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  1. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_executive.pdf
    January 01, 2006 - Osteoarthritis increases with age: the incidence and prevalence increase two- to tenfold from age 30 … to 65 and continue to increase after age 65. … evaluated short-term use, celecoxib caused fewer ulcer complications than nonselective NSAIDs and did not increase … Adequate pain relief at the expense of an increase in CV risk, for example, could be an acceptable tradeoff … Others may consider even a marginal increase in CV risk unacceptable.
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_disposition-comments.pdf
    March 01, 2012 - However, these studies did not show an increase in mild cardiac events with raloxifene. … Vasodilation events are hot flashes, and raloxifene is known to increase the risk of hot flashes. … These large trials also did not detect an increase of mild cardiac events with raloxifene. … The finding of an increase in mild cardiac events associated with raloxifene is incorrect and should … As opposed to the observational literature, we did not find a statistically significant increase in
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-draft-appendi-c.xlsx
    January 01, 2024 - Increase in refined cereals (rice and pasta) to account for difference in animal protein HFD: Increase … fruits/vegetables and substitute usual cereals with whole grain products to achieve 25 g/d increase … (up to 0.8 mmol/day) Lemons and increased fiber intake Magnesium deficiency: Increase in fiber intake … in area), 2-possible stone growth (10% to 50% increase in area), 3-no change in stone size (less than … in area), 2-possible stone growth (10% to 50% increase in area), 3-no change in stone size (less than
  4. effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
    October 01, 2015 - In the INPULSIS-2 trial, patients treated with nintedanib had a significant increase in time to the … In an effort to increase the suitable donor lung supply, new alternatives such as the use of lungs … The experts generally agreed that this intervention has high potential to increase the quantity and … The experts generally agreed that this intervention has high potential to increase the quantity and … Patient health outcomes could be improved by the purported increase in lung tissue quality from the
  5. effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1506.pdf
    June 01, 2015 - to Aid Surgical Planning  Key Facts: Surgery performed on or near vital organs and structures can increase … Time dedicated to patient management may increase when clinicians initially prescribe digital medicines … Ongoing data review and patient followup may continue to increase the time clinicians spend on patient … Long-term cost savings may be realized if digital medicines increase adherence enough to improve patient … Health disparities: Health disparities may increase for patients who do not have reliable access to
  6. effectivehealthcare.ahrq.gov/sites/default/files/ch_4-user-guide-to-ocer_130129.pdf
    January 01, 2010 - In panel C, there is an increase in the likelihood of the outcome with each exposure that diminishes … Panel H shows a linear increase in the risk/benefit associated with exposure. … Continued exposure to oral corticosteroids may continue to increase the risk of fracture associated … scenario is panel I, which shows a large change in risk/benefit upon initial exposure and then an increase … For example, additional exposure to the vaccine for mumps during childhood will not increase or decrease
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/health-information-exchange_executive.pdf
    December 01, 2015 - reductions in radiology alone.9-11 A United States–based ambulatory study found a reduced rate of increase … were mixed, with one study reporting fewer consultations and cost savings7 and another reporting an increase … care summaries, and/or medication lists with an outside provider.2 This represents an 85-percent increase … since 2008 and a 23-percent increase since 2013. … since 2008 and a 21-percent increase since 2013.
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-executive-sum.pdf
    January 01, 2024 - There may be no increase in risk of serious adverse events (SOE: low) or withdrawal due to adverse events … THC to CBD ratio) versus placebo, updated meta-analyses changed pooled estimates for nausea (large increase … in risk) and 4 WAEs (moderate increase in risk) from nonstatistically significant
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_executive.pdf
    March 01, 2013 - multicomponent diet including high fiber57 with a control diet suggested that a high-fiber diet may increase … participant characteristics, including race, body morphometry, and comorbid conditions that might increase … – Does low dietary calcium increase recurrent stone risk? … – Does low animal protein lower or increase recurrent stone risk?
