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  1. effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_disposition-comments.pdf
    January 01, 2015 - We have discussed this issue in our limitations section of the report. … Some context around this issue would be valuable. … This seems to me to be a somewhat major issue for future reports. … Same issue, provide the names of specific drugs. … Can you please address this issue in the report? We agree.
  2. effectivehealthcare.ahrq.gov/sites/default/files/cer-236-maternal-fetal-child-outcomes-disposition-comments.pdf
    April 15, 2021 - The same issue is true throughout the document. … We added some text for clarity on the issue of plausible confounding. … As with the issue of PPHN, the issue of autism spectrum disorder and maternal SSRI treatment have been … We added text to implications for research on this issue. … This is an issue for nearly all the studies reporting harms.
  3. effectivehealthcare.ahrq.gov/sites/default/files/mental-illness-disparities_disposition-comments.pdf
    May 26, 2016 - General Comments This is an interesting technical brief on a topic that is a very important issue … Peer Reviewer #1 Findings My main issue with this section is that the findings presented are extremely … Peer Reviewer #1 Findings A relatively minor issue is that the Findings section also has a copious … Peer Reviewer #1 Summary and Implications One very minor point – the semicolon issue also appears … Response Peer Reviewer #4 General Comments The authors do a good job of addressing a very complex issue
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pain-chronic_disposition-comments.pdf
    September 01, 2011 - This particularly becomes an issue when it is taken into consideration that the most frequent diagnosis … Peer Reviewer #4 Summary and Implications Regarding the decline in access section, One issue … It addresses a very complex issue in an in depth and efficient manner.
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/telehealth-covid-19-disposition-comments.pdf
    January 03, 2023 - While we agree that licensing may be an issue, we did not find any studies addressing this issue. … We have now explicitly included this issue as a limitation of the evidence in the Discussion.
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia-update_disposition-comments.pdf
    April 25, 2013 - In this regard, as alluded in this report, ESA dose may be the important issue, not the hematocrit … ESA dosing may be the important issue. … The related issue examined here was use of dose escalation. … Also, please note that we have pointed this issue out in both Executive Summary and Discussion. … The issue of radiotherapy trials has been discussed.
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_disposition-comments.pdf
    March 01, 2012 - This may be primarily an issue of the use of appropriate technical language. … This is seldom an issue for antiepileptic drugs unless they are given intraveneously. … This may be a simple issue of using terminology that may only be used to pharmacists. … Peer Reviewer #4 General The issue of brand vs. generic is important. … We agree that teratogenicity is an important issue.
  8. effectivehealthcare.ahrq.gov/sites/default/files/cer-230-prostate-cancer-comments.pdf
    September 17, 2020 - AS) to emphasize this issue better. • We have clarified that the results for EBRT plus ADT vs.
  9. effectivehealthcare.ahrq.gov/sites/default/files/outcome-definition-and-measurement-chapter-6.pptx
    January 01, 2013 - For prospective or retrospective studies with contemporaneous comparators, this is usually not an issue … Missing data, an issue covered in more detail in chapter 10, pose a particular problem with PROs, since
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-child-interventions_disposition-comments.pdf
    February 11, 2013 - dilemma is related to the parameters of the report and the few numbers of studies that address the issue … N/A Peer Reviewer #2 General The Background frames importance of the issue well, with pertinent … The review would benefit from further consideration of the effects of this scoping issue on the results … I think it would be important to include the issue of risk and protective factors that moderate PTSD … The same issue appears to be the case with the OTT intervention. Please see prior response.
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-imaging_disposition-comments.pdf
    October 01, 2014 - We agree that this is an important issue and have added text to that effect to page 20 in the Summary … We agree with this point and, as described above, have added text to the document to address this issue … None of the articles we reviewed identified this as an issue. … In addition the issue of how much imaging is needed for restaging is unknown.
  12. effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
    February 01, 2018 - Threats From the Left: Truncation The issue of left truncation, a form of selection bias, arises when … related to their diagnosis that occurred prior to study enrollment.6 Ray gives an overview of this issue … Continuity of care can also be an issue. … This issue is closely related to that of interval censoring. 10 Managing Missing Data in Patient … Missing Potential Outcomes and Causal Inference To put the issue of missing data into perspective,
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/stem-cell-children-future_research.pdf
    February 01, 2012 - At issue is whether the creation of such a formal document affects outcomes. … However, for the purposes of this review, we considered it 4 methodological issue, which would … Experts involved in the CER considered this issue and agreed that an examination of regimens should … However, for the purposes of this review we considered it methodological issue, which would draw on … Finally, the issue of uniform reporting of outcome data to allow patient comparison of HSCT outcomes
  14. effectivehealthcare.ahrq.gov/sites/default/files/tech-brief-37-opiod-use-adults-comments.pdf
    November 03, 2020 - The issue of harms and benefits of dose reduction in patients on LTOT is a complicated issue in all … Findings Page 56, Line 49-56: this is a very important issue. … Pain Medicine, Volume 17, Issue 11, 1 November 2016, Pages 2036–2046. … Youve falsely framed the issue regarding pain care. … You wouldnt last 5 minutes debating me on the issue.
  15. effectivehealthcare.ahrq.gov/sites/default/files/ahrq-healthcare-horizon-scan-protocol-operations-manual_130826.pdf
    August 01, 2013 - horizon scanning team members or to allow team members to set alerts that will notify them when a new issue … For each issue of the Potential High Impact Interventions report, the results of the comment and ratings
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-interventions-maltreatment-child_disposition-comments.pdf
    April 15, 2013 - We agree with the reviewer and more clearly call attention to this issue in the report (see Scope and … We would note that this issue is addressed, in part, by the “low” strength of evidence grade (see … This issue is raised in the Research Gaps section, 1st paragraph, Future Research Needs section, 1st … Regarding the issue of efficacy vs. … In the main Report, this issue is addressed in both the Population section of the Methods chapter
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-future_research.pdf
    October 26, 2012 - Enrollment and consent of critically ill patients could be an issue. … Availability of data or ability to recruit Recruitment could be an issue due to willingness to be … Resource use, size and duration Recruitment could be an issue due to willingness to be randomized … Enrollment and consent of critically ill patients could be an issue. … Enrollment and consent of critically ill patients could be an issue.
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_disposition-comments.pdf
    August 01, 2012 - ASN supports AHRQ’s efforts to address this issue through a draft CER, and appreciates that AHRQ took … These QOL outcomes represent an important public health issue in the aging U.S. population who are … The issue of race/ethnicity is relatively neglected in this report. … ASN is concerned that the issue of patient race/ethnicity is relatively neglected in the draft CER. … These QOL outcomes represent an important public health issue in the aging U.S. population who are
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
    February 01, 2012 - Obstructive sleep apnea (OSA) is an important public health issue, with challenges for diagnosis and … OSA is an important public health issue, due to the considerable mortality and morbidity associated … OSA is an important public health issue, due to the considerable mortality and morbidity associated … As the study is cross-sectional in nature, the duration of the study is not an issue. … Ethical Issues The major ethical issue in this study design is the risk of a false negative report,
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-disorders-imaging_disposition-comments.pdf
    November 01, 2011 - It may be good to at least mention this as an issue as part of the context. … and views taken - part of the issue for uMRI described in the WA report was the use of additional images … imaging methods (pg 16, lines 10-13) to rule out specific pathologies is to some extent a safety issue … and the conflicting input from Key Informants, it was not considered appropriate to expand on this issue … (Results) Findings, page 25, lines 12-13 To what extent should this be considered as a safety issue

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