).ti … ((chronic or pain) and (back or spine or spinal or cervical or radicular or neck or knee or
hip)).ti … Intensive gait training for older adults with
symptomatic knee osteoarthritis. … Randomized controlled trial
of diclofenac sodium gel in knee osteoarthritis. … Tapentadol prolonged-release for moderate-to-severe chronic
osteoarthritis knee pain: a double-blind
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-rept-1-acute-pain.xlsx
May 29, 2025 - postoperative complications NR Fair
Brouwers, 2021 Postoperative to outpatient The Netherlands Total knee … B
Knee Injury and Osteoarthritis Outcome Score- Activities of Daily Living (mean [SD], 0 to 100 scale … B
Knee Injury and Osteoarthritis Outcome Score- knee related QOL (mean [SD], 0 to 100 scale, higher score … Knee or hip arthroplasty Nonpharmacological therapy vs. no nonpharmacological therapy A: Music therapy … =0.64 NR NR NR Florida Nurses Association Fair
Rian, 2021 Postoperative to outpatient Norway Total knee
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-report-2-acute-pain.pdf
May 01, 2022 - Knee Surg
Sports Traumatol Arthrosc.
2021;29(5):1362-9. doi: 10.1007/s00167-
020-06401-x. … Knee.
2021;29:216-21. doi:
10.1016/j.knee.2021.01.020. PMID:
33640620. … Opioid use patterns after primary total knee
replacement. … knee arthroplasty. … J Knee Surg. 2020 doi:
10.1055/s-0040-1721035. PMID: 33241542.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-report-3-acute-pain.pdf
June 01, 2022 - Knee Surg
Sports Traumatol Arthrosc.
2021;29(5):1362-9. doi: 10.1007/s00167-
020-06401-x. … Knee.
2021;29:216-21. doi:
10.1016/j.knee.2021.01.020. PMID:
33640620. … Opioid use patterns after primary total knee
replacement. … knee arthroplasty. … J Knee Surg. 2020 doi:
10.1055/s-0040-1721035. PMID: 33241542.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-3-acute-pain.xlsx
May 29, 2025 - postoperative complications NR Fair
Brouwers, 2021 Postoperative to outpatient The Netherlands Total knee … B
Knee Injury and Osteoarthritis Outcome Score- Activities of Daily Living (mean [SD], 0 to 100 scale … B
Knee Injury and Osteoarthritis Outcome Score- knee related QOL (mean [SD], 0 to 100 scale, higher score … None Poor
Ilyas, 2021 Outpatient United States Outpatient orthopedic surgery (shoulder, elbow, wrist, knee … Knee or hip arthroplasty Nonpharmacological therapy vs. no nonpharmacological therapy A: Music therapy
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-2-acute-pain.xlsx
May 29, 2025 - postoperative complications NR Fair
Brouwers, 2021 Postoperative to outpatient The Netherlands Total knee … B
Knee Injury and Osteoarthritis Outcome Score- Activities of Daily Living (mean [SD], 0 to 100 scale … B
Knee Injury and Osteoarthritis Outcome Score- knee related QOL (mean [SD], 0 to 100 scale, higher score … None Poor
Ilyas, 2021 Outpatient United States Outpatient orthopedic surgery (shoulder, elbow, wrist, knee … Knee or hip arthroplasty Nonpharmacological therapy vs. no nonpharmacological therapy A: Music therapy
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - N Randomized
N Analyzed Intervention Duration (Weeks) Funding Source
Hudson, 2021
New Zealand
Good Knee … Placebo 14 Government
Khan Panezai, 2021
Pakistan
Fair Knee OA Age, mean: 49
Female: 70%
Race: NR
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-2-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - Nortriptyline for pain in knee osteoarthritis:
a double-blind randomised controlled trial in
New Zealand … An Updated
Systematic Review and Meta-analysis of
Duloxetine for Knee Osteoarthritis Pain. … Effectiveness and safety of non-steroidal
anti-inflammatory drugs and opioid
treatment for knee and … Efficacy of piroxicam mesotherapy in
