-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_clinician.pdf
January 01, 2016 - However, evidence was insufficient to determine the comparative effectiveness of RP
and WW for mortality … compared with those treated with 3D-CRT alone. (���)
All other treatment
comparisons
Evidence is insufficient … Insufficient: ��� Evidence either is unavailable or does not permit a conclusion. … Evidence is insufficient to determine which subgroups of
patients might benefit most from these therapies … NCCN and
the American Urological Association may be informative in
this regard.
–� Evidence was insufficient
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-257-antenatal-care-evidence-summary.pdf
June 01, 2022 - o There is insufficient evidence for numerous prioritized outcomes of interest
(e.g., completion of … o There is insufficient evidence for numerous prioritized outcomes. … Numerous prioritized outcomes had insufficient evidence. … Numerous prioritized outcomes had insufficient evidence. … Numerous prioritized outcomes have no or
insufficient evidence.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_executive.pdf
September 01, 2009 - cancer No difference No difference No difference Insufficient
+ ++
All-cause death3 No difference No … difference No difference Insufficient
+++ +++
Vertebral fracture No difference No difference 7 (5, … 9) 44 (25, 61)
+ +++ ++
Nonvertebral fracture Insufficient 3 (0.2, 5) No difference 34 (8, 56)
++ ++ … difference
Insufficient Data are inadequate to calculate outcomes or are not reported.
5
Key Question … +++ ++
Cataracts 13 (5, 21) No difference No difference Insufficient
More with tamoxifen + +++
1Study
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fibromyalgia_executive.pdf
January 01, 2015 - • Insufficient: Evidence is either unavailable or does not
permit a conclusion. … Key Points
• Evidence is largely insufficient to determine subgroup
effects for interventions other … Brief details for the subgroups with
insufficient evidence are provided second. … Three RCTs provided insufficient evidence for
duloxetine treatment and generalized anxiety disorder … Race showed insufficient evidence of mixed effects
of duloxetine.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_executive.pdf
February 01, 2012 - Insufficient evidence:
• The body of evidence on neurocognitive or
neurodevelopmental outcomes with … single HSCT
compared with symptom management and/or disease
natural history is insufficient to draw … Insufficient evidence:
• The overall body of evidence is insufficient to draw
conclusions about the … • Although the overall body of evidence is insufficient
to come to conclusions about the relative … For most
conditions addressed in this systematic review, evidence
is insufficient to draw conclusions
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-215-depression-older-adults-executive-summary.pdf
March 01, 2019 - SOE could have four grades (high (+++), moderate
(++), low (+), or insufficient). … Outcomes graded with insufficient evidence
are listed as such. … evidence: mortality
Adverse events
Fewer with escitalopram (+),
NNT 5 (3 to 19)12
Insufficient: … fluoxetine (+)7,8,16
Insufficient evidence: mortality
No data Adverse events
Similar with paroxetine … fluoxetine (++)9
Insufficient evidence: mortality
SSRI vs.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-outcomes-chronic-kidney-rapid-research.pdf
November 01, 2024 - o There is insufficient evidence for reduction of IL1β (1 high quality single-arm study28), and
for … evidence
• Alb (3 – 6 months) • insufficient
evidence
• Lipids (3 – 6
months)
• insufficient … We find insufficient
evidence for no change in TNFα (one moderate quality34 SR) post-NSPT. … There is insufficient evidence for these markers. … We find insufficient evidence for no change in TNFα (one
moderate quality34 SR) post-NSPT.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation_executive.pdf
June 01, 2013 - In these
situations, a grade of insufficient was assigned. … SOE = Insufficient (1 study, 40 patients) SOE = Insufficient (no studies)
Beta blockers vs. calcium … channel
blockers in patients taking digoxin
SOE = Insufficient (1 study, 29 patients) SOE = Insufficient … digoxin alone
SOE = Insufficient (1 study, 52 patients) SOE = Insufficient (no studies)
Calcium channel … SOE = Insufficient (2 studies, 1,705 patients)
Heart failure symptoms SOE = Insufficient (2 studies
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-252-infantile-epilepsies-executive-summary.pdf
October 01, 2022 - on other
medications (topiramate, lamotrigine, phenytoin, vigabatrin, rufinamide,
stiripentol) were insufficient … Studies of topiramate, lamotrigine, phenytoin,
vigabatrin, rufinamide, and stiripentol were insufficient … The study of tumor resection
was inconclusive (SOE: Insufficient). … For dietary treatments, evidence on adverse
effects was insufficient to permit conclusions.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_executive.pdf
November 01, 2014 - Reviewers can assign one of four strength-of-
evidence grades: high, medium, low, or insufficient. … PK/PD Measures for Dosing
or Monitoring
Evidence was insufficient for clinical response, mechanical … of death and
leaving AMA)
1 prospective
cohort (n=638)
High NA Direct Precise Insufficient
AMA … Evidence is insufficient to draw conclusions about the
effect of continuous infusions compared with … Consequently, evidence was insufficient.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_executive.pdf
June 01, 2011 - ARB); events reported, it was difficult to discern any differential
Insufficient effect of ACEIs versus … ARB); of treatment success based on use of a single antihypertensive
Insufficient for ARBs compared … ARB);
Insufficient There were no studies that evaluated these outcomes in direct
(DRI vs. … For RCTs, this translates to a difference in
renin inhibitors differ in safety, Insufficient rates of … Are there Insufficient (ACEI Evidence does not support conclusions regarding the
subgroups of patients—based
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mrsa-screening-2010_executive.pdf
January 01, 2010 - In summary, the SOE is insufficient to support or refute
the statement that, compared with no screening … However, the available
evidence is insufficient to reach a conclusion regarding the
effectiveness of … Many of the included studies provided insufficient
information about the full scope of interventions … Implications for Clinical and Policy
Decisionmaking
Insufficient evidence is currently available to … There is also insufficient evidence
to support or refute the effectiveness of MRSA screening
on any
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_clinician.pdf
October 01, 2015 - Direct
evidence was insufficient to permit conclusions about whether
one type of intervention was more … Insufficient: ��� Evidence either is unavailable or does not permit a conclusion.
