-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_surveillance.pdf
August 01, 2012 - Fasting BG: 2
pooled RCTs
found increased
fasting BG with
rhGH vs. … Glucose
Intolerance:
7 RCTs found no
increased risk
with rhGH. … Up-to-date Up-to-date
Diabetes:
7 RCTs found no
increased risk
with rhGH. … Body
weight increased about
10kg, marked
improvement in
FEV1; decrease in
HbA1c. … Increased
IGFBP may be the
result of production
by tumors.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd-2005_executive.pdf
January 01, 2005 - antireflux medications
may have higher rates of esophagitis if they have
any of the following factors: increased … Higher rate of esophagitis relapse while on maintenance medical
treatment was associated with: increased … Psychiatric history was associated with worse outcomes (3 studies:
increased symptoms, increased dysphagia … , or increased surgical
failure). … Laparoscopic fundoplication vs. open fundoplication at 5-year
followup (1 RCT): difficulty with belching and increased
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
January 01, 2023 - There may be a large increased
risk of dizziness and sedation and a moderately
increased risk of nausea … risk of sedation,
and large increased risk of nausea and dizziness … • Opioids are probably associated with increased
risk of short-term adverse events versus
nonopioid … Being prescribed an opioid for acute low back
pain or postoperative pain might be associated
with increased … NSAIDs have increased risk of serious
gastrointestinal, liver dysfunction, and
cardiovascular adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_surveillance.pdf
March 01, 2013 - (Insufficient)
A new meta-analysis
concluded that no oral
DMARDs were associated with
increased … Biologics neither decreased nor increased
cardiovascular risks in the elderly. … No
increased incidence
of malignancy, TB
reactivation or
hepatitis was found. … Prednisone
associated with
dose-dependent
increased risk. … Biologics neither decreased nor increased
cardiovascular risks in the elderly.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_surveillance.pdf
March 01, 2013 - (Insufficient)
A new meta-analysis
concluded that no oral
DMARDs were associated with
increased … Biologics neither decreased nor increased
cardiovascular risks in the elderly. … No
increased incidence
of malignancy, TB
reactivation or
hepatitis was found. … Prednisone
associated with
dose-dependent
increased risk. … Biologics neither decreased nor increased
cardiovascular risks in the elderly.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-2-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - Consistent with prior
evidence, gabapentin was associated with increased risk of dizziness, sedation … One trial found increased risk of serious adverse events with gabapentin. … risk of dizziness
and somnolence.16
2 RCTs (n=366) found
increased risk of
dizziness.6,7,9 … 1 RCT (n=306) found
increased risk of SAEs,
sedation, and visual
disturbances.6,7
1 RCT (n=60) … found
increased risk of WAEs
and nonsignificantly
increased risk of sedation
and cognitive effects
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-executive-sum.pdf
January 01, 2024 - There may be a large increased risk of dizziness and
sedation (SOE: low) and a moderate increased risk … THC (high THC to CBD) may be associated with small
improvement in pain severity (SOE: low), but with increased … Synthetic and
purified THC is probably associated with a large increased risk of dizziness (SOE:
moderate … THC plus CBD is probably associated with large
increased risk of nausea (SOE: moderate). … Effect size: None (i.e., no effect/no statistically significant effect), small, moderate, or large increased
-
effectivehealthcare.ahrq.gov/sites/default/files/rfviia.pptx
May 01, 2010 - In the past decade, off-label use of rFVIIa in the hospital has significantly increased. … While mainly used for hemophilia and related conditions, off-label use of rFVIIa has increased in the … morbidity, and increased mortality. … In addition, for some uses, rFVIIa produces an increased risk of thromboembolism. … There is no evidence of effect on mortality or of increased thromboembolic events with treatment.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rfviia.pptx
May 01, 2010 - In the past decade, off-label use of rFVIIa in the hospital has significantly increased. … While mainly used for hemophilia and related conditions, off-label use of rFVIIa has increased in the … morbidity, and increased mortality. … In addition, for some uses, rFVIIa produces an increased risk of thromboembolism. … There is no evidence of effect on mortality or of increased thromboembolic events with treatment.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0407_01-20-2011.pdf
January 01, 2011 - intervention, bypass surgery
Outcome(s): Improvements in mortality, morbidity, quality of life; increased … )
PAD is a prevalent disease associated with an increased risk of cardiovascular events.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-evidence-summary-2022-update_0.pdf
