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effectivehealthcare.ahrq.gov/sites/default/files/related_files/long-term-care-adults_disposition-comments.pdf
November 07, 2012 - Although there is no easy solution to this problem,
a more extensive discussion about how this phenomenon … do a quantitative analysis. … Reviewer #1 Results The tables are nicely presented but the reader has to do a lot of work
to determine … not have to do so
much work. … This report will make a contribution to policy and
practice decisions about how long-term services and
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-pharmacologic-treatment_research-protocol.pdf
December 27, 2016 - prospective or retrospective
observational cohort studies, case-controlled
studies
Case series, case … reports, nonsystematic
reviews, systematic reviews with or without
meta-analysis†
Publication
Language … answer our Key Questions as
recommended by the EPC methods guide.19 We will consider how important … Technical Experts do not do analysis of any kind nor do
Source: www.effectivehealthcare.ahrq.gov … They have not reviewed the report, except as
given the opportunity to do so through the peer or public
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening_research.pdf
June 01, 2013 - complexity (e.g., do existing methods need to be refined?) … One of the logistical
issues is how best to screen surgical outpatients prior to surgery (if a screening … gloving would be how to conduct a
randomized study in one institution; a multicenter study may be the … o How many sites to swab?
o How many swabs/site?
• Haith L. … • How do improved patient outcomes and associated costs link back to
a screening program when multiple
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_disposition-comments.pdf
December 16, 2014 - do well. … do for strength of evidence in
the subsequent section? … A
key issue is how can the results of the present analysis be used to insure
that future trials ask … This Reviewer would be very interested in how the
unique expertise of this group can be channeled to … As such we do not consider them a
source of original data.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-quantitative-synthesis_methods.pdf
October 01, 2010 - model or how to handle heterogeneity, remain crucial considerations and are often the subject
of controversy … Examples to illustrate how to make appropriate
decisions based on evaluation of different types of … upon
study characteristics, though little guidance and consensus exists on how to interpret the results … assumptions only lead to small changes in the estimates and do not affect the
conclusions. … How vague is vague?
-
effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_conductingquantitativesynthesis.pdf
October 01, 2010 - model or how to handle heterogeneity, remain crucial considerations and are often the subject
of controversy … Examples to illustrate how to make appropriate
decisions based on evaluation of different types of … upon
study characteristics, though little guidance and consensus exists on how to interpret the results … assumptions only lead to small changes in the estimates and do not affect the
conclusions. … How vague is vague?
-
effectivehealthcare.ahrq.gov/sites/default/files/s13.pdf
October 01, 2007 - They may also be
vulnerable to random error, or confounding by a variable such as
another drug, a disease … However, patients
often do not know which drugs they take at the time of the
interview, and know less … and persistence (for how long does the pa-
tient take the drug?). … drug are different from people who do not, in
that they have an indication for therapy. … Yet, these data are not accessible to the research
community, and we do not know when or if they will
-
effectivehealthcare.ahrq.gov/sites/default/files/s29.pdf
October 01, 2007 - We
don’t tend to give people a reason why we do that . . .. … I do not see a call for each person to
sign an informed consent because they are not taking exper-
imental … It was also noted that automated
systems used to manage copayments do not adjust well to
special circumstances … What do you do at the end
of the study with that patient and that copay?” … As 1 subject said, “That’s
how we do it anyway. And that’s how the formulary works.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_surveillance.pdf
March 01, 2013 - • How out of date is that portion of the CER? … less of a
signal to update than the former)? … Conclusion is
possibly out of
date if diabetes
risk is a concern
to stakeholders. … How quickly do systematic reviews go out of
date? A survival analysis. … Do Not Know
KQ1: For patients with RA, do drug therapies differ in their ability to reduce disease
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_surveillance.pdf
March 01, 2013 - • How out of date is that portion of the CER? … less of a
signal to update than the former)? … Conclusion is
possibly out of
date if diabetes
risk is a concern
to stakeholders. … How quickly do systematic reviews go out of
date? A survival analysis. … Do Not Know
KQ1: For patients with RA, do drug therapies differ in their ability to reduce disease
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_disposition-comments.pdf
May 01, 2013 - see a more concise description of US study
populations and how they relate to population
demographics … We have added a qualitative discussion of how
the U.S. studies compare to the other included
studies … We have added a qualitative discussion of how
the U.S. studies compare to the other included
studies … How can one
recommend the instrument without specifying a
cutpoint? … Further discussion of how
to target high risk populations or the implications of
adding a question
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-omega-3_research-protocol.pdf
September 02, 2016 - How to Use Basic Search ClinicalTrials.gov U.S. … (addresses or autobiography or bibliography or biography or case
reports or comment or congresses … (addresses or autobiography or bibliography or biography or case reports or
comment or congresses … process such as: referring to a random
number table, using a computer random number generator, coin … Do any specific outcomes have a high risk of
bias (different than others)?
