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www.uspreventiveservicestaskforce.org/home/getfilebytoken/aRJ-3-AWuVvmC_kmoGCVHp
include
mortality; health-
related quality of
life; hypertensive
disorders of
pregnancy;
postpartum
hemorrhage … include
mortality; health-
related quality of
life; hypertensive
disorders of
pregnancy;
postpartum
hemorrhage … mortality; health-
related quality of
life; hypertensive
disorders of
pregnancy);
postpartum
hemorrhage
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/aspirin-to-prevent-cardiovascular-disease-preventive-medication
April 26, 2022 - or leading to death), extracranial hemorrhage (inclusive of all bleeding except intracranial bleeding … ), major gastrointestinal bleeding, intracranial hemorrhage (inclusive of hemorrhagic stroke, subarachnoid … hemorrhage, and subdural hemorrhage), and hemorrhagic stroke. … and extracranial hemorrhage. … to primary CVD prevention populations, including individuals with comorbidities
Extracranial hemorrhage
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/iron-deficiency-anemia-in-pregnant-women-screening-and-supplementation
July 07, 2022 - Maternal health outcomes: Mortality; health-related quality of life; preeclampsia (severe); postpartum hemorrhage … Maternal health outcomes: Mortality; health-related quality of life; preeclampsia (severe); postpartum hemorrhage
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/4fdC2JLwP_um_yZe4WZRaa
April 01, 2009 - Harms from aspirin include the risks of serious upper GI bleeding and hemorrhagic
stroke. … An individual’s risk for GI bleeding from aspirin increases with age:
How often should you
assess net … Taking a higher dose is no
more effective and is associated with a
higher risk of bleeding. … Concomitant NSAID or anticoagulant
therapy increases the risk of GI bleeding. … Prior GI ulcer, GI bleeding, or GI pain also increases
risk by a factor of 2–3.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication-2007
March 15, 2007 - Aspirin increases the incidence of gastrointestinal bleeding and hemorrhagic stroke; NSAIDs increase … the incidence of gastrointestinal bleeding and renal impairment, especially in the elderly. … aspirin and NSAID use: There is good evidence that aspirin increases the incidence of gastrointestinal bleeding … There is good evidence that NSAIDs increase the incidence of gastrointestinal bleeding and renal impairment … which are good-quality studies, found an OR of 5.36 (CI, 1.79 to 16.1) for perforations, ulcers, and bleeding
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
April 11, 2016 - risk (for example, history of GI ulcers, recent bleeding, or use of medications that increase bleeding … The risk for GI bleeding may increase with the dosage. … for GI or intracranial bleeding. … Meanwhile, bleeding harms may occur in the short term. … risk or enhance the bleeding effect of aspirin.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/MLeu_yFpPwzcZwKG6fw5ZY
April 26, 2022 - Harms included increased nonfatal major
gastrointestinal bleeding and intracranial hemorrhage. … an intracra-
nial hemorrhage event. … and
intracranial hemorrhage. … and intracranial hemorrhage. … and intracranial hemorrhage.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/by8VJVre6h6BmadrGxaFMM
April 01, 2016 - risk (for
example, history of GI ulcers, recent bleeding, or use of
medications that increase bleeding … GI and Intracranial Bleeding
Evidence shows that risk for GI bleeding, with and
without aspirin use, … risk
for GI or intracranial bleeding … These trials reported ma-
jor GI bleeding events, defined as GI bleeding requir-
Aspirin Use for the … Increased harms may result from factors that either
increase bleeding risk or enhance the bleeding effect
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/c-7ARQE9RuXKjjpeLABkaH
March 01, 2007 - aspirin and NSAID use:
There is good evidence that aspirin increases the inci-
dence of gastrointestinal bleeding … There is good evidence that NSAIDs increase the in-
cidence of gastrointestinal bleeding and renal impairment … The USPSTF found good-quality evidence that aspi-
rin increases the incidence of gastrointestinal bleeding … which are
good-quality studies, found an OR of 5.36 (CI, 1.79 to
16.1) for perforations, ulcers, and bleeding … use to prevent colorectal can-
cer because of potential side effects, especially gastrointes-
tinal bleeding
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-prophylaxis-pregnancy-1996
January 01, 1996 - complications associated with preeclampsia include abruptio placentae, acute renal failure, cerebral hemorrhage … was noted in the aspirin group it was not associated with the occurrence or severity of postpartum hemorrhage … , however, nor were there significant differences in abruptio placentae or other antepartum bleeding. … and neonatal intracranial hemorrhage. 12 , 27 Maternal effects were seen with doses of 1,500-2,500 … Bleeding problems have not generally been reported at low doses (60-150 mg/day), 28-30 although most
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan-aspirin-to-prevent-cancer/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
October 07, 2013 - benefits or harms are proposed: diabetes, liver disease, ulcer disease, and previous gastrointestinal bleeding … What valid risk prediction tools to determine bleeding risk (e.g., gastrointestinal bleeding, hemorrhagic … stroke, other major bleeding) are available for persons who are not contraindicated for regular aspirin … incidence
Advanced adenoma incidence