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
    September 01, 2014 - Table 1 on pg 32 of 411: what is meant by “Limited” —is it a limited increase or decrease? … For example, the omega-3 FA Lovaza increases LDL-C, while Vascepa does neither increase or decrease … Second, what was reported from ARBITER 6 (Taylor et al., 2009, ARBITER 6) was not a mean increase in … Increase in creatinine defines acute kidney injury, independent of the eventual outcome. … One would be very concerned that physicians increase or add drugs when patients are not adhering to
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-disease-medicine_research-protocol.pdf
    November 01, 2010 - • Patient factors that may increase risk for CKD incidence, worsening or complications, and that … - Patient factors that may increase risk for CKD incidence, worsening or complications, and that … - Patient factors that may increase risk for CKD incidence, worsening or complications, and that
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/rfviia.pptx
    May 01, 2010 - Off-label, in-hospital rFVIIa use was estimated to be 125 cases in 2000, underwent a moderate increase … to 0.053) No effect* (●●○) Medium (41-119 mg/kg) 29/399 (7.3) 13/378 (3.4) 0.035 (0.008 to 0.062) Increase … with rFVIIa (●●○) High (≥120 mg/kg) 8/115 (7.0) 0/107 (0) 0.063 (0.011 to 0.114) Increase with rFVIIa … These results suggest that there is an increase in arterial thromboembolic events with rFVIIa use vs. … Overall Strength of Evidence Adult cardiac surgery 19/203 (9.4) 8/170 (4.7) 0.053 (0.01 to 0.096) Increase
  13. effectivehealthcare.ahrq.gov/sites/default/files/rfviia.pptx
    May 01, 2010 - Off-label, in-hospital rFVIIa use was estimated to be 125 cases in 2000, underwent a moderate increase … to 0.053) No effect* (●●○) Medium (41-119 mg/kg) 29/399 (7.3) 13/378 (3.4) 0.035 (0.008 to 0.062) Increase … with rFVIIa (●●○) High (≥120 mg/kg) 8/115 (7.0) 0/107 (0) 0.063 (0.011 to 0.114) Increase with rFVIIa … These results suggest that there is an increase in arterial thromboembolic events with rFVIIa use vs. … Overall Strength of Evidence Adult cardiac surgery 19/203 (9.4) 8/170 (4.7) 0.053 (0.01 to 0.096) Increase
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_surveillance.pdf
    January 30, 2013 - Key Question 3: increase the maternal harms of arrhythmia, heart failure, hyperglycemia, hypokalemia … Key Question 4: increase the neonatal terbutaline-related harms of hypoglycemia, hypocalcemia, and ileus … Key Question 4: increase the neonatal terbutaline-related harms of hypoglycemia, hypocalcemia, and ileus … Key Question 3: increase the maternal harms of arrhythmia, heart failure, hyperglycemia, hypokalemia, … Key Question 4: increase the neonatal terbutaline-related harms of hypoglycemia, hypocalcemia, and ileus
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/preterm-birth-terbutaline-pump_surveillance.pdf
    January 30, 2013 - Key Question 3: increase the maternal harms of arrhythmia, heart failure, hyperglycemia, hypokalemia … Key Question 4: increase the neonatal terbutaline-related harms of hypoglycemia, hypocalcemia, and ileus … Key Question 4: increase the neonatal terbutaline-related harms of hypoglycemia, hypocalcemia, and ileus … Key Question 3: increase the maternal harms of arrhythmia, heart failure, hyperglycemia, hypokalemia, … Key Question 4: increase the neonatal terbutaline-related harms of hypoglycemia, hypocalcemia, and ileus
  16. #05 DEPRESSION (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/05_depression_potential_high_impact_2012-12-10.pdf
    January 01, 2012 - This delay can increase suicide risk and mortality. … depressive episodes in patients with bipolar disorder or MDD. 28,32 Ketamine has been shown to increase … That is, patient volume in infusion centers might increase, which, in turn, would require increased … For these reasons, most experts believe, this intervention would increase the per-patient cost of care … On one hand, if the program is proven effective in increasing patient use of services, an increase
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
    July 26, 2012 - It seems unlikely, however, that reduction of soft drink consumption would increase risk of mortality … Epidemiological data suggest that low calcium diets increase risk of kidney stones, and differences … stated in referring to the Borghi 2002 trial that its findings suggested “low dietary calcium may increase … asymptomatic stones may opt for surgery if their stones show evidence of growth or if they have an increase … placebo), the 95% confidence intervals excluded a clinically significant increase in risk of recurrence
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-research-protocol.pdf
    April 11, 2018 - corticosteroids have historically only be used in stable COPD, but there is emerging evidence that an increase
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-evidence-communication_executive.pdf
    November 01, 2013 - addresses the comparative effectiveness of communicating evidence in various contents and formats that increase … communicate evidence so that target audiences can better understand it; the strategies are meant to increase … many settings (e.g., postal and electronic mail; electronic/ digital, social, and mass media) to increase … the reach of information • Increase motivation to use and apply such information—Increasing interest … through champions (also known as “cheerleaders”), opinion/thought leaders, or social networks • Increase
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
    March 01, 2013 - Summary • Composite outcomes typically increase statistical efficiency. … Furthermore, the proportion of event for each intervention group usually increases with the increase … of study duration and the estimated RD may increase accordingly. … Alternatively, investigators could present results as a relative risk reduction or relative risk increase … the combined RR was 1.36 (95% CI, 1.09–1.69).25 This finding could be expressed as a relative risk increase

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