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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/advanced-care-decision-aids_disposition-comments.pdf
    July 29, 2014 - We revised the paragraph to clarify the issue that people who are not directly experiencing a specific … We agree with the comment, and the technical brief does take up this issue in greater detail in the … We agree that this issue is still aspirational. … The one issue they miss is the need to develop a broad array of decision aids that can be used to augment … Coping with or adapting to uncertainty is an important issue.
  2. effectivehealthcare.ahrq.gov/sites/default/files/palliative-care-tools-disposition.pdf
    May 04, 2017 - We addressed the issue of proxy response in several ways – in the detailed appendices, in the column … asked for their subjective opinions. 33 Peer Reviewer #3 Findings Lines 54-55 again put out an issue … the report mentions this fact, there should be a specific, direct recommendation related to this issue … #6 Next Steps agree Thank you for your comment. 73 Peer Reviewer #6 Clarity and Usability my main issue … We appreciate this very valuable additional information you have provided and we have added this issue
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/palliative-care-tools-disposition.pdf
    May 04, 2017 - We addressed the issue of proxy response in several ways – in the detailed appendices, in the column … asked for their subjective opinions. 33 Peer Reviewer #3 Findings Lines 54-55 again put out an issue … the report mentions this fact, there should be a specific, direct recommendation related to this issue … #6 Next Steps agree Thank you for your comment. 73 Peer Reviewer #6 Clarity and Usability my main issue … We appreciate this very valuable additional information you have provided and we have added this issue
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/quality-gap-palliative-hospice_disposition-comments.pdf
    October 01, 2012 - Regarding the issue of heterogeneity, the following language was added to limitations: “Despite this … that we did not address costs: “Due to our focus on clinical outcomes, we also did not address the issue … This issue may be semantic; the authors may be using the term "quality improvement" quite loosely and … I found the Key Questions to be well stated and get to the critical issue of tying the research to … We have addressed the title and this issue in the text, with others’ comments – see comment 23: We
  5. effectivehealthcare.ahrq.gov/sites/default/files/protocol-social-isolation.pdf
    January 01, 2013 - Reducing social isolation in older adults has been identified as a priority issue and an area for potential
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible-disposition-comments_0.pdf
    March 03, 2025 - We revised the sentences to clarify this issue.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/pain-chronic_research-protocol.pdf
    July 28, 2010 - Evidence-based Practice Center Technical Brief Protocol Source: www.effectivehealthcare.ahrq.gov Published Online: July 28, 2010 1 Evidence-based Practice Center Technical Brief Protocol Project Title: Technical Brief - Multidisciplinary Pain Programs for Chronic Non-Cancer Pain I. Background an…
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-treatment-future_research.pdf
    February 01, 2012 - Obstructive sleep apnea (OSA) is an important public health issue, with challenges for diagnosis and … OSA is an important public health issue, due to the considerable mortality and morbidity associated … OSA is an important public health issue, due to the considerable mortality and morbidity associated … Ethical Issues The primary ethical issue (beyond the standard ethical issues in conducting a randomized … Ethical Issues The primary ethical issue (beyond the standard ethical issues in conducting a randomized
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-genetic.ppt
    June 01, 2012 - PowerPoint Presentation Challenges in and Principles for Conducting Systematic Reviews of Genetic Tests Used as Predictive Indicators Prepared for: The Agency for Healthcare Research and Quality (AHRQ) Training Modules for Medical Test Reviews Methods Guide www.ahrq.gov Challenges in and Principles for Conducting…
  10. effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-genetic.ppt
    June 01, 2012 - PowerPoint Presentation Challenges in and Principles for Conducting Systematic Reviews of Genetic Tests Used as Predictive Indicators Prepared for: The Agency for Healthcare Research and Quality (AHRQ) Training Modules for Medical Test Reviews Methods Guide www.ahrq.gov Challenges in and Principles for Conducting…
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-future_research.pdf
    May 01, 2012 - Recruitment might depend on the overall attrition in the original RCT and retention over time is an issue … across different trials may be a challenge, and the willingness of researchers to share data can be an issue … consideration remained a question for the team at project completion and will be an important ongoing issue
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-disposition-comments.pdf
    August 29, 2023 - TEP #1 Introduction Clear concise statement of the scope of the clinical issue at hand and presentation … One thing I wish was done more adequately throughout was the speaking to this issue of patient prognosis
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertensive-disorders-pregnancy-disposition-comments.pdf
    May 31, 2023 - Another reviewer commented that the report should “discuss in a more detailed the issue of racism and
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/smoking-pregnancy-infants_disposition-comments.pdf
    February 25, 2014 - We have elaborated by including additional citations and describing the significance of this issue. … Reviewer 3 (TEP) Methods One issue which I think is a little confusing is that the intervention components … It was a major paper in the special issue of Tobacco Control, and was written for use to conduct a Process … This is an issue that has multiple facets to why an individual starts smoking, continues to smoke and … Issue here is that the summaries seems to differ from each other; shouldn’t they be consistent?
  15. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1412.pdf
    December 01, 2014 - Opioid misuse has been recognized as a significant public health issue. In 2014, the U.S. … saving lives, reducing costs of emergency care for overdose, and addressing a critical public health issue … need and health outcomes: Five experts thought that opioid overdose is a significant public health issue
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/obesity-child_disposition-comments.pdf
    June 10, 2013 - Thank you for your comment 3 Peer Reviewer 1 General Comments The issue that most concerns me is … This was an applicability issue and is discussed in the discussion. 37 TEP 2 General Comments … We addressed this issue in several places in our discussion. … We discussed this issue during the early stages of the study. … We addressed this issue in our discussion.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_disposition-comments.pdf
    August 23, 2013 - For KQ4 the literature is too small to draw any conclusion regarding a clinically important issue of … We now discuss this issue in the Discussion section. … Gastrointestinal bleeding is a central issue for atrial fibrillation therapies. … We have addressed this issue by reducing the repetition. … We have addressed this issue by reducing the repetition.
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-outcomes_methods.pdf
    July 01, 2012 - issues, but in other cases, such as a test that demonstrates widely metastatic cancer, this could be an issue … A second issue is possible impact on health insurance eligibility.
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/phenylketonuria_research-protocol.pdf
    March 29, 2011 - Cochrane Database of Systematic Reviews 2010, Issue 8. Art. No.: CD001507. … Cochrane Database of Systematic Reviews 2010, Issue 6. Art. No.: CD008005. … Cochrane Database of Systematic Reviews 2010, Issue 8. Art. No.: CD001507. … Cochrane Database of Systematic Reviews 2010, Issue 6. Art. No.: CD008005. … Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD001304.
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adult-treatment_disposition-comments.pdf
    April 03, 2013 - This is an extremely important issue and it's terrific to see this being raised. … Thank you, we agree that this is an important issue to raise. … propagate beliefs that are not based on good evidence (i.e., anecdotes); rather, we think this issue … See responses to other related comments about this issue. … This is a huge and undocumented issue in most RCTs.

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