-
effectivehealthcare.ahrq.gov/sites/default/files/celiac-disease_disposition-comments.pdf
January 28, 2016 - Unfortunately, the question of how to best
find celiac disease in the general population was
beyond … We do not feel this evidence is sufficient. … I do not believe that this study is
relevant to a discussion of harms related to
endoscopy, as there … Do GI symptoms identify them? … Unfortunately, the question of how to best find celiac
disease in the general population was beyond
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-topic-refinement_methods.pdf
January 01, 2013 - To do so may require a balanced compromise that considers the relative importance
and/or practicality … and harms, such as the inclusion of many study types (small trials, case series,
and case reports) … participate and those who do not). … How to most effectively identify and engage stakeholders? … KQ5: How do the efficacy, effectiveness, safety or adverse effects of treatment with DMARDs differ between
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/disabilities-quality-improvement-outcomes_disposition-comments.pdf
October 15, 2012 - do in rehab! … nice sense of how there is a need to mix and
match service types to meet the need of individuals depending … Medical practitioners may need special
knowledge about how to treat a given disease in the context of … how it was developed and how it can be used. … It is a shame that you do not have room to
describe relevant population for measurement as this would
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
April 30, 2014 - To do otherwise, is to misdirect the
practicing community on the road to enlightened prevention of … I would like the authors to expand a bit on how they feel
this could be done with the current set of … not include a definition for "peritonitis or intra-
abdominal abscess" - how were these outcomes assessed … I do not think you
have to prove that they are the same. … pleased to do it!
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-195-disposition-comments-uterine-fibroids.pdf
December 14, 2017 - Likewise
the limited data do not show that UAE is a safe option for women who
wish to conceive. " … TEP Reviewer#4 Results How do you know if power calc. were not included? … Basically, how do the patient populations across these studies
differ? … To do a study with fertility as an endpoint requires
2000 women and is simply not possible. … Thank you for your comment, but we do not see a need to change this
text.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
November 20, 2013 - We do agree with the reviewer that there are a number of
prognostic models that were created to assess … We do agree with the reviewer that we do need better
approaches to utilize the prognostic model data … How did you weigh this
and how did you choose the 35 reports among others? … A component of directness is how well the populations in
the studies correspond to the population that … If I know the age and sex of a person, do I really
need to measure BNP on top of that?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
June 15, 2010 - TF can encompass a number of subgroups of patients who do not adequately respond to
interventions for … How do the harms compare across different interventions? … Question 3:
How do these therapies compare in different populations (for example, different depressive … statement has been added to clarify how results will be grouped with respect to the
different monotherapy … The TEP does not do analysis of any kind
nor contribute to the writing of the report.
X.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-bias_methods.pdf
July 01, 2012 - In particular, a key consideration in a review is
how much influence a particular study should have … others to a body of
literature. … A second common challenge is how to apply each criterion in a way that is appropriate to the
goals of … Reviewers must also carefully consider how to handle inadequate reporting. … How to Review the
Evidence: Systematic Identification and
Review of the Scientific Literature.