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341. EXHIBIT 4.1 Costs for the Most Frequent Diagnoses
     hcup-us.ahrq.gov/reports/factsandfigures/figures/2005/2005_4_1A.jsp
     January 01, 2005 - $5,288.5931 $8,402.7643 $8,870.2610 2.5 2.8 2.9 6 7 7 2 Septicemia (blood infection … graft 268.176235 377.944255 415.802266             2 Septicemia (blood infection

342. Infographic - All-Cause Readmissions for Septicemia (pdf file)
     hcup-us.ahrq.gov/reports/infographics/278_septicemia-readmits.pdf
     January 01, 2018 - Septicemia 2018 had the highest number of adult readmissions in 30 days readmissions *Blood stream infection

343. Healthcare Cost and Utilization Project (HCUP) KID Notes
     hcup-us.ahrq.gov/db/vars/female/kidnote.jsp
     September 01, 2008 - following two conditions: Patients with the Major Diagnosis Code of "Human Immunodeficiency Virus Infection … FEMALE is set to missing (.) in the Central Distributor SID for records involving substance abuse or HIV infection

344. Healthcare Cost and Utilization Project (HCUP) NIS Notes
     hcup-us.ahrq.gov/db/vars/female/nisnote.jsp
     September 01, 2008 - following two conditions: Patients with the Major Diagnosis Code of "Human Immunodeficiency Virus Infection … FEMALE is set to missing (.) in the Central Distributor SID for records involving substance abuse or HIV infection

345. Conditions With the Largest Number of Adult Hospital Readmissions by Payer, 2011 (pdf file)
     hcup-us.ahrq.gov/reports/statbriefs/sb172-Conditions-Readmissions-Payer.pdf
     November 01, 2013 - Septicemia contributed 92,900 readmissions, and urinary tract infections contributed 56,900 readmissions … 3.8 21.5 Cardiac dysrhythmias 69,400 3.8 835 3.5 16.2 Urinary tract infections … Readmission rates among these conditions ranged from 6.5 for skin and subcutaneous tissue infections … 14.7 Pancreatic disorders (not diabetes) 5,800 3.6 52 3.4 15.5 Skin and subcutaneous tissue infections

346. Summary (pdf file)
     hcup-us.ahrq.gov/reports/methods/KIDComp1997Final.pdf
     March 16, 2001 - 24,688 651 135: Intestinal infection 23,524 2601 196: Normal pregnancy and/or delivery 22,306 669 … 154: Noninfectious gastroenteritis 21,794 612 159: Urinary tract infections 21,775 597 181: Other … 11 83: Epilepsy, convulsions 135: Intestinal infection 12 7: Viral infections Rank1 Diagnoses classified … 24,688 24,688 135: Intestinal infection 23,524 22,306 196: Normal pregnancy and/or delivery … 22,306 23,524 154: Noninfectious gastroenteritis 21,794 21,775 159: Urinary tract infections

347. Patient Safety and Adverse Events, 2011 and 2014 (pdf file)
     hcup-us.ahrq.gov/reports/statbriefs/sb237-Patient-Safety-Adverse-Events-2011-2014.pdf
     January 01, 2014 - The percentage of hospitals with no catheter- related blood stream infections increased the most, from … Rate Serious infection that occurs when harmful bacteria enter the bloodstream through a tube inserted … 2014, the largest decline was noted in the number of central venous catheter- related blood stream infections … Iatrogenic pneumothorax rate (PSI 06)b 0.27 0.24 –11.1 Central venous catheter-related blood stream infection … 11) In hospital fall with hip fracture rate (PSI 08) Central venous catheter-related blood stream infection

348. PRCCSR-ChangeLog-v20211-v20221 (xls file)
     hcup-us.ahrq.gov/toolssoftware/ccsr/PRCCSR-ChangeLog-v20211-v20221.xlsx
     October 01, 2021 - Description In v2022.1, Y/N In v2021.1, Y/N MAM015 Measurement and monitoring, NEC XXE5XM5 Measurement of Infection … Technology Group 5 Y N MAM010 Other cardiovascular system measurement and monitoring XXE5XM5 Measurement of Infection … Detection, New Technology Group 5 N Y MAM015 Measurement and monitoring, NEC XXE5XN6 Measurement of Infection … Technology Group 6 Y N MAM010 Other cardiovascular system measurement and monitoring XXE5XN6 Measurement of Infection … Whole Blood mRNA, New Technology Group 7 MAM015 Measurement and monitoring, NEC XXE5XV7 Measurement of Infection

