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121. HCUP Statistical Brief #123: Components of Growth in Inpatient Hospital Costs, 1997-2009 (pdf file)
     hcup-us.ahrq.gov/reports/statbriefs/sb123.pdf
     November 01, 2011 - annual growth), osteoarthritis (12.7 percent average annual growth), skin and subcutaneous tissue infections … 0.9 1.7 $1.0 $2.5 8.3% 3.5 4.7 $0.7 $1.3 5.7% Urinary tract infections 0.8 0.8 $0.7 $1.3 4.7% 6.6 … rates (stays per population): � septicemia, � osteoarthritis, � skin and subcutaneous tissue infections … intervertebral disc disorders, other back problems Osteoarthritis Skin and subcutaneous tissue infections … Urinary tract infections Cardiac dysrhythmias Nonspecific chest pain Complications of surgical

122. Maskedstats Nrd 2022 Core Weighted (pdf file)
     hcup-us.ahrq.gov/db/nation/nrd/stats/MaskedStats_NRD_2022_Core_Weighted.PDF
     January 01, 2022 - INFECTION OF NERVOUS SYSTEM EXCEPT VIRAL MENINGITIS WITH CC 4,785 0.01% 99: NON-BACTERIAL INFECTION … INFECTION OF NERVOUS SYSTEM EXCEPT VIRAL MENINGITIS WITH CC 1,623 0.00% please refer to the section … WITH MCC 4,115 0.01% 486: KNEE PROCEDURES WITH PRINCIPAL DIAGNOSIS OF INFECTION WITH CC 8,875 0.03% … WITHOUT PRINCIPAL DIAGNOSIS OF INFECTION WITH CC/MCC 7,950 0.02% 489: KNEE PROCEDURES WITHOUT PRINCIPAL … DIAGNOSIS OF INFECTION WITHOUT CC/MCC 6,872 0.02% 492: LOWER EXTREMITY AND HUMERUS PROCEDURES EXCEPT

123. Neds 2007 Maskedstats Ip (pdf file)
     hcup-us.ahrq.gov/db/nation/neds/stats/NEDS_2007_MaskedStats_IP.PDF
     January 01, 2007 - W CC 547 0.02 502: KNEE PROCEDURES W PDX OF INFECTION W/O CC 196 0.01 503: KNEE PROCEDURES W/O PDX … OF INFECTION 937 0.03 504: EXTENSIVE BURNS OR FULL THICKNESS BURNS W MV 96+ HRS W SKIN GRAFT 149 0.00 … W MCC 68 0.01 486: KNEE PROCEDURES W PDX OF INFECTION W CC 103 0.01 487: KNEE PROCEDURES W PDX OF … INFECTION W/O CC/MCC 90 0.01 488: KNEE PROCEDURES W/O PDX OF INFECTION W CC/MCC 122 0.01 489: KNEE … PROCEDURES W/O PDX OF INFECTION W/O CC/MCC 165 0.02 please refer to the section on Description of

124. Neds 2007V2 Maskedstats Ip (pdf file)
     hcup-us.ahrq.gov/db/nation/neds/stats/NEDS_2007v2_MaskedStats_IP.PDF
     April 09, 2010 - W CC 558 0.02 502: KNEE PROCEDURES W PDX OF INFECTION W/O CC 213 0.01 503: KNEE PROCEDURES W/O PDX … OF INFECTION 949 0.03 504: EXTENSIVE BURNS OR FULL THICKNESS BURNS W MV 96+ HRS W SKIN GRAFT 113 0.00 … W MCC 65 0.01 486: KNEE PROCEDURES W PDX OF INFECTION W CC 115 0.01 487: KNEE PROCEDURES W PDX OF … INFECTION W/O CC/MCC 89 0.01 488: KNEE PROCEDURES W/O PDX OF INFECTION W CC/MCC 129 0.01 489: KNEE … PROCEDURES W/O PDX OF INFECTION W/O CC/MCC 164 0.02 please refer to the section on Description of

125. Exhibit 2.4 Average Length of Stay and Average Charges
     hcup-us.ahrq.gov/reports/factsandfigures/figures/2005/2005_2_4.jsp
     January 01, 2005 - genital disorders 87.9 2.946 2.5 0.033557 16,300 397 126 Other upper respiratory infections … 25 Cancer of uterus 43.1 2.461 4.4 0.110400 25,900 941 159 Urinary tract infections … leg) 266.8 7.510 4.6 0.072925 29,100 1,067 197 Skin and subcutaneous tissue infections … Diseases of white blood cells 54.2 3.001 5.1 0.074065 22,700 800 8 Other infections … and poliomyelitis (polio and other brain or spinal infections) 8.9 0.373 13.2 0.409036

