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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-prevention_disposition-comments.pdf
    May 08, 2013 - Cochrane Database of Systematic Reviews, Issue 4, 2011, doi:10.1002/14651858.CD001735.pub4" We did … Thank you for commenting on this important issue. … (page 25) Thank you for commenting on this important issue. … Thank you for commenting on this important issue. … See response to previous comment by this reviewer Peer Reviewer #8 Results Results: My main issue
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-disposition-comments.pdf
    August 29, 2023 - TEP #1 Introduction Clear concise statement of the scope of the clinical issue at hand and presentation … One thing I wish was done more adequately throughout was the speaking to this issue of patient prognosis
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertensive-disorders-pregnancy-disposition-comments.pdf
    May 31, 2023 - Another reviewer commented that the report should “discuss in a more detailed the issue of racism and
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/pain-chronic_research-protocol.pdf
    July 28, 2010 - Evidence-based Practice Center Technical Brief Protocol Source: www.effectivehealthcare.ahrq.gov Published Online: July 28, 2010 1 Evidence-based Practice Center Technical Brief Protocol Project Title: Technical Brief - Multidisciplinary Pain Programs for Chronic Non-Cancer Pain I. Background an…
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-genetic.ppt
    June 01, 2012 - PowerPoint Presentation Challenges in and Principles for Conducting Systematic Reviews of Genetic Tests Used as Predictive Indicators Prepared for: The Agency for Healthcare Research and Quality (AHRQ) Training Modules for Medical Test Reviews Methods Guide www.ahrq.gov Challenges in and Principles for Conducting…
  6. effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-genetic.ppt
    June 01, 2012 - PowerPoint Presentation Challenges in and Principles for Conducting Systematic Reviews of Genetic Tests Used as Predictive Indicators Prepared for: The Agency for Healthcare Research and Quality (AHRQ) Training Modules for Medical Test Reviews Methods Guide www.ahrq.gov Challenges in and Principles for Conducting…
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-treatment-future_research.pdf
    February 01, 2012 - Obstructive sleep apnea (OSA) is an important public health issue, with challenges for diagnosis and … OSA is an important public health issue, due to the considerable mortality and morbidity associated … OSA is an important public health issue, due to the considerable mortality and morbidity associated … Ethical Issues The primary ethical issue (beyond the standard ethical issues in conducting a randomized … Ethical Issues The primary ethical issue (beyond the standard ethical issues in conducting a randomized
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-future_research.pdf
    May 01, 2012 - Recruitment might depend on the overall attrition in the original RCT and retention over time is an issue … across different trials may be a challenge, and the willingness of researchers to share data can be an issue … consideration remained a question for the team at project completion and will be an important ongoing issue
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/scope-communicating-evolving-evidence-white-paper_0.pdf
    June 01, 2025 - White Paper: Living Systematic Reviews: Practical Considerations for Adapting Scope and Communicating the Evolving Evidence White Paper Living Systematic Reviews: Practical Considerations for Adapting Scope and Communicating the Evolving Evidence White Paper Living Systematic Reviews: Practical Conside…
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_disposition-comments.pdf
    December 16, 2014 - The issue with all cause death is quantifying comorbidity using a validated metric which has not been … A key issue is how can the results of the present analysis be used to insure that future trials ask … The central issue is are these questions in fact answerable, and if so how. … We believe that it is beyond the purview of this report to call for a national dialogue on this issue … Key question 4 attempted to address the issue of whether differences in tumor risk categories affected
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/vitamin-d-calcium_disposition-comments.pdf
    September 15, 2014 - No mention of assay issue either despite mention in Purpose. … The lack of agreed definitions is a persisting issue that can cause huge confusion to readerships. … They do not pointed out that compliance was a major issue in some of the largest studies and thus not … Regarding the compliance issue, we now cite the findings of several of the included studies, where … We addressed the issue of hypercalciuria in our assessment of the adverse events reported in studies
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/disposition-of-comments-cer-192-anxiety-in-children.pdf
    August 31, 2017 - Recognizing that it is difficult to categorize, many people will likely take issue with what is deemed … We addressed this issue by confining the primary analyses to studies that included mixed samples. … We added a sentence to the methods section to emphasize this issue. … We are quite clear about this issue and we have evaluated side effects as “any side effect”, “side … Regarding the quality (NIMH funded or small studies), we believe that the issue is not about who funded
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/advanced-care-decision-aids_disposition-comments.pdf
    July 29, 2014 - We revised the paragraph to clarify the issue that people who are not directly experiencing a specific … We agree with the comment, and the technical brief does take up this issue in greater detail in the … We agree that this issue is still aspirational. … The one issue they miss is the need to develop a broad array of decision aids that can be used to augment … Coping with or adapting to uncertainty is an important issue.
  14. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1412.pdf
    December 01, 2014 - Opioid misuse has been recognized as a significant public health issue. In 2014, the U.S. … saving lives, reducing costs of emergency care for overdose, and addressing a critical public health issue … need and health outcomes: Five experts thought that opioid overdose is a significant public health issue
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-outcomes_methods.pdf
    July 01, 2012 - issues, but in other cases, such as a test that demonstrates widely metastatic cancer, this could be an issue … A second issue is possible impact on health insurance eligibility.
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adult-treatment_disposition-comments.pdf
    April 03, 2013 - This is an extremely important issue and it's terrific to see this being raised. … Thank you, we agree that this is an important issue to raise. … propagate beliefs that are not based on good evidence (i.e., anecdotes); rather, we think this issue … See responses to other related comments about this issue. … This is a huge and undocumented issue in most RCTs.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-quantitative-synthesis_methods.pdf
    October 01, 2010 - The key points and recommendations for each covered issue are summarized in Table 2. … This article does not address every major issue relevant to meta-analyses.
  18. effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_conductingquantitativesynthesis.pdf
    October 01, 2010 - The key points and recommendations for each covered issue are summarized in Table 2. … This article does not address every major issue relevant to meta-analyses.
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd-disposition-120104.pdf
    April 01, 2011 - one (Mastronarde et al. in the New England Journal of Medicine, 2009; 636:1487-99.8) addressed the issue … However, we are aware of the importance of the FDA alerts, and have included a discussion of this issue … that importance of the variability in diagnosis of GERD but to incorporate a discussion of this issue … that importance of the variability in diagnosis of GERD but to incorporate a discussion of this issue … that importance of the variability in diagnosis of GERD but to incorporate a discussion of this issue
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-257-antenatal-care-disposition-comments.pdf
    June 28, 2022 - We added this as an issue in the limitations section.

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