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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy_disposition-comments.pdf
    March 11, 2010 - This is not a minimal issue as it is associated with over- treatment harms. … This section is attempting to explore the issue of persons living in medically under-served areas who … Results One issue not addressed was that PPVs of core biopsy performed by surgeons are much lower than … We attempted to address this issue but were unable. … We have added additional information about the ADH issue to the text.
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_disposition-comments.pdf
    May 01, 2013 - This report speaks to this issue. Thank you. … Again this issue comes up in Potential Harms of Screening in the discussion of treatment for minor … This report barely addresses the issue and should not be viewed as any kind of a primary source. … We agree that the issue of how priors affect posttest probability is an important one. … This is a very important issue and has been glossed over by the authors.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/stem-cell-children-future_research.pdf
    February 01, 2012 - At issue is whether the creation of such a formal document affects outcomes. … However, for the purposes of this review, we considered it 4 methodological issue, which would … Experts involved in the CER considered this issue and agreed that an examination of regimens should … However, for the purposes of this review we considered it methodological issue, which would draw on … Finally, the issue of uniform reporting of outcome data to allow patient comparison of HSCT outcomes
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
    December 14, 2015 - We provide information on this issue in the Discussion section of the report. … Thank you for pointing out this issue. … We have addressed this issue in the Discussion section of the report. … We have addressed this issue in the Discussion section of the report. … We have addressed this issue in the Discussion section of the report.
  5. effectivehealthcare.ahrq.gov/sites/default/files/ahrq-healthcare-horizon-scan-protocol-operations-manual_130826.pdf
    August 01, 2013 - horizon scanning team members or to allow team members to set alerts that will notify them when a new issue … For each issue of the Potential High Impact Interventions report, the results of the comment and ratings
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-future_research.pdf
    October 26, 2012 - Enrollment and consent of critically ill patients could be an issue. … Availability of data or ability to recruit Recruitment could be an issue due to willingness to be … Resource use, size and duration Recruitment could be an issue due to willingness to be randomized … Enrollment and consent of critically ill patients could be an issue. … Enrollment and consent of critically ill patients could be an issue.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
    February 01, 2012 - Obstructive sleep apnea (OSA) is an important public health issue, with challenges for diagnosis and … OSA is an important public health issue, due to the considerable mortality and morbidity associated … OSA is an important public health issue, due to the considerable mortality and morbidity associated … As the study is cross-sectional in nature, the duration of the study is not an issue. … Ethical Issues The major ethical issue in this study design is the risk of a false negative report,
  8. effectivehealthcare.ahrq.gov/sites/default/files/tech-brief-37-opiod-use-adults-comments.pdf
    November 03, 2020 - The issue of harms and benefits of dose reduction in patients on LTOT is a complicated issue in all … Findings Page 56, Line 49-56: this is a very important issue. … Pain Medicine, Volume 17, Issue 11, 1 November 2016, Pages 2036–2046. … Youve falsely framed the issue regarding pain care. … You wouldnt last 5 minutes debating me on the issue.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-disorders-imaging_disposition-comments.pdf
    November 01, 2011 - It may be good to at least mention this as an issue as part of the context. … and views taken - part of the issue for uMRI described in the WA report was the use of additional images … imaging methods (pg 16, lines 10-13) to rule out specific pathologies is to some extent a safety issue … and the conflicting input from Key Informants, it was not considered appropriate to expand on this issue … (Results) Findings, page 25, lines 12-13 To what extent should this be considered as a safety issue
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-genetic_methods.pdf
    July 01, 2012 - Methods Guide for Medical Test Reviews Chapter 11 11-1 Chapter 11 Challenges in and Principles for Conducting Systematic Reviews of Genetic Tests Used as Predictive Indicators Daniel E. Jonas, M.D., M.P.H., University of North Carolina Timothy J. Wilt, M.D., M.P.H., Department of Veterans Affairs Heal…
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_disposition-comments.pdf
    January 27, 2016 - Further studies – adding more statistical power – would resolve this issue. … The main issue is to be consistent in summarizing the effects of different interventions. … We have expanded the future research section as well, including this issue. 221. … At minimum, this issue should be prominently recognised in the limitations. … Frames the issue nicely and provides sufficient background.