126. Maskedstats Nrd 2015Q1Q3 Severity (pdf file)
     hcup-us.ahrq.gov/db/nation/nrd/stats/MaskedStats_NRD_2015Q1Q3_Severity.PDF
     October 31, 2017 - of nervous system 4,922 0.04% 50: Non-bacterial infections of nervous system exc viral meningitis 5,722 … resp dist synd/oth maj resp cond 2,186 0.02% 613: Neonate birthwt 1500-1999g w congenital/perinatal infection … w resp dist synd/oth maj resp cond 2,244 0.02% 623: Neonate bwt 2000-2499g w congenital/perinatal infection … w resp dist synd/oth maj resp cond 6,843 0.05% 636: Neonate birthwt >2499g w congenital/perinatal infection … , post-traumatic, other device infections 57,076 0.44% 722: Fever 18,997 0.15% 723: Viral illness 16,099

127. Nrd 2014 Maskedstats Severity (pdf file)
     hcup-us.ahrq.gov/db/nation/nrd/stats/NRD_2014_MaskedStats_Severity.PDF
     January 01, 2014 - of nervous system 5,533 0.04% 50: Non-bacterial infections of nervous system exc viral meningitis 6,907 … resp dist synd/oth maj resp cond 2,524 0.02% 613: Neonate birthwt 1500-1999g w congenital/perinatal infection … w resp dist synd/oth maj resp cond 2,529 0.02% 623: Neonate bwt 2000-2499g w congenital/perinatal infection … w resp dist synd/oth maj resp cond 7,687 0.05% 636: Neonate birthwt >2499g w congenital/perinatal infection … , post-traumatic, other device infections 67,641 0.45% 722: Fever 22,643 0.15% 723: Viral illness 18,753

128. Statistical Brief #150
     hcup-us.ahrq.gov/reports/statbriefs/sb150.jsp
     March 01, 2013 - In addition, more serious complications such as colitis, bloodstream infection, meningitis, joint infection … Other infections with known agents were far less common. … and ED visits with a diagnosis code of 008.45, Clostridium difficile , were excluded because this infection … –008.49 x x Unspecified bacterial intestinal infection 008.5 x x Rotavirus enteritis … June 10, 2011 Vital Signs: Incidence and Trends of Infection with Pathogens Transmitted Commonly Through

129. Neds 2015Q1Q3 Ip Maskedstats (pdf file)
     hcup-us.ahrq.gov/db/nation/neds/stats/NEDS_2015Q1Q3_IP_MaskedStats.PDF
     October 01, 2014 - W MCC 314 0.01 486: KNEE PROCEDURES W PDX OF INFECTION W CC 578 0.02 487: KNEE PROCEDURES W PDX OF … INFECTION W/O CC/MCC 286 0.01 488: KNEE PROCEDURES W/O PDX OF INFECTION W CC/MCC 505 0.02 489: KNEE … PROCEDURES W/O PDX OF INFECTION W/O CC/MCC 440 0.01 492: LOWER EXTREM & HUMER PROC EXCEPT HIP,FOOT, … INFECTION W/O CC/MCC 286 0.01 488: KNEE PROCEDURES W/O PDX OF INFECTION W CC/MCC 505 0.02 489: KNEE … 7: Viral infection 7,805 0.25 8: Other infections; including parasitic 2,128 0.07 9: Sexually transmitted

130. Ff 2009 Section5 (pdf file)
     hcup-us.ahrq.gov/reports/factsandfigures/2009/pdfs/FF_2009_section5.pdf
     January 01, 2009 -  Hospitalization for urinary tract infections in females was 2.5 times higher than in males. … Infections such as septicemia, skin and subcutaneous tissue infections, and urinary tract infections …  Skin infections were another common condition among children 3 to 5 years old. … The rate of stays for skin infections between males and females were similar. …  Skin infections were another common condition among children 10 to 14 year olds.

131. Maskedstats Nis 2019 Core Weighted (pdf file)
     hcup-us.ahrq.gov/db/nation/nis/tools/stats/MaskedStats_NIS_2019_Core_Weighted.PDF
     January 01, 2019 - JOINT/LIMB REATTACHMENT PROCEDURE OF UPPER EXTREMITIES 140,920 0.40% 485: KNEE PROCEDURES W PDX OF INFECTION … W MCC 2,985 0.01% 486: KNEE PROCEDURES W PDX OF INFECTION W CC 7,635 0.02% 487: KNEE PROCEDURES W … PDX OF INFECTION W/O CC/MCC 2,845 0.01% 488: KNEE PROCEDURES W/O PDX OF INFECTION W CC/MCC 10,185 0.03% … 489: KNEE PROCEDURES W/O PDX OF INFECTION W/O CC/MCC 10,840 0.03% 492: LOWER EXTREM & HUMER PROC EXCEPT … PROC W CC 34,640 0.10% 858: POSTOPERATIVE OR POST-TRAUMATIC INFECTIONS W O.R.

