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21. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0136_07-21-2009.pdf
    January 01, 2009 - It has been suggested that it is the most common indication for referral to women's health services.

22. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/angina-heart-attack-treatments_research-protocol.pdf
    December 11, 2012 -  Pantoprazole  Omeprazole  Lansoprazole  Rabeprazole  Esomeprazole • For patients with indication … triple therapy, defined as dual antiplatelet therapy in patients with UA/NSTEMI who also have an indication … • In patients with an indication for oral anticoagulant therapy, what are the risks and benefits of … In patients with an indication for long-term anticoagulant therapy, what are the comparative effectiveness … twice daily Oral (an intravenous formulation is commercially available) Approved No approved indication

23. Progestogens-Preterm-Birth Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth_executive.pdf
    September 01, 2012 - Within each KQ, we organized the evidence by aspects of the question, such as indication and formulation … One unique indication, asymptomatic short cervix, had a randomized trial of progesterone vaginal gel … after completion of our initial systematic review, bringing the total number of women studied for this indication … Our update identified eight additional randomized trials, one for the indication of prior preterm birth … Use of progestogens for this indication is based on evidence of moderate strength, based on small numbers

24. Updating Current Effectiveness Reviews (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-assessment-research-updates_research.pdf
    September 15, 2008 - , as well as the identification of potential safety issues and whether new evidence suggests a new indication … for a treatment or a new treatment for an existing indication. … New indication for existing or new treatment Still valid Possibly out of date Probably out … New indication for existing or new treatment Still valid Possibly out of date Probably out … New indication for existing or new treatment Still valid Possibly out of date Probably out

25. Disclosure Policy and Form (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-ki-tep-confidentiality-form-fillable.pdf
    August 01, 2020 - If they agree to provide comments, comments will be de-identified such that there will be no indication

26. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0174_10-20-2009.pdf
    January 01, 2009 - There is some indication that non-pharmacologic therapies are underutilized in patients with OA and

27. Refining Key Questions: Interactive Case Study Quiz
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/rfviia.pptx
    May 01, 2010 - of potential uses—prophylaxis, treatment, and end-stage—whereas the bar representing the off-label indication … Applicability diminished by mismatch between existing research and real-world patterns of indication … thereby compromised by small study size, use of indirect outcomes, and heterogeneity in dosage and indication … Mean Differences in Mortality and Thromboembolic Event Rates by Study and rFVIIa Indication This figure … but failed to show an effect of rFVIIa on other outcomes, including mortality. rFVIIa use for this indication

28. Refining Key Questions: Interactive Case Study Quiz
    effectivehealthcare.ahrq.gov/sites/default/files/rfviia.pptx
    May 01, 2010 - of potential uses—prophylaxis, treatment, and end-stage—whereas the bar representing the off-label indication … Applicability diminished by mismatch between existing research and real-world patterns of indication … thereby compromised by small study size, use of indirect outcomes, and heterogeneity in dosage and indication … Mean Differences in Mortality and Thromboembolic Event Rates by Study and rFVIIa Indication This figure … but failed to show an effect of rFVIIa on other outcomes, including mortality. rFVIIa use for this indication

29. Kidney-Disease-Medicine Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_executive.pdf
    January 01, 2012 - from CKD screening requires that the treatment benefits CKD populations who 3 would have had no indication … for such treatment in the absence of CKD or that, among patients with an indication for the treatment … Patients with hyperlipidemia and no coronary artery disease may not otherwise have an indication for … Patients with systolic CHF already have an indication for beta blockers, regardless of whether they … However, as patients with systolic CHF already have an indication for beta blocker treatment, testing

30. S143 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/s143.pdf
    October 01, 2007 - Objectives: We sought to evaluate the ability of propensity score matching to mitigate confounding by indication … Chief among them is the indication for the drug—a patient must have the condition for which the drug … - lished.16,17 We sought to demonstrate what might happen when attempting to address confounding by indication … However, observational studies of efficacy must address concerns of bias—especially con- founding by indication

31. Covariate Selection for Observational Comparative Effectiveness Research
    effectivehealthcare.ahrq.gov/sites/default/files/covariate-selection-chapter-7.pptx
    January 01, 2013 - Provider actions Confounding by indication: Prescribers choose treatments for patients who they believe … Sources of Confounding Sources of Confounding Provider Actions Confounding by indication Also referred … to as “channeling bias,” confounding by indication is common and often difficult to control in comparative … Confounding by indication and channeling over time: the risks of beta 2-agonists. … Confounding by indication: the case of calcium channel blockers.