349. Statistical Brief #10
     hcup-us.ahrq.gov/reports/statbriefs/sb10.jsp
     July 10, 2006 - had the highest rates of admission for elderly asthma, pediatric gastroenteritis, and urinary tract infection … Hispanics had the highest rates of hospitalization for pediatric gastroenteritis and urinary tract infection … Asians had the lowest rates of hospitalization for urinary tract infection, dehydration, and bacterial … obstructive pulmonary disease — Pediatric gastroenteritis — Perforated appendix — Urinary tract infections … Bacterial pneumonia, dehydration, urinary tract infections, and perforated appendix include individuals

350. Nis 2007 Maskedstats Severity (pdf file)
     hcup-us.ahrq.gov/db/nation/nis/tools/stats/NIS_2007_MaskedStats_Severity.PDF
     January 01, 2007 - WO CC 851 0.01 441: ACUTE MAJOR EYE INFECTIONS W CC 319 0.00 442: ACUTE MAJOR EYE INFECTIONS W MCC … WO CC 486 0.01 5011: KNEE PROC W PDX OF INFECTION W CC 707 0.01 5012: KNEE PROC W PDX OF INFECTION … OF NERV SYS WO CC 870 0.01 5601: BACT & TB INFECTIONS OF NERV SYS W CC 799 0.01 5602: BACT & TB INFECTIONS … Infection 136 0.00 INF06: Coccidioidomycosis 571 0.01 INF07: Coxsackie and ECHO Infections 173 0.00 … 14921 0.19 INF83: Other Fungal Infections 722 0.01 INF84: Other Infectious and Parasitic Infections

351. Seddbrochure 050218 (pdf file)
     hcup-us.ahrq.gov/news/exhibit_booth/SEDDBrochure_050218.pdf
     May 16, 2018 - care • Trends and correlations between emergency department use and environmental events • Emerging infections

352. Neds 2007V2 Maskedstats Core Weighted (pdf file)
     hcup-us.ahrq.gov/db/nation/neds/stats/NEDS_2007v2_MaskedStats_Core_Weighted.PDF
     April 09, 2010 - 0.03 7: Viral infection 1,417,458 1.16 8: Other infections; including parasitic 159,965 0.13 9: Sexually … transmitted infections (not HIV or hepatitis) 40,009 0.03 10: Immunizations and screening for infectious … chronic tonsillitis 373,029 0.30 125: Acute bronchitis 1,430,039 1.17 126: Other upper respiratory infections … unspecified renal failure 343,599 0.28 158: Chronic renal failure 40,654 0.03 159: Urinary tract infections … 211,079 0.17 196: Normal pregnancy and/or delivery 84,413 0.07 197: Skin and subcutaneous tissue infections

353. Neds 2008 Maskedstats Core Weighted (pdf file)
     hcup-us.ahrq.gov/db/nation/neds/stats/NEDS_2008_MaskedStats_Core_Weighted.PDF
     January 01, 2008 - 0.04 7: Viral infection 1,521,161 1.22 8: Other infections; including parasitic 171,783 0.14 9: Sexually … transmitted infections (not HIV or hepatitis) 44,477 0.04 10: Immunizations and screening for infectious … chronic tonsillitis 367,669 0.29 125: Acute bronchitis 1,546,294 1.24 126: Other upper respiratory infections … unspecified renal failure 366,051 0.29 158: Chronic renal failure 45,447 0.04 159: Urinary tract infections … 225,018 0.18 196: Normal pregnancy and/or delivery 88,453 0.07 197: Skin and subcutaneous tissue infections

