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Total Results: 1,494 records

Showing results for "harms".

241. Methods-Guidance-Applicability Methods (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-applicability_methods.pdf
     January 01, 2011 - Reviews are systematic reviews of existing research on the effectiveness, comparative effectiveness, and harms … Even when an intervention has constant relative effects, the absolute benefits and harms will vary among … Thus, the balance of benefits and harms in the study are likely to overestimate those that would be … the same collection of studies is used to answer multiple questions (for example, the benefits and harms … AHRQ series paper 4: assessing harms when comparing medical interventions: AHRQ and the Effective

242. uterine-fibroids-protocol-160301 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/uterine-fibroids_research-protocol.pdf
     March 01, 2016 - In addition, the Key Questions address the potential harms associated with morcellation, as well as … What is the comparative effectiveness (benefits and harms) of treatments for uterine fibroids, including … in Source: www.effectivehealthcare.ahrq.gov Published online: March 1, 2016 4   addition to harms … We will prespecify the harms that we will extract and will use consistent and precise terminology for … We will use an adapted version of the McMaster Quality Assessment Scale of Harms tool to assess harms

243. Methods Guide Atkins (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methods_guide_atkins.pdf
     January 01, 2011 - Reviews are systematic reviews of existing research on the effectiveness, comparative effectiveness, and harms … Even when an intervention has constant relative effects, the absolute benefits and harms will vary among … Thus, the balance of benefits and harms in the study are likely to overestimate those that would be … the same collection of studies is used to answer multiple questions (for example, the benefits and harms … AHRQ series paper 4: assessing harms when comparing medical interventions: AHRQ and the Effective

244. Effectiveness of Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypothyroidism-hyperthyroidism-screening-treatment_disposition-comments.pdf
     February 01, 2012 - are not sure this "skews the review" since the review is not evaluating the overall benefits and harms … of screening, but rather the benefits and harms of screening to detect borderline abnormal TSH values … elderly where given the noted findings of overtreatment (and subsequent harms related to this)...less … Peer Reviewer #4 Introduction p. 14, line 3--suggest inserting "of screening" between harms and of … Peer Reviewer #6 General Comments Review of harms associated with subclinical thyroid dysfunction

245. Pharmacologic Management of Acute Pain by EMS in the Prehospital Setting Protocol Amendment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-ems-protocol-amendment.pdf
     January 28, 2019 - Potential issues include direct harms of prehospital analgesia to the EMS provider themselves. … How do harms vary by patient characteristics? KQ2b. … How do harms vary by routes of administration, dosing, and timing? KQ2c. … How do harms vary by patient characteristics? KQ4b. … How do harms vary by routes of administration, dosing, and timing?

246. Stem-Cell-Children Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_executive.pdf
     February 01, 2012 - malignancies) might be mitigated.7,8,9,10 The Key Questions for this review compared benefits and harms … For pediatric patients with malignant solid tumors, what are the comparative harms of HSCT and conventional … For pediatric patients with inherited metabolic diseases, what are the comparative harms of HSCT, ERT … For pediatric patients with autoimmune diseases, what are the comparative harms of HSCT, immunosuppressants … main consideration in this systematic review was the comparative balance of long-term benefits and harms

247. C- Evidence-based Practice Center Technical Brief Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-disorders-imaging_research-protocol.pdf
     August 05, 2010 - this technical brief is to describe the current state of use, enumerate the potential benefits and harms … 1: What are the operating principles of positional MRI, and what are the potential benefits and harms … What are the potential safety issues and harms of positional MRI technologies? … For potential harms with positional MRI instrumentation, we will query the FDA Manufacturer and User … Moreover, we will record the outcomes being assessed in each study, including testing related harms,

248. Management of Infantile Hemangioma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_clinician.pdf
     June 01, 2016 - However, few studies have assessed potential long-term harms associated with beta-blocker use in infants … There was moderate SOE that steroids were associated with harms — some of which may be short lived … a systematic review evaluating the evidence regarding the efficacy, comparative effectiveness, and harms … ��Evidence related to the effectiveness and harms of beta- blockers other than propranolol and timolol … ��Few studies have assessed the potential long-term harms associated with using beta-blockers to treat

249. Treatment of Stage I-III Squamous Cell Anal Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/anal-cancer-protocol.pdf
     September 26, 2023 - Purpose of this review This systematic review will assess the effectiveness and harms of treatment … Several commenters noted lack of completed RCTs or other credible evidence for effectiveness and harms … What are the effectiveness and harms of different radiation therapy doses, volumes, and fractionation … What are the effectiveness and harms of different combinations of chemotherapy and radiation therapy … What are the effectiveness and harms of immunotherapy for initial treatment of stages I-III squamous

250. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-2007_executive.pdf
     January 01, 2007 - This review summarizes the evidence on the comparative long-term benefits and harms of ACEIs vs. … strength of evidence and brief conclusions from this review of the comparative long-term benefits and harms … Evidence on comparative long-term benefits and harms of ACEIs vs. … Evidence on comparative long-term benefits and harms of ACEIs vs. … treatment of essential hypertension, there is a paucity of comparative evidence for long-term benefits and harms

251. Psychosocial and Pharmacologic Interventions for Disruptive Behavior Disorders in Children and Adolescents: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_clinician.pdf
     August 01, 2016 - medications reported in included studies were mild or moderate, but the ability of the studies to detect harms … partially mediate effectiveness. �� Given that studies of pharmacologic interventions were short term, harms … Note: Clinicians are advised to refer to harms data from other sources that might include more extensive … inform decisions about treatment and therapy. �� The long-term effectiveness and potential long-term harms … certain treatment approach might be suitable for a given patient �� The available evidence for the harms

252. Interventions for Breathlessness in Patients With Advanced Cancer: Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
     November 01, 2020 - American Society for Clinical Oncology prepare a clinical practice guideline on comparative benefits and harms … What are the harms of nonpharmacological and pharmacological interventions for improving breathlessness … • Few studies reported harms, which limited our ability to draw conclusions Pharmacological interventions

253. Executive Summary_Comparative Effectiveness Review No. 252: Management of Infantile Epilepsies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-252-infantile-epilepsies-executive-summary.pdf
     October 01, 2022 - Thus, providers and caregivers must balance seizure control with the potential harms of treatment. … dietary treatments, and 12 studies of surgery met inclusion criteria for our examination of treatment harms … Only pharmacotherapy studies collected and reported harms systematically.

254. Recombinant-Factor-Viia Clinician (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/recombinant-factor-viia_clinician.pdf
     October 01, 2010 - Usual Care Evidence on Harms vs. … ) bleeding control by itself is not enough to influence direct outcomes, or 2) the risk of overall harms … How is it being used, and what is the evidence of benefits and harms for treated patients?

255. Binge-Eating Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/binge-eating_executive.pdf
     December 01, 2015 - all harms were limited to pharmacotherapy intervention trials (reported in 33 trials). … Harms associated with treating BED patients and discontinuations from studies attributable to harms … Evidence for Harms Associated With Treatments for Binge-Eating Disorder We identified potential harms … In addition, we found that harms were measured in only pharmacotherapeutic treatments. … Overall, treatment benefits outweighed harms; harms were limited to medications and were severe and

256. Disposition of Comments: CER 228, Nonopioid Pharmacologic Treatments for Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-228-nonopioid-pharm-chronic-pain-comments.pdf
     April 16, 2020 - Nice job including information on potential harms of treatment as well as information on withdrawals … Although evidence was limited, serious harms were not reported with the interventions. … NSAID, acetaminophen, etc.), examining outcomes, harms and effectiveness. … no evidence of harms from noninvasive nonpharmacological treatments, to modest harms associated with … nonopioid pharmacologic treatments, to the potential for serious harms from opioid therapy if safe

257. Pharmacotherapy for Adults with Alcohol-Use Disorders in Outpatient Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy-surveillance.pdf
     September 01, 2017 - o Original conclusions are likely current for harms and comparative harms of medications approved for … • The harms of baclofen may not be current. … The original SR did not report on harms of baclofen. … In the prior SR, no studies reported harms. … Yes Likely current Quetiapine No studies reported harms.

258. Trauma Informed Care: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-informed-care-executive-summary.pdf
     January 01, 2025 - components are defined and operationalized, and the state of the evidence on effectiveness and potential harms … Studies did not report harms, adverse events, or unintended consequences of TIC. … operationalized, TIC is being widely implemented; yet research on TIC’s effectiveness and potential harms

259. EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-computerized-cds-protocol.pdf
     May 08, 2023 - What is the rationale for using computerized clinical decision support to prevent or mitigate the harms … For topics that focus on a PSP that may address a variety of different harms, we will answer Review … Questions 1 and 2 by focusing on the harms and patient safety measures or indicators that are addressed … the review questions, and will include author, year, study design, frequency and severity of the harms … 1 and 2 by focusing on the harms and patient safety measures or indicators that are addressed in the

260. FRN 35 - Preventive Pharmacological Treatments for Migraine in Adults: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-future_research.pdf
     April 01, 2013 - Data from these RCTs and additional eligible nonrandomized studies was synthesized for harms. … (I, C) • What is the dose response relationship on harms for prevention of episodic migraine? … Harms related to intervention not typically life threatening. … (P) Harms of Treatment E16. … (P) Harms of Treatment C16.