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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-pregnancy-postpartum_research-protocol.pdf
    March 29, 2013 - Finally, we will identify issues that future studies should address so that the woman with perinatal … We will summarize issues of applicability qualitatively. V. References 1. Halbreich U. … information to the EPC to identify literature search strategies and recommend approaches to specific issues
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-risk-of-bias.pdf
    December 01, 2017 - trained • Pilot test assessment of risk-of-bias tools using a small subset of studies • Identify issues … Finally, identify issues and revise tools or training as needed Stage 3.
  3. effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_disposition-comments.pdf
    January 01, 2015 - of knowledge, but my concern is that the presentation to the average clinician is not clear on the issues … We welcome the opportunity to clarify these important issues. … TEP Reviewer #1 Clarity and Usability As noted above, the major controversial issues in anti- glycemic … This includes a discussion of the methodologic issues that you pointed out. … We agree that these are very important issues.
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-usability-testing.pdf
    November 01, 2018 - Possible issues with colours for printed? Vs PDF E-1 Appendix E. … And your thought process, you know, you’ve identified the key issues, you’ve looked at some of the … Other participants, although they appreciated the presentation, identified a number of issues and how … To overcome any issues related to the colours of the dots, one participant suggested using different … Knowledge Gaps and Other Issues  Evidence on the long-term benefits and harms of antipsychotics (and
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-classification_research.pdf
    December 01, 2010 - reports, AHRQ supports empiric research by the EPCs to help understand or improve complex methodologic issues … The results likely reflect issues with the taxonomy itself, as well as attributes of the studies that … These issues have led some authors to direct systematic reviewers to focus on features of designs rather … to clinical, social science/behavioral, economic, and other health care organization and delivery issues … These issues have led some authors to direct systematic reviewers to focus on features of designs rather
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research.pdf
    March 01, 2018 - reports, AHRQ supports empiric research by the EPCs to help understand or improve complex methodologic issues … Throughout the process we logged challenges and issues, as well as tracked the time and effort to complete … Studies (Subjects) Study Limitations Consistency Directness Precision Reporting Bias Other Issues … Because of these issues, we could have missed some studies and misclassified the records as “unmatched … The ClinicalTrials.gov results database--update and key issues.
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_disposition-comments.pdf
    January 07, 2016 - beginning of the discussions (or better yet, the introductions) so that the reader is aware of these issues … value of this report is questionable, driven in large part by the nature of the clinical trials and issues … These issues need to be considered and discussed in the methodologic approach. … Did the authors attempt to address these issues and found them wanting for evidence and thus they are … work with KDIGO, there are parts of the world that still may use high osmolar contrast due to cost issues
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
    December 14, 2012 - #5 KI General Overall, I think this evidence review is very thorough and did not have any major issues … Aspects of handling that relate to GEP assays are discussed in the report; general issues that relate
  9. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1306.pdf
    June 01, 2013 - A long-acting formulation might address these issues.
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_disposition-comments.pdf
    March 01, 2012 - It lumps diverse issues. … Pellock, M.D., American Epilepsy Society President 2011 Results Issues concerning AED risks and … From our reading of the draft CER document, these issues are inadequately addressed. … The key questions are on target with the current controversial issues related to AED prescribing in … For adults there are issues related to driving, employment, and disability.
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-health-children_executive.pdf
    December 01, 2016 - evidence base,5,7 some outcomes for children with mental health problems remain suboptimal because of issues … For example, our focus on children and adolescents with existing mental health issues (rather than the … risk of mental health issues only) did not enable focus on prevention. … Information on pragmatic issues related to implementation (fidelity, adaptation, and minimum elements … Methodology issues in implementation science. Med Care Res Rev. 2013;51 (Suppl 2):S32-40. 61.