354. Neds 2007 Maskedstats Core Weighted (pdf file)
     hcup-us.ahrq.gov/db/nation/neds/stats/NEDS_2007_MaskedStats_Core_Weighted.PDF
     January 01, 2007 - 0.03 7: Viral infection 1,497,225 1.22 8: Other infections; including parasitic 161,236 0.13 9: Sexually … transmitted infections (not HIV or hepatitis) 43,501 0.04 10: Immunizations and screening for infectious … chronic tonsillitis 369,016 0.30 125: Acute bronchitis 1,430,057 1.17 126: Other upper respiratory infections … unspecified renal failure 342,541 0.28 158: Chronic renal failure 40,594 0.03 159: Urinary tract infections … 221,630 0.18 196: Normal pregnancy and/or delivery 97,896 0.08 197: Skin and subcutaneous tissue infections

355. Readmissions to U.S. Hospitals by Diagnosis, 2010 (pdf file)
     hcup-us.ahrq.gov/reports/statbriefs/sb153.pdf
     March 01, 2013 - 576,902 64,680 11.2 14 Urinary tract infections 522,921 84,858 16.2 15 Acute myocardial infarction … erythematosus and connective tissue disorders 18,850 5,123 27.2 7 Mycoses 23,026 6,222 27.0 8 HIV infection … 1 Tuberculosis 5,064 653 12.9 2 Septicemia (except in labor) 696,122 145,896 21.0 3 Bacterial infection … , unspecified site 5,654 721 12.8 4 Mycoses 23,026 6,222 27.0 5 HIV infection 34,958 9,230 26.4 … 6 Hepatitis 37,480 11,593 30.9 7 Viral infections 56,477 5,849 10.4 10 Immunizations and screening

356. Statistical Brief #153
     hcup-us.ahrq.gov/reports/statbriefs/sb153.jsp
     April 01, 2013 - disc disorders, other back problems 579,103 47,774 8.2 13 Skin and subcutaneous tissue infections … 576,902 64,680 11.2 14 Urinary tract infections 522,921 84,858 16.2 15 Acute … 653 12.9 2 Septicemia (except in labor) 696,122 145,896 21.0 3 Bacterial infection … , unspecified site 5,654 721 12.8 4 Mycoses 23,026 6,222 27.0 5 HIV infection … 34,958 9,230 26.4 6 Hepatitis 37,480 11,593 30.9 7 Viral infections 56,477

357. Slide 1 (pdf file)
     hcup-us.ahrq.gov/datainnovations/ICD10Imp_Romano_NAHDO_October2016.pdf
     October 27, 2016 - Constructed 10 expert work groups with 84 participants: ▪ Cancer, Cardiac, Critical Care/Pulmonary, Infection … Numerator) 12 1.417 PQI 11 Bacterial Pneumonia Admission Rate (Numerator) 23 1.000 PQI 12 Urinary Tract Infection … Numerator) 12 1.417 PQI 11 Bacterial Pneumonia Admission Rate (Numerator) 23 1.000 PQI 12 Urinary Tract Infection … Numerator) 29 0.935 PQI 11 Bacterial Pneumonia Admission Rate (Numerator) 37 1.081 PQI 12 Urinary Tract Infection

358. Most Common Diagnoses and Procedures in U.S. Community Hospitals, 1996
     hcup-us.ahrq.gov/reports/natstats/commdx/table1e.htm
     February 11, 2011 - Skin and subcutaneous tissue infections [197] 9,724 7.85 0.03 … Skin and subcutaneous tissue infections [197] 3,855 4.05 0.01

359. Most Common Diagnoses and Procedures in U.S. Community Hospitals, 1996
     hcup-us.ahrq.gov/reports/natstats/commdx/table1i.htm
     February 11, 2011 - Urinary tract infections [159] 3,445 5.87 0.01 … Urinary tract infections [159] 5,009 9.03 0.01

360. Most Common Diagnoses and Procedures in U.S. Community Hospitals, 1996
     hcup-us.ahrq.gov/reports/natstats/commdx/table1f.htm
     February 11, 2011 - Urinary tract infections [159] 3,811 4.07 0.01 … Urinary tract infections [159] 3,092 3.54 0.01