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www.uspreventiveservicestaskforce.org/home/getfilebytoken/by8VJVre6h6BmadrGxaFMM
April 01, 2016 - risk (for
example, history of GI ulcers, recent bleeding, or use of
medications that increase bleeding … GI and Intracranial Bleeding
Evidence shows that risk for GI bleeding, with and
without aspirin use, … risk
for GI or intracranial bleeding … These trials reported ma-
jor GI bleeding events, defined as GI bleeding requir-
Aspirin Use for the … Increased harms may result from factors that either
increase bleeding risk or enhance the bleeding effect
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/fXJESRpEwCmPh-FQobvtAY
July 10, 2018 - (0.5% vs 0.5%; relative risk [RR],
1.13 [95% CI, 0.44-2.91]).30 Major hemorrhage (defined as nonfa- … tal or fatal hemorrhagic CVA, fatal or nonfatal subarachnoid or
subdural hemorrhage, gastrointestinal … bleeding requiring admis-
sion, and other bleeding requiring hospital admission) in the AAA
trial was … (defined as nonfatal
or fatal hemorrhagic
CVA, fatal or nonfatal
subarachnoid/
subdural hemorrhage, … GI bleeding requiring
admission, and other
bleeding requiring
hospital admission)
1 (n = 3350) Major
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/c-7ARQE9RuXKjjpeLABkaH
March 01, 2007 - aspirin and NSAID use:
There is good evidence that aspirin increases the inci-
dence of gastrointestinal bleeding … There is good evidence that NSAIDs increase the in-
cidence of gastrointestinal bleeding and renal impairment … The USPSTF found good-quality evidence that aspi-
rin increases the incidence of gastrointestinal bleeding … which are
good-quality studies, found an OR of 5.36 (CI, 1.79 to
16.1) for perforations, ulcers, and bleeding … use to prevent colorectal can-
cer because of potential side effects, especially gastrointes-
tinal bleeding
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/qguycZWFxAQfzsJJFwEn23
January 25, 2022 - In SCREEN-AF, authors re-
ported 0 intracranial hemorrhages.43 The 2 RCTs evaluating continu-
ous patch … events; it reported 1 fatal intracerebral hemorrhage
in the warfarin group and only reported bleeding … BAATAF defines major bleeding as intracranial
bleeding, fatal bleeding, or bleeding that led to transfusion … outcomes)
Bleeding outcomes (2 RCTs):
0 intracranial hemorrhages or major bleeding
events after 6 mo … : pooled RR, 1.8 (95% CI, 0.85-3.7)
Intracranial hemorrhage: pooled RR, 1.9 (95% CI,
0.56-6.7)
Previously
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/aspirin-use-to-prevent-cardiovascular-disease-preventive-medication
May 14, 2020 - Does regular aspirin use increase major gastrointestinal bleeding, intracranial bleeding, or other serious … defined by age, sex, 10-year cardiovascular risk, diagnosis of diabetes mellitus, race/ethnicity, or bleeding … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … , defined as bleeding requiring transfusion or hospitalization or leading to death (including but not … limited to gastrointestinal bleeding), hemorrhagic stroke, or other serious harms
KQ 1: Intermediate
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/aspirin-to-prevent-cardiovascular-disease-preventive-medication
May 14, 2020 - Does regular aspirin use increase major gastrointestinal bleeding, intracranial bleeding, or other serious … defined by age, sex, 10-year cardiovascular risk, diagnosis of diabetes mellitus, race/ethnicity, or bleeding … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … , defined as bleeding requiring transfusion or hospitalization or leading to death (including but not … limited to gastrointestinal bleeding), hemorrhagic stroke, or other serious harms
KQ 1: Intermediate
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/atrial-fibrillation-screening-with-electrocardiography-august-2018
July 14, 2016 - KQ 8: Any harms requiring unexpected or unwanted medical attention (e.g., hemorrhagic stroke, major bleeding … , allergic reaction)
KQs 6, 8: Nonserious events (e.g., bleeding not requiring or resulting in medical
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan-aspirin-to-prevent-cancer/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
October 07, 2013 - benefits or harms are proposed: diabetes, liver disease, ulcer disease, and previous gastrointestinal bleeding … What valid risk prediction tools to determine bleeding risk (e.g., gastrointestinal bleeding, hemorrhagic … stroke, other major bleeding) are available for persons who are not contraindicated for regular aspirin … incidence
Advanced adenoma incidence
Advanced neoplasia
KQs 6, 7 (harms):
Gastrointestinal bleeding … Precancerous markers
Progression or metastasis
Recurrence
KQs 6, 7 (harms):
Postoperative or minor bleeding
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-prophylaxis-pregnancy-1996
January 01, 1996 - complications associated with preeclampsia include abruptio placentae, acute renal failure, cerebral hemorrhage … was noted in the aspirin group it was not associated with the occurrence or severity of postpartum hemorrhage … , however, nor were there significant differences in abruptio placentae or other antepartum bleeding. … and neonatal intracranial hemorrhage. 12 , 27 Maternal effects were seen with doses of 1,500-2,500 … Bleeding problems have not generally been reported at low doses (60-150 mg/day), 28-30 although most
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/atrial-fibrillation-screening-with-electrocardiography
August 07, 2018 - , major extracranial bleeding, intracerebral hemorrhage, minor bleeding, and a composite outcome of ischemic … stroke or intracerebral hemorrhage. … Relative Risk of Major Bleeding, Major Extracranial Bleeding, and Intracranial Hemorrhage for Warfarin … intracerebral hemorrhage in the warfarin group and only reported bleeding events leading to withdrawal … Intracranial hemorrhage: SPAF I events included 1 fatal intracerebral hemorrhage and 1 subdural hematoma
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/atrial-fibrillation-screening-with-electrocardiography-august-2018
