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effectivehealthcare.ahrq.gov/sites/default/files/outcome-definition-and-measurement-chapter-6.pptx
January 01, 2013 - Describe how to use a validated, standard instrument to measure patient-reported outcomes
Address issues … describes implications of the nature of the proposed outcomes for the study design, and enumerates issues … Issues specific to patient-reported outcomes include self-report and differential missing data. … Other situations that may give rise to issues of differential misclassification of outcomes include: … Summary Checklist (3 of 3)
Guidance Key Considerations
Address issues of bias expected to arise and
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-future_research.pdf
October 26, 2012 - Ethical issues are moderate. … Ethical, legal, and social
issues
Ethical issues are low, since patients/providers
select treatment … No major legal or ethical issues. Ethical issues are low. … Ethical, legal, and
social issues
Ethical issues are moderate, as the effectiveness of
the intervention … Ethical, legal, and
social issues
Ethical issues are moderate, as the effectiveness of
the novel
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/future-research-prioritization-methods_research.pdf
January 01, 2013 - ‡ Evidence gaps that address specific methods issues would not use PICOTS framework
¥ May require … low-income, rural/inner city, minorities, or
other individuals with special health care or access issues … to reduce health inequities; potential to allow assessment of ethical, legal, social issues pertaining … The studies needed to answer many questions may not be feasible
due to issues such as study design, … capacity, ethical issues, duration, or rarity of disease.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/epc-making-sure-evidence-understood.pdf
July 01, 2020 - Engaging with AHRQ may
improve the ability to focus evidence reviews on the issues that are important … These reviews focus on a variety of clinical,
behavioral, economic, and other issues. … selection criteria
• You can help AHRQ refine, or focus, an in-
progress report on the most important issues … Technical briefs provide an overview of
issues related to emerging technologies or clinical interventions
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/medical-interventions-comparing_methods.pdf
November 01, 2008 - This Guide presents issues key to the development of Comparative
Effectiveness Reviews and describes … recommended approaches for addressing difficult, frequently
encountered methodological issues. … This means identifying the most important issues under the priority conditions and
the optimal time … In addition to the familiar issues raised in a systematic review or meta-analysis of a single
intervention … produced by different
organizations and collaborations and build on these activities, focusing on issues
-
effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_slutsky_comparing_medical_interventions.pdf
November 01, 2008 - This Guide presents issues key to the development of Comparative
Effectiveness Reviews and describes … recommended approaches for addressing difficult, frequently
encountered methodological issues. … This means identifying the most important issues under the priority conditions and
the optimal time … In addition to the familiar issues raised in a systematic review or meta-analysis of a single
intervention … produced by different
organizations and collaborations and build on these activities, focusing on issues
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/improving-utility-evidence-synthesis-white-paper.pdf
April 01, 2021 - reports, AHRQ supports empiric research
by the EPCs to help understand or improve complex methodologic issues … We discussed issues
until no one voiced disagreements.
4
Findings
Literature Review … Coverage with
evidence development: an examination of
conceptual and policy issues. … HCV, Determination of
whether to treat HCV,
Choice of HCV treatment,
Preventing HCV
transmission, Issues … Qualitat
ive
Method
s
KI
contribut
ed to
findings
Performed
grey
literature
searches
Major issues
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-adolescents_research-protocol.pdf
March 29, 2011 - Access to Care
• Respondents commented that issues with gaining access to treatment, including legal … and
procedural issues, often complicate care for individuals with ASD. … We
acknowledge that access to care is critically important; however, investigating such issues is … We will discuss issues of access to care in the
introduction and summary portions of the review. … Autism spectrum disorders in adolescence and early adulthood: characteristics and
issues.
-
effectivehealthcare.ahrq.gov/sites/default/files/linking-evidence-reviews-tools.pdf
May 29, 2025 - Listen to the Evidence
Overall Findings
Lifestyle Interventions
Results
Harms
Implementations Issues
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
February 01, 2012 - no
ethical issues directly related to such a study. … Ethical Issues
The primary ethical issue (beyond the standard ethical issues in conducting an RCT) pertains … Thus, there would be no ethical
issues in analyzing this data. … Ethical Issues
Since data would be collected from existing studies, there would be no ethical issues … Ethical Issues
There are no ethical issues of concern.