January 01, 2022 - There may be a large increased risk of dizziness and sedation and a moderate
increased risk of nausea … Synthetic THC (high-THC to CBD) may be associated with moderate
improvement in pain severity, but with increased … risk of sedation, and potential
increased risk of nausea versus placebo. … Synthetic THC is probably associated
with a large increased risk of dizziness. … Effect size: None (i.e., no effect/no statistically significant effect), small, moderate, or large increased
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-mortality-elderly_research.pdf
March 01, 2009 - These data suggest that increased risk of CV deaths might explain about half of
the excess mortality … All specific causes
of deaths except for arrhythmic death and death due to mental disorders were increased … Increased risk of OOH cardiovascular death can be partly explained by increased risk of
arrhythmias … There have been no reports of increased risk of death in conventional vs. atypical APM
initiators due … Our results indicating no increased risk of CV or OOH CV deaths by conventional APM
vs. atypical APM
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0313_02-09-2009.pdf
January 01, 2009 - Preventive steps can include medications, increased fluid intake, and change in other
dietary habits … increasing/decreasing intake of certain minerals, decreasing animal protein intake,
reduced sodium, and increased
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-1-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - the original meta-analysis was low or insufficient and
new evidence could increase the SOE due to increased … With the addition
of one new RCT, the SOE rating for increased dry mouth with tricyclic antidepressants … Increased dry mouth
with TCAs (SOE:
Low);* evidence on
other adverse events
(SOE: Insufficient) … Anticonvulsants
short-term
No increased risk of SAEs,
moderate increase in WAEs
• SOE: Moderate … One good-quality
RCT (n=201) found nortriptyline associated with increased likelihood of dry mouth
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/atypical-antipsychotics-seniors-death_research.pdf
August 01, 2007 - The observed 32% increased mortality risk of conventional APMs is
unlikely to be explained by confounding … Medicare patients eligible for state-funded low-income pharmacy
assistance programs found a 37% increased … Mortality was meaningfully increased in conventional than
atypical APM users in multivariable adjusted … Comparing the most frequently prescribed
APMs individually with risperidone showed increased mortality … Our results are remarkably close to the increased 180-day mortality of conventional APMs
observed in
-
effectivehealthcare.ahrq.gov/sites/default/files/module_ii1.ppt
June 01, 2011 - The benefits of engaging stakeholders in the research process include:
Increased clarity of research … Increased knowledge exchange. … Increased relevancy and context. … Increased application of evidence.
Increased dissemination avenues. … Stakeholders can be one of the greatest assets to increased dissemination of research results.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-radiation_research.pdf
November 01, 2012 - By
2005, that proportion had increased to 82
percent.9 Prior examinations of the same
database have … Use of IMRT alone or in combination
with other therapies increased from 62.2
percent of all radiation … The propor-
tion of radiation users who used IMRT
plus brachytherapy increased slightly
over the same … The share of radiation users
who used HDR alone or any PBRT also
increased slightly over the period … The only brachytherapy use that increased
was IMRT + brachytherapy.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioids-chronic-pain-surveillance-report-1-final.pdf
April 01, 2022 - • Two new cohort studies found opioid discontinuation or dose reductions associated with
increased … Harms by dose
or duration
Opioids associated with
increased risk of overdose and 1
observational … study found higher
dose of opioids associated with
increased risk of mortality
• SOE: Low, based … Long- vs. short-
acting opioids
Long-acting opioids associated
with increased risk of overdose
vs … For overdose, 20–50 MME was associated with
increased risk versus less than 20 MME (adjusted OR 2.39
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
March 01, 2012 - Evidence is high
for an increased risk for this event. … Evidence is high
for an increased risk for this event. … Evidence is
high for an increased risk for this event. … A systematic review
of four trials confirms the increased risk for infection. … High A pooled analysis of four trials of denosumab found an increased risk for infection.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_executive.pdf
March 01, 2012 - Metabolic syndrome increased the
odds of symptomatic DVT while congestive heart failure
increased the … L M
DVT 3 OBS No Significantly increased risk. L L
KQ 4–8. … DTI 2 RCTs Yes Significantly increased odds, OR 4.74 (2.99 to 7.49),
NNH 11. … VKA 2 RCT Yes Significantly increased odds OR 2.63 (1.31 to 5.28),
NNH 23 to 64. … efficacy and increased bleeding.