-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-adolescents_surveillance.pdf
July 01, 2014 - Most
reported improved core symptoms but
each study had different approach. … Most reported improved
core symptoms but each study had different
approach. … Medical Interventions
One retrospective case-series6
reported improved core symptoms
with oxcarbazepine … One
RCT9 reported improved core
symptoms with fluoxetine treatment. … Behavioral Interventions
One nonrandomized study4 reported
improved parental and sibling
outcomes
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_surveillance.pdf
March 14, 2013 - Health status
improved inconsistently with treatment with
DMARDs. … One
expert expressed that they
show that both tocilizumab
and canakinumab caused
improved CHAQ in … Also all JIA core set
response variables improved
significantly over 27 months of
etanercept treatment … All ab regimens led to
improved MRI, HAQ and SF-36
scores, with 10mg/kg showing
the greatest improvements … Health status
improved inconsistently with treatment with
DMARDs.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_surveillance.pdf
March 14, 2013 - Health status
improved inconsistently with treatment with
DMARDs. … One
expert expressed that they
show that both tocilizumab
and canakinumab caused
improved CHAQ in … Also all JIA core set
response variables improved
significantly over 27 months of
etanercept treatment … All ab regimens led to
improved MRI, HAQ and SF-36
scores, with 10mg/kg showing
the greatest improvements … Health status
improved inconsistently with treatment with
DMARDs.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-appendix-3.xlsx
June 24, 2022 - Duke-M Protocol The validity of RWE from retrospective observational studies is improved with prespecification … Duke-M Reproducibility The validity of RWE from retrospective observational studies is improved with … NAM2017 Improved communication from leadership within the biopharmaceutical industry and regulatory sectors … Drug development processes could be improved by applying lessons learned and best practices from those … NAM2017 Need for improved transparency -sharing of study methods and outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1512.pdf
December 01, 2015 - Most were observed early in the course of treatment and improved over time,” the
company stated.11 … Patient-reported weight-related quality of life improved from baseline on the Impact of Weight on
Quality … with T2DM and BMIs of 30–35 kg/m2.50 Investigators
found that at 6 months, the surgery group had improved … expert noted, “Specialists caring for patients with T1DM are interested in
inhaled insulin as an improved … Improved diabetic
macular edema outcomes with Iluvien therapy is likely to decrease the incidence of
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/insomnia_disposition-comments.pdf
December 30, 2015 - Introduction Page 4
Table 2 in both main document and executive summary
The definition of CBT can be improved … patient-centered
outcomes such as mood and well-being, quality of life,
and productivity through improved … mood; secondary were considered ‘secondary’ to
improved sleep (not direct consequences of the
treatment … For instance, it is not entirely clear how this review
can conclude that doxepin improved global outcomes … Should the next to last sentence read ‘Low
strength evidence shows that zolpidem improved sleep
onset
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_surveillance.pdf
April 01, 2012 - Two
reported reductions in sleepiness
and one improved quality of life. … The results were
inconsistent across studies as to which outcomes
were improved with surgery compared … The strength of evidence is moderate
that a higher ESS score is also associated with
improved compliance … The quality of life improved
only in the CPAP group (p=0.01)
Sharma, 201121; India Crossover
RCT … The results were
inconsistent across studies as to which
outcomes were improved with surgery
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-outcomes-diabetes-rapid-research.pdf
November 01, 2024 - of dental treatment over two months and
found that continued dental treatment was associated with improved … Two of the URs25,26 of high quality concluded that NSPT is associated
with improved glycemic control … Improved glycemic control (HbA1c):
• 3 months: −0.49% (95% CI [−
0.63, − 0.35], p < 0.001), (18
studies … Improved glycemic control:
• HbA1c: -0.32%(95%CI: [-0.50,
-0.15], p<0.001)
• FPG: -11.59 mg/dl; 95% … Nonsurgical
Periodontal Treatment Improved the Type 2
Diabetes Mellitus Status in Smokers: A
Randomized
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetic-neuropathy-disposition-170707.pdf
March 24, 2017 - No
treatments improved quality of life (low SOE). … inhibitors are more
effective than anticonvulsants THIS IS NOT REALLY
THE CASE however, no treatments improved … spinal
stimulation, the conclusion should be expanded to
something like, "compared to placebo pain is
improved … but there is not adequate data on improved
function.