25
High Priority Future Research
-
effectivehealthcare.ahrq.gov/sites/default/files/communicating_risk_vulnerable_populations_kreps.ppt
May 29, 2025 - Cultural issues influencing effective health communication
Beliefs, values, norms, & expectations
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nursing-home-safety_research-protocol.pdf
July 22, 2015 - Key safety issues identified in multiple sources, and of particular interest in this Technical
Brief … reasons for NH litigation (falls, pressure ulcers, weight loss, medication
errors).9 The NH safety issues … These outcomes broadly represent key
NH safety issues and encompass multiple related issues. … , with more than 100 RCTs
anticipated across the span of patient safety issues. … Are there important differences in patient safety issues for short-stay versus long-stay
residents?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-future_research.pdf
February 01, 2012 - The stakeholders prioritized general
medication safety and effectiveness issues across disorders over … The project team considered these methodological shortcomings of existing research and the issues
were … Evidence gaps for methodological issues
12. … • Incorporates issues around both clinical benefits and potential clinical harms. … Otherwise, issues are minimal,
given study is observational.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertensive-disorders-pregnancy-disposition-comments.pdf
May 31, 2023 - EPC authors believe these issues are very important for the authors of
clinical practice guidelines … related to reporting of specific outcomes, for
example, decreased deep tendon reflexes, breastfeeding issues … May 31, 2023
7
Commenter Section Comment Response
NCHR General The review focuses on practical issues … Such issues include, but are not limited to, case finding (early
diagnosis), continuity and continued … Also lacks discussion of urban/rural
issues, promote and encourage advent of telehealth for rural outreach
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/horizon-scan_research-protocol.pdf
December 01, 2011 - Issues Discussed When Analysts Present Proposed Topics at Topic Nomination
Meetings
1. … Clinical Provider(s) and Training/Credentialing Issues
13. … Potential Patient and Clinical Staff Safety Issues
17. … Patient Safety Issues (if applicable)
15. Required Resources
16. … Major changes in adoption and/or implementation issues
4.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/psychiatric-readmissions_research-protocol.pdf
December 31, 2014 - adherence with outpatient care, in some cases readmission
may be more related to community resources issues … have become too brief (in
the context of financial pressures and limited outpatient support4) and (2) issues … vary by
patient demographics, diagnosis, and coexisting conditions; and specific
harms or safety issues … Identify important issues raised by the use of these management strategies for
reducing readmissions … to reduce readmissions), 2 (context in which management strategies are used),
and 4 (key important issues
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/data-repository-reviews_white-paper.pdf
September 01, 2012 - reports, AHRQ supports empiric research
by the EPCs to help understand or improve complex methodologic issues … from a number of relevant disciplines, as well as input from
consultants on informatics and legal issues … In order to gain a thorough understanding of the issues
underpinning the creation of the proposed repository … Therefore, many of the issues
raised in this report remain in flux, and their eventual resolution will … Similarly, though we have attempted to be thorough in laying out the relevant
issues to be resolved
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/children-special-needs-transition_research-protocol.pdf
October 01, 2013 - Finally, the proposed
Technical Brief will outline training and barriers, discuss issues of importance … How do currently used approaches to transitioning health care address the complexity of
health issues … Issues and future research
Source: www.effectivehealthcare.ahrq.gov
Published online: October 2013 … We will engage Key Informants to identify issues
related to definitions, clinical areas, population, … Healthcare transition in persons
with intellectual disabilities: general issues, the Maastricht model
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effectivehealthcare.ahrq.gov/sites/default/files/communicating_risk_media_wilkes.ppt
April 01, 2006 - Some of the most important medical issues are not covered
Inaccurate reporting can generate false hopes … Information That Is Withheld or Not Explained
Issues sometimes go unreported in the media because the … community does not want to discuss problems publicly or fears that journalists will not understand the issues … Those who understand the complexities of newsworthy issues in medicine and public health should work
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-237-evidence-summary-palliative-care-ambulatory.pdf
February 01, 2021 - primary care and common serious illnesses, but none
addressed the important ambulatory palliative care issues … of multimorbidity or frailty or
issues of health equity. … Key
study limitations included issues with blinding of outcomes assessment and variations in
outcome