Advanced neoplasia
KQs 6, 7 (harms):
Gastrointestinal bleeding … Precancerous markers
Progression or metastasis
Recurrence
KQs 6, 7 (harms):
Postoperative or minor bleeding
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/low-dose-aspirin-use-for-the-prevention-of-morbidity-and-mortality-from-preeclampsia-preventive-medication
September 28, 2021 - There were no significant associations of aspirin use with risk of postpartum hemorrhage (pooled RR, … intracranial bleeding. … No greater risk of placental abruption, postpartum hemorrhage, or fetal intracranial bleeding was identified … There were no statistically significant differences in the risk of abruption or postpartum hemorrhage … harms were uncommon and showed null effects for differences in risk of postpartum hemorrhage (pooled
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/aspirin-to-prevent-cardiovascular-disease-preventive-medication
May 14, 2020 - Does regular aspirin use increase major gastrointestinal bleeding, intracranial bleeding, or other serious … defined by age, sex, 10-year cardiovascular risk, diagnosis of diabetes mellitus, race/ethnicity, or bleeding … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … , defined as bleeding requiring transfusion or hospitalization or leading to death (including but not … limited to gastrointestinal bleeding), hemorrhagic stroke, or other serious harms
KQ 1: Intermediate
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/iron-deficiency-anemia-in-pregnant-women-screening-and-supplementation
August 20, 2024 - statistically significant differences in maternal quality of life, rates of gestational diabetes, maternal hemorrhage … (2 trials; 23 , 48 n = 341), although rates of hemorrhage were low (eTable 1 in the JAMA Supplement … Prenatal anemia and postpartum hemorrhage risk: a systematic review and meta-analysis. … 2 RCTs (n = 341)
Two studies report no statistically significant difference in rates of maternal hemorrhage … No reporting bias detected
Low event rates in both studies
Fair
Insufficient for maternal hemorrhage
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication-2007
March 15, 2007 - One systematic review pooled gastrointestinal bleeding incidence among large cardiovascular studies and … is also increased (OR, 1.9 [CI, 1.1 to 3.1]), although death from gastrointestinal bleeding itself is … prevent an ischemic stroke event, and would cause 1 hemorrhagic stroke and 1 major gastrointestinal hemorrhage … all-cause mortality and cardiovascular mortality, despite the increased incidence of major gastrointestinal hemorrhage … Risk of bleeding complications with antiplatelet agents: meta-analysis of 338, 191 patients enrolled
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/pnyU5fxhdBUtCdvJ3GyqzR
March 01, 2007 - One systematic review pooled gas-
trointestinal bleeding incidence among large cardiovascular
studies … Ulcer
bleeding or perforation occurred in 0.34% and 0.86% of
patients taking low-dose (325 mg every 2 … 3.1]), although death from
gastrointestinal bleeding itself is rare (53). … prevent an ischemic stroke event,
and would cause 1 hemorrhagic stroke and 1 major gastro-
intestinal hemorrhage … mortality and cardiovascular mor-
tality, despite the increased incidence of major gastrointes-
tinal hemorrhage
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/low-dose-aspirin-use-for-the-prevention-of-morbidity-and-mortality-from-preeclampsia-preventive-medication-september-2014
September 09, 2014 - , or fetal intracranial bleeding. … risk for preeclampsia has not been shown to increase the occurrence of placental abruption; postpartum hemorrhage … ; or fetal harms, such as intracranial bleeding and congenital anomalies. … The pooled relative risk for intracranial hemorrhage in neonates (6 studies; n = 22,158) was 0.84 ( … , fetal intracranial bleeding, or perinatal mortality.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/2GDCmTe7akyrAHsTMbfz72
May 06, 2022 - 1
Does regular aspirin use increase major gastrointestinal bleeding, intracranial bleeding, or other … or
leading to death), extracranial hemorrhage (inclusive of all bleed-
ing except intracranial bleeding … ), major gastrointestinal bleeding,
intracranial hemorrhage (inclusive of hemorrhagic stroke, sub-
arachnoid … hemorrhage, and subdural hemorrhage), and hemor-
rhagic stroke. … and extracranial hemorrhage.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/4zmYnqJXLv8g4LzLrrDDrm
December 01, 2014 - , or fetal
intracranial bleeding. … for
preeclampsia has not been shown to increase the occur-
rence of placental abruption; postpartum hemorrhage … ; or
fetal harms, such as intracranial bleeding and congenital
anomalies. … The pooled relative risk for intracranial hemorrhage in
neonates (6 studies; n � 22 158) was 0.84 (CI … , fetal intracranial bleeding, or
perinatal mortality.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/iron-deficiency-anemia-in-pregnant-women-screening-and-supplementation
August 20, 2024 - California Maternal Quality Care Collaborative toolkit on improving the health care response to obstetric hemorrhage … ( https://www.cmqcc.org/resources-tool-kits/toolkits/ob-hemorrhage-toolkit ). … interpretation of this evidence. 1 , 17 In 4 trials reporting maternal gestational diabetes and maternal hemorrhage … and 2 trials 21 , 29 (n = 341) found no statistically significant differences in rates of maternal hemorrhage … potential outcomes included, but were not limited to, maternal health-related quality of life, postpartum hemorrhage