-
effectivehealthcare.ahrq.gov/sites/default/files/prostate-cancer-therapies-summary.pdf
September 01, 2020 - prostatectomy (RP) may reduce
mortality and metastases more than watchful waiting (WW) but causes more harms … Harms were lowest with AM
compared with RP or EBR plus AD or AS versus photodynamic therapy. … Associated harms were unclear. … Harms are greater
with RP.
AM was compared with RP or EBR plus AD in PSA screen–detected CLPC. … However, it may
also result in an increase in harms.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain_executive.pdf
October 01, 2011 - Key Question Strength of Evidence Conclusion
GI and CV harms: Celecoxib High for GI harms vs.
nonselective … GI and CV harms: Partially
selective NSAIDs
GI harms: Moderate for
meloxicam and etodolac
(fewer trials … GI and CV harms:
Nonselective NSAIDs
GI harms: High for naproxen,
ibuprofen, and diclofenac
(consistent … Key Question Strength of Evidence Conclusion
GI and CV harms:
Nonselective NSAIDs
(continued)
CV harms … GI and CV harms: Aspirin Moderate for GI and CV
harms (many trials, but almost
exclusively in patients
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/should-subclinical-hypothroidism-be-treated
March 21, 2008 - how well the test, treatment, or intervention works There is significant potential for side effects/harms … Harms: Are there risks, side effects, or harms you are concerned about? … specify what those are:
There are potential harms … from treatment and potential harms from non treatment.
9. … What are the benefits and harms of treating patients with subclinical hypothroidism vs watchfull waiting
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-treatment_executive.pdf
May 01, 2013 - They were included for the assessment of
harms if they reported on harms of treatments for which
data … (continued)
Harms: Local Wound Applications
Dressings and topical therapies Moderate Harms reported … harms by ulcer characteristics. … harms by patient characteristics. … harms by patient care setting.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND__0250_05-20-2010.pdf
January 01, 2010 - What are the benefits and harms of rhythm control compared to rate control
(including newer agents)? … What are the benefits and harms of strict versus more
lenient rate control?
2. … What are the benefits and harms of different anticoagulation and antiplatelet agents
and monitoring … What are the benefits and harms of antiarrhythmic agents for acute conversion of
AF to sinus rhythm … What are the benefits and harms of ACEIs, ARBs and statins in the prevention of
new AF and progression
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-executive-170505.pdf
May 01, 2017 - High SOE
for clinically
significant harms
associated with
risperidone
Harms including weight gain … High SOE
for clinically
significant harms
associated with
aripiprazole
Harms including weight gain … Low SOE for
minimal harms
No clinically significant harms reported in any study
N-acetylcysteine … Low SOE for
minimal harms
No study reported harms considered clinically
important
Table B. … Harms reporting varied across studies; some studies
amply described how harms were tracked, while others
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0024_06-09-2008.pdf
January 01, 2008 - effects of treating older patients with antipsychotics and requests
information on the benefits and harms … ), do the typical and atypical
antipsychotic drugs differ in benefits (efficacy, effectiveness) or harms … schizophrenia, do the atypical
antipsychotic drugs differ in benefits (efficacy, effectiveness) or harms … ,
do the typical and atypical antipsychotic drugs differ in benefits (efficacy,
effectiveness) or harms … review from the EHC Program focus on key long-term, real life effectiveness
trials and comparative harms
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/research-protocol-osteoporosis_2.pdf
October 05, 2018 - Osteoporosis treatment harms vary by drug class. … >100 subjects for rare
harms and >1000 subjects
for other harms
KQ 5:
Effect of
drug
treatment … Timing Setting Study Design
KQ 7:
Harms of
drug
treatment
holidays
KQ8:
Predictors
of harms … >100 subjects for rare
harms and >1000 for other
harms
Abbreviations: ALP = alkaline phosphatase … )
• Harms (Serious adverse events and specific harms as listed in Table 2)
Outcome
predictors
(
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-care-key-questions.pdf
January 01, 2022 - the
state of the science related to the effectiveness of TIC on health and healthcare
outcomes and harms … What is the evidence of benefits and/or harms of TIC on outcomes for
patients/clients?
1a. … What is the evidence of benefits and/or harms of TIC on outcomes for
patients/clients?
