-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/_SfjkGNHBnLqn8ySe7kAdg
April 01, 2016 - CVD) and colorec-
tal cancer (CRC) but also increases the risk for gastrointestinal
(GI) and cerebral hemorrhages … 10-year CVD risk of 20% or less, and no history of CVD and
without elevated risk for GI or cerebral hemorrhages … Implication
Middle-aged men and women without elevated risk for
gastrointestinal or cerebral hemorrhage … Quality-adjusted life ex-
pectancy (QALE) and loss of QALE for patients with ischemic stroke
and intracerebral hemorrhage … GI bleeding case fatalities
represent the probability of dying from GI bleeding by age.
-
www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-use-prevent-cardiovascular-disease-colorectal-cancer-preventive-medication-2002
January 01, 2002 - prevention of myocardial infarction, and potential harms, such as gastrointestinal and intracranial bleeding … patients with heart disease or stroke, demonstrate that aspirin increases rates of gastrointestinal bleeding … Estimated rates of major gastrointestinal bleeding episodes are approximately 2 to 4 per 1,000 middle-aged … Gastrointestinal bleeding during low-dose aspirin administration for prevention of arterial occlusive … No effect CHD events ** : 1-4 avoided Hemorrhagic strokes *** : 0-2 caused Major gastrointestinal bleeding
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/Q4J7tsThw_6nwfB-p-f5Hp
March 01, 2009 - reduction in myocardial
infarctions outweighs the potential harm of an increase in gastro-
intestinal hemorrhage … of a reduction in ischemic strokes outweighs the
potential harm of an increase in gastrointestinal hemorrhage … of a
reduction in ischemic strokes outweighs the potential harm
of an increase in gastrointestinal hemorrhage … includes serious hemorrhage,
perforation, or other complications leading to hospitalization or death … includes serious
hemorrhage, perforation, or other complications leading to hospitalization
or death
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan-aspirin-to-prevent-cardiovascular-diseas/aspirin-to-prevent-cardiovascular-disease-and-cancer
October 07, 2013 - Does regular aspirin use increase gastrointestinal bleeding, hemorrhagic stroke, or other serious harms … ., diabetes mellitus, decreased ankle–brachial index, or elevated blood pressure), gastrointestinal bleeding … or hemorrhagic stroke risk factors (including history of gastrointestinal bleeding, ulcers, or nonsteroidal … stroke, death from MI or stroke, all-cause mortality, or quality of life
KQ 2: Gastrointestinal bleeding
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan-aspirin-to-prevent-cardiovascular-diseas/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
October 07, 2013 - Does regular aspirin use increase gastrointestinal bleeding, hemorrhagic stroke, or other serious harms … ., diabetes mellitus, decreased ankle–brachial index, or elevated blood pressure), gastrointestinal bleeding … or hemorrhagic stroke risk factors (including history of gastrointestinal bleeding, ulcers, or nonsteroidal … stroke, death from MI or stroke, all-cause mortality, or quality of life
KQ 2: Gastrointestinal bleeding
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/low-dose-aspirin-use-for-the-prevention-of-morbidity-and-mortality-from-preeclampsia-preventive-medication
September 26, 2019 - low platelet count (HELLP) syndrome
Eclampsia, puerperal cerebrovascular disorder, cerebrovascular hemorrhage … of well-being or quality of life
Potential treatment harms:
Abruptio placentae
Postpartum hemorrhage … Gastrointestinal complications (e.g., bleeding ulcer)
Fetal/neonatal/child outcomes:
Preterm … gestational age)
Stillbirth or neonatal mortality
Potential treatment harms:
Intracranial fetal bleeding
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-modeling-study/aspirin-to-prevent-cardiovascular-disease-preventive-medication
April 26, 2022 - Harms included increased nonfatal major gastrointestinal bleeding and intracranial hemorrhage. … an intracranial hemorrhage event. … and intracranial hemorrhage. … and intracranial hemorrhage. … and intracranial hemorrhage.
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/LPaUxRbrTshfsYVVTzenEQ
April 26, 2022 - Bleeding Risk
The risk for gastrointestinal bleeding, intracranial hemorrhage, and
hemorrhagic stroke … • Both CVD risk and risk for gastrointestinal bleeding, intracranial hemorrhage, and hemorrhagic stroke … ported a variety of outcomes, including total major bleeds (defined
as a composite of intracranial hemorrhage … , and subdural hemorrhage).14,25
When looking at studies reporting on the harms of low-dose as-
pirin … and
intracranial hemorrhage, and has no effect on the risk of CVD mor-
tality.
