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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/dietary-supplements_research-protocol.pdf
    December 15, 2010 - heart failure or other cardiovascular disease use some form of CAM.8,10 Dietary supplementation, including … Grey literature will be identified through a search of trial registries (including ClinicalTrials.gov … Data—including baseline value, final value, within-treatment change or between-treatment difference, … Including studies in languages other than English is recommended for CAM topics.1,2 However, there is … Review authors may want to search without language restrictions and decisions about including reports
  2. 8 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-harms_methods.pdf
    November 01, 2008 - Use multiple sources of information, including clinical experts and stakeholders, to identify important … Gather evidence on harms from a broad range of sources, including observational studies, particularly … In addition to evaluating results of published RCTs, CER authors should consider including results … To conduct formal quantitative meta-analysis, including published and unpublished RCTs or outcomes. … However, CERs should match inclusion criteria to the reasons for including observational studies.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_research-protocol.pdf
    January 30, 2014 - Although DBD-specific preventive interventions have been developed, practical considerations including … Furthermore, the medication prescribing increases were greater for non-approved indications including … Anti-psychotic drugs have FDA approval for a limited set of specific indications in children, including … Decisional dilemmas Wide variations in clinical management of DBDs, including the use of polypharmacy … Setting We are focusing on interventions in the clinical setting, including medical or psychosocial
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/telehealth-acute-chronic_research-protocol.pdf
    February 15, 2017 - Relationships among the providers and patients involved including whether these are new or ongoing … Settings including • Type of health care organization including the organizational structure (e.g. … Payment models or requirements or limits for payment including • The payer/insurance for the patient … Study Designs • Comparative studies, including trials and observational studies. … Study Designs: We will include comparative studies of any design including trials and cohort studies
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/smoking-pregnancy-infants_executive.pdf
    February 01, 2014 - Nearly 443,000 U.S. deaths are attributable annually to cigarette smoking, which makes tobacco, including … Key Question 4: What is the effect of components of the smoking cessation intervention, including who … Discordant classifications were resolved in team meetings including senior investigators. … Several interventions warrant additional research and replication, including better assessments. … Intervention timing varies substantially across studies, including early and late in pregnancy.
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mass-casualty-events-scarce-resources_executive.pdf
    June 01, 2012 - offered insights on identifying and defining key parameters for the review, such as criteria for including … This helped identify reports from research and advocacy organizations, including non–peer-reviewed reports … A wide range of provider-oriented strategies has been tested in various contexts, including actual MCEs … Despite the fact that our review spanned more than 20 years of preparedness research, including the … Other threats, including natural disasters, and other challenges, such as health systems operations
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/crohns-disease_disposition-comments.pdf
    February 25, 2014 - Consider including trial for Pediatic KQs 1 and 2. … Consider including in Report. … Consider including trial for Pediatric KQ 1and 2. … Consider including in report. … Consider including in report.
  8. - (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease-future_research.pdf
    July 01, 2016 - Identification of Ongoing Research Clinical research repositories and research-related sites including … the introduction of biologics into the treatment algorithm for inflammatory diseases, including Crohn … comparisons within and between treatment classes • Risk stratification for treatment choice (including … treatments and response to prior treatments) • Outcomes other than CDAI not routinely assessed including … the introduction of biologics into the treatment algorithm for inflammatory diseases, including Crohn
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-comments.pdf
    November 04, 2020 - We have incorporated a reference to the large body of evidence (including nonrandomized trial evidence … each of the domains and how they were measured, including referencing both EPC, Cochrane, and any … Consider defining it—including how it differs from remission or other measures of recovery. … We have updated the results and methods including providing more information about how these types … The criteria for including which examples in each column is unclear.
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-review-no-touch-modalities.pdf
    May 01, 2022 - After manual processes, no- touch disinfection modalities also may be used, including ultraviolet light … When compared to standard cleaning (including bleach), UVL also was associated with lower CD surface … However, authors noted several potential confounders that may have played a role including a statistically … Comprehensive cancer center 2012 to 2013 Standard cleaning* (including bleach) vs. … Acute care non-ICU hospital beds at a community hospital 25.5 months, including 3.5 months
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/quality-gap-palliative-hospice_disposition-comments.pdf
    October 01, 2012 - At the end of the KQ1 results for the continuity section: “For all outcomes, when including only the … including all possible articles that could be considered a QI intervention. … The authors make reference to including samples with a 1- year mortality greater than 50%, though it … Every attempt was made to include all populations including children and the elderly and those with … More description of the studies - including why it is counted as QI study.
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-cancer-imaging_research-protocol.pdf
    December 17, 2013 - brain, and had a 5-year relative survival rate of only 23 percent.1 Several imaging modalities, including … We will describe the accuracy, benefits and potential risks of each modality, including sensitivity … Question 2 will provide the context for how each of the imaging modalities is currently used, including … assessing outcomes of different imaging strategies, as well as contextual issues that may affect use, including … criteria, we will design data abstraction forms to gather pertinent information from each article, including
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/atypical-antipsychotics-off-label-update_research-protocol.pdf
    May 19, 2010 - How have trends in utilization changed in recent years, including inpatient versus outpatient use? … years old) and adolescents (12 – 17 years old) with the following disorders: • Eating disorders, including … Settings: All settings in which trials take place, including inpatient hospitalization, outpatient treatment … Sub-Question 2: How do atypical antipsychotic medications compare with other drugs, including first … use is any use of the medication that is not specifically mentioned in the FDA approval labeling (including
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin_research-protocol.pdf
    September 08, 2011 - in Patients with Suspected Infection Population(s):  Adult patients with suspected infection including … 8, 2011  Bacteremia  Sepsis  Septic shock  Pediatric patients with suspected infection including … pulmonary disease o Pneumonia o Osteomyelitis Patients being treated for systemic infection including … of participants and flow of participants through steps of study o Treatment allocation methods (including … Key Informants Key Informants are the end users of research, including patients and caregivers,
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
    September 20, 2013 - for all KQs is women who have been referred for biopsy for the diagnosis of primary breast cancer (including …  Dissemination (seeding) of cancerous cells along the needle track  Patient-centered outcomes (including … ● Setting Studies in all geographic locations and care settings will be evaluated, including … Any additional studies that meet the eligibility criteria, including those that are identified through … We will perform additional sensitivity analyses including leave-one-out meta-analysis, all-subsets meta
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule_research-protocol.pdf
    March 14, 2012 - ○ For KQs 1 and 2, the comparators are conventional diagnostic tests for suspected gastroparesis, including … and 4, the comparators are conventional diagnostic tests for suspected slow- transit constipation, including … Transit time (including time to stomach emptying, time to small bowel emptying, time to colon emptying … For the assessment of harms, we will be including any patient population that was evaluated with the … For the assessment of harms, we will be including any patient population that was evaluated with the
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar-2010_research-protocol.pdf
    January 01, 2010 - The resultant hyperglycemia, if untreated, can lead to long-term complications, including microvascular … In addition, several other factors appear to be especially relevant, including the age of the patient … Age: very young children, adolescents, and adults, including older adults (age >65 years)? c. … Age: very young children, adolescents, and adults, including older adults (age >65 years)? c. … We will not be including the following devices because they are no longer used in the United States
  18. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-medical-update_research-protocol.pdf
    February 16, 2016 - as similarly aged adolescents without an ASD; other care costs were also higher in this population, including … report one or more outcomes of interest and include children at least 2 years of age and up to and including … We will require that studies including mixed age (children and adolescents or adults) populations either … Information Packets (SIPs) The Scientific Resource Center (SRC) will notify relevant stakeholders (including … Medications Addressed in Recent RCTs Including Children with ASD Drug   Company     Anticonvulsants  
  19. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain_executive.pdf
    October 01, 2011 - The total costs for arthritis, including osteoarthritis, may be greater than 2 percent of the gross domestic … Food and Drug Administration (FDA) as pharmaceuticals, including glucosamine and chondroitin.5 Opioid … COX-1 mediates the mucosal protection of the gastrointestinal mucosa, including protection from acid … COX-2 is found throughout the body, including joint and muscle, and mediates effects on pain and inflammation … Pharmaceutical manufacturers were invited to submit scientific information packets, including citations
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_research-protocol.pdf
    February 04, 2014 - Several grading instruments have been created to assess these, including the National Cancer Institute … The data elements to be abstracted will include the following: • Patient characteristics, including: … Additional (optional) domains including strength of association (magnitude of effect), dose-response … Assessment of reporting bias for individual studies depends on many factors including availability … In the EPC grading system, a body of evidence including RCTs is assigned a provisional SOE grade of

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