August 07, 2018 - , major extracranial bleeding, intracerebral hemorrhage, minor bleeding, and a composite outcome of ischemic … stroke or intracerebral hemorrhage. … Relative Risk of Major Bleeding, Major Extracranial Bleeding, and Intracranial Hemorrhage for Warfarin … intracerebral hemorrhage in the warfarin group and only reported bleeding events leading to withdrawal … Intracranial hemorrhage: SPAF I events included 1 fatal intracerebral hemorrhage and 1 subdural hematoma
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/crPsNJ_R5SFnJhuT2CEpkr
March 01, 2019 - , intracerebral hemorrhage, minor
bleeding, and a composite outcome of ischemic stroke or intracere- … bral hemorrhage. … Relative Risk of Major Bleeding, Major Extracranial Bleeding, and Intracranial Hemorrhage for Warfarin … intracerebral
hemorrhage in the warfarin group and only reported bleeding events leading to
withdrawal … Intracranial hemorrhage: SPAF I events included 1
fatal intracerebral hemorrhage and 1 subdural hematoma
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/aspirin-use-to-prevent-cardiovascular-disease-and-colorectal-cancer-preventive-medication
January 30, 2020 - Does regular aspirin use increase major gastrointestinal bleeding, intracranial bleeding, or other serious … priori subgroups defined by age, sex, 10-year cardiovascular risk, diagnosis of diabetes mellitus, or bleeding … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … , defined as bleeding requiring transfusion or hospitalization or leading to death (including but not … limited to gastrointestinal bleeding), hemorrhagic stroke, or other serious harms
KQ 1: Intermediate
-
www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/aspirin-use-to-prevent-cardiovascular-disease-preventive-medication
January 30, 2020 - Does regular aspirin use increase major gastrointestinal bleeding, intracranial bleeding, or other serious … priori subgroups defined by age, sex, 10-year cardiovascular risk, diagnosis of diabetes mellitus, or bleeding … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … , defined as bleeding requiring transfusion or hospitalization or leading to death (including but not … limited to gastrointestinal bleeding), hemorrhagic stroke, or other serious harms
KQ 1: Intermediate
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication
March 15, 2007 - One systematic review pooled gastrointestinal bleeding incidence among large cardiovascular studies and … is also increased (OR, 1.9 [CI, 1.1 to 3.1]), although death from gastrointestinal bleeding itself is … prevent an ischemic stroke event, and would cause 1 hemorrhagic stroke and 1 major gastrointestinal hemorrhage … all-cause mortality and cardiovascular mortality, despite the increased incidence of major gastrointestinal hemorrhage … Risk of bleeding complications with antiplatelet agents: meta-analysis of 338, 191 patients enrolled
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication-2007
March 15, 2007 - One systematic review pooled gastrointestinal bleeding incidence among large cardiovascular studies and … is also increased (OR, 1.9 [CI, 1.1 to 3.1]), although death from gastrointestinal bleeding itself is … prevent an ischemic stroke event, and would cause 1 hemorrhagic stroke and 1 major gastrointestinal hemorrhage … all-cause mortality and cardiovascular mortality, despite the increased incidence of major gastrointestinal hemorrhage … Risk of bleeding complications with antiplatelet agents: meta-analysis of 338, 191 patients enrolled
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/pnyU5fxhdBUtCdvJ3GyqzR
March 01, 2007 - One systematic review pooled gas-
trointestinal bleeding incidence among large cardiovascular
studies … Ulcer
bleeding or perforation occurred in 0.34% and 0.86% of
patients taking low-dose (325 mg every 2 … 3.1]), although death from
gastrointestinal bleeding itself is rare (53). … prevent an ischemic stroke event,
and would cause 1 hemorrhagic stroke and 1 major gastro-
intestinal hemorrhage … mortality and cardiovascular mor-
tality, despite the increased incidence of major gastrointes-
tinal hemorrhage
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/low-dose-aspirin-use-for-the-prevention-of-morbidity-and-mortality-from-preeclampsia-preventive-medication
September 28, 2021 - There were no significant associations of aspirin use with risk of postpartum hemorrhage (pooled RR, … intracranial bleeding. … No greater risk of placental abruption, postpartum hemorrhage, or fetal intracranial bleeding was identified … There were no statistically significant differences in the risk of abruption or postpartum hemorrhage … harms were uncommon and showed null effects for differences in risk of postpartum hemorrhage (pooled
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/low-dose-aspirin-use-for-the-prevention-of-morbidity-and-mortality-from-preeclampsia-preventive-medication-september-2014
September 09, 2014 - , or fetal intracranial bleeding. … risk for preeclampsia has not been shown to increase the occurrence of placental abruption; postpartum hemorrhage … ; or fetal harms, such as intracranial bleeding and congenital anomalies. … The pooled relative risk for intracranial hemorrhage in neonates (6 studies; n = 22,158) was 0.84 ( … , fetal intracranial bleeding, or perinatal mortality.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/iron-deficiency-anemia-in-pregnant-women-screening-and-supplementation
August 20, 2024 - statistically significant differences in maternal quality of life, rates of gestational diabetes, maternal hemorrhage … (2 trials; 23 , 48 n = 341), although rates of hemorrhage were low (eTable 1 in the JAMA Supplement … Prenatal anemia and postpartum hemorrhage risk: a systematic review and meta-analysis. … 2 RCTs (n = 341)
Two studies report no statistically significant difference in rates of maternal hemorrhage … No reporting bias detected
Low event rates in both studies
Fair
Insufficient for maternal hemorrhage