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
March 24, 2017 - No
treatments improved quality of life (low SOE). … inhibitors are more
effective than anticonvulsants THIS IS NOT REALLY
THE CASE however, no treatments improved … spinal
stimulation, the conclusion should be expanded to
something like, "compared to placebo pain is
improved … but there is not adequate data on improved
function.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin_research-protocol.pdf
September 08, 2011 - Improved/
earlier
diagnosis of
local or
systemic
infection
Improved
selection,
exclusion, or … timing of
antibiotic therapy
Improved
intermediate out-
comes (antibiotic
exposure, duration … of antibiotic
therapy, length of
stay, response to
therapy)
Improved morbidity,
function, quality
-
effectivehealthcare.ahrq.gov/sites/default/files/14_substance_abuse_potential_high_impact_2012-12-11.pdf
January 01, 2012 - They viewed this
intervention as having some ability to meet the need for improved patient adherence … results from the phase III confirmatory study suggested that
treatment with the implant significantly improved … buprenorphine implant.
25-31
Experts generally agreed that opioid-dependence therapies that offer improved … with
7
currently available therapies’ initial costs, but some stated that if adherence is improved
-
effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1412.pdf
February 01, 2015 - Intranasal insulin
treatment improved patients’ cognitive performance (p<0.05; measured by delayed … cognitive improvements when
administered 20 IU intranasal insulin, but only male patients’ cognition improved … the same research group reported that
patients with AD or MCI who carried the ApoE-ε4 allele had improved … cognitive scores declined with the same
treatment; however, all patients’ working memory performance improved
-
effectivehealthcare.ahrq.gov/sites/default/files/developmental-delays-horizon-scan-high-impact-1406.pdf
June 01, 2014 - research supports a hypothesis that
ES-3
earlier diagnosis and intervention may result in improved … studies have reported that intranasal oxytocin increases
systemic oxytocin levels that may be linked to improved … 3
in high-functioning adult males with ASDs (n=40) reported that a single 24 IU oxytocin dose
improved … enrolling adolescent patients with ASDs (n=16), two different oxytocin
dosages were associated with improved
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/Evidence%20Summary_0_0.pdf
April 01, 2020 - studies of participants with a wide
range of depressive disorders (MDD, PDD, or DD
NOS) suggests improved … benefit
Adolescents
with MDD
Response Risk difference
(CGI-I of 1 or 2
indicating very
much improved … or improved):
362/1,000; 95% CI,
239 more cases to
485 more cases
1 RCT
(n=219)23
Imprecision … or improved):
362/1,000; 95% CI,
239 more cases to
485 more cases
1 RCT
(n=219)23
Imprecision … Combination pharmacotherapy may not be
associated with improved depressive symptoms
when compared with
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-treatment-adherence_disposition-comments.pdf
December 20, 2012 - Section Comment Response
FDA Executive Summary On page ES-1, An addition to this introduction may be
improved … with the inclusion of a notation that outcome of
treatment improved with the development/usage of pegylated … Most notably and relevant are the improvement in
adherence issues that were associated with the improved … Three
studies suggested adherence was
improved, whereas the other two
showed lower adherence level … Given
the inconsistency of the findings, the
lack of evidence showing improved
clinical outcomes,
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
July 01, 2011 - analytic framework
depicts the chain of logic that evidence must support to
link the interventions to improved … The results were
inconsistent across studies as to which outcomes were
improved with surgery compared … The strength of
evidence is moderate that a higher ESS score is also
associated with improved compliance … The strength of evidence is
moderate that higher ESS is also associated with improved
compliance. … None
improved compliance.
-
effectivehealthcare.ahrq.gov/sites/default/files/13_pulmonary_potential_high_impact_2012-12-11.pdf
January 01, 2012 - Cystic Fibrosis in
Patients with G551D-CFTR Mutation
Key Facts: Current therapies for CF have improved … Cystic Fibrosis in
Patients with G551D-CFTR Mutation
Current therapies for cystic fibrosis (CF) have improved … coverage, patient copayments, real-world
clinical efficacy, and offsets of other health care costs from improved
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
April 01, 2013 - including
diagnostic accuracy (clinical validity) for prostate cancer, intermediate outcomes (e.g., improved … including
diagnostic accuracy (clinical validity) for prostate cancer, intermediate outcomes (e.g., improved … The CER analyses revealed that PCA3 had improved diagnostic accuracy compared with
tPSA in identifying … including diagnostic accuracy (clinical
validity) for prostate cancer, intermediate outcomes (e.g., improved … With regard to the intermediate outcome of improved decisionmaking, PCA3 does have the
potential to
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/binge-eating_executive.pdf
December 01, 2015 - Ultimately, the information produced in this review is
intended to contribute to improved care for patients … Even though
patients improved, many did not achieve abstinence
with antidepressants; 41 percent of … Lisdexamfetamine improved binge-eating outcomes. … We have two recommendations for improved designs. … Change in attachment
insecurity is related to improved outcomes 1-year post group
therapy in women