treatment of knee osteoarthritis: a
randomized clinical trial. … Efficacy of
duloxetine in patients with knee
osteoarthritis or chronic low back pain with
early pain
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - 12 Short 2 33 0 33 NR NR NR NR NR NR NR NR 1 33 33 NR NR NR NR NR NR NR 0 33 33
Hudson, 2021 Good Knee … NR 4 99 NR NR NR NR NR NR NR NR 86 99 102 Sweating 31 99 102 58 99 102 NR NR NR
Hudson, 2021 Good Knee
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-1-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - difference between nortriptyline
versus placebo in pain
improvement, function, or quality
of life in knee … Nortriptyline for pain in knee osteoarthritis:
a double-blind randomised controlled trial in
New Zealand … An Updated
Systematic Review and Meta-analysis of
Duloxetine for Knee Osteoarthritis Pain. … Efficacy of piroxicam mesotherapy in
treatment of knee osteoarthritis: a
randomized clinical trial. … Efficacy of
duloxetine in patients with knee
osteoarthritis or chronic low back pain with
early pain
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/thromboembolism-update-disposition.pdf
June 22, 2017 - Tricompartmental knee
replacement and unicompartmental knee
replacement There is a major difference … American
Association of
Hip and Knee
Surgeons
(Michael J. … American
Association of
Hip and Knee
Surgeons
(Michael J. … American
Association of
Hip and Knee
Surgeons
(Michael J. … American
Association of
Hip and Knee
Surgeons
(Michael J.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-213-lower-limb-protheses-evidence-summary.pdf
September 01, 2018 - long-
term LLP use; 11 to 22 percent of
patients abandon their LLP after 1
year; people with above-the-knee … amputations are more likely to
abandon their prostheses than people
with below-the-knee amputations; … Only
one study, which compared a specific microprocessor
knee (Genium™) to any prior used knee (mostly … another
microprocessor knee, C-Leg™), analyzed the most
important aspect of the KQ, namely whether … and, mostly, the C-Leg
microprocessor knee).
-
effectivehealthcare.ahrq.gov/sites/default/files/noninvasive-nonpharm-pain-summary.pdf
April 01, 2020 - rehabilitation
(MDR)
– Neck pain: Exercise, low-level laser, mind-body
practices, massage, acupuncture
– Knee … Comparative Effectiveness of Interventions
Knee Osteoarthritis Pain
• One new trial found that more … For example, new trials of exercise
versus nonactive comparators in chronic low back
pain and knee … For knee OA, effect sizes were
upgraded for functional improvement to moderate
at intermediate-term … Treatment
of Osteoarthritis of the Knee: An Update Review.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - 12 Short 2 33 0 33 NR NR NR NR NR NR NR NR 1 33 33 NR NR NR NR NR NR NR 0 33 33
Hudson, 2021 Good Knee … NR 4 99 NR NR NR NR NR NR NR NR 86 99 102 Sweating 31 99 102 58 99 102 NR NR NR
Hudson, 2021 Good Knee
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - N Randomized
N Analyzed Intervention Duration (Weeks) Funding Source
Hudson, 2021
New Zealand
Good Knee
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/impact-healthcare-algorithms-racial-ethnic-disparities-March-2.pdf
May 15, 2023 - disadvantaged
• But story isn’t as simple as it looks
• Typical exercise in literature, e.g.,
for knee … literature
► Black patients’ pain not reflected
in disease severity
• Leads to allocation of non
knee-based … Pain
X-ray
Looks
normal
‘Not in the
knee’
Current SOTA
Measuring osteoarthritis severity … experience
• But once we have data: a very straightforward ML
problem
► If pain is predictable from knee … image
− …Pain is in the knee (not in the head, coping, …)
Algorithm closes nearly half the pain gap