2a. … of TIC
(KQ1)
Youth (children and adolescents),
effectiveness and harms of TIC (KQ2)
Population … of TIC
(KQ1)
Youth (children and adolescents),
effectiveness and harms of TIC (KQ2)
Intervention
-
effectivehealthcare.ahrq.gov/health-topics/urethral-disorders
September 15, 2014 - Chronic Urinary Retention: Comparative Effectiveness and Harms of Treatments
Systematic Review
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/what-is-the-most-effective-therapy-for-a-depressed-patient-who-has-not-responded-to-an-ssri
March 17, 2008 - how well the test, treatment, or intervention works There is significant potential for side effects/harms … Screening or diagnosis/identification for a particular disease, or risk assessment for a disease Risks or harms … Harms: Are there risks, side effects, or harms you are concerned about? … specify what those are:
There are potential harms … to the different treatment options and there are potential harms of inadequate treatmeent.
9.
-
effectivehealthcare.ahrq.gov/sites/default/files/communicating_risk_international_king.ppt
January 01, 2005 - Explicit approach to translation of evidence (but not rating of strength)
Explicit description of harms … (not available for review)
Approach to translating evidence not described
Included description of harms … How does product discuss strength of evidence about benefits and/or harms? … NZGG:
HRT—New Information for Women
Appropriate Audience Compare Alternatives Benefits and Harms … Pain Guidelines Group:
Acute Low Back Pain
Appropriate Audience Compare Alternatives Benefits and Harms
-
effectivehealthcare.ahrq.gov/health-topics/urine-and-urination
September 15, 2014 - Chronic Urinary Retention: Comparative Effectiveness and Harms of Treatments
Systematic Review
-
effectivehealthcare.ahrq.gov/products/multiple-sclerosis/research
April 28, 2015 - disease-modifying treatment (DMT) for multiple sclerosis (MS) by examining the long-term benefits and harms … information: 16 of these contained complete information to allow full analysis of long-term benefits and harms … Limited low-strength evidence suggests that long-term harms do not differ from short-term harms.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-234-headaches-pregnancy-summary.pdf
November 01, 2020 - A single primary study provided insufficient (direct) evidence to make
conclusions about the harms … The
uncertainty about the comparative effectiveness and harms of various treatment options
underscores … ;
fetal/child harms were not reported. … No indirect evidence regarding harms of nonpharmacologic interventions
in pregnancy was identified … For
additional information on harms, we also searched for relevant SRs of interventions in
women in
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-234-headaches-pregnancy-summary.pdf
November 01, 2020 - A single primary study provided insufficient (direct) evidence to make
conclusions about the harms … The
uncertainty about the comparative effectiveness and harms of various treatment options
underscores … ;
fetal/child harms were not reported. … No indirect evidence regarding harms of nonpharmacologic interventions
in pregnancy was identified … For
additional information on harms, we also searched for relevant SRs of interventions in
women in
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND__0355_09-22-2010.pdf
January 01, 2010 - Anonymous individual
Nomination
Summary:
The nominator questions the comparative effectiveness and harms … to another insomnia intervention
Outcome(s): Quality of life, sleep quality, fatigue, and harms … For patients with insomnia, how do commonly used medications compare for
effectiveness and harms, including … Insomnia can be associated with various harms,
including decreased quality of life, cognitive deficits … A review on this topic will help to compare the relative
benefits and harms of these interventions.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - Harms of tricyclic antidepressants versus placebo
Author, Year Quality Pain Population Drug Class Drug … Harms of pregabalin versus placebo
Author, Year Quality Pain Population Drug Class Drug Assessment Time … Harms of pregabalin CR versus IR
Author, Year Quality Pain Population Drug Class Drug Assessment Time … Harms of cannabis versus placebo
Author, Year Quality Pain Population Drug Assessment Time (Wk) Time … Harms of lidocaine patch versus placebo
Author, Year Quality Pain Population Drug Assessment Time (Wk
-
effectivehealthcare.ahrq.gov/products/depression-postpartum-screening/research
April 09, 2013 - Structured Abstract
Objectives
To describe the benefits and harms of specific tools and strategies … evaluated the performance of screening instruments for postpartum depression, potential benefits and harms … estimate the effects of screening for postpartum depression on the overall balance of benefits and harms … Because the balance of benefits and harms, at both the individual level and health system level, is highly
-
effectivehealthcare.ahrq.gov/products/ear-infection/research
May 04, 2013 - Structured Abstract
Objectives
To compare benefits and harms of strategies currently in use for managing … We compared benefits and harms among these treatments: tympanostomy tubes (TT), myringotomy (myr), adenoidectomy … Findings are reported for clinical and functional outcomes, and harms. … adenoid reduce OME and improve hearing in the short term, but both treatments also have associated harms