Results

Total Results: 1,494 records

Showing results for "harms".

441. CERs Report cover (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/future05-breastcancer-10-5-2010final.pdf
     September 01, 2010 - (2) What is the evidence for harms? … Patient - how do women weigh the benefits/harms of chemoprophylaxis? b. … Harms to testing/ screening Harms Side effects Adverse events BB CC Population Interventions Medication … Which factors predict who is most susceptible to harms of therapy vs. benefits? … Strategies could be tested that optimize benefits and minimize harms.

442. White Paper: Enhancing Systematic Review Methods by Incorporating Unpublished Drug Trials (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/unpublished-drug-trials-white-paper.pdf
     December 01, 2024 - This can lead to inflated efficacy estimates and underestimated harms or burdens, as unpublished studies … often document negative efficacy outcomes and/or harms. … investigational treatment does not demonstrate the expected benefit or improvement) or those showing harms … Review Project (DERP), we identified important discrepancies in the conclusions about the comparative harms … Bias in the reporting of harms in clinical trials of second-generation antidepressants for depression

443. Pharmacologic and Non-pharmacologic Therapies in Adult Patients with Acute Exacerbation of COPD: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-research-protocol.pdf
     April 11, 2018 - Uncertainties relate to the benefits and harms of emerging pharmacologic and non-pharmacologic treatments … , the benefits and harms of antibiotics and systemic corticosteroids in mild AECOPD, the benefits and … view of trying to reduce prescriptions of antibiotics, where safely possible, to reduce potential harms … In adult patients with mild acute exacerbation of COPD, what are the benefits and harms of systemic … In adult patients with acute exacerbation of COPD, what are the benefits and harms of combinations of

444. Acs-Pci-Adjunctive-Devices Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-pci-adjunctive-devices_research-protocol.pdf
     July 01, 2010 - 2 Objective To perform a comparative effectiveness review examining the benefits and harms … embolization in patients with ACS who are undergoing PCI of native vessels and the various benefits and harms … and harms of those devices, we developed an analytic framework to map specific linkages from comparisons … needed to assess for applicability (as specified in section F below), and prespecified benefits and harms … followup periods, improper definitions for outcomes, composite end points Outcomes (benefits and harms

445. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/pressure-ulcer-prevention_research-protocol.pdf
     January 10, 2012 - Question 4 What are the harms of interventions for the prevention of pressure ulcers? a. … Do the harms of preventive interventions differ according to the general category of impairment the … Do the harms of preventive interventions differ according to setting * ? c. … Do the harms of preventive interventions differ according to patient characteristics ‡ ? … /stage o Resource utilization (e.g., length of stay and number of hospitalizations)  KQ 4: o Harms

446. Gout-managment-protocol-141103 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_research-protocol.pdf
     November 03, 2014 - It is well established that specialists systematically rate the benefits and harms of treatment more … In patients with acute gout, what are the benefits and harms of different pharmacological therapies … Does effectiveness (benefits and harms) differ according to patient baseline demographic characteristics … Does effectiveness (benefits and harms) differ according to disease severity, including initial clinical … In adults with gout, what are the benefits and harms of different dietary therapies and life style measures

447. Acute Treatments for Episodic Migraine: Surveillance Report 3 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-3.pdf
     August 01, 2022 - harms, infections, cardiovascular events, cognitive harms, and psychological harms (e.g., depression … gastrointestinal-related harms, cardiovascular-related harms, kidney- related harms, falls, fractures … , motor vehicle accidents, endocrinological A-3 harms, infections, cognitive harms, and psychological … harms (e.g., depression)? … Misuse, opioid use disorder, overdose and other harms KQ2.

448. Rapid Evidence Product Addressing Social Isolation To Improve the Health of Older Adults A Rapid Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-social-isolation-older-adults-final.pdf
     February 01, 2019 - Five of 16 studies reported on harms and none were clinically significant. … The same study did not report whether they looked for or found harms of the interventions. … Of note, only one-quarter of the studies reported on harms. … Harms that were measured included death, hospitalization, and general adverse events. … Assessing harms when comparing medical interventions. 2008. 62.

449. Methods Guide for Comparative Effectiveness Reviews - Avoiding Bias in Selecting Studies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias_methods.pdf
     February 01, 2013 - and may overestimate benefits for oral anticoagulants and underestimate harms for short term effects … may exclude large body of consistent studies that may yield valuable information on benefits or harms … , SRs should focus on assessing a range of patient-centered outcomes, including both benefits and harms … The scope of included outcomes should address both effectiveness and harms on which strength of the … AHRQ series paper 4: assessing harms when comparing medical interventions: AHRQ and the effective

450. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/stem-cell-children_research-protocol.pdf
     November 01, 2010 - Despite this increase in survival, both immediate harms associated with HSCT (e.g., graft-versus-host … Second, comparative harms data are equally difficult to obtain, but further separating out the harms … Is there an explanation of how harms were identified? 2. … Were harms attributed to the study intervention likely causally associated? 6. … McMaster Quality Assessment Scale of Harms (McHarm) for primary studies. 2005.

