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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label-update_disposition-comments.pdf
    September 01, 2011 - Patient heterogenity is an issue in most of our analyses. … Reviewer 2 Discussion / KQ1 47 The issue is lack of information, not known disparities. … corrected TEP #1 Results 31 p. 47 - "another issue which arose..." - another issue which was noted
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_disposition-comments.pdf
    July 01, 2012 - To better address this issue of potential variability by diagnostic groups, we have modified our presentation … Again, my main issue about the analysis is stated in the General Comments above, regarding the decision … As described above, we considered this issue carefully and give summary estimates by subgroups when … We considered this issue but do not think it is an important source of bias for this outcome. … To better address this issue of potential variability by diagnostic groups, we have modified our presentation
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-comments.pdf
    November 04, 2020 - There is the issue of how to get an overall ROB rating. … And separately there is the issue of how 2 items might interact (eg maybe dont ding for unblinding … We agree that this is a complicated issue. … General Comments Whichever approach you decide is best going forward, I think that an important issue … November 4, 2020 29 Commenter and Affiliation Section Comment Response Peer Reviewer 3 Results The issue
  4. effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-revised-comments.pdf
    December 29, 2020 - All sides of this issue should be part of the CDC board's discussions. … Pain Medicine, Volume 17, Issue 11, 1 November 2016, Pages 2036–2046. … This is such a monumental applicability issue, it seriously weakens AHRQ’s conclusions, and should … In doing so you are framing the issue against the value of opioids. … In doing so you are framing the issue against the value of opioids.
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/polyunsaturated-fatty-protocol.pdf
    January 01, 2024 - assessor), the trial will be considered to be at high risk of bias ● If one risk of bias or quality issue
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/saturated-fat-replacement-protocol.pdf
    January 01, 2024 - assessor), the trial will be considered to be at high risk of bias ● If one risk of bias or quality issue
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse_disposition-comments.pdf
    July 10, 2012 - This is primarily a population level issue. … There are many studies identified which address this issue. … See response to comment #1 (as this comment is directly related to that issue). … We have included a paragraph about the assessment issue in the ES as well as in the Discussion. … This is not a small semantic or grammatical issue.
  8. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/telehealth-during-COVID-19-amendments.pdf
    April 28, 2022 - informatics https://informatics.bmj.com/ Lancet digital health https://www.thelancet.com/journals/landig/issue … 10.1007/s10916-020-01593-8.pdf https://informatics.bmj.com/ https://www.thelancet.com/journals/landig/issue
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy-disposition-170415.pdf
    January 17, 2017 - delivery interventions to optimize care and prevent complications, though we agree this is an important issue … An important issue that was not evaluated is pulmonary decompensation following tonsillectomy in children … The real issue here is PTH that is minor and does not require surgery/re-admission vs. … We have noted this as an issue for future research. … together the results of various studies of tonsillectomy for recurrent infection oversimplifies the issue
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/glucocorticoid-injections_clinician.pdf
    June 01, 2016 - Glucocorticoid Injections for Spinal Stenosis: A Brief Summary of Findings for Clinicians KEY CLINICAL ISSUE
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/back-pain-imaging_clinician.pdf
    April 01, 2016 - Adults: A Brief Summary of Findings and Key Points for Clinician-Patient Discussions KEY CLINICAL ISSUE
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/insulin-blood-sugar-2010_disposition-comments.pdf
    January 01, 2010 - Journal of Diabetes Science and Technology Volume 5, Issue 5, September 2011; Michael J. … We do not feel that this issue affects our overall conclusions but have added this important caveat … The issue that the beneficial effect of the sensor-augmented pump could be do the rt- CGM or the insulin … The issue of compliance and benefit was also investigated by Pickup and in JDRF and has strong rationale … We have added the following statement to the "Future Research" needs sections regarding that issue:
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-disposition-comments.pdf
    April 23, 2019 - We corrected this issue in the revised introduction. … This is an issue in need of future research, as we discussed in the revised discussion section. … Further, the lack of such data from eligible trials and the importance of further investigating this issue … However, we addressed the issue of undertreatment in the future research recommendations part of the
  14. effectivehealthcare.ahrq.gov/sites/default/files/technical-brief-36-patient-engagement-comments.pdf
    August 26, 2020 - The authors acknowledge and the brief affirms a core issue with the research: Though we talk often … This is problematic because her needs are lifelong and this will be a long-term issue.
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/long-covid-protocol.pdf
    February 18, 2023 - some proposed models of care address both conditions.17 Long COVID is an important public health issue
  16. S58 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s58.pdf
    October 01, 2007 - require multiple types of expertise including knowledge of the conditions, populations and drugs at issue
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-health-children_disposition-comments.pdf
    December 19, 2016 - Peer Reviewer 1 Results There is one journal that recently published a special issue on routine outcome … measurement and another journal has a special issue on that topic in press. … We do not, as a rule, issue calls for specific types of funding. … Peer Reviewer 5 Clarity and Usability I hope they will bring out the importance of the issue more … Yes, we discuss these issue now in the report.
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
    April 01, 2013 - Research Question 2.2 addresses the issue of whether the magnitude of changes in prediction for biopsy … Table 5 provides the study design evaluation for Research Question 2.2, which addresses the issue of … antigen; tPSA = total prostate-specific antigen 19 While an optimal manner of looking at this issue … A better understanding of this issue is needed if PCA3 is to be properly evaluated in the context of
  19. effectivehealthcare.ahrq.gov/sites/default/files/ch_6-user-guide-to-ocer_130129.pdf
    October 30, 2012 - For prospective or retrospective studies with contemporaneous comparators, this is usually not an issue … Missing data, an issue covered in more detail in chapter 10, pose a particular problem with PROs, since … If this issue is not taken into account in the data analysis, and scores are only recorded for living
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-applicability_methods.pdf
    January 01, 2011 - Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No.: CD002755. … Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD001923.

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