  12. effectivehealthcare.ahrq.gov/sites/default/files/cognitive-decline-disposition-170707pdf.pdf
    March 24, 2017 - Issues related to changing concepts and definitions for cognitive disorders are discussed appropriately … The most frequent reason was inadequate follow up time (i.e. less than 6 months) or study design issues … Obviously long followups raise design issues around attrition. … We have specifically acknowledged IADL effects and the issues involved in merging short term effects … We cannot speak to the issues of venture capital for commercial ventures.
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cognitive-decline-disposition-170707pdf.pdf
    March 24, 2017 - Issues related to changing concepts and definitions for cognitive disorders are discussed appropriately … The most frequent reason was inadequate follow up time (i.e. less than 6 months) or study design issues … Obviously long followups raise design issues around attrition. … We have specifically acknowledged IADL effects and the issues involved in merging short term effects … We cannot speak to the issues of venture capital for commercial ventures.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-disposition-120516.pdf
    October 01, 2011 - Reviewer #3 Introduction The Introduction is clear and describes many of the important clinical issues … Results The following information is provided to support the lack of crossover or contamination issues … We agree that more research is needed to address some of the issues brought up by the reviewer (such … This comment does not provide specific issues in the report to address. … In a post-publication report by the editors of BMJ (4), a number of issues were raised including the
  15. effectivehealthcare.ahrq.gov/sites/default/files/pregnancy_hi_impact.pdf
    January 01, 2012 - care visits are typically scheduled to provide an opportunity to discuss pregnancy-related health issues … One expert with a clinical perspective noted that, “My poorest patients with access issues have cell … initial increase in costs, the reduction in costs stemming from long term complications of health issues … These shunts are replaced several times during the patient’s lifetime. 1 Other issues with this postnatal … based on parents “wishing to decrease substantive risks of life-long developmental and neurologic issues
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-treatment-adherence_disposition-comments.pdf
    December 20, 2012 - Most notably and relevant are the improvement in adherence issues that were associated with the improved … Nonetheless, we included good-quality and representative studies addressing these issues. … it would be feasible to create a single comprehensive intervention that would address all of these issues … discuss the problem of the search cut-off date, the problems of a qualitative approach, potential issues … The NVHR welcomes AHRQ’s attention to these issues. Thank you. No response necessary.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/disabilities-quality-improvement-outcomes_disposition-comments.pdf
    October 15, 2012 - General This report begins with an excellent conceptual framework for considering outcome measurement issues … General The Academy strongly supports the investment of time and resources by AHRQ into studying issues … rather than on the person and his or her need for basic medical care for the management of generic issues … Public Comments #3 APTA Introduction Additionally, although APTA recognizes the issues with including … Peer Reviewer #3 Discussion Would recommend tightening or reformatting the “research issues and
  18. effectivehealthcare.ahrq.gov/sites/default/files/home-based-care_disposition-comments.pdf
    February 16, 2016 - Finally, the discussion could have been better framed in the context of key policy issues that are now … Cost issues w Edes study-- see above would have a summary of the pre/post issues, rather than … Page 12, line 48: Issues related to programs reporting mortality. … Many of the issues with the Hughes study were considered, and thus it was given a fair rather than
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-adolescents_disposition-comments.pdf
    August 27, 2012 - The report did not address the issues of aging. … See specific responses to quality scoring issues noted. … Peer Reviewer #3 Results [quality scoring issues] For example, the studies by McDougle (1986, 1988) … Peer Reviewer #3 Results [quality scoring issues] The study by Laugeson (2009) included ratings from … Peer Reviewer #3 Results [quality scoring issues] However, the study by Garcia-Villamisar (2010) is
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
    November 20, 2013 - Rev 5 General Methodological issues not considered in results or disc and need to be. … We have addressed several methodological issues in our results and Discussion sections. … We would be happy to speak to any additional methodological issues the reviewer would like us to address … Comment Response Rev 6 General Overall, excellent but requires revision in places, particularly on the issues … Also, all variables in models like these add to the total model and confounding is usually not an issues

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