132. Kid 2019 Maskedstats Core Weighted (pdf file)
     hcup-us.ahrq.gov/db/nation/kid/tools/stats/KID_2019_MaskedStats_Core_Weighted.PDF
     January 01, 2019 - MAJOR JOINT/LIMB REATTACHMENT PROCEDURE OF UPPER EXTREMITIES <= 50 *.**% 485: KNEE PROCEDURES W PDX OF INFECTION … W MCC <= 50 *.**% 486: KNEE PROCEDURES W PDX OF INFECTION W CC 177 0.00% 487: KNEE PROCEDURES W PDX … OF INFECTION W/O CC/MCC 200 0.00% 488: KNEE PROCEDURES W/O PDX OF INFECTION W CC/MCC 508 0.01% 489 … : KNEE PROCEDURES W/O PDX OF INFECTION W/O CC/MCC 963 0.02% 492: LOWER EXTREM & HUMER PROC EXCEPT HIP … PROC W MCC 628 0.01% 857: POSTOPERATIVE OR POST-TRAUMATIC INFECTIONS W O.R.

133. Kid 2019 Maskedstats Core Weighted V2 (pdf file)
     hcup-us.ahrq.gov/db/nation/kid/tools/stats/KID_2019_MaskedStats_Core_Weighted_V2.PDF
     January 01, 2019 - MAJOR JOINT/LIMB REATTACHMENT PROCEDURE OF UPPER EXTREMITIES <= 50 *.**% 485: KNEE PROCEDURES W PDX OF INFECTION … W MCC <= 50 *.**% 486: KNEE PROCEDURES W PDX OF INFECTION W CC 177 0.00% 487: KNEE PROCEDURES W PDX … OF INFECTION W/O CC/MCC 200 0.00% 488: KNEE PROCEDURES W/O PDX OF INFECTION W CC/MCC 508 0.01% 489 … : KNEE PROCEDURES W/O PDX OF INFECTION W/O CC/MCC 963 0.02% 492: LOWER EXTREM & HUMER PROC EXCEPT HIP … PROC W MCC 628 0.01% 857: POSTOPERATIVE OR POST-TRAUMATIC INFECTIONS W O.R.

134. Maskedstats Nis 2019 Core Weighted V2 (pdf file)
     hcup-us.ahrq.gov/db/nation/nis/tools/stats/MaskedStats_NIS_2019_Core_Weighted_V2.PDF
     January 01, 2019 - JOINT/LIMB REATTACHMENT PROCEDURE OF UPPER EXTREMITIES 140,920 0.40% 485: KNEE PROCEDURES W PDX OF INFECTION … W MCC 2,985 0.01% 486: KNEE PROCEDURES W PDX OF INFECTION W CC 7,635 0.02% 487: KNEE PROCEDURES W … PDX OF INFECTION W/O CC/MCC 2,845 0.01% 488: KNEE PROCEDURES W/O PDX OF INFECTION W CC/MCC 10,185 0.03% … 489: KNEE PROCEDURES W/O PDX OF INFECTION W/O CC/MCC 10,840 0.03% 492: LOWER EXTREM & HUMER PROC EXCEPT … PROC W CC 34,640 0.10% 858: POSTOPERATIVE OR POST-TRAUMATIC INFECTIONS W O.R.

135. Maskedstats Nis 2021 Core Weighted (pdf file)
     hcup-us.ahrq.gov/db/nation/nis/tools/stats/MaskedStats_NIS_2021_Core_Weighted.PDF
     January 01, 2021 - INFECTION OF NERVOUS SYSTEM EXCEPT VIRAL MENINGITIS WITH CC 7,185 0.02% 99: NON-BACTERIAL INFECTION … WITH MCC 3,490 0.01% 486: KNEE PROCEDURES WITH PRINCIPAL DIAGNOSIS OF INFECTION WITH CC 8,770 0.03% … 487: KNEE PROCEDURES WITH PRINCIPAL DIAGNOSIS OF INFECTION WITHOUT CC/MCC 3,075 0.01% 488: KNEE PROCEDURES … WITHOUT PRINCIPAL DIAGNOSIS OF INFECTION WITH CC/MCC 7,430 0.02% 489: KNEE PROCEDURES WITHOUT PRINCIPAL … DIAGNOSIS OF INFECTION WITHOUT CC/MCC 5,730 0.02% 492: LOWER EXTREMITY AND HUMERUS PROCEDURES EXCEPT