32. #06 Developmental Delays ADHD, and Autism (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/developmental-delays-horizon-scan-high-impact-1306.pdf
    June 01, 2013 - Manufacturers may have pursued regulatory approval of intranasal oxytocin for this indication, but … care for treating social dysfunction in ASDs, given the absence of other medication options for this indication … Laboratories, Ltd., of Tokyo, Japan, may have pursued regulatory approval of intranasal oxytocin for this indication … about a potential disparity in the use of the intervention in female patients (because an approved indication

33. Intermittent Inhalded Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-194-evidence-summary-corticosteroids-asthma.pdf
    October 01, 2017 - In this report, controller medications are defined by the timing and indication for use rather than … Likewise, for this report, quick relief therapy is defined by the timing and indication for use rather

34. Llewellyn-Thomas (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/llewellyn-thomas.pdf
    January 01, 2011 - . • End result is indication  of pt.’s overall favored option, at either the “coarse-­‐grained” or … www.effectivehealthcare.ahrq.gov/index.cfm) � • End result is also an indication

35. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1412.pdf
    February 01, 2015 - disease (AD), leading investigators to study serotonin-boosting drugs, such as citalopram, for this indication … searches of American and international registries found no significant ongoing clinical trials for this indication … Without additional clinical data, off-label use may be limited for this indication. … may address this unmet need, as a well-tolerated, potentially disease-modifying treatment for this indication … changes observed during intravenous administration.4,10 Consequently, most clinical trials for this indication

36. #05 DEPRESSION (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1312.pdf
    October 01, 2014 - FDA has granted fast-track status for this indication. … receptor might prevent excessive cortisol activity, potentially relieving PMD symptoms.11 For this indication … FDA has granted the agent fast-track status for this indication.1 FDA approved Korlym in 2012 for treating … These payers consider mifepristone investigational or unproven for this indication and do not provide … Manufacturers of scopolamine do not appear to be pursuing an official indication for treating depression

37. DEcIDE 33: Summary Variables in Observational Resesarch: Propensity Scores and Disease Risk Scores (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
    May 01, 2012 - ................................................................................. 1 Confounding by Indication … Confounding by Indication Confounding by indication is a specific type of confounding that is commonly … In some cases confounding by indication can be intractable. … Another problem with addressing confounding by indication arises when the indications are not adequately … Since LDL level is a primary indication for statin therapy and higher LDL levels are anticipated to

38. antibiotics-respiratory-infection-protocol-140922 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
    September 22, 2014 - Key Question 2: For patients with an acute respiratory tract infection (RTI) and no clear indication … Key Question 3: For patients with an acute respiratory tract infection (RTI) and no clear indication … Key Question 4: For patients with an acute respiratory tract infection (RTI) and no clear indication … sinusitis; cough and common cold.4 2) Parents of pediatric patients with acute RTI and no clear indication … indication! for!antibiotics! 2)!Adults!and/or! children!without! acute!RTI! 3)!Clinicians!in!

39. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/stem-cell-children_research-protocol.pdf
    November 01, 2010 - The role of HSCT in pediatric diseases depends in part on the indication for which it is being used. … PICOTS Indication 1. … of HSCT; quality of life (QOL) T: All durations of follow-up will be included S: Inpatient Indication … Level of Evidence for the Narrative Reviews by Indication Disease Type Supporting Literature Malignant … Is the treatment setting for the particular disease indication included in the systematic review?

40. Improving Medication Safety in High Risk Medicare Beneficiaries Toolkit (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-therapy-management-1_research.pdf
    July 01, 2012 - o Medication List – regroup by indication, in medical as well as layman’s terminology. … o Regroup by indication, in layman’s terminology. … Is the drug dose form not appropriate for the indication? (2.2) c. … Is there no clear indication for use of the drug in this patient? (2.5) f. … Is there an untreated indication for which drug therapy is available?