451. Glaucoma-Treatment Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-treatment_surveillance.pdf
     January 01, 2013 - KQ 6: What are the harms associated with medical, laser, and other surgical treatments for open-angle … timolol in a RCT.5 Beta blocker prep comparisons One crossover study showed no difference in harms … • The profile of harms does not differ between one- and two-site combined cataract and glaucoma … New Evidence: KQ6b: Harms Associated With Laser and Other Surgical Treatments for Open-Angle … • The profile of harms does not differ between one- and two-site combined New Evidence:

452. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-health-children_research-protocol.pdf
     December 11, 2015 - An improved understanding of the comparative benefits, harms, and modifiers of the available strategies … Key Question 2: What are the harms of these D/I/QI mental health strategies? … For KQ 2 and KQ 3 studies on moderators of harms, we will include experimental studies noted above, … We identify studies that address KQ 3, moderators of strategy effectiveness or harms, as those that … compare effectiveness or harms of a particular strategy between two or more levels of the moderator

453. Colorectal-Cancer-Screening Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-screening_executive.pdf
     February 01, 2012 - Harms. What are the potential harms of fecal DNA testing? Figure A. … Analytic framework of the benefits and harms of fecal DNA testing in screening for colorectal cancer … of Screening Screening Harms of Management/ Surveillance Harms of Treatment 4 5 6 3 2 b a … We did not find any studies that specifically evaluated the harms of fecal DNA testing. … The major hypothesized harms of fecal DNA testing are the sequelae from diagnostic inaccuracy (false

454. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy_disposition-comments.pdf
     March 11, 2010 - Methods An important weakness in this report is not addressing false-positive harms. … This is not a minimal issue as it is associated with over- treatment harms. … I think that not including harms of overdiagnosis is a problem. … We have modified the paragraph to indicate that there are harms associated with false-positive exams … Results How are the authors defining some of these harms in the original papers?

455. Dementia-Agitation-Aggression Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-agitation-aggression_research-protocol.pdf
     November 13, 2014 - Studies specifically addressing treatment harms may also include retrospective cohort studies. … We will assess harms as dichotomous variables to acknowledge the inherent difficulties of assessing … harms, and also to simplify analysis. … There are various ways to assess harms; each has problems. … The non-pharmacologic interventions addressed in this review have a low incidence of harms.

456. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0277_03-10-2008.pdf
     January 01, 2008 - prevalence of adverse events associated with HSCT, a comprehensive review that focuses on both benefits and harms

457. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0215_01-06-2010.pdf
     January 01, 2010 - on this topic would help to inform clinical practice surrounding the treatment of RLS including any harms

458. Topic Brief: Accelerated Partial Breast Irradiation for Breast Cancer (pdf file)
     effectivehealthcare.ahrq.gov/system/files/docs/topic-brief-apbi-breast-cancer.pdf
     August 01, 2022 - and proton radiation therapy, intra-operative radiotherapy) on ipsilateral breast cancer outcomes, harms … Breast cancer recurrence, short- and long-term harms (e.g., Radiation Therapy Oncology Group scores … Comparators Pre-operative imaging assessment for PBI WBI Outcomes Cavity visualization score, harms … Cosmesis, treatment toxicities, other short- and long- term harms (e.g., Radiation Therapy Oncology … Incorporates issues around both clinical benefits and potential clinical harms Yes 2d.

459. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-postpartum-screening_research-protocol.pdf
     May 01, 2013 - incorrectly identified as being depressed, and potential adverse effects of labeling” as potential harms … but found no evidence for any of these harms.19 Whether any of these harms is more likely when screening … patients, providers, and policymakers must consider the tradeoffs between the likely benefits and harms … Question 5 What are the comparative harms of screening for postpartum depression when compared to … of different strategies based on the literature review, using the benefits and harms listed above.

460. Disposition of Comments for CER 147 Menopausal Symptoms: Comparative Effectiveness of Therapies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause_disposition-comments.pdf
     March 05, 2015 - Key questions 3 (potential benefits and harms beyond symptoms of non- HT agents) and 4 (analysis of … Authors should specifically note that this review does not address the benefits and harms of available … In “Limitations of the Evidence Base on Other Benefits and Harms” this seems like an ideal place to … It is unclear why the harms are depicted using a different pathway (swervy line) rather than another … The wiggly line is convention to designate harms.