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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/aspirin-use-prevent-cardiovascular-disease-colorectal-cancer-preventive-medication-2002
January 15, 2002 - The rate of intracranial hemorrhage with aspirin use was 0.2 percent per year in patients aged 75 years … Aspirin use increased the odds of gastrointestinal hemorrhage (summary OR, 1.68; 95 percent CI, 1.51 … used meta-regression to examine the effect of aspirin dosage on the incidence of gastrointestinal hemorrhage … or cerebral hemorrhage). … included fatal and life-threatening hemorrhages that required transfusion, surgery, or both.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/xUc_vXf7323faUQY7SePhT
January 01, 2002 - Estimates of aspirin’s role in hemorrhagic stroke and intracranial hemorrhage
Note: BMD indicates British … The rate of intracranial hemorrhage with aspirin
use was 0.2% per year in patients aged 75 years
or younger … Aspirin use
increased the odds of gastrointestinal hemorrhage
(summary OR, 1.68; 95% CI, 1.51 to 1.88 … hemorrhages that required transfusion, surgery, or both. … or cerebral hemorrhage).
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-bleeding-risks-with-aspirin-use/aspirin-to-prevent-cardiovascular-disease-and-cancer
April 11, 2016 - Intracranial bleeding included hemorrhagic stroke and intracerebral, subdural, and subarachnoid hemorrhage … The broader definition made little difference, so we focused on hemorrhagic stroke (or intracerebral hemorrhage … in both short- and long-term aspirin users, particularly women, and subarachnoid hemorrhages in men … ; HS = hemorrhagic stroke; ICH = intracranial hemorrhage … Data from reference. 15
† Data from reference. 15
‡ Includes GI bleeding, intracranial hemorrhage
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-bleeding-risks-with-aspirin-use/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
April 11, 2016 - Intracranial bleeding included hemorrhagic stroke and intracerebral, subdural, and subarachnoid hemorrhage … The broader definition made little difference, so we focused on hemorrhagic stroke (or intracerebral hemorrhage … in both short- and long-term aspirin users, particularly women, and subarachnoid hemorrhages in men … ; HS = hemorrhagic stroke; ICH = intracranial hemorrhage … Data from reference. 15
† Data from reference. 15
‡ Includes GI bleeding, intracranial hemorrhage
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/cLuJZx55Z6ApzYv836rkSp
February 23, 2009 - Encourage aspirin use
when potential CVD benefit
(MIs prevented)
outweighs potential harm
of GI hemorrhage … of MIs prevented (men) and strokes prevented (women) outweighs the potential harm
of increased GI hemorrhage … NSAID use and history of GI ulcers raise the risk of serious GI bleeding considerably and should be considered … NSAID use combined with aspirin use approximately quadruples the risk of serious GI bleeding compared … The rate of serious bleeding in aspirin users is approximately 2 – 3 times higher in patients with a
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/j69Hq5ALvzg74e-ngkzSep
April 01, 2016 - of Internal Medicine 1
http://www.annals.org
stroke and intracerebral, subdural, and subarachnoid
hemorrhage … broader definition made little differ-
ence, so we focused on hemorrhagic stroke (or intrace-
rebral hemorrhage … in both short- and long-
term aspirin users, particularly women, and subarach-
noid hemorrhages in men … ; HS = hemorrhagic stroke; ICH = intracranial hemorrhage.
* Very-low-dose aspirin use was defined as … Data from reference 15.
† Data from reference 15.
‡ Includes GI bleeding, intracranial hemorrhage, and
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/rhd-incompatibility-screening-1996
January 01, 1996 - , the risk of isoimmunization increases whenever such hemorrhage is likely to occur, including after … For women with transplacental hemorrhages >30 mL of fetal blood, the risk of D isoimmunization developing … Clinical high-risk designation does not predict excess fetal-maternal hemorrhage. … The incidence of significant fetomaternal hemorrhage in patients undergoing cesarean section. … Detecting fetomaternal hemorrhage: a comparison of five methods.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-for-the-prevention-of-cardiovascular-disease-preventive-medication
March 15, 2009 - reduction in myocardial infarctions outweighs the potential harm due to an increase in gastrointestinal hemorrhage … of a reduction in ischemic strokes outweighs the potential harm of an increase in gastrointestinal hemorrhage … Encourage aspirin use when potential CVD benefit (strokes prevented) outweighs potential harm of GI hemorrhage … includes serious hemorrhage, perforation, or other complications leading to hospitalization or death … includes serious hemorrhage, perforation, or other complications leading to hospitalization or death
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-for-the-prevention-of-cardiovascular-disease-preventive-medication-2009
March 15, 2009 - reduction in myocardial infarctions outweighs the potential harm due to an increase in gastrointestinal hemorrhage … of a reduction in ischemic strokes outweighs the potential harm of an increase in gastrointestinal hemorrhage … Encourage aspirin use when potential CVD benefit (strokes prevented) outweighs potential harm of GI hemorrhage … includes serious hemorrhage, perforation, or other complications leading to hospitalization or death … includes serious hemorrhage, perforation, or other complications leading to hospitalization or death
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/bC4oNwsek4uY3SJZf4S7zm
April 01, 2022 - years or older without signs or symptoms of CVD or known CVD and
who are not at increased risk for bleeding … (eg, no history of gastrointestinal ulcers, recent bleeding, or other
medical conditions, or taking … medications that increase bleeding risk). … , intra-
cranial bleeding, and hemorrhagic stroke … • Both CVD risk and risk for gastrointestinal bleeding, intracranial hemorrhage, and hemorrhagic
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/rts4chTw2sVprMEF5xpMYS
April 01, 2022 - years or older without signs or symptoms of CVD or known CVD and
who are not at increased risk for bleeding … (eg, no history of gastrointestinal ulcers, recent bleeding, or other
medical conditions, or taking … medications that increase bleeding risk). … , intra-
cranial bleeding, and hemorrhagic stroke … • Both CVD risk and risk for gastrointestinal bleeding, intracranial hemorrhage, and hemorrhagic
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary10/aspirin-for-the-prevention-of-cardiovascular-disease-preventive-medication
March 15, 2009 - bleeding events, in both men and women. … prevention of CVD events (KQ2), we used the terms aspirin , cardiovascular diseases , gastrointestinal hemorrhage … , and cerebral-hemorrhage . … , serious bleeding episodes, hemorrhagic stroke, or cerebral hemorrhage for harms. … episodes in the aspirin group and 1 in the control group; no intracranial hemorrhages occurred during
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary10/aspirin-for-the-prevention-of-cardiovascular-disease-preventive-medication-2009
March 15, 2009 - bleeding events, in both men and women. … prevention of CVD events (KQ2), we used the terms aspirin , cardiovascular diseases , gastrointestinal hemorrhage … , and cerebral-hemorrhage . … , serious bleeding episodes, hemorrhagic stroke, or cerebral hemorrhage for harms. … episodes in the aspirin group and 1 in the control group; no intracranial hemorrhages occurred during
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www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/current-members/wanda-k-nicholson-md-mph-mba
March 01, 2024 - She also chaired the Committee on Childbirth and Postpartum Hemorrhage for the International Federation … Gynecology and Obstetrics (FIGO) where she spearheaded efforts to develop protocols to prevent postpartum hemorrhage
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/t6yV6ZMHngeWgmTsoMMefM
March 01, 2009 - bleeding events, in both men and women. … prevention
of CVD events (KQ2), we used the terms aspirin, cardio-
vascular diseases, gastrointestinal hemorrhage … , and cerebral-
hemorrhage. … , serious bleeding episodes,
hemorrhagic stroke, or cerebral hemorrhage for harms. … episodes in the aspirin group and 1 in the
control group; no intracranial hemorrhages occurred dur-
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/aspirin-use-to-prevent-preeclampsia-and-related-morbidity-and-mortality-preventive-medication1
June 20, 2019 - low platelet count (HELLP) syndrome
Eclampsia, puerperal cerebrovascular disorder, cerebrovascular hemorrhage … of well-being or quality of life
Potential treatment harms:
Abruptio placentae
Postpartum hemorrhage … Gastrointestinal complications (e.g., bleeding ulcer)
Fetal/neonatal/child outcomes:
Preterm … gestational age)
Stillbirth or neonatal mortality
Potential treatment harms:
Intracranial fetal bleeding
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www.uspreventiveservicestaskforce.org/uspstf/document/decision-analysis-for-aspirin/aspirin-to-prevent-cardiovascular-disease-and-cancer
April 11, 2016 - CVD) and colorectal cancer (CRC) but also increases the risk for gastrointestinal (GI) and cerebral hemorrhages … 10-year CVD risk of 20% or less, and no history of CVD and without elevated risk for GI or cerebral hemorrhages … to inform community-based bleeding risks. 47 We did not account for heterogeneity in GI bleeding risks … Quality-adjusted life expectancy (QALE) and loss of QALE for patients with ischemic stroke and intracerebral hemorrhage … GI bleeding case fatalities represent the probability of dying from GI bleeding by age.
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www.uspreventiveservicestaskforce.org/uspstf/document/decision-analysis-for-aspirin/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
April 11, 2016 - CVD) and colorectal cancer (CRC) but also increases the risk for gastrointestinal (GI) and cerebral hemorrhages … 10-year CVD risk of 20% or less, and no history of CVD and without elevated risk for GI or cerebral hemorrhages … to inform community-based bleeding risks. 47 We did not account for heterogeneity in GI bleeding risks … Quality-adjusted life expectancy (QALE) and loss of QALE for patients with ischemic stroke and intracerebral hemorrhage … GI bleeding case fatalities represent the probability of dying from GI bleeding by age.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-to-prevent-cardiovascular-disease-preventive-medication
April 26, 2022 - Both CVD risk and risk for gastrointestinal bleeding, intracranial hemorrhage, and hemorrhagic stroke … Bleeding Risk
The risk for gastrointestinal bleeding, intracranial hemorrhage, and hemorrhagic stroke … reported a variety of outcomes, including total major bleeds (defined as a composite of intracranial hemorrhage … , and subdural hemorrhage). 14 , 25
When looking at studies reporting on the harms of low-dose aspirin … and intracranial hemorrhage, and has no effect on the risk of CVD mortality.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-prophylaxis-myocardial-infarction-preventive-medication-1996
January 01, 1996 - significantly higher in the aspirin group, only one case (which was unconfirmed) of fatal gastrointestinal hemorrhage … history of early-onset coronary artery disease) and who lack a history of gastrointestinal or other bleeding … problems and other risk factors for bleeding or cerebral hemorrhage. 31 This policy is currently under … of the findings suggests that further study of the relationship between aspirin therapy and cerebral hemorrhage … problems, or other risk factors for bleeding or cerebral hemorrhage), the benefits may outweigh the