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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-disposition-120516.pdf
    October 01, 2011 - Reviewer #3 Introduction The Introduction is clear and describes many of the important clinical issues … Results The following information is provided to support the lack of crossover or contamination issues … We agree that more research is needed to address some of the issues brought up by the reviewer (such … This comment does not provide specific issues in the report to address. … In a post-publication report by the editors of BMJ (4), a number of issues were raised including the
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-treatment-adherence_disposition-comments.pdf
    December 20, 2012 - Most notably and relevant are the improvement in adherence issues that were associated with the improved … Nonetheless, we included good-quality and representative studies addressing these issues. … it would be feasible to create a single comprehensive intervention that would address all of these issues … discuss the problem of the search cut-off date, the problems of a qualitative approach, potential issues … The NVHR welcomes AHRQ’s attention to these issues. Thank you. No response necessary.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pregnancy_hi_impact.pdf
    January 01, 2012 - care visits are typically scheduled to provide an opportunity to discuss pregnancy-related health issues … One expert with a clinical perspective noted that, “My poorest patients with access issues have cell … initial increase in costs, the reduction in costs stemming from long term complications of health issues … These shunts are replaced several times during the patient’s lifetime. 1 Other issues with this postnatal … based on parents “wishing to decrease substantive risks of life-long developmental and neurologic issues
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/disabilities-quality-improvement-outcomes_disposition-comments.pdf
    October 15, 2012 - General This report begins with an excellent conceptual framework for considering outcome measurement issues … General The Academy strongly supports the investment of time and resources by AHRQ into studying issues … rather than on the person and his or her need for basic medical care for the management of generic issues … Public Comments #3 APTA Introduction Additionally, although APTA recognizes the issues with including … Peer Reviewer #3 Discussion Would recommend tightening or reformatting the “research issues and
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_disposition-comments.pdf
    October 01, 2010 - This limitation has been added to the Remaining Issues/Future Research section. … These limitations have been added to the Remaining Issues/Future Research section. … We also note under “Remaining Issues and Future Research” that “Further investigations on the efficacy … General Although we agree with the investigator’s list of remaining issues, some critical issues not … Whether a patient has recurrent AF or not, is partly determined by These relevant issues regarding
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/omega-3-maternity_research-protocol.pdf
    May 18, 2015 - cohort studies (RCTs are likely to be rare, and case-control studies are inadequate to address these issues … The Key Questions* The key questions address both issues of efficacy (i.e., causal relationships from … those related to uncertainty of dietary assessment measurements and compliance).14-16 Any quality issues … studies) Study Limitations Directness Consistency Precision Reporting bias Other Issues … information to the EPC to identify literature search strategies and recommend approaches to specific issues
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_executive.pdf
    May 01, 2013 - sufficient data on the most appropriate screening instrument and the optimal time(s) for screening, issues … selection of participants, measurement of interventions/exposures, addressing any design-specific issues … We summarized issues of applicability qualitatively. … Institute of Medicine report on depression in parents,5 both of which noted similar methodological issues … Ideally, some of these studies could address issues relevant to differences in timing, setting, or
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
    July 26, 2012 - Affiliation Section Comment Response Peer Reviewer #1 Introduction The introduction summarizes the issues … We also have recommended that these issues be addressed in future research studies. … Peer Reviewer #3 Discussion In the section “Future Research Recommendations”General Issues: The authors … I like that there is "general issues" as well as research recommendations for each key question. … We addressed these issues in the Discussion and added these recommendations to the Future Research
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
    November 20, 2013 - Rev 5 General Methodological issues not considered in results or disc and need to be. … We have addressed several methodological issues in our results and Discussion sections. … We would be happy to speak to any additional methodological issues the reviewer would like us to address … Comment Response Rev 6 General Overall, excellent but requires revision in places, particularly on the issues … Also, all variables in models like these add to the total model and confounding is usually not an issues
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-finding-evidence_methods.pdf
    January 01, 2011 - This Guide presents issues key to the development of Comparative Effectiveness Reviews and describes … recommended approaches for addressing difficult, frequently encountered methodological issues. … An exploration of methodological issues using the ISPOT meta-analyses. … Issues in the registration of clinical trials. JAMA 2007 May 16;297(19):2112-2120. 87. … 2005 Walker-Dilks, 2008 Wong, 2006 CommunityWISE http://www.oxmill.com/communitywise/ Community issues
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-adolescents_disposition-comments.pdf
    August 27, 2012 - The report did not address the issues of aging. … See specific responses to quality scoring issues noted. … Peer Reviewer #3 Results [quality scoring issues] For example, the studies by McDougle (1986, 1988) … Peer Reviewer #3 Results [quality scoring issues] The study by Laugeson (2009) included ratings from … Peer Reviewer #3 Results [quality scoring issues] However, the study by Garcia-Villamisar (2010) is
  12. effectivehealthcare.ahrq.gov/sites/default/files/home-based-care_disposition-comments.pdf
    February 16, 2016 - Finally, the discussion could have been better framed in the context of key policy issues that are now … Cost issues w Edes study-- see above would have a summary of the pre/post issues, rather than … Page 12, line 48: Issues related to programs reporting mortality. … Many of the issues with the Hughes study were considered, and thus it was given a fair rather than
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/preterm-birth-terbutaline-pump_research-protocol.pdf
    October 18, 2010 - Further, observational studies have been identified that explore issues of terbutaline safety. … Clinical issues surrounding the use of terbutaline sulfate for preterm labor. … identify literature search strategies, review the draft report and recommend approaches to specific issues … Clinical issues surrounding the use of terbutaline sulfate for preterm labor.
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-adherence-interventions_research-protocol.pdf
    August 18, 2011 - Currently, available guidelines and recommendations that address issues related to medication adherence … Furthermore, adherence is not the focus of these guidelines, but rather one among several issues discussed … Summary and Objectives To address the issues outlined above, the overarching goal of our systematic … information to the EPC to identify literature search strategies and recommend approaches to specific issues
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/major-depressive-disorder_research-protocol.pdf
    November 24, 2014 - Background and Objectives for the Systematic Review Clinical and Methodological Issues Context. … This review will focus on two key issues facing primary care physicians: 1. … Therefore, study questions, design issues, and methodological approaches do not necessarily represent … information to the EPC to identify literature search strategies and recommend approaches to specific issues
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/infantile-hemangioma_disposition-comments.pdf
    January 15, 2016 - discussing intraspinal IH - spinal hemangioma and vertebral hemangioma are usually a misnomer due to issues … TEP reviewer #4 General ES 17 I understand the issues with US BUT Age is a big consideration for … Questions not directly issues of effectiveness were considered contextual questions. … imaging modalities but rather was focusing on determining the risk of underlying spinal/spinal cord issues
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
    June 01, 2012 - and comparator, the outcomes measured, settings, and timing of assessments to identify specific issues … We summarized issues of applicability qualitatively. … Study results on these issues were reported for the total patient population and did not separate the … aware that there are several noncomparator studies of each of the NIT modalities that address these issues

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