-
www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/iron-deficiency-anemia-during-pregnancy-screening-supplementation
April 07, 2022 - Maternal health outcomes: Mortality; health-related quality of life; preeclampsia (severe); postpartum hemorrhage … Maternal health outcomes: Mortality; health-related quality of life; preeclampsia (severe); postpartum hemorrhage
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/aRJ-3-AWuVvmC_kmoGCVHp
July 22, 2024 - include
mortality; health-
related quality of
life; hypertensive
disorders of
pregnancy;
postpartum
hemorrhage … include
mortality; health-
related quality of
life; hypertensive
disorders of
pregnancy;
postpartum
hemorrhage … mortality; health-
related quality of
life; hypertensive
disorders of
pregnancy);
postpartum
hemorrhage
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/aspirin-to-prevent-cardiovascular-disease-preventive-medication
April 26, 2022 - or leading to death), extracranial hemorrhage (inclusive of all bleeding except intracranial bleeding … ), major gastrointestinal bleeding, intracranial hemorrhage (inclusive of hemorrhagic stroke, subarachnoid … hemorrhage, and subdural hemorrhage), and hemorrhagic stroke. … and extracranial hemorrhage. … to primary CVD prevention populations, including individuals with comorbidities
Extracranial hemorrhage
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/iron-deficiency-anemia-during-pregnancy-screening-supplementation
July 07, 2022 - Maternal health outcomes: Mortality; health-related quality of life; preeclampsia (severe); postpartum hemorrhage … Maternal health outcomes: Mortality; health-related quality of life; preeclampsia (severe); postpartum hemorrhage
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/iron-deficiency-anemia-in-pregnant-women-screening-and-supplementation
July 07, 2022 - Maternal health outcomes: Mortality; health-related quality of life; preeclampsia (severe); postpartum hemorrhage … Maternal health outcomes: Mortality; health-related quality of life; preeclampsia (severe); postpartum hemorrhage
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/atrial-fibrillation-screening
January 25, 2022 - In SCREEN-AF, authors reported 0 intracranial hemorrhages. 43 The 2 RCTs evaluating continuous patch … b AFASAK did not specify severity of most bleeding events; it reported 1 fatal intracerebral hemorrhage … BAATAF defines major bleeding as intracranial bleeding, fatal bleeding, or bleeding that led to transfusion … led to ICU admission. c SPAFI included 1 fatal intracerebral hemorrhage and 1 subdural hematoma with … outcomes)
Bleeding outcomes (2 RCTs): 0 intracranial hemorrhages or major bleeding events after
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/4fdC2JLwP_um_yZe4WZRaa
April 01, 2009 - Harms from aspirin include the risks of serious upper GI bleeding and hemorrhagic
stroke. … An individual’s risk for GI bleeding from aspirin increases with age:
How often should you
assess net … Taking a higher dose is no
more effective and is associated with a
higher risk of bleeding. … Concomitant NSAID or anticoagulant
therapy increases the risk of GI bleeding. … Prior GI ulcer, GI bleeding, or GI pain also increases
risk by a factor of 2–3.
-
www.uspreventiveservicestaskforce.org/uspstf/wanda-k-nicholson-md-mph-mba
March 01, 2022 - She is chair of the Committee on Childbirth and Postpartum Hemorrhage for the International Federation
-
www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/peripheral-artery-disease-in-adults-screening-with-the-ankle-brachial-index
July 10, 2018 - (0.5% vs 0.5%; relative risk [RR], 1.13 [95% CI, 0.44-2.91]). 30 Major hemorrhage (defined as nonfatal … or fatal hemorrhagic CVA, fatal or nonfatal subarachnoid or subdural hemorrhage, gastrointestinal bleeding … (defined as nonfatal or fatal hemorrhagic CVA, fatal or nonfatal subarachnoid/subdural hemorrhage, GI … bleeding requiring admission, and other bleeding requiring hospital admission)
1 (n = 3350)
Major … hemorrhage did not reach statistical significance but was slightly higher in the aspirin group: 2.0%
-
www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
April 11, 2016 - risk (for example, history of GI ulcers, recent bleeding, or use of medications that increase bleeding … The risk for GI bleeding may increase with the dosage. … for GI or intracranial bleeding. … Meanwhile, bleeding harms may occur in the short term. … risk or enhance the bleeding effect of aspirin.
-
www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication-2007
March 15, 2007 - Aspirin increases the incidence of gastrointestinal bleeding and hemorrhagic stroke; NSAIDs increase … the incidence of gastrointestinal bleeding and renal impairment, especially in the elderly. … aspirin and NSAID use: There is good evidence that aspirin increases the incidence of gastrointestinal bleeding … There is good evidence that NSAIDs increase the incidence of gastrointestinal bleeding and renal impairment … which are good-quality studies, found an OR of 5.36 (CI, 1.79 to 16.1) for perforations, ulcers, and bleeding
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/MLeu_yFpPwzcZwKG6fw5ZY
April 26, 2022 - Harms included increased nonfatal major
gastrointestinal bleeding and intracranial hemorrhage. … an intracra-
nial hemorrhage event. … and
intracranial hemorrhage. … and intracranial hemorrhage. … and intracranial hemorrhage.