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-kidney-disease-anemia-2011_disposition-comments.pdf
    January 01, 2011 - Key Question #1: I think the issue of patient-centered outcomes is important, but trying to see if outcomes … It will be published in the Kidney International Supplement, August 15, 2012 issue, but it will also … We mentioned the sample storage issue in “Applicability and Implications for Clinical and Policy Decisionmaking
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-269-respectful-maternity-care-disposition-comments.pdf
    January 02, 2024 - We highlight this issue in the Future Research Needs and Opportunities section of the Executive … This issue is addressed in the ES and the discussion but we are limited to high level summary of … We also recognize this important issue. … Please see discussion section implications, 4.4 where we describe this issue: Before the widespread … While this is an important issue it is not within the scope of this review.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-prevention_disposition-comments.pdf
    May 08, 2013 - Cochrane Database of Systematic Reviews, Issue 4, 2011, doi:10.1002/14651858.CD001735.pub4" We did … Thank you for commenting on this important issue. … (page 25) Thank you for commenting on this important issue. … Thank you for commenting on this important issue. … See response to previous comment by this reviewer Peer Reviewer #8 Results Results: My main issue
  15. OUTLINE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-end-of-life-measures-framework_research.pdf
    April 01, 2010 - OUTLINE The DEcIDE (Developing Evidence to Inform Decisions about Effectiveness) network is part of AHRQ’s Effective Health Care Program. It is a collaborative network of research centers that support the rapid development of new scientific information and analytic tools. The DEcIDE network assists health care p…
  16. OUTLINE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-quality-indicator-framework_research.pdf
    April 01, 2010 - OUTLINE The DEcIDE (Developing Evidence to Inform Decisions about Effectiveness) network is part of AHRQ’s Effective Health Care Program. It is a collaborative network of research centers that support the rapid development of new scientific information and analytic tools. The DEcIDE network assists health care p…
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-221-copd-comments_0.pdf
    October 11, 2019 - We agree that small number of studies per meta- analysis is an issue. … Peer reviewer #1 General Comments In conjunction with this issue the review consistently states that … Peer reviewer #1 Methods Methods: Yes with the exceptions of the statistical issue I raised above and … We agree that small number of studies per meta- analysis is an issue.
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_disposition-comments.pdf
    December 16, 2014 - The issue with all cause death is quantifying comorbidity using a validated metric which has not been … A key issue is how can the results of the present analysis be used to insure that future trials ask … The central issue is are these questions in fact answerable, and if so how. … We believe that it is beyond the purview of this report to call for a national dialogue on this issue … Key question 4 attempted to address the issue of whether differences in tumor risk categories affected
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/vitamin-d-calcium_disposition-comments.pdf
    September 15, 2014 - No mention of assay issue either despite mention in Purpose. … The lack of agreed definitions is a persisting issue that can cause huge confusion to readerships. … They do not pointed out that compliance was a major issue in some of the largest studies and thus not … Regarding the compliance issue, we now cite the findings of several of the included studies, where … We addressed the issue of hypercalciuria in our assessment of the adverse events reported in studies
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/disposition-of-comments-cer-192-anxiety-in-children.pdf
    August 31, 2017 - Recognizing that it is difficult to categorize, many people will likely take issue with what is deemed … We addressed this issue by confining the primary analyses to studies that included mixed samples. … We added a sentence to the methods section to emphasize this issue. … We are quite clear about this issue and we have evaluated side effects as “any side effect”, “side … Regarding the quality (NIMH funded or small studies), we believe that the issue is not about who funded

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