1 Owens DK, Lohr KN … over 3 months
(low SOE) but not at 6 months (low SOE).
�� Emergency room (ER) visits: Evidence was insufficient … trials assessed the effectiveness of
transitional care interventions at 30 days.
�� Evidence was insufficient … trials directly compared one type of
transitional care intervention with another.
�� Evidence was insufficient
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/venous-ulcers-treatment_executive.pdf
January 01, 2014 - Hydrocolloids vs. other dressings (4) Insufficient We were unable to draw a conclusion. … antimicrobial dressings (2)
Insufficient We were unable to draw a conclusion. … compression alone (0)
Insufficient We were unable to draw a conclusion. … PLSVS + valve transplantation (1)
Insufficient We are unable to draw a conclusion. … Insufficient = Evidence is unavailable or does not permit a conclusion.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-231-dementia-interventions-evidence-summary_0.pdf
August 01, 2020 - (low-strength evidence)
• For all other outcomes and interventions, we found the evidence was insufficient … pilots that had not undergone traditional efficacy testing, and/or had high risk of
bias, and provided insufficient … researching these populations; therefore, we erred on the side of assessing a
body of research as insufficient … evidence to support interventions and programs
for active, widespread dissemination because evidence was insufficient … global conclusions, largely similar to past reviews,10 are that the amount of
high-quality evidence is insufficient
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/stakeholder-engagement_research.pdf
September 01, 2011 - Contextual factors particularly important to the Work Group
when the evidence is low or insufficient … cancer No difference No difference + No difference
++ Insufficient
All-cause death No difference … No difference
+++
No difference
+++ Insufficient
Vertebral fracture No difference No difference … Insufficient = data inadequate or not reported.
Table 2. … They suggested the need for
reports to go beyond conclusions of insufficient evidence and statements
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-executive-summary.pdf
August 01, 2024 - with 5FU, CRT with 5FU plus MMC
improved several effectiveness outcomes (low SOE), but evidence was insufficient … late harms (moderate to low SOE),
lowered acute hematologic toxicity (moderate SOE), and evidence was insufficient … Evidence was
insufficient for remaining comparisons (not shown in Table A) including local excision … Evidence was insufficient for patient-
reported outcomes such as bowel, urinary, and sexual function. … Low
Note: Remaining comparisons not mentioned in the table received an insufficient grade.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
October 01, 2014 - Surveillance
settings
Unit of analysis:
patients with
HCC
MRI or PET Insufficient No evidence … MRI
Sensitivity:
Moderate
Specificity:
Insufficient
Sensitivity was 0.65 (95% CI, 0.41 to 0.84) … Multiple imaging
modalities
Various
combinations
Sensitivity:
Insufficient
Specificity:
Insufficient … US with contrast Sensitivity: Low Specificity:
Insufficient
No study using HCC lesions as the unit … Specificity: Insufficient
Evidence was insufficient to determine effects of different reference standards
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/celiac-disease_clinician.pdf
July 01, 2016 - Evidence is insufficient
to determine the comparative accuracy of different types
of algorithms. … The SOE is also insufficient to determine the
accuracy of diagnostic tests in specific populations, … Insufficient: ��� Evidence either is unavailable or does not permit a conclusion. … The strength of evidence
was insufficient to determine the comparative accuracy of the
different algorithms … and
specificity of 98 percent (95% CI: 95.0% to 99.0%).
�� Patients without GI symptoms: There is insufficient
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
October 01, 2015 - We found
insufficient evidence to draw conclusions about the effect of
N-acetylcysteine on mortality … The evidence also was insufficient to
draw conclusions about potential differences between the
two … The SOE was insufficient that mortality, the need for renal
replacement therapy, cardiac events, and … The SOE was insufficient that mortality, the need for renal
replacement therapy, cardiac events, and … The SOE was insufficient
to make conclusions about the impact of adenosine
antagonists on the need