136. Maskedstats Nis 2022 Core Weighted (pdf file)
     hcup-us.ahrq.gov/db/nation/nis/tools/stats/MaskedStats_NIS_2022_Core_Weighted.PDF
     January 01, 2022 - INFECTION OF NERVOUS SYSTEM EXCEPT VIRAL MENINGITIS WITH CC 7,120 0.02% 99: NON-BACTERIAL INFECTION … WITH MCC 3,995 0.01% 486: KNEE PROCEDURES WITH PRINCIPAL DIAGNOSIS OF INFECTION WITH CC 8,635 0.03% … 487: KNEE PROCEDURES WITH PRINCIPAL DIAGNOSIS OF INFECTION WITHOUT CC/MCC 3,355 0.01% 488: KNEE PROCEDURES … WITHOUT PRINCIPAL DIAGNOSIS OF INFECTION WITH CC/MCC 8,395 0.03% 489: KNEE PROCEDURES WITHOUT PRINCIPAL … DIAGNOSIS OF INFECTION WITHOUT CC/MCC 7,525 0.02% 492: LOWER EXTREMITY AND HUMERUS PROCEDURES EXCEPT

137. Maskedstats Nis 2020 Core Weighted V2 (pdf file)
     hcup-us.ahrq.gov/db/nation/nis/tools/stats/MaskedStats_NIS_2020_Core_Weighted_V2.PDF
     January 01, 2020 - INFECTION OF NERVOUS SYSTEM EXCEPT VIRAL MENINGITIS WITH CC 6,825 0.02% 99: NON-BACTERIAL INFECTION … WITH MCC 3,085 0.01% 486: KNEE PROCEDURES WITH PRINCIPAL DIAGNOSIS OF INFECTION WITH CC 8,220 0.03% … 487: KNEE PROCEDURES WITH PRINCIPAL DIAGNOSIS OF INFECTION WITHOUT CC/MCC 3,025 0.01% 488: KNEE PROCEDURES … WITHOUT PRINCIPAL DIAGNOSIS OF INFECTION WITH CC/MCC 8,105 0.03% 489: KNEE PROCEDURES WITHOUT PRINCIPAL … DIAGNOSIS OF INFECTION WITHOUT CC/MCC 8,145 0.03% 492: LOWER EXTREMITY AND HUMERUS PROCEDURES EXCEPT

138. Statistical Brief #145
     hcup-us.ahrq.gov/reports/statbriefs/sb145.jsp
     December 01, 2012 - Infection-related diagnoses predominate—septicemia, pneumonia, and UTI. … Other infection-related diagnoses predominate—septicemia, pneumonia, and UTI. … Readmissions following Hospitalizations with Clostridium difficile Infections, 2009 . … B. " Clostridium difficile Infection in Patients Discharged from U.S. … Infection Control and Hospital Epidemiology . 2012 Jan;33(1):20-8.

139. Neds 2019 Ip Maskedstats (pdf file)
     hcup-us.ahrq.gov/db/nation/neds/stats/NEDS_2019_IP_MaskedStats.PDF
     January 01, 2019 - W MCC 486 0.01 486: KNEE PROCEDURES W PDX OF INFECTION W CC 846 0.02 487: KNEE PROCEDURES W PDX OF … INFECTION W/O CC/MCC 302 0.01 please refer to the section on Description of Data Elements. … W CC/MCC 1,227 0.03 489: KNEE PROCEDURES W/O PDX OF INFECTION W/O CC/MCC 733 0.02 492: LOWER EXTREM … W MCC 487 0.01 486: KNEE PROCEDURES W PDX OF INFECTION W CC 846 0.02 487: KNEE PROCEDURES W PDX OF … INFECTION W/O CC/MCC 301 0.01 please refer to the section on Description of Data Elements.

140. Neds 2021 Ip Maskedstats (pdf file)
     hcup-us.ahrq.gov/db/nation/neds/stats/NEDS_2021_IP_MaskedStats.PDF
     January 01, 2021 - WITH MCC 532 0.01 486: KNEE PROCEDURES WITH PRINCIPAL DIAGNOSIS OF INFECTION WITH CC 1,117 0.02 487 … : KNEE PROCEDURES WITH PRINCIPAL DIAGNOSIS OF INFECTION WITHOUT CC/MCC 381 0.01 488: KNEE PROCEDURES … WITHOUT PRINCIPAL DIAGNOSIS OF INFECTION WITH CC/MCC 980 0.02 489: KNEE PROCEDURES WITHOUT PRINCIPAL … DIAGNOSIS OF INFECTION WITHOUT CC/MCC 508 0.01 please refer to the section on Description of Data … : KNEE PROCEDURES WITH PRINCIPAL DIAGNOSIS OF INFECTION WITHOUT CC/MCC 381 0.01 488: KNEE PROCEDURES