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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/bundled-payments-quality-effects_disposition-comments.pdf
    August 24, 2012 - This was a formatting issue, bullets were added to the figure as suggested by the reviewer. … In order to emphasize this limitation, we have referenced this issue in the abstract (under limitations … We added a brief discussion of this issue to the summary and discussion chapter. … We added a brief discussion of this issue to the summary and discussion chapter. … We added a brief discussion of this issue to the summary and discussion chapter.
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_disposition-comments.pdf
    December 01, 2011 - At some point should address the issue of nomenclature: whether some minimal‐risk prostate cancers … There is a very brief reference to this issue in the research section, but it may be worthwhile to … Will Rogers is more an issue when it comes to questions like extent of lymphadenectomy and quality … The goal going forward is to move toward consensus across prospective cohorts, and this issue is not … We agree this is a key issue for the conference attendees to discuss.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/children-special-needs-transition_research-protocol.pdf
    October 01, 2013 - children-special-needs-transition-protocol-131003 Evidence-based Practice Center Te c h n i c a l B rie f P r o t o co l Project Title: Transitions Care for Children With Sp…
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-updates_methods.pdf
    July 01, 2011 - Preventive Services Task Force (USPSTF) has addressed the issue of updating its clinical guideline … and followed up 362 SRs in the Cochrane Database of SRs from their original publication in 1998 (Issue … 2) to 2002 (Issue 2).
  5. effectivehealthcare.ahrq.gov/sites/default/files/cer-237-evidence-summary-palliative-care-ambulatory.pdf
    February 01, 2021 - Evidence Summary: CER 237_Integrating Palliative Care in Ambulatory Care of Noncancer Serious Chronic Illness Comparative Effectiveness Review Number 237 Integrating Palliative Care in Ambulatory Care of Noncancer Serious Illness Evidence Summary Main Points Background and Purpose In the Unit…
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/registries-forums_research_0.pdf
    May 01, 2014 - • The domain is a topic, issue, or concern of interest shared by the individuals who participate … implementation of a Web-based CoP, and advised that the sponsor proactively consider how to address this issue … or altruism.42 The sponsor should encourage this viewpoint while marketing the CoP and address the issue … Existing Web-based CoPs have approached this issue in different ways, depending upon their individual
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-knee-future_research.pdf
    February 01, 2013 - Availability of data/ability to recruit Not likely to be an issue given the prevalence of knee OA. … Availability of data/ability to recruit Not likely to be an issue given the prevalence of Knee OA … Not likely to be an issue given the prevalence of Knee OA. … Availability of data/ability to recruit Not likely to be an issue given the prevalence of knee OA. … Availability of data/ability to recruit Not likely to be an issue given the prevalence of knee OA
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_disposition-comments.pdf
    May 27, 2010 - This issue requires more study. No action necessary. General Comment 4. … If the issue of equipoise is at play in the eyes of first degree stakeholders, would such a trial be … Further, . . . continues to independently and aggressively engage the issue of IMRT terminology and … This issue requires more study. No action necessary. General Comment 4.
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/distributed-network-blueprint_research.pdf
    June 01, 2010 - Ensuring that data holders can retain local control over all uses and users of their data is a key issue
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_disposition-comments.pdf
    September 29, 2014 - The authors also should explicitly recognize the degree to which the issue of pharmacogenomics can challenge … For another issue, even with the information provided in Appendix E it remains difficult to appreciate … In light of the foundational nature of this issue, it seems incumbent on the authors to indicate the … I think that the issue of abuse/addiction was handled particularly well in that the lack of uniformity … Peer Reviewer 7 General Comments The issue of the relationship between chronic opioid use and both
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-disposition.pdf
    May 26, 2017 - TEP Reviewer #5 General Comments One issue for the medical report that should be addressed early
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/vte-prophyalaxis_disposition-comments.pdf
    May 29, 2013 - For KQ6, the 1st 4 key points deal with the rather unimportant issue of IVCF use rather than the much … that the patients in the studies reflect the typical population We agree and have discussed this issue … To address the selection bias issue, the authors recently conducted a propensity matched analysis which … As always the key issue will be funding research in special populations. … is usually considered a complication of DVT We appreciate the comments and have clarified this issue
  13. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1306.pdf
    June 01, 2013 - #14 SUBSTANCE ABUSE AHRQ Healthcare Horizon Scanning System – Potential High-Impact Interventions Report Priority Area 14: Substance Abuse Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 540 Gaither Road Rockville, MD 20850 www.ahrq.…
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse_disposition-comments.pdf
    July 10, 2012 - This is primarily a population level issue. … There are many studies identified which address this issue. … See response to comment #1 (as this comment is directly related to that issue). … We have included a paragraph about the assessment issue in the ES as well as in the Discussion. … This is not a small semantic or grammatical issue.
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_disposition-comments.pdf
    July 01, 2012 - To better address this issue of potential variability by diagnostic groups, we have modified our presentation … Again, my main issue about the analysis is stated in the General Comments above, regarding the decision … As described above, we considered this issue carefully and give summary estimates by subgroups when … We considered this issue but do not think it is an important source of bias for this outcome. … To better address this issue of potential variability by diagnostic groups, we have modified our presentation
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-disposition-comments.pdf
    May 14, 2025 - We have searched and corrected the two instances of this issue. … Further, on the issue of industry sponsorship and risk of bias, we note the following language from … Finally, although the report raises the issue of alternative endpoints, it does little to recognize … Not cited was a paper that directly assessed this issue and concluded that “MCED-detected cancers … We have updated and revised the references with respect to this issue.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/back-pain-imaging_clinician.pdf
    April 01, 2016 - Adults: A Brief Summary of Findings and Key Points for Clinician-Patient Discussions KEY CLINICAL ISSUE
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/glucocorticoid-injections_clinician.pdf
    June 01, 2016 - Glucocorticoid Injections for Spinal Stenosis: A Brief Summary of Findings for Clinicians KEY CLINICAL ISSUE
  19. Slide 1 (ppt file)

    effectivehealthcare.ahrq.gov/sites/default/files/module_ii1.ppt
    June 01, 2011 - Slide 1 Engaging Stakeholders in the Effective Health Care Program Information and tools for researchers and investigators Numeric
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-comments.pdf
    November 04, 2020 - There is the issue of how to get an overall ROB rating. … And separately there is the issue of how 2 items might interact (eg maybe dont ding for unblinding … We agree that this is a complicated issue. … General Comments Whichever approach you decide is best going forward, I think that an important issue … November 4, 2020 29 Commenter and Affiliation Section Comment Response Peer Reviewer 3 Results The issue

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