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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/key-informant-interviews-research.pdf
    December 19, 2017 - reports, AHRQ supports empiric research by the EPCs to help understand or improve complex methodologic issues … Prior to the focus group discussion, the KIs were sent a summary of the key issues that came out of … The summary of key issues that was created following the individual interviews and focus group discussion … of the things they gave us was called ‘Considerations for Key Informants,’ which were questions and issues … Prior to today’s discussion, we sent out a summary of the key issues that came out of the individual
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias-individual-studies_methods.pdf
    March 01, 2012 - This Guide presents issues key to the development of Comparative Effectiveness Reviews and describes … recommended approaches for addressing difficult, frequently encountered methodological issues. … conflict of interest, to rate a study as high risk of bias, although reviewers should report these issues … Quasi- experimentation: design and analysis issues for field settings. … The Handbook emphasizes that topics within the other domain should focus on issues related to bias
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_disposition-comments.pdf
    December 11, 2012 - This report is critical since it clearly outlines the issues, provides an extensive review of the literature … These issues should be addressed somewhere in the review. Thank you. … Thank you Peer Reviewer #8 Introduction The authors do a reasonable job at introducing the topic and issues … A registry will not advance the critical issues that need to be answered through high quality scientific
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/meditation_research-protocol.pdf
    October 17, 2012 - Due to issues of scope, and to ensure consistency with the nomination, our review will largely focus … In a situation where double blinding may not be feasible, the burden of the design issues is higher … We will evaluate the selection process of these studies to determine such issues around applicability … information to the EPC to identify literature search strategies and recommend approaches to specific issues
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-research-report-unhealthy-alcohol-use-final.pdf
    September 01, 2018 - reports, AHRQ supports empiric research by the EPCs to help understand or improve complex methodologic issues … Suggestions for improvement focused on issues of clarity and organization, as well as making the package … Suggestions from KIs about how to improve the package focused on issues of clarity and organization … If we were to implement this package elsewhere, what are the most important issues to keep in mind?
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label-update_disposition-comments.pdf
    September 01, 2011 - We have tried our best to highlight the evidence and the issues, but recognize it is not the role … 13 Reviewer Comment Section Page Comment Response BMS Executive Summary - Remaining Issues … ES- 14 In the “remaining issues” section on page 14, it is mentioned that “It would facilitate … Treatment and prescribing issues are complicated.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-metaanalysis_methods.pdf
    July 01, 2012 - These framing issues are addressed in other chapters of this Medical Test Methods Guide.6–8 Further, … Syntheses of medical test data often focus on test performance, and much of the attention to statistical issues … expected that readers are versed in clinical research methodology and familiar with methodological issues … We will expand on some of these issues. 8-4 Figure 8–1a.
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/pneumonia-antibiotic-treatment_research-protocol.pdf
    July 19, 2013 - www.effectivehealthcare.ahrq.gov Published online: July 19, 2013 5 In their consensus document on controversial issues … study assessed as having high risk of bias has significant risk of bias (e.g., stemming from serious issues … Consensus document on controversial issues for the treatment of hospital- associated pneumonia. … information to the EPC to identify literature search strategies and recommend approaches to specific issues
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-ems-protocol-amendment.pdf
    January 28, 2019 - current review. 2 In addition to the effectiveness and harms of prehospital analgesia, issues … Potential issues include direct harms of prehospital analgesia to the EMS provider themselves. … information to the EPC to identify literature search strategies and suggest approaches to specific issues
  10. S16 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s16.pdf
    October 01, 2007 - from industry-funded trials may remain unpublished, limiting the ability to examine potential safety issues … Subgroup analysis within trials can help explore impor- tant issues of heterogeneity of treatment effect15 … Considering usual medical care in clinical trial design: scientific and ethical issues.
  11. effectivehealthcare.ahrq.gov/sites/default/files/comparator-selection-in-observational-chapter-5.pptx
    January 01, 2013 - , the use of a historical control needs to be justified after considering associated methodological issues … in observed and unobserved domains as they are sampled differently or different source populations Issues … On the other hand, implantable devices or surgical procedures do not generally have adherence issues
  12. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
    January 01, 2007 - All the same issues noted for RA of short- and long-term risks and safety, as well as performance in … Remaining Issues Most of the trials were conducted in RA patients; data are limited for PsA patients. … Issues similar to those for RA with respect to long-term outcomes and early initiation are also important
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
    October 01, 2015 - this conclusion; one study included only patients with CKD, two included only patients with cardiac issues … Two studies included only CKD patients, one included patients with cardiac issues, and one had a general … Recent issues in contrast- induced nephropathy. Int J Urol. 2011 Oct;18(10):686-90.
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-pregnancy-postpartum_research-protocol.pdf
    March 29, 2013 - Finally, we will identify issues that future studies should address so that the woman with perinatal … We will summarize issues of applicability qualitatively. V. References 1. Halbreich U. … information to the EPC to identify literature search strategies and recommend approaches to specific issues
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-risk-of-bias.pdf
    December 01, 2017 - trained • Pilot test assessment of risk-of-bias tools using a small subset of studies • Identify issues … Finally, identify issues and revise tools or training as needed Stage 3.
  16. effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_disposition-comments.pdf
    January 01, 2015 - of knowledge, but my concern is that the presentation to the average clinician is not clear on the issues … We welcome the opportunity to clarify these important issues. … TEP Reviewer #1 Clarity and Usability As noted above, the major controversial issues in anti- glycemic … This includes a discussion of the methodologic issues that you pointed out. … We agree that these are very important issues.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-usability-testing.pdf
    November 01, 2018 - Possible issues with colours for printed? Vs PDF E-1 Appendix E. … And your thought process, you know, you’ve identified the key issues, you’ve looked at some of the … Other participants, although they appreciated the presentation, identified a number of issues and how … To overcome any issues related to the colours of the dots, one participant suggested using different … Knowledge Gaps and Other Issues  Evidence on the long-term benefits and harms of antipsychotics (and
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-classification_research.pdf
    December 01, 2010 - reports, AHRQ supports empiric research by the EPCs to help understand or improve complex methodologic issues … The results likely reflect issues with the taxonomy itself, as well as attributes of the studies that … These issues have led some authors to direct systematic reviewers to focus on features of designs rather … to clinical, social science/behavioral, economic, and other health care organization and delivery issues … These issues have led some authors to direct systematic reviewers to focus on features of designs rather
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research.pdf
    March 01, 2018 - reports, AHRQ supports empiric research by the EPCs to help understand or improve complex methodologic issues … Throughout the process we logged challenges and issues, as well as tracked the time and effort to complete … Studies (Subjects) Study Limitations Consistency Directness Precision Reporting Bias Other Issues … Because of these issues, we could have missed some studies and misclassified the records as “unmatched … The ClinicalTrials.gov results database--update and key issues.
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_disposition-comments.pdf
    March 01, 2012 - It lumps diverse issues. … Pellock, M.D., American Epilepsy Society President 2011 Results Issues concerning AED risks and … From our reading of the draft CER document, these issues are inadequately addressed. … The key questions are on target with the current controversial issues related to AED prescribing in … For adults there are issues related to driving, employment, and disability.

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