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  1. JAMA (pdf file)

    www.uspreventiveservicestaskforce.org/home/getfilebytoken/eko8Cp28pZ3SHHfyvTXJW5
    May 13, 2025 - Eligible screening harms in- cluded false-positive or false-negative results and psychoso- cial harms … fetal harms, and other maternal harms. … ) addressed the harms of treatment (KQ3). … 1 What are the harms of screening for syphilis in pregnant adolescents and adults? … for bounding of potential harms.
  2. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/syphilis-infection-in-pregnancy-screening
    May 13, 2025 - The purpose of this review was to conduct a limited update of the evidence for the benefits and harms … of screening and harms of treatment of syphilis during pregnancy for the US Preventive Services Task … Eligible screening harms included false-positive or false-negative results and psychosocial harms. … ) addressed the harms of treatment (KQ3). … bounding of potential harms.
  3. www.uspreventiveservicestaskforce.org/home/getfilebytoken/RkeQEwKRWULreuWecXG8S-
    July 01, 2013 - Benefits and Harms of Computed Tomography Lung Cancer Screening Programs for High Risk Populations … Benefits and Harms of Computed Tomography Lung Cancer Screening Programs for High-Risk Populations … Benefits and Harms of Computed Tomography Lung Cancer Screening Programs for High-Risk Populations. … Table 2 shows the benefits of these scenarios and Table 3 shows the harms. … Benefits and Harms of Lung Cancer Screening 7 CISNET Lung Cancer Working Group 3.
  4. www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/syphilis-infection-pregnant-persons
    December 01, 2022 - What are the harms of screening for syphilis in pregnant persons? … What are the harms of treatment of syphilis with penicillin during pregnancy to pregnant persons or newborns … Comparisons KQ 1: No screening KQ 2: No comparator necessary for studies on psychosocial harms … of screening (e.g., false-positive and false-negative results, stigma, psychosocial harms) KQ 3: … , Jarish-Herxheimer reaction, fetal harms, other maternal harms) Cost-effectiveness or cost-related
  5. www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/lipid-disorders-in-children-screening
    August 19, 2021 - What are the harms of screening for FH or multifactorial dyslipidemia in children and adolescents? … What are the harms of treatment of FH or multifactorial dyslipidemia in children and adolescents? … 20 years or younger at time of screening or treatment initiation KQs 4, 5 (Treatment benefits and harms … ): Psychosocial effects Overdiagnosis False positives/negatives    KQ 5 (Treatment harms) … : All harms from: Lipid-lowering medications (e.g., adverse events, long-term safety, overtreatment
  6. www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/individualizing-cancer-screening-older-adults
    March 01, 2021 - of treatment, and harms related to prioritization of medical care. … Harms of screening tests.   … Harms of disease treatment . … Given treatment harms, are the additional months of survival worthwhile to patients? … Harms (and benefits) of screening need to be expanded to include HRQL outcomes.
  7. www.uspreventiveservicestaskforce.org/Home/GetFileByToken/-BbKrbuLt9RAPvf3BQrUMW
    of screening and treatment, including psychological harms and harms from active surveillance. … Men who are more interested in avoiding the potential harms may choose not to be screened. … For these men, active treatment has no benefit and puts them at risk for significant harms. … The benefits and harms of screening What’s the latest evidence on the benefits of screening? … One of the most important harms is frequent false-positive results.
  8. www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/2025-06/USPSTF-cost-considerations-2025-update.pdf
    January 01, 2025 - Task Force recommendations are based on the benefits and harms, not the cost, of the service. … evidence related to cost-effectiveness, it excludes costs from its determination of the benefits and harms … Benefits and Harms Assessment in Determining Recommendation Grades Recommendation grades are based on … the quality and strength of the available evidence about the potential benefits and harms of the preventive … service, as well as the size of the potential benefits and harms.
  9. www.uspreventiveservicestaskforce.org/home/getfilebytoken/TEqfQsqZ92eykPeTQBZx-h
    outweigh the harms. … The harms of screening earlier than age 21 years outweigh the benefits. … The benefits of screening after age 65 years do not outweigh the potential harms. … The harms of screening after hysterectomy outweigh the benefits. … The potential harms of screening with HPV testing (alone or with cytology) outweigh the potential
  10. www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/osteoporosis-screening
    November 18, 2021 - What are the harms of screening for fracture risk or osteoporosis? 4. … What are the harms associated with selected FDA-approved medications? … Screening Comparators KQs 1, 3 (Screening benefits and harms): No screening. … KQ 3 (Screening harms): Overdiagnosis. … KQ 5 (Treatment harms): Total adverse events. Total serious adverse events.
  11. www.uspreventiveservicestaskforce.org/home/getfilebytoken/ZgcL6cF6JsFzwRRhaSnqc9
    December 01, 2022 - term benefits compared with best medical therapy alone in historic trials but can result in surgical harms … 2 What are the harms associated with revascularization of asymptomatic carotid artery stenosis? … 3 Harms of screening 2 Harms of intervention 4 Asymptomatic adults Mortality Stroke Quality of … The 2 trials, 2 national data sets, and 3 surgical regis- tries reported procedural harms associated … of screening No studies examined direct harms of screening Stroke after angiography: 0.4% and 1.2%
  12. www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/syphilis-infection-pregnant-persons
    March 02, 2023 - What are the harms of screening for syphilis in pregnant persons? … What are the harms of treatment of syphilis with penicillin during pregnancy to pregnant persons or newborns … of screening (e.g., false-positive and false-negative results, stigma, and psychosocial harms) KQ … 3: Harms of treatment of syphilis with penicillin during pregnancy (e.g., allergic reaction, premature … labor, Jarish-Herxheimer reaction, fetal harms, and other maternal harms) Cost-effectiveness or
  13. www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/syphilis-infection-in-pregnancy-screening
    March 02, 2023 - What are the harms of screening for syphilis in pregnant persons? … What are the harms of treatment of syphilis with penicillin during pregnancy to pregnant persons or newborns … of screening (e.g., false-positive and false-negative results, stigma, and psychosocial harms) KQ … 3: Harms of treatment of syphilis with penicillin during pregnancy (e.g., allergic reaction, premature … labor, Jarish-Herxheimer reaction, fetal harms, and other maternal harms) Cost-effectiveness or
  14. www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/obesity-in-children-and-adolescents-screening
    June 30, 2022 - Are there harms associated with weight management interventions for children and adolescents? … Are there harms associated with diagnosing children and adolescents as being overweight or having obesity … in the healthcare setting (e.g., harms associated with labeling)? … What are the harms of stigma and weight bias? What is the extent of weight bias in healthcare? … Are there long-term harms of weight loss attempts during childhood or adolescence?
  15. www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/uspstf-cost-considerations-fact-sheet-2021.pdf
    January 01, 2021 - Task Force recommendations are based on the benefits and harms, not the cost, of the service. … evidence related to cost-effectiveness, it excludes costs from its determination of the benefits and harms … Benefits and Harms Assessment in Determining Recommendation Grades Recommendation grades are based on … the quality and strength of the available evidence about the potential benefits and harms of the preventive … service, as well as the size of the potential benefits and harms.
  16. www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/uspstf-cost-considerations-fact-sheet-2021_0.pdf
    January 01, 2021 - Task Force recommendations are based on the benefits and harms, not the cost, of the service. … evidence related to cost-effectiveness, it excludes costs from its determination of the benefits and harms … Benefits and Harms Assessment in Determining Recommendation Grades Recommendation grades are based on … the quality and strength of the available evidence about the potential benefits and harms of the preventive … service, as well as the size of the potential benefits and harms.
  17. www.uspreventiveservicestaskforce.org/home/getfilebytoken/hWPZYvUZJXUQghbFtSDC42
    August 01, 2011 - Harms of Detection and Early Intervention Screening may yield false-positive results. … The USPSTF found inadequate evidence on the harms of screening for bladder cancer. … There is inadequate evidence on harms of screening for bladder cancer. … • Potential harms: False-positive results may lead to anxiety and unneeded evaluations, harms from … screen- ing tests, and the benefits and harms of treatment.
  18. www.uspreventiveservicestaskforce.org/home/getfilebytoken/_2-KL_eHkuBhbGrzcAHsB-
    June 01, 2022 - Evidence is lack- ing, and the balance of benefits and harms cannot be determined. … As a result, the balance of ben- efits and harms cannot be determined. … small, based on the likely minimal harms of using screening tools, limited evidence of harms, and the … Harms of early detection and intervention • Inadequate evidence to assess the potential harms of screening … Potential Harms Potential harms of screening for MDD in young children or for suicide risk in children
  19. www.uspreventiveservicestaskforce.org/uspstf/recommendation/bladder-cancer-in-adults-screening
    August 15, 2011 - There is inadequate evidence on harms of screening for bladder cancer. … harms from cystoscopy and biopsy, harms from labeling and unnecessary treatments, and overdiagnosis. … harms from cystoscopy and biopsy, harms from labeling or unnecessary treatments (such as transurethral … screening tests, and the benefits and harms of treatment. … Potential Harms of Screening and Treatment The USPSTF found inadequate evidence on the harms associated
  20. www.uspreventiveservicestaskforce.org/home/getfilebytoken/Nq6dYEj2eZxLhVhBrWCD-j
    July 01, 2024 - , the Task Force concluded that the evidence is insufficient to assess the balance of benefits and harms … The Task Force identified evidence gaps and the need for more research on: • the benefits and harms … • the effect of screening on the incidence of bladder cancer and subsequent treatments; and • the harms … bladder cancer in asymptomatic populations; outcomes of treatment for screen-detected bladder cancer; or harms

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