- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/vitamin-d-calcium_research-protocol.pdf September 13, 2013 - symptoms 
 Cardiovascular death 
 Study-specific combinations of cardiovascular events 
 
o Cancer (incident … of cardiovascular events 
• CVD intermediate outcomes (diagnosis of hypertension, blood pressure, incident 
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-2.pdf February 01, 2018 - - Not preferred when there is heterogeneity 
between studies in duration and incident 
rates
- Preferred 
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf March 01, 2012 - to 
fractures alone have been nearly $20 
billion.2 A recent projection of the burden 
and costs of incident … another post hoc analysis of data from the same 
trial found that alendronate reduced the risk of 
incident 
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_disposition-comments.pdf December 01, 2011 - An Evidence Review of Active Surveillance in Men with Localized Prostate Cancer
 
Source: http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-
reports/?productid=859&pageaction=displayproduct 
Published Online: December 2011  
 
 
 
Comparative Effectiveness Research Review Disposition …  
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_surveillance.pdf August 01, 2012 - CER # 23: 
Effectiveness of Recombinant Human Growth Hormone (rhGH) 
in the Treatment of Patients with Cystic Fibrosis 
 
Original release date:  
October 2010 
 
Surveillance Report 1st Assessment: November, 2011 
Surveillance Report 2nd Assessment: August 2012 
 
Key Findings 1st Assessment: 
• All conclusions for KQ…  
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-diff-infections_research-protocol.pdf May 24, 2010 - Consensus also exists for treatment of severe initial incident 
CDAD with vancomycin. 
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf March 01, 2011 - Estimated annual number of incident and recurrent, non-fatal and fatal venous 
thromboembolism (VTE) 
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-bone-fracture_research-protocol.pdf May 14, 2010 - due to fractures alone have been nearly $20 billion.2 A recent projection of the 
burden and costs of incident 
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveillance-report-2.xlsx September 30, 2015 - Appendix Table D-1. RCTs
	Table D-1. Randomized controlled trials
	Author, Year	Study Design
Duration	Setting
Country	Eligibility Criteria	Interventions	Sample Characteristics	Screened
Eligible
Randomized
Analyzed	Results	Adverse Events and Withdrawals Due to Adverse Events	Sponsor	Quality
	Hruschak, 2021	RCT
Duration:…  
- 
                                        
effectivehealthcare.ahrq.gov/products/asthma-immunotherapy-2011/research 
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/ch-7-user-guide-to-ocer_130129.pdf March 29, 2012 - selection in this chapter focus primarily on fixed 
treatment comparisons when employing the so-
called “incident … Pharmacoepidemiological studies that do not 
restrict analyses to incident episodes of treatments 
are … of time-varying 
noncompliance in the effect of randomized highly 
active antiretroviral therapy on incident 
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/tx-for-localized-prostate-cancer_surveillanceassesment_20120614.pdf May 01, 2012 - CER #13:  
Comparative Effectiveness of Therapies for Clinically 
Localized Prostate Cancer 
 
Original release date:  
February 2008 
 
Surveillance Report:  
May 2012 
 
Key Findings: 
• The PIVOT trial was identified, making many of the 
existing key conclusions out of date. 
• Key questions 1, 2, and 4 were found t…  
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tx-for-localized-prostate-cancer_surveillanceassesment_20120614.pdf May 01, 2012 - CER #13:  
Comparative Effectiveness of Therapies for Clinically 
Localized Prostate Cancer 
 
Original release date:  
February 2008 
 
Surveillance Report:  
May 2012 
 
Key Findings: 
• The PIVOT trial was identified, making many of the 
existing key conclusions out of date. 
• Key questions 1, 2, and 4 were found t…  
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/vitamin-d-calcium_executive.pdf September 01, 2014 - An assessment 
of the association between serum 25(OH)D and incident 
hypertension in 1,211 participants … association, with men in 
the lowest two quartiles and in the highest quartile at 
higher risk for incident … hypertension at baseline, at 7 years the trial found the 
combined supplementation had no effect on incident 
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf July 01, 2011 - Thus, only a low
strength of evidence exists that a high AHI (>30
events/hr) is associated with incident … that came to 
(continued) uncertain conclusions regarding the possible association between 
AHI and incident … hypertension.
• There were 2 studies (1 quality A, 1 quality B) that suggested an 
association between AHI and incident … The  strength of evidence is low that a higher AHI is 
associated with incident diabetes, though possibly 
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_surveillance.pdf December 01, 2012 - VTE Surveillance Assessment_49_low_SPI
	
  
	
  
 
CER # 49: 
	
  
Comparative effectiveness review of Venous Thromboembolism Prophylaxis in 
Orthopedic Surgery	
    
 
 
Original release date: 
March 2012 
 
Surveillance Report: 
December 2012 
 
 
Key Findings:  
 
• Key questions (KQs) 1-4,7-11 are uptodate …  
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf October 01, 2015 - 1
Comparative Effectiveness Review 
Number 156
Contrast-Induced Nephropathy: Comparative 
Effectiveness of Preventive Measures
Executive Summary
Background
The administration of iodinated contrast 
media is an essential component of many 
diagnostic and therapeutic procedures 
that involve radiologic imaging. One 
…  
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/tympanostomy-tubes_research-protocol.pdf November 16, 2015 - Untitled
  
Source: www.effectivehealthcare.ahrq.gov 
Published online: November 16, 2015        
     
   
 
Evidence-based Practice Center Systematic Review Protocol 
Project Title: Tympanostomy Tubes 
 
I. Background and Objectives for  the Systematic Review 
Uncertainty in the comparative effectiveness of tym…  
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/s96.pdf October 01, 2007 - ORIGINAL ARTICLE
Evaluation and Overview of the National Electronic Injury
Surveillance System-Cooperative Adverse Drug Event
Surveillance Project (NEISS-CADES)
Michael A. Jhung, MD, MPH,* Daniel S. Budnitz, MD, MPH,* Aaron B. Mendelsohn, PhD,*†
Kelly N. Weidenbach, MPH,* Theresa D. Nelson, MS,‡ and Daniel A. Polloc…  
- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-complaints-tests-children_executive.pdf March 01, 2012 - 1
Comparative Effectiveness Review 
Number 50
Antinuclear Antibody, Rheumatoid Factor, and 
Cyclic-Citrullinated Peptide Tests for Evaluating  
Musculoskeletal Complaints in Children
Executive Summary
Background
Musculoskeletal (MSK) pain is common 
in children and adolescents, with an